Article
Orthopedics
Ruijie Xie, Xiongjie Huang, Qianlong Liu, Mingjiang Liu
Summary: This study found a positive relationship between HDL-C levels and lumbar bone mineral density (BMD) in individuals aged 20-59. The relationship was maintained in women and blacks but not in men and whites. In men and whites, the relationship followed a U-shaped curve with the same inflection point of 0.98 mmol/L. HDL-C measurement could be used as a sensitive biomarker for early detection of osteoporosis and guiding therapy.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yuchen Tang, Shenghong Wang, Qiong Yi, Yayi Xia, Bin Geng
Summary: This study found an inverse correlation between HDL-C levels and BMD, especially prominent in females, where high HDL-C levels may indicate an increased risk of osteoporosis, requiring close monitoring of BMD and early intervention.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Medicine, General & Internal
Ruijie Xie, Xiongjie Huang, Ya Zhang, Qianlong Liu, Mingjiang Liu
Summary: This study found a negative relationship between low-density lipoprotein cholesterol (LDL-C) and lumbar bone mineral density (BMD) in individuals aged 20 to 59. This negative relationship was present in different genders and races, except for Blacks and other races. In other races, the relationship between LDL-C and BMD followed an inverted U-shaped curve.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xin Zhao, Jianbin Sun, Sixu Xin, Xiaomei Zhang
Summary: This study analyzed the association between blood lipid metabolism and osteoporosis (OP) in older adults with type 2 diabetes mellitus (T2DM). The results showed that higher levels of low-density lipoprotein cholesterol (LDL-C) were associated with OP, while higher levels of high-density lipoprotein cholesterol (HDL-C) were associated with non-osteoporotic patients. Age, parathyroid hormone (PTH), total cholesterol (TC), and LDL-C were negatively linked to bone mineral density (BMD), while body mass index (BMI), uric acid (UA) level, HDL-C level, and glomerular filtration rate (eGFR) were positively related to BMD. In postmenopausal women, raised LDL-C was an independent risk factor for OP, while raised HDL-C was protective. Conclusion: Blood lipid levels are related to sex in older T2DM patients, with HDL-C being a protective factor for OP in both men and women, and LDL-C being a predictor for OP in postmenopausal women.
Article
Endocrinology & Metabolism
Pei Yang, DongDong Li, Xiaokang Li, Zongbiao Tan, Huan Wang, Xiaona Niu, Yang Han, Cheng Lian
Summary: This study investigated the relationship between HDL-C levels and intertrochanter bone mineral density. The results showed a negative correlation between HDL-C and intertrochanter BMD. Subgroup analysis revealed negative correlations among 60-70-year-olds, non-Hispanic whites, and obese individuals. The relationship between HDL-C and intertrochanter BMD was an inverted U-shaped curve in men and hormone users, and a U-shaped curve in other Hispanic and premenopausal individuals.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Patricia Paula da Fonseca Grili, Camila Vilarinho Vidigal, Geise Ferreira da Cruz, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Taisa Sabrina Silva Pereira, Valdete Regina Guandalini
Summary: This study aimed to identify nutrient patterns (NPs) and their association with bone mineral density (BMD) categories in postmenopausal women. The results showed that lower consumption of NP1 and NP2 was associated with an increased risk of osteopenia, but not osteoporosis.
Article
Orthopedics
Xiaozhi Sun, Xiaotao Wu
Summary: Higher levels of apolipoprotein A1 (ApoA1) are associated with increased risk of osteoporosis, indicating the involvement of lipid metabolism in bone metabolism.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Immunology
Anjali Sharma, Donald R. Hoover, Qiuhu Shi, Phyllis C. Tien, Kathleen M. Weber, Jayesh G. Shah, Michael T. Yin
Summary: Among pre-, peri-, and postmenopausal women, low bone mineral density (BMD) was more common in women with HIV compared to those without HIV. HIV infection and menopausal stage were independent predictors of lower BMD and had additive effects on lumbar spine and total hip BMD.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Nutrition & Dietetics
Briana M. Nosal, Junichi R. Sakaki, Zachary Macdonald, Kyle Mahoney, Kijoon Kim, Matthew Madore, Staci Thornton, Thi Dong Binh Tran, George Weinstock, Elaine Choung-Hee Lee, Ock K. Chun
Summary: This study aimed to examine the dose-dependent effects of blackcurrant supplementation on preventing bone loss in adult women. The results showed that blackcurrant supplementation decreased the loss of whole-body bone mineral density and increased the marker of bone formation, P1NP. Further studies with larger samples and different skeletal conditions are needed to confirm these findings.
Article
Orthopedics
Peng Gu, Bin Pu, BaiHang Chen, XiaoHui Zheng, ZhanPeng Zeng, WeiDong Luo
Summary: This study investigated the relationship between serum high-density lipoprotein (HDL-C) and spinal bone mineral density (BMD) in adults over 40 years old under different serum 25-hydroxyvitamin D (25 (OH) D) levels. It was found that in females aged 40-59 years with vitamin D insufficiency or deficiency, higher serum HDL-C was associated with lower total spinal BMD. However, no similar relationship was found in populations with sufficient vitamin D levels or in males with vitamin D insufficiency or deficiency.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Medicine, General & Internal
Wei Wang, Zhe Yuan Chen, Fen Yan Lv, Mei Tu, Xiu Li Guo
Summary: This study evaluates the correlation of serum HDL-c and apolipoprotein A1 (APOA1) with bone metabolism in Chinese postmenopausal women with type 2 diabetes mellitus (T2DM). The results show that APOA1 is more strongly associated with bone metabolism compared to HDL-c.
FRONTIERS IN MEDICINE
(2023)
Article
Orthopedics
Li Cao, Wei Wu, Xiangyu Deng, Haoyu Guo, Feifei Pu, Zengwu Shao
Summary: This study examined the relationship between total cholesterol and total bone mineral density (BMD) among 10,039 US participants. The results showed a negative correlation between total cholesterol levels and total BMD among participants aged 20-29 years. In other races, this relationship exhibited a nonlinear association, with an inflection point. Therefore, maintaining a reasonable total cholesterol level may be an approach to prevent osteoporosis or osteopenia in young adults and individuals with diabetes.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Medicine, General & Internal
Peng Wang, Cong Chen, Chunhao Song, Jun Jia, Yuanhao Wang, Weidong Mu
Summary: This study investigated the relationship between total cholesterol, triglycerides, and total lumbar bone mineral density (BMD) in adults. The results showed that high levels of total cholesterol and relatively low levels of triglycerides were significantly associated with total lumbar BMD in adults aged 50 years and over.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Lingnan Zhang, Qilong Liu, Xianshang Zeng, Wenshan Gao, Yanan Niu, Xiaoyong Ma, Huijun Xie, Xiaozhe Zhou, Weiguang Yu, Guixing Xu
Summary: The study found that low HDL and high LDL levels may be associated with the occurrence of osteoporosis in postmenopausal women.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Hassan Sadeghi, Alireza Ashraf, Neda Zeynali, Bahareh Ebrahimi, Deborah A. Jehu
Summary: This study found that the single leg stance test, timed-up-and-go test, and age are important factors in predicting bone mineral density in postmenopausal women. These results suggest that the prediction of bone mineral density is not only associated with age, but also closely related to balance and functional mobility.
Article
Geriatrics & Gerontology
Alicia Garcia-Vigara, Antonio Cano, Julio Fernandez-Garrido, J. A. Carbonell-Asins, Juan J. Tarin, M. Luz Sanchez-Sanchez
Summary: This study analyzed the association between the use of ICT (specifically internet functions and social media) and frailty status in postmenopausal midlife and elderly women. The study found that women who did not use ICT were more likely to be frail.
Review
Endocrinology & Metabolism
Pierluigi Moccia, Rocio Belda-Montesinos, Aitana Monllor-Tormos, Peter Chedraui, Antonio Cano
Summary: The menopausal transition is associated with an increase in adiposity, particularly in the abdominal area, and a decrease in lean mass. Changes in energy expenditure and food intake also play a role, with the estrogen receptor alpha isoform being a key factor in fat accrual. Additional hormonal factors, including androgens and FSH, may also contribute to changes in body composition during menopause.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Juan J. Tarin, Miguel A. Garcia-Perez, Antonio Cano
Summary: Scientific assessment on the use of postmortem sperm for reproductive purposes suggests that it is premature to apply this procedure clinically without appropriate and comprehensive analyses. Further studies should focus on potential postmortem alterations of sperm DNA, RNAs, and proteins, as well as genetic and epigenetic analyses of sperm, pre-implantation embryos, and newborns, utilizing non-human mammalian models.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Miguel A. Tejada, Ana I. Santos-Llamas, Lesley Escriva, Juan J. Tarin, Antonio Cano, Maria J. Fernandez-Ramirez, Paulina Nunez-Badinez, Bianca De Leo, Philippa T. K. Saunders, Victor Vidal, Florent Barthas, Katy Vincent, Patrick J. Sweeney, Rowland R. Sillito, James Douglas Armstrong, Jens Nagel, Raul Gomez
Summary: A new mouse model of endometriosis-associated pain, which evaluates non-evoked responses more relevant to the patient experience, was developed in this study. The model showed significant differences in pain responses and behavior measures between the endometriosis and control groups, providing a better preclinical platform for drug testing.
Review
Nutrition & Dietetics
Celia Bauset, Ana Martinez-Aspas, Sara Smith-Ballester, Alicia Garcia-Vigara, Aitana Monllor-Tormos, Fawzi Kadi, Andreas Nilsson, Antonio Cano
Summary: Menopause leads to a decrease in estrogen levels and an increase in fat content, increasing the risk of metabolic syndrome. Nut ingestion may help reduce the risk of metabolic syndrome, especially by improving lipid and carbohydrate metabolism.
Article
Geriatrics & Gerontology
Alicia Garcia-Vigara, Victor Martin-Gonzalez, Juan-Antonio Carbonell, Celia Bauset-Castello, Ana Martinez-Aspas, Aitana Monllor-Tormos, Miguel-Angel Garcia-Perez, Juan J. Tarin, Antonio Cano
Summary: This study investigated the usability of telephone-based telehealth in a women's health outpatient clinic and explored whether the severity of the COVID pandemic affected its usage. The results indicated that regardless of the pandemic stage, respondents preferred in-person visits.
Review
Biochemistry & Molecular Biology
Miguel A. Tejada, Carles Antunez, Paulina Nunez-Badinez, Bianca De Leo, Philippa T. Saunders, Katy Vincent, Antonio Cano, Jens Nagel, Raul Gomez
Summary: Chronic pain induced by endometriosis is a significant issue for women, but there is a lack of long-term pharmacological treatments that can relieve pain without affecting fertility. The absence of a reliable rodent model that replicates human physiopathological characteristics, including pain symptoms, has hindered progress in this field. This study reviewed the existing endometriosis models in rodents and examined the type of behavioral tests used to evaluate pain. The findings identified both reflex and non-reflex tests that can be utilized to study endometriosis-induced pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Alicia Garcia-Vigara, Aitana Monllor-Tormos, Miguel Angel Garcia-Perez, Juan J. Tarin, Antonio Cano
Summary: This study analyzed the association between genetic variants of the vitamin D receptor gene and dynapenia in postmenopausal women. The study found that the TT genotype of the rs11568820 SNP of the vitamin D receptor gene was associated with decreased grip strength in community-dwelling postmenopausal women.
Article
Pharmacology & Pharmacy
Serge Rozenberg, Nick Panay, Marco Gambacciani, Antonio Cano, Sarah Gray, Katrin Schaudig
Summary: Around 80% of women suffer from menopause-related symptoms, but only 20/30% seek treatment, leading to a lack of education for healthcare professionals and a decrease in MHT prescription. Experts propose strategies to overcome barriers, including providing appropriate training and education.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Ester Ortiz, Carlos J. Pena, Juan-Jose Hidalgo, Aitana Monllor-Tormos, Irene Zolfaroli, Maria-Jose Vila, Maria Sanchez-Serrano, Antonio Pellicer, Antonio Cano
Summary: Ovarian decortication plus chemotherapy has a detrimental effect on ovarian function, resulting in decreased ovarian reserve and primary ovarian insufficiency. Age is also a predictor of POI and irregular menstrual cycles.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Public, Environmental & Occupational Health
Juan J. Tarin, Eva Pascual, Miguel A. Garcia-Perez, Aitana Monllor-Tormos, Antonio Cano
Summary: There is an association between male and female infertility diagnoses and duration of infertility in couples seeking assisted reproductive technology (ART) treatment for the first time. Men with oligo-, astheno-, and teratozoospermia (ACOAT) have higher odds of having a duration of infertility > 2 years. Women from ACOAT couples with > 2 years of infertility have shorter menstrual cycles, lower antral follicular count (AFC) values, and lower serum anti-Mullerian hormone (AMH) levels.
REPRODUCTIVE HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Raul Gomez, Miguel A. Tejada, Victor Rodriguez-Garcia, Octavio Burgues, Ana I. Santos-Llamas, Andrea Martinez-Massa, Antonio Marin-Montes, Juan J. Tarin, Antonio Cano
Summary: The expression of RANK protein and mRNA in epithelial ovarian cancer shows a gradient change according to malignancy and tumor staging, and may be associated with disease evolution and tumor aggressiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Lum Kastrati, Dion Groothof, Hugo G. Quezada-Pinedo, Hamidreza Raeisi-Dehkordi, Lia Bally, Martin H. De Borst, Stephan J. L. Bakker, Pedro-Marques Vidal, Michele F. Eisenga, Taulant Muka
Summary: The study aimed to examine the association between iron biomarkers and menopausal status and assess whether these biomarkers can help differentiate menopausal status beyond age. The results showed that iron biomarkers were significantly associated with menopausal status in both cohorts and modestly improved a model with age alone for differentiating menopause status.
Article
Geriatrics & Gerontology
Osvaldo P. Almeida, Christopher Etherton-Beer, Frank Sanfilippo, David B. Preen, Amy Page
Summary: The use of antineoplastic medications has been found to be associated with a decreased risk of dementia, which may contribute to the development of novel approaches for dementia prevention.
Article
Geriatrics & Gerontology
Bamini Gopinath, Diana Tang, George Burlutsky, Paul Mitchell
Summary: This study used a cohort of community-dwelling adults to establish the 10-year incidence and predictors of dizziness/vertigo, and its impacts on health-related quality of life. The results showed that age and presence of migraine were significant predictors of incident dizziness/vertigo, and dizziness/vertigo was associated with a significant decrease in quality of life.
Article
Geriatrics & Gerontology
Yuto Kiuchi, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Kazuhei Nishimoto, Hyuma Makizako, Hiroyuki Shimada
Summary: This study found that high dietary diversity is associated with a lower risk of incident disability among sarcopenic Japanese older adults.
Article
Geriatrics & Gerontology
C. . Tamer Erel, Ipek Betul Ozcivit Erkan, Neslihan Gokmen Inan, Kubra Hamzaoglu Canbolat, Sena Alkan, Dildar Konukoglu, Yalim Dikmen
Summary: This study aimed to compare the clinical course and outcomes of Covid-19 between premenopausal and postmenopausal women, and investigate the factors that influence disease severity. The results showed that premenopausal women had a more favorable prognosis, and age, postmenopausal status, and serum levels of dehydroepiandrosterone sulfate were important predictors of the severity of Covid-19 in women.
Article
Geriatrics & Gerontology
Kazuhei Nishimoto, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Yuto Kiuchi, Hiroyuki Shimada
Summary: The combination of urinary incontinence and low life-space activity/mobility is associated with an increased risk of incident disability among older adults, while having urinary incontinence but high life-space activity/mobility is not associated with an increased risk of incident disability.
Review
Geriatrics & Gerontology
Nikolaos Evangelinakis, Eleni V. Geladari, Charalampia V. Geladari, Adamantia Kontogeorgi, Georgios-Konstantinos Papaioannou, Melpomeni Peppa, Sophia Kalantaridou
Summary: Premature ovarian insufficiency and ovarian aging are complex conditions that affect women's reproductive health and overall well-being. This review explores the influence of environmental factors, including endocrine-disrupting chemicals and lifestyle choices, on the development and progression of these conditions. Understanding the impact of environmental factors is important for public and clinical health contexts.
Article
Geriatrics & Gerontology
Adela Castello, Miguel Rodriguez-Barranco, Virginia Lope, Marcela Guevara, Sandra Colorado-Yohar, Ane Dorronsoro, Jose Ramon Quiros, Carlota Castro-Espin, Carmen Sayon-Orea, Carmen Santiuste, Pilar Amiano, Cristina Lasheras, Maria-Jose Sanchez, Marina Pollan
Summary: The study found that the intake of foods such as high-fat dairy products, red and processed meats, refined grains, sweets, caloric drinks, convenience food and sauces might be associated with a higher risk of breast cancer.