Megakaryocytic hyperplasia in myeloproliferative neoplasms is driven by disordered proliferative, apoptotic and epigenetic mechanisms

Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3

(2014) Meghan B. Azad et al.   Autophagy

Distinct clinical characteristics of myeloproliferative neoplasms with calreticulin mutations

(2014) H. Andrikovics et al.   HAEMATOLOGICA

Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value

(2014) A M Vannucchi et al.   LEUKEMIA

Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia

(2013) G. Rotunno et al.   BLOOD

Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

(2013) J. Nangalia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

(2013) Thorsten Klampfl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-Apoptotic Pathways in Bone Marrow and Megakaryocytes in Myeloproliferative Neoplasia

(2013) Suzanne M. Koopmans et al.   PATHOBIOLOGY

Prognostic Significance of Bcl-2 and p53 Protein Expressions and Ki67 Proliferative Index in Diffuse Large B-cell Lymphoma

(2013) Betül Bolat Küçükzeybek et al.   Turkish Journal of Hematology

Genetic defects in PRC2 components other than EZH2 are not common in myeloid malignancies

(2012) L. I. Kroeze et al.   BLOOD

Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival

(2012) M. A. Debrincat et al.   BLOOD

Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages

(2012) T Kodama et al.   CELL DEATH AND DIFFERENTIATION

Calreticulin signaling in health and disease

(2012) Wen-An Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and Myelofibrosis

(2012) Raquel Tognon et al.   Journal of Hematology & Oncology

Impaired apoptosis of megakaryocytes and bone marrow mononuclear cells in essential thrombocythemia: correlation with JAK2V617F mutational status and cytoreductive therapy

(2012) Jacek Treliński et al.   MEDICAL ONCOLOGY

Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease

(2012) A. Herrera-Merchan et al.   Nature Communications

Reproducibility of Histologic Classification in Nonfibrotic Myeloproliferative Neoplasia

(2011) Suzanne M. Koopmans et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

New mutations and pathogenesis of myeloproliferative neoplasms

(2011) W. Vainchenker et al.   BLOOD

Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms

(2011) J. Score et al.   BLOOD

Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index

(2011) Yoshizo Kimura et al.   CANCER SCIENCE

European Bone Marrow Working Group trial on reproducibility of World Health Organization criteria to discriminate essential thrombocythemia from prefibrotic primary myelofibrosis

(2011) T. Buhr et al.   HAEMATOLOGICA

Myeloproliferative Neoplasms: Molecular Pathophysiology, Essential Clinical Understanding, and Treatment Strategies

(2011) Ayalew Tefferi et al.   JOURNAL OF CLINICAL ONCOLOGY

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

(2011) Emma C. Josefsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms

(2011) M Brecqueville et al.   Blood Cancer Journal

Genetic and Epigenetic Complexity in Myeloproliferative Neoplasms

(2011) N. C. P. Cross   Hematology-American Society of Hematology Education Program

Clinical utility of routineMPLexon 10 analysis in the diagnosis of essential thrombocythaemia and primary myelofibrosis

(2010) Elaine M. Boyd et al.   BRITISH JOURNAL OF HAEMATOLOGY

Guideline for investigation and management of adults and children presenting with a thrombocytosis

(2010) Claire N. Harrison et al.   BRITISH JOURNAL OF HAEMATOLOGY

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

Apoptotic Processes in Megakaryocytes and Platelets

(2010) Michael J. White et al.   SEMINARS IN HEMATOLOGY

Different immunophenotypical apoptotic profiles characterise megakaryocytes of essential thrombocythaemia and primary myelofibrosis

(2009) A M Florena et al.   JOURNAL OF CLINICAL PATHOLOGY

MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort

(2008) P. A. Beer et al.   BLOOD

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

(2008) M Vogler et al.   CELL DEATH AND DIFFERENTIATION

Expression profiling of apoptosis-related genes in megakaryocytes: BNIP3 is downregulated in primary myelofibrosis

(2008) Katharina Theophile et al.   EXPERIMENTAL HEMATOLOGY

Substitution of Pseudokinase Domain Residue Val-617 by Large Non-polar Amino Acids Causes Activation of JAK2

(2008) Alexandra Dusa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JAK2 and MPL mutations in myeloproliferative neoplasms: discovery and science

(2008) O Kilpivaara et al.   LEUKEMIA

JAK2V617F mutation and spontaneous megakaryocytic or erythroid colony formation in patients with essential thrombocythaemia (ET) or polycythaemia vera (PV)

(2008) Satu Mustjoki et al.   LEUKEMIA RESEARCH

Roles of the EZH2 histone methyltransferase in cancer epigenetics

(2008) Jeffrey A. Simon et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY