Article
Biochemistry & Molecular Biology
Marcella Reale, Erica Costantini, Lisa Aielli, Fabrizio Di Giuseppe, Stefania Angelucci, Mohammad A. A. Kamal, Nigel H. H. Greig
Summary: This study characterized the proteomic view of the hippocampus in a model of enhanced senescence and compared it with a model of normal aging. The results showed that increased neuroinflammation and changes in cholinergic components play important roles in age-related cognitive decline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
J. Roig-Soriano, C. Grinan-Ferre, J. F. Espinosa-Parrilla, C. R. Abraham, A. Bosch, M. Pallas, Miguel Chillon
Summary: This study investigated the expression of Klotho (KL) isoforms using AAV9 to prevent age-related features in a senescence-accelerated mouse model. The results showed that both secreted and transmembrane KL isoforms improved cognitive performance, physical state parameters, and various molecular variables associated with aging. The study also revealed the potential role of KL isoforms in epigenetic regulation and age-related bone structure alteration.
Article
Immunology
Andres Fernandez, Elena Quintana, Patricia Velasco, Belen Moreno-Jimenez, Belen de Andres, Maria Luisa Gaspar, Isabel Liste, Marcal Vilar, Helena Mira, Eva Cano
Summary: The study found that aged SAMP8 mice exhibit many features of aging-related neuroinflammation, including increased protein aggregates and elevated levels of inflammatory mediator IL-1 beta. Compared to the control group, SAMP8 mice showed a more significant neuroinflammatory response.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Endocrinology & Metabolism
Yuting Wang, Song Li, Liming Zhao, Peng Cheng, Jian Liu, Fengjing Guo, Jun Xiao, Wentao Zhu, Anmin Chen
Summary: Progressive bone loss during aging leads to osteoporosis, which is a common and impactful condition in elderly populations. This study found that a metabolite called itaconate plays a crucial regulatory role during inflammaging, inhibiting osteoclast activity and maintaining bone homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Michael J. Butler, Sabrina E. Mackey-Alfonso, Nashali Massa, Kedryn K. Baskin, Ruth M. Barrientos
Summary: Consumption of diets high in saturated fatty acids and/or refined carbohydrates is associated with negative effects on brain health, while diets rich in polyunsaturated fatty acids have protective effects. The study demonstrates that docosahexaenoic acid (DHA) can mitigate the harmful effects of palmitate, a saturated fat, on cellular responses in microglia and neurons.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Hasmik Jasmine Samvelyan, John Cummings Mathers, Timothy Michael Skerry
Summary: The study suggests that fasting/feeding interventions can enhance bone response to mechanical loading in young mice, but not in older mice. The endocrine responses to feeding timing differ between older and young mice, which may affect bone adaptation to loading.
Article
Chemistry, Medicinal
Dolors Puigoriol-Illamola, Julia Companys-Alemany, Kris McGuire, Natalie Z. M. Homer, Rosana Leiva, Santiago Vazquez, Damian J. Mole, Christian Grinan-Ferre, Merce Pallas
Summary: The study showed that inhibition of 11 beta-HSD1 with RL-118 alleviated the detrimental effects of chronic mild stress on cognition and behavior in SAMP8 mice, including epigenetic changes. Results indicated that RL-118 treatment reversed the effects of CMS on DNA methylation, hydroxymethylation, and histone phosphorylation, while also altering ROS-induced damage.
Review
Biochemistry & Molecular Biology
Ana Pinar-Gutierrez, Cristina Garcia-Fontana, Beatriz Garcia-Fontana, Manuel Munoz-Torres
Summary: Recent scientific evidence suggests that obese patients, especially those with higher visceral adipose tissue content, have an increased risk of fractures. This contradicts the belief that obesity offers protection against fractures. Obesity can accentuate age-related changes in older individuals, leading to a higher risk of falls and fractures. Factors such as chronic proinflammatory status, altered adipokine secretion, vitamin D deficiency, insulin resistance, and reduced mobility contribute to the greater risk in obese older individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Courtney L. Millar, Alyssa B. Dufour, James R. Hebert, Nitin Shivappa, Olivia Okereke, Douglas P. Kiel, Marian T. Hannan, Shivani Sahni, Roger Fielding
Summary: There is a correlation between a proinflammatory diet and increased risk of frailty, particularly among those with depressive symptoms. Further investigation is needed.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Immunology
Annika Doeding, Svenja Zimmermann, Ahmed Maghames, Michael Reimann, Judit Symmank, Maria Thuermer, Markus H. Graler, Michael Wolf, Collin Jacobs, Andreas Koeberle, Bernd Sigusch, Ulrike Schulze-Spate
Summary: This study investigates the effects of different dietary fatty acids on bone microarchitecture and inflammation in a mouse model of periodontal disease. The results suggest that an olive oil-based Mediterranean-style diet can mitigate the negative effects of saturated fatty acids on bone and promote bone tissue resilience after oral bacterial infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kristine Stromsnes, Angela G. Correas, Jenny Lehmann, Juan Gambini, Gloria Olaso-Gonzalez
Summary: Inflammation is a physiological process in the body's defenses and tissue repair, but chronic inflammation can stimulate the development of various diseases. As people age, inflammation becomes more chronic. Certain foods, like saturated fats, have pro-inflammatory activity.
Article
Biochemistry & Molecular Biology
Sixia Yang, Tingting Pei, Linshuang Wang, Yi Zeng, Wenxu Li, Shihua Yan, Wei Xiao, Weidong Cheng
Summary: The study found that Salidroside has a protective effect in aging-related renal fibrosis. It can reduce renal dysfunction, decrease mesangial hyperplasia, and regulate proteins related to ferroptosis.
Review
Biochemistry & Molecular Biology
Undurti N. Das
Summary: Lipids are crucial for cell membrane composition, with polyunsaturated fatty acids playing a key role. Aging cells often lack essential fatty acids and their metabolites, with changes in desaturase activity affecting cell health and disease development.
Article
Endocrinology & Metabolism
Kelsey M. Mangano, Sabrina E. Noel, Chao-Qiang Lai, Jacob J. Christensen, Jose M. Ordovas, Bess Dawson-Hughes, Katherine L. Tucker, Laurence D. Parnell
Summary: The study found a negative correlation between high intake of fruits and vegetables and osteoporosis prevalence. Metabolite analysis revealed biochemical processes such as caffeine metabolism and fatty acid metabolism. The research suggests that increasing intake of dark leafy greens, berries and melons may affect osteoporosis risk in middle-aged and older adults through sex-specific metabolic pathways.
Review
Endocrinology & Metabolism
Kari Martyniak, Fei Wei, Amelia Ballesteros, Teerin Meckmongkol, Ashley Calder, Timothy Gilbertson, Nina Orlovskaya, Melanie J. Coathup
Summary: Age-related bone loss is inevitable and osteoporosis is projected to increase with the growing elderly population. Obesity and osteoporosis are closely related, and diet plays a significant role in bone regeneration and repair. Dietary polyunsaturated fats, particularly omega-3 fatty acids, have been associated with increased bone regeneration and improved strength, while omega-6 fatty acids may increase fracture risk. This suggests a potential role for omega-3 fatty acids in reducing bone loss in the aging population, indicating a need for amendments to nutritional recommendations.
Article
Gastroenterology & Hepatology
Cecile Vors, Laurie Joumard-Cubizolles, Manon Lecomte, Emmanuel Combe, Lemlih Ouchchane, Jocelyne Drai, Ketsia Raynal, Florent Joffre, Laure Meiller, Melanie Le Barz, Patrice Gaborit, Aurelie Caille, Monique Sothier, Carla Domingues-Faria, Adeline Blot, Aurelie Wauquier, Emilie Blond, Valerie Sauvinet, Genevieve Gesan-Guiziou, Jean-Pierre Bodin, Philippe Moulin, David Cheillan, Hubert Vidal, Beatrice Morio, Eddy Cotte, Francoise Morel-Laporte, Martine Laville, Annick Bernalier-Donadille, Stephanie Lambert-Porcheron, Corinne Malpuech-Brugere, Marie-Caroline Michalski
Article
Nutrition & Dietetics
Fabienne Laugerette, Cecile Vors, Maud Alligier, Gaelle Pineau, Jocelyne Drai, Carole Knibbe, Beatrice Morio, Stephanie Lambert-Porcheron, Martine Laville, Hubert Vidal, Marie-Caroline Michalski
Article
Endocrinology & Metabolism
Allan de Oliveira Lira, Jose Luiz de Brito Alves, Mariana Pinheiro Fernandes, Diogo Vasconcelos, David Filipe Santana, Joao Henrique da Costa-Silva, Beatrice Morio, Carol Gois Leandro, Luciano Pirola
WORLD JOURNAL OF DIABETES
(2020)
Article
Nutrition & Dietetics
Karla Fabiola Corral-Jara, Laura Cantini, Nathalie Poupin, Tao Ye, Jean Paul Rigaudiere, Sarah De Saint Vincent, Alexandre Pinel, Beatrice Morio, Frederic Capel
Article
Cell Biology
Beatrice Morio, Baptiste Panthu, Arthur Bassot, Jennifer Rieusset
Summary: The liver plays a crucial role in coordinating the metabolic flexibility of the body, with hepatocyte mitochondria being key partners in this process. This review covers the metabolic and signaling pathways carried by liver mitochondria, as well as their role in health and metabolic disorders associated with obesity.
Article
Nutrition & Dietetics
Alexandre Pinel, Jean Paul Rigaudiere, Chrystele Jouve, Christophe Montaurier, Celine Jousse, Marie LHomme, Beatrice Morio, Frederic Capel
Summary: Transgenerational and continuous intake of EPA may help reduce cardiovascular and metabolic risks related to an unbalanced diet by modulating insulin sensitivity, fatty acid metabolism, and fibrosis in skeletal muscle.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Multidisciplinary Sciences
G. J. P. Rautureau, B. Morio, S. Guibert, C. Lefevre, J. Perrier, A. Alves, M. A. Chauvin, C. Pinteur, M. A. Monet, M. Godet, A. M. Madec, J. Rieusset, A. Mey, Baptiste Panthu
Summary: Obesity is linked to respiratory diseases, affecting the lung and liver the most. High-fat high-sugar diet induces specific metabolic changes in various organs, with the lung showing the second most severe effects, including decreased one-carbon metabolism and increased lipid accumulation.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Aline Maria Nunes de Lira Gomes Bloise, Aiany Cibelle Simoes-Alves, Alves Debora Santos, Beatrice Morio, Joao Henrique Costa-Silva
Summary: Nutrition transition is a global phenomenon characterized by increased consumption of fat-rich diets and high prevalence of obesity. While reducing saturated fatty acids intake is a consensus in preventing metabolic diseases, fatty acids of different chain lengths may have different cardiometabolic effects. Short and medium-chain SFA may provide beneficial health effects in cardiometabolic prevention.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Jeremy Bellien, Erwan Bozec, Frederic Bounoure, Hakim Khettab, Julie Malloizel-Delaunay, Mohamed Skiba, Michele Iacob, Nathalie Donnadieu, Aude Coquard, Beatrice Morio, Brigitte Laillet, Jean-Paul Rigaudiere, Jean-Michel Chardigny, Christelle Monteil, Cathy Vendeville, Alain Mercier, Anne-Francoise Cailleux, Anne Blanchard, Jacques Amar, Leopold K. Fezeu, Bruno Pannier, Alessandra Bura-Riviere, Pierre Boutouyrie, Robinson Joannides
Summary: This study assessed the cardiovascular and metabolic effects of camelina oil in hypertensive patients with metabolic syndrome. The results showed that camelina oil supplementation did not improve vascular function but adversely affected glucose metabolism.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Arthur Bassot, Carina Prip-Buus, Anais Alves, Olivier Berdeaux, Johan Perrier, Veronique Lenoir, Jingwei Ji-Cao, Marie-Agnes Berger, Emmanuelle Loizon, Stephanie Cabaret, Baptiste Panthu, Jennifer Rieusset, Beatrice Morio
Summary: This study demonstrates the impact of Grp75 or Mfn2 silencing and overexpression on triglyceride accumulation and cholesterol storage in MAMs, promoting fatty liver through distinct cellular pathways. Both proteins play crucial roles in hepatic lipid and cholesterol metabolism in obesity and NAFLD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Mauricio Castro-Sepulveda, Beatrice Morio, Mauro Tunon-Suarez, Sebastian Jannas-Vela, Francisco Diaz-Castro, Jennifer Rieusset, Hermann Zbinden-Foncea
Summary: This study aimed to investigate the mitochondrial dynamics response in human peripheral blood mononuclear cells during the metabolic transition from fasting to feeding. The results demonstrated that this transition reduces mitochondria-ER interactions, induces mitochondrial fission, and reduces mitochondrial cristae density in human PBMCs.
Review
Physiology
Morgane Couchet, Charlotte Breuillard, Christelle Corne, John Rendu, Beatrice Morio, Uwe Schlattner, Christophe Moinard
Summary: Ornithine transcarbamylase (OTC) is a widely distributed enzyme in organisms, catalyzing the production of L-citrulline and playing a crucial role in the urea cycle. OTC is mainly expressed in the liver and intestine in mammals, influencing amino acid homeostasis significantly.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alexandre Pinel, Jean-Paul Rigaudiere, Beatrice Morio, Frederic Capel
Summary: The study showed that continuous intake of EPA-rich fish oil for three generations could reduce activation of inflammatory processes, maintain metabolic homeostasis, and decrease dysregulation of cholesterol metabolism and mitochondrial functions in response to an obesogenic diet. Continuous intake of long chain n-3 PUFA may be beneficial in preventing the effects of energy-dense, nutrient-poor foods.
Article
Cardiac & Cardiovascular Systems
Vivien Chavanelle, Stephanie Chanon, Claudie Pinteur, Emmanuelle Loizon, Guillaume Vial, Yolanda E. Otero, Florian Le Joubioux, Thierry Maugard, Sebastien L. Peltier, Pascal Sirvent, Beatrice Morio
Summary: The study showed that TOTUM-63 significantly reduced food intake, limited weight gain, and improved glucose homeostasis in animal models of obesity, potentially through modulation of GLP-1 and PYY.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Nutrition & Dietetics
Anais Alves, Frederic Lamarche, Remy Lefebvre, Eva Drevet Mulard, Arthur Bassot, Stephanie Chanon, Emmanuelle Loizon, Claudie Pinteur, Aline Maria Nunes de Lira Gomes Bloise, Murielle Godet, Gilles J. P. Rautureau, Baptiste Panthu, Beatrice Morio
Summary: The interactions between mitochondria and the endoplasmic reticulum, known as MAMs, are altered in the liver in obesity, which leads to disruption of the insulin signaling pathway. The plasma level of glycine is decreased in obesity, and the decrease is strongly correlated with the severity of insulin resistance. Glycine supplementation can promote MAM integrity and improve insulin response in hepatocytes, but it does not have a beneficial effect on the overall metabolic profile in obese mice.
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
