Article
Public, Environmental & Occupational Health
F. Foglia, M. T. Della Rocca, C. Melardo, B. M. Nastri, M. Manfredini, F. Montella, A. De Filippis, E. Finamore, Galdiero Massimiliano
Summary: This study aimed to describe the epidemiology of bloodstream infections (BSI) and antimicrobial resistance patterns among its common bacterial causes. Gram-positive bacteria were the most predominant pathogens, followed by Gram-negative bacteria. The study found a general decrease in antimicrobial resistance amongst BSI pathogens in the latter years. Coagulase-negative Staphylococci, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and enterococci were the most frequently identified bacterial pathogens.
PATHOGENS AND GLOBAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Luciana Rodrigues Pires de Campos, Marina Farrel Cortes, Beatriz Deo, Camila Rizek, Sania Santos, Lauro Perdigao, Silvia Figueiredo Costa
Summary: Mechanical ventilation, surgery, and hemodialysis are independent risk factors for multidrug-resistant bloodstream infections in critically ill trauma patients. Carbapenemase (KPC) is the main mechanism of resistance, and cross-transmission may contribute to its spread.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Infectious Diseases
Nityanand Jain, Inese Jansone, Tatjana Obidenova, Raimonds Simanis, Janis Meisters, Dagnija Straupmane, Aigars Reinis
Summary: This study conducted a retrospective analysis of microbiological data from a large public hospital in Latvia from 2017 to 2020, investigating antimicrobial resistance trends for 19 gram-negative bacterial genera. It found that carbapenems were most effective against GNBs while some bacteria showed significant increases in resistance rates against certain antibiotics. Despite lower prescription levels of penicillin group antimicrobials compared to the European average, GNBs exhibited high average resistant rates, indicating the role of ESBL+ isolates in resistance rates. Constant vigilance and proper infection control measures are necessary to track emerging trends in AMR in GNBs.
Article
Medicine, General & Internal
Marta Klos, Estera Jachowicz, Monika Pomorska-Wesolowska, Dorota Romaniszyn, Grzegorz Kandzierski, Jadwiga Wojkowska-Mach
Summary: This study highlights the antimicrobial resistance among Enterobacteriaceae isolated from bloodstream infections in hospitals in southern Poland. The predominant pathogen identified was Escherichia coli in internal medicine and surgery units, while Klebsiella pneumoniae was more frequently isolated in intensive care units. Enterobacteriaceae demonstrated high resistance to most antimicrobial agents.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Clair L. Firth, Annemarie Kaesbohrer, Peter Pless, Sandra Koeberl-Jelovcan, Walter Obritzhauser
Summary: The assumed link between high levels of antimicrobial use on farms and the presence of antimicrobial-resistant (AMR) bacteria was not statistically proven in this study of 50 dairy farms in Austria. While 26% of the farms had ESBL-producing E. coli, there was no significant difference between high and low antimicrobial users. Only one farm was confirmed to have MRSA.
Article
Infectious Diseases
Isabella A. Tickler, Diane Kawa, Anne E. Obradovich, Ferric C. Fang, Fred C. Tenover
Summary: A total of 199 Gram-negative bacterial isolates from urinary tract infections and 162 from bloodstream infections were collected from 12 healthcare systems throughout the United States between May 2021 and August 2022. The study characterized the isolates that were resistant to cephalosporins or carbapenems through antimicrobial susceptibility testing and whole genome sequencing. The results showed a wide range of carbapenemase-mediated resistance, with blaKPC-3 and blaKPC-2 being the most common carbapenemase genes identified. Additionally, extended-spectrum beta-lactamase genes and AmpC genes were also detected in a significant number of isolates. Importantly, some of the carbapenemase-producing organisms were still susceptible to certain antibiotics.
Article
Infectious Diseases
Marie Clemenceau, Samira Ahmed-Elie, Aurelie Vilfaillot, Richard Chocron, Fabrice Compain, David Lebeaux, Patrick Grohs
Summary: The study found that the spread of ESBL producers in the community has an impact on the management of patients with bloodstream infections involving Enterobacterales in emergency departments. The rate of appropriate treatment decreased, and using combination therapy was more appropriate than monotherapy.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Microbiology
Andreas G. Tofarides, Panagiotis Dimitriou, Georgios K. Nikolopoulos, Dimitrios Rogkas, Christina Flourou, Elina Khattab, Diamanto Kasapi, Chara Azina, Eirini Christaki
Summary: Klebsiella pneumoniae is a leading cause of hospital-acquired infections, and resistant strains are becoming increasingly common. This study found that recent antimicrobial use and heart disease are associated with bloodstream infections caused by ESBL-producing Klebsiella pneumoniae.
Review
Public, Environmental & Occupational Health
Theethawat Uea-Anuwong, Kaylee A. Byers, Lloyd Christian Wahl, Omid Nekouei, Yrjo Tapio Grohn, Ioannis Magouras
Summary: This scoping review synthesized research findings on antimicrobial resistance (AMR) in Rattus spp. and found that peridomestic Rattus spp. can carry multiple antimicrobial resistant bacteria, indicating their potential to serve as reservoirs and spreaders of AMR, posing a threat to human and animal health.
Article
Microbiology
Maria J. H. O'Hagan, Ana V. Pascual-Linaza, Catherine Couzens, Clare Holmes, Colin Bell, Nessie Spence, Robert J. Huey, Julie A. Murphy, Ryan Devaney, Angela Lahuerta-Marin
Summary: This study aimed to explore the prevalence of antimicrobial resistant (AMR) bacteria in two common wildlife species in Northern Ireland. The results showed that ESBLs and Salmonella spp. with multi-drug resistance were found in badger and fox faecal samples, while no MRSA were detected in nasopharyngeal swabs from both species. These findings provide important baseline data for further research on the origin of the found resistance and highlight the need for similar surveys in environmental samples to better understand AMR dynamics and its impact on wildlife, domestic livestock, and humans.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Daniel Antonio Vazquez-Sanchez, Sara Grillo, Anna Carrera-Salinas, Aida Gonzalez-Diaz, Guillermo Cuervo, Inmaculada Grau, Mariana Camoez, Sara Marti, Damaris Berbel, Fe Tubau, Carmen Ardanuy, Miquel Pujol, Jordi Camara, M. Angeles Dominguez
Summary: This study analyzed the molecular and clinical epidemiology of MRSA-BSI in adult patients in Barcelona from 1990 to 2019. The study found an increase in patient age, comorbidities, community-onset healthcare-associated acquisition, and mortality rates during this period. The proportion of catheter-related BSIs decreased. Current MRSA-BSIs are mainly caused by CC5-IV and CC8-IV clones, with lower antimicrobial resistance rates. However, certain drugs still show high resistance. CC22-IV clones are showing an increasing trend of daptomycin resistance.
Article
Infectious Diseases
Cailin Liu, Min Xu, Xiaogai Li, Huiyue Dong, Liang Ming
Summary: This study investigated the distribution and antimicrobial resistance of bloodstream infection pathogens at a tertiary-care hospital in China. The results revealed a significant increase in carbapenem-resistant Klebsiella pneumoniae and a decline in carbapenem-resistant Escherichia coli. The isolation rate of methicillin-resistant coagulase-negative staphylococci also showed a significant decrease.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Microbiology
Jiarong Zhang, Jingjing Tu, Yongping Chen, Xiaoya Jin
Summary: This study investigates the clinical epidemiological characteristics and drug resistance of S. aureus strains in the First Affiliated Hospital of Wenzhou Medical University in 2018, aiming to improve the prevention and control of S. aureus infection. Among the 105 S. aureus isolates from inpatients, 31 isolates were MRSA. The prevalence and distribution of MRSA in different departments are reported.
Article
Genetics & Heredity
Guido Werner, Natacha Couto, Edward J. Feil, Angela Novais, Kristin Hegstad, Benjamin P. Howden, Alexander W. Friedrich, Sandra Reuter
Summary: High-throughput bacterial genomic sequencing and bioinformatic analysis have improved the speed and efficiency of applying genomics to outbreak analysis and public health surveillance. Targeted pathogens and diseases with different modes of transmission are the main focus, along with major healthcare-associated pathogens. This article discusses current and future public health priorities in genome-based surveillance of healthcare-associated pathogens, highlighting challenges and potential solutions.
MICROBIAL GENOMICS
(2023)
Article
Parasitology
Ewerton da Silva Ferreira, Aline Stephanie Perez Gomez, Taynna Vernalha Rocha Almeida, Carlos Henrique Michiles Frank, Sabrina Araujo de Melo, Eveny Perlize Melo Marinho, Sergio Damasceno Pinto, Pablo Vinicius Silveira Feitoza, Rossicleia Lins Monte, Michele de Souza Bastos
Summary: In this study, a retrospective analysis of blood culture records from patients with suspected bloodstream infections was conducted. The findings revealed the presence of antimicrobial resistant pathogens, especially methicillin-resistant Staphylococcus aureus, methicillin-resistant S. epidermidis, and extended-spectrum beta-lactamase-producing Enterobacteriaceae. These results highlight the importance of ongoing vigilance and rational use of antimicrobial agents.
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2023)