Article
Endocrinology & Metabolism
Nipith Charoenngam, Caroline M. Apovian, Chatlert Pongchaiyakul
Summary: This study aims to determine the association of lean mass and fat mass with bone mineral density in Thais. The results show that in men, lean mass index is positively correlated with lumbar spine and femoral neck bone density, while fat mass index is negatively correlated with femoral neck bone density. In women, both lean mass and fat mass index are positively correlated with lumbar spine and femoral neck bone density. These findings indicate a sex-specific influence of fat mass on bone density in Thais.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biophysics
Dermot O'Rourke, Belinda R. Beck, Amy T. Harding, Steven L. Watson, Peter Pivonka, Saulo Martelli
Summary: This study aimed to determine the principal changes in bone mineral density (BMD) and geometry induced by exercise that have the greatest effect on femoral neck strength. The results showed that changes in the superior neck and distal cortex were most important during single-leg stance, while the superior neck, medial head, and lateral trochanter were most important during a sideways fall. Exercise interventions targeting BMD changes in specific regions can improve femoral neck strength in different scenarios.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Orthopedics
Ning Xia, Yun Cai, Wei Wang, Chen Bao, Yunming Li, Qingyun Xie, Wei Xu, Da Liu
Summary: This study aimed to investigate the relationship between bone-related biomarkers and femoral neck bone mineral density (BMD) and maximum load (L-max), in order to find an indicator that can reflect femoral neck bone loss and reduced bone strength. The results showed that serum CTX was more sensitive to differences in bone mass and bone strength of femoral neck compared to other indicators, and it could be considered as a surrogate marker for OPN and COL-I. Early measurement of CTX could facilitate the diagnosis of osteopenia and provide a theoretical basis for delaying the occurrence of femoral neck OP and fragility fractures.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Endocrinology & Metabolism
Xiaoqin Lu, Jiapei Wei, Yupeng Liu, Yangzhen Lu
Summary: This meta-analysis of 10 randomised controlled trials suggests that exercise has a statistically significant, but relatively mild, improvement effect on bone mineral density in middle-aged and older men, indicating that exercise has the potential to be a safe and effective way to prevent bone loss in men.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Endocrinology & Metabolism
Song Chen, Changhua Zheng, Tianlai Chen, Jinchen Chen, Yuancheng Pan, Shunyou Chen
Summary: Our study found no association between genetically predicted milk consumption and bone mineral density. However, in women, higher genetically predicted milk intake was positively associated with increased bone mineral density in the femoral neck.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Hikaru Otsuka, Hiroki Tabata, Huicong Shi, Hideyoshi Kaga, Yuki Someya, Abudurezake Abulaiti, Hitoshi Naito, Futaba Umemura, Saori Kakehi, Muneaki Ishijima, Ryuzo Kawamori, Hirotaka Watada, Yoshifumi Tamura
Summary: The study found that women with exercise habits in both adolescence and old age have a lower prevalence of osteoporosis and higher lumbar spine bone density. Men with exercise habits in old age have significantly higher lumbar spine bone density compared to those without, but there was no significant association between exercise habits and osteoporosis prevalence in men.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Melanie Kistler-Fischbacher, Benjamin K. Weeks, Belinda R. Beck
Summary: This systematic review evaluates the effects of exercise on bone health in postmenopausal women, suggesting that moderate to high intensity interventions, especially those combining resistance and impact training, are most beneficial for bone mass. Only high intensity exercise appears to improve structural parameters of bone strength, while low and moderate intensity interventions do not show notable benefits. The heterogeneity in study quality and outcomes limits the ability to draw strong conclusions.
Article
Endocrinology & Metabolism
Carrie-Anne Ng, David Scott, Markus J. Seibel, Robert G. Cumming, Vasi Naganathan, Fiona M. Blyth, David G. Le Couteur, Louise M. Waite, David J. Handelsman, Vasant Hirani
Summary: High-impact physical activities with bone strains of high magnitude and frequency can benefit bone health in older men. Engaging in activities with high and rapid impact helps maintain higher bone mineral density and reduce the risk of falls, while high energy expenditure is associated with a reduced falls risk. Integrating traditional physical activity data with bone loading estimates may enhance the understanding of the relationships between physical activity and bone health.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Irene Zolfaroli, Ester Ortiz, Miguel-Angel Garcia-Perez, Juan Jose Hidalgo-Mora, Juan J. Tarin, Antonio Cano
Summary: This study found a positive association between high-density lipoprotein cholesterol (HDL-C) levels and bone mineral density (BMD) at the lumbar spine and femoral neck in postmenopausal women, while other lipid parameters did not show significant associations. Additionally, factors such as age and body mass index were also related to BMD.
Article
Orthopedics
Jun Chen, Liming Zhu, Xiaocong Yao, Zhongxin Zhu
Summary: This study evaluated the association between waist circumference (WC) and femoral neck bone mineral density (BMD) among older adults using the NHANES database. The results showed a positive correlation between WC and femoral neck BMD in non-adjusted models, but a negative correlation after adjusting for body mass index (BMI). Subgroup analysis revealed that this negative correlation was only present in men. Furthermore, an inverted U-shaped curve relationship between WC and femoral neck BMD was identified.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Medicine, General & Internal
Kazuyoshi Shigehara, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami
Summary: Bone fracture due to osteoporosis is a significant issue for elderly men, and testosterone replacement therapy has shown benefits in improving bone mineral density in symptomatic hypogonadal men with osteopenia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Michelle Mages, Mahdieh Shojaa, Matthias Kohl, Simon von Stengel, Clemens Becker, Markus Gosch, Franz Jakob, Katharina Kerschan-Schindl, Bernd Kladny, Nicole Kloeckner, Uwe Lange, Stefan Middeldorf, Stefan Peters, Daniel Schoene, Cornel C. Sieber, Reina Tholen, Friederike E. Thomasius, Michael Uder, Wolfgang Kemmler
Summary: Evidence for the effect of exercise on Bone Mineral Density (BMD) in men is limited compared to postmenopausal women. The study found a low but significant impact of exercise on BMD in men, with no specific exercise recommendations currently available for male cohorts.
Article
Biochemistry & Molecular Biology
Ewa Jowko, Barbara Dlugolecka, Igor Cieslinski, Jadwiga Kotowska
Summary: The aim of this study was to identify relevant factors that affect bone mineral content (BMC) and bone mineral density (BMD) in young, healthy men reaching peak bone mass. The results showed that age, BMI, engaging in combat and team sports at a competitive level, and certain genetic polymorphisms were significant predictors of BMD/BMC at different skeletal sites. Specifically, the SOD2 AG genotype was associated with lower BMC values, while the VDR FokI GG genotype was associated with lower BMD. However, the CALCR AG genotype was linked to higher arm BMD. These findings suggest that sports training may mitigate the negative impact of genetic factors on bone tissue and reduce the risk of osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Xin-ping Li, Ping Zhang, Shi-wen Zhu, Ming-hui Yang, Xin-bao Wu, Xie-yuan Jiang
Summary: The mortality rate is high after hip fractures, but the 1-year mortality rate differs between intertrochanteric fractures and femoral neck fractures. Older age and high Charlson comorbidity index score are risk factors for intertrochanteric fractures, while treatment with zoledronic acid can improve survival rate. In femoral neck fracture patients, physicians should pay careful attention to male patients, older patients, and those with high numbers of comorbidities.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Multidisciplinary Sciences
Chen Deng, Jason C. Gillette, Timothy R. Derrick
Summary: This study recruited older and young adults to estimate femoral neck stress during stair ascent and descent. Different stress patterns were found for different age groups at different peaks during stair ascent, providing valuable information for hip fracture prevention and design of osteogenic exercises.
Article
Sport Sciences
Laura Keylock, Paul Felton, Peter Alway, Katherine Brooke-Wavell, Nicholas Peirce, Mark King
Summary: This study investigates lumbar bone mineral density adaptation in adolescent cricket fast bowlers and its relationship with fast bowling technique. Thoracolumbar and lumbopelvic motion are implicated in the etiology of the unique lumbar bone adaptation observed in fast bowlers whereas vertical ground reaction force, independent of body mass, was not.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Sport Sciences
Thomas G. Balshaw, Garry J. Massey, Thomas M. Maden-Wilkinson, Marcel B. Lanza, Jonathan P. Folland
Summary: This cross-sectional study compared explosive strength and underlying muscular characteristics between long-term maximum strength-trained and untrained individuals. The study found that long-term maximum strength-trained individuals had greater maximum voluntary torque, muscle size, and absolute explosive torque compared to untrained individuals. However, their relative explosive torque and evoked torque were lower, indicating slower contractile properties.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Physiology
Emmet J. Mc Dermott, Thomas G. Balshaw, Katherine Brooke-Wavell, Thomas M. Maden-Wilkinson, Jonathan P. Folland
Summary: This study compared the neuromechanics of different types of concentric isoinertial resistance training contractions in older adults. The results showed that fast/ballistic contractions produced significantly greater power, force, velocity, and muscle activation, making them a more effective stimulus for training neuromuscular power in older adults.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Sport Sciences
Peter Alway, Thamindu Wedatilake, Nicholas Peirce, Anna Warren, Mark King, Katherine Brooke-Wavell
Summary: The aim of this study was to investigate if there are differences in bone mineral density (BMD) and bone asymmetry among female cricket fast bowlers, spin bowlers, and batters. The results showed that all cricketers had higher BMD at the total body, lumbar spine, and proximal femurs compared to a reference population. Fast bowlers had significantly greater BMD on the contralateral side of the lumbar spine, suggesting asymmetry in lumbar loading patterns.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Neurosciences
Rachel Malcolm, Simon Cooper, Jonathan P. Folland, Christopher J. Tyler, Caroline Sunderland
Summary: This study demonstrates the effects of a competitive hockey match on cognition, including improved response times for simple perception tasks and complex executive function tasks during the match, but decreased working memory at the end of the match. These findings have implications for performance optimization and strategies to improve cognitive domains.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Daniela Souza de Oliveira, Andrea Casolo, Thomas G. Balshaw, Sumiaki Maeo, Marcel Bahia Lanza, Neil R. W. Martin, Nicola Maffulli, Thomas Mehari Kinfe, Bjoern M. Eskofier, Jonathan P. Folland, Dario Farina, Alessandro Del Vecchio
Summary: This study systematically investigated the anatomical and neural factors influencing high-density surface electromyography (HD-sEMG) decomposition. The results showed that anatomical factors such as subcutaneous tissue thickness, distribution of motor unit territories, and maximum anatomical cross-sectional area have a significant impact on the accuracy of HD-sEMG decomposition.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Physiology
Thomas G. Balshaw, Mark P. Funnell, Emmet McDermott, Thomas M. Maden-Wilkinson, Sean Abela, Btool Quteishat, Max Edsey, Lewis J. James, Jonathan P. Folland
Summary: This study found that supplementation with bioactive collagen peptides (CP) can enhance the functional, structural, and contractile adaptations of skeletal muscle to resistance training (RT). CP supplementation can increase muscle volume and strength, with a more pronounced effect on quadriceps remodeling.
Article
Sport Sciences
Jakob Skarabot, Jonathan P. Folland, Jules Forsyth, Apostolos Vazoukis, Ales Holobar, Alessandro Del Vecchio
Summary: This study examined the motor unit (MU) discharge properties and MU conduction velocity in long-term resistance-trained (RT) and untrained (UT) men. The results showed that both groups had similar MU discharge characteristics during maximal and submaximal contractions, while the RT group had higher MU conduction velocity, which may explain the strength difference between the two groups.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vijay Papineni, Sharon Dieu, Winston Joseph Rennie
Summary: This article reports a case of cutaneous furuncular myiasis caused by the human botfly, which was confirmed using ultrasound and treated with surgery. The aim of the article is to raise awareness of this condition.
INDIAN JOURNAL OF RADIOLOGY AND IMAGING
(2023)
Article
Sport Sciences
Benjamin W. C. Jerome, Michael Stoeckl, Ben Mackriell, Thomas Seidl, Christian W. W. Dawson, Daniel T. P. Fong, Jonathan P. P. Folland
Summary: This study investigated the effect of match structure variables on the physical demands and intensity of elite soccer. The study found that physical demands were higher when the ball was in play compared to when it was out of play. Additionally, possession of the ball also influenced physical intensity, with higher rates of distance covered during possession.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Neurosciences
Andrea Casolo, Sumiaki Maeo, Thomas G. Balshaw, Marcel B. Lanza, Neil R. W. Martin, Stefano Nuccio, Tatiana Moro, Antonio Paoli, Francesco Felici, Nicola Maffulli, Bjoern Eskofier, Thomas M. Kinfe, Jonathan P. Folland, Dario Farina, Alessandro Del Vecchio
Summary: By combining non-invasive high-density surface EMG with muscle biopsy, the study investigated the relation between motor unit conduction velocity and muscle fibre diameter in the biceps brachii muscle. The results show the possibility of estimating muscle fibre size using conduction velocity estimates with low bias and individual error.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Sport Sciences
Emmet J. Mc Dermott, Thomas G. Balshaw, Katherine Brooke-Wavell, Thomas M. Maden-Wilkinson, Jonathan P. Folland
Summary: A prior eccentric lowering phase before a concentric lift can improve muscle power and velocity in older adults, making it an important component of resistance exercise for this population.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Sport Sciences
Mark J. Hutson, Emma O'Donnell, Katherine Brooke-Wavell, Lewis J. James, Conor J. Raleigh, Brian P. Carson, Craig Sale, Richard C. Blagrove
Summary: Low energy availability (LEA) is common in active individuals and has negative impact on bone turnover in young females. High-impact exercise can promote bone health and may be beneficial during LEA periods. Restricting energy intake for 3 days reduces morning basal bone formation rate, but high-impact jumping can prevent an increase in bone resorption rate and benefit long-term bone health.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Sport Sciences
Laura Keylock, Peter Alway, William Johnson, Nicola Crabtree, Mark King, Nicholas Peirce, Katherine Brooke-Wavell
Summary: Elite adult male fast bowlers have high lumbar spine bone mineral, particularly on the contralateral side to their bowling arm. The study found that lumbar vertebral adaptation to fast bowling substantially increased with age, especially on the contralateral side.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.