Article
Gastroenterology & Hepatology
Kali Zhou, Tiffany Lim, Jennifer L. L. Dodge, Norah A. A. Terrault, Lynne R. R. Wilkens, V. Wendy Setiawan
Summary: Lifestyle factors are closely associated with the risk of hepatocellular carcinoma (HCC). Modifying adverse lifestyle behaviors, particularly coffee intake, can have a substantial impact on the burden of HCC in diverse populations.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Environmental Sciences
Leonardo Trasande, Buyun Liu, Wei Bao
Summary: The study found that high-molecular weight phthalate metabolites, especially DEHP, were associated with increased mortality. Extrapolating to the 55-64 year old American population, the estimated attributable deaths related to phthalate exposure exceeded 90,000, with lost economic productivity in the billions of dollars.
ENVIRONMENTAL POLLUTION
(2022)
Article
Cell Biology
Guangqi Liu, Zheng Xie, Yuanjie Pang, Tao Huang, Yangmu Huang
Summary: This study found that older individuals in China who adhered to the 4-dimension lifestyle pattern (4DL) had a lower overall mortality risk than those who did not. Additionally, the risk of mortality accompanied by hypertension, respiratory disease, or dementia was also significantly reduced. The positive effects of 4DL on longevity should be acknowledged in China's older population, especially for the younger elderly.
Article
Geriatrics & Gerontology
Changqing Sun, Huimin Liu, Fei Xu, Ying Qin, Panpan Wang, Qianyu Zhou, Dandan Liu, Shanqun Jia, Qiang Zhang
Summary: This study found that unhealthy lifestyle factors are associated with mortality among Chinese elderly population. Low BMI, smoking, no fruit eating, and no physical inactivity were identified as risk factors for total mortality. Unhealthy lifestyle factors have a cumulative effect on mortality. Older adults with multiple unhealthy factors have a higher risk of death.
Article
Anesthesiology
Natalie Melton, Robert Talarico, Faraj Abdallah, Paul E. Beaule, Sylvain Boet, Alan J. Forster, Shannon M. Fernando, Allen Huang, Colin J. L. McCartney, Bradley Meulenkamp, Jeff Perry, Barbara Power, Reva Ramlogan, Monica Taljaard, Peter Tanuseputro, Carl van Walraven, Duminda N. Wijeysundera, Daniel I. McIsaac
Summary: This study found that the use of nerve blocks in hip fracture patients is not associated with higher rates of potentially nerve block-attributable adverse events, although these findings may be influenced by limitations in routinely collected administrative data.
Article
Medicine, General & Internal
Peng Hu, Murui Zheng, Jun Huang, Huan-Ying Fan, Chun-Jiang Fan, Hui-Hong Ruan, Yue-Shuang Yuan, Wenjing Zhao, Harry H. X. Wang, Hai Deng, Xudong Liu
Summary: This cohort study examines the association between multidimensional lifestyle factors and mortality risk in Chinese populations. The study finds that a higher number of healthy lifestyle factors is associated with a reduced risk of death. Additionally, adherence to a lifestyle pattern characterized by non-smoking and low-level alcohol drinking also reduces the risk of all-cause mortality.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Beate Sander, Yaron Finkelstein, Hong Lu, Chenthila Nagamuthu, Erin Graves, Lauren C. Ramsay, Jeffrey C. Kwong, Suzanne Schuh
Summary: This study aimed to determine the healthcare costs of bronchiolitis in infants, finding that the average 1-year cost was $4,313 per patient. Costs were higher in the initial 10 days and the first 180 days, with most expenses going towards hospitalizations.
Article
Endocrinology & Metabolism
Eugene Han, Kyung-do Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Seung-Hyun Ko, Yong-Ho Lee
Summary: This study investigates the relationship between severe hypoglycemia and dementia subtypes, as well as their combined effect on overall mortality in patients with type 2 diabetes. The results indicate that severe hypoglycemia is associated with dementia, particularly Alzheimer's disease, and the combination of severe hypoglycemia and dementia leads to higher overall mortality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Xiaoyan Wu, Wenjie Wang, Dandan Zhang, Fangzhou Zhu
Summary: The study found a negative correlation between overall nutritional status and cancer mortality, indicating that healthier nutritional status is associated with a lower cancer mortality rate. Not smoking, exercising regularly, and maintaining a healthy weight interact with overall nutritional status to reduce the risk of cancer mortality. Adherence to a healthier overall nutritional status, lifestyle habits, and optimal weight can prevent premature death from cancer.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Maurice M. O'Connell, John P. Ferguson
Summary: This study introduces a new metric, PS-PAF, which measures disease burden attributable to different mediating pathways. The results show that different mediating pathways explain varying proportions of stroke disease burden, with alternative pathways explaining a large proportion of the disease burden due to physical inactivity.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Oncology
Byung Kyu Park, Jeong Hun Seo, Jae Bock Chung, Jung Kyu Choi
Summary: The study revealed that smoking, obesity, and diabetes are significant risk factors for pancreatic cancer in the Korean population. Lifestyle modifications targeting smoking cessation and weight management could be beneficial for pancreatic cancer prevention.
BRITISH JOURNAL OF CANCER
(2022)
Article
Environmental Sciences
Yukiko Nishihama, Shoji F. Nakayama, Takahiro Tabuchi
Summary: Multiple factors were found to be significantly associated with LBW, with factors such as parity, history of adenomyosis, hypertension disorder of pregnancy, maternal age at birth, prepregnancy body mass index, gestational weight gain, maternal smoking, and lead exposure being identified as major risk factors. The study suggests that reducing lead exposure to the lowest quartile and eliminating maternal smoking could lead to a significant reduction in the number of LBW births.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Zhi Du, Min Lin, Yuanmeng Tian, Li Jing, Shuang Liu, Guangxiao Li, Tong Jia, Qun Sun, Lei Shi, Jixu Sun, Wen Tian, Liying Xing
Summary: This study found a high prevalence of atrial fibrillation (AF) in hypertensive individuals, with underuse of oral anticoagulant therapy. Hypertensive individuals with AF had a significantly increased risk of cardiovascular disease-related mortality compared to those without AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Tao Wang, Congcong Ding, Wei Zhou, Lingjuan Zhu, Chao Yu, Xiao Huang, Huihui Bao, Xiaoshu Cheng
Summary: This study examined the association between combined lifestyle behaviors and all-cause and cardiovascular disease (CVD) mortality in Jiangxi province, China. The results showed that an unfavorable lifestyle was associated with a substantially increased risk of all-cause and CVD mortality.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
X. J. Lee, A. J. Stewardson, L. J. Worth, N. Graves, T. M. Wozniak
Summary: The study found that Escherichia coli urinary tract infections had the most significant impact on hospital length of stay among the 5 studied pathogens, and that antimicrobial-resistant infections resulted in higher healthcare costs for patients infected with third-generation cephalosporin or methicillin-resistant strains.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Siyeon Suh, Sol Lee, Ho Gym, Sanghyuk Yoon, Seunghwan Park, Jihi Cha, Do-Hyung Kwon, YunSu Yang, Sun Ha Jee
Summary: COVID-19, caused by SARS-CoV-2, is a global threat that directly and indirectly affects the entire population. Multiple studies have been conducted to understand the transmission and severity of the disease, revealing that ACE2, TMPRSS2, and IFITM3 are key genes involved in SARS-CoV-2 infection, with certain SNPs associated with increased infection and severity.
BMC INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Dong-Hyuk Park, Wonhee Cho, Yong-Ho Lee, Sun Ha Jee, Justin Y. Jeon
Summary: This study aimed to improve the predictability of undiagnosed diabetes mellitus (UnDM) by adding resting heart rate (RHR) to the existing prediction model, and to develop a model using easily assessable variables such as gender, RHR, age, and waist circumference (WC). The results showed that adding RHR to the model improved specificity and the Youden index. Furthermore, using only gender, RHR, age, and WC in the model yielded comparable outcomes to the existing model.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Oncology
Xiang Shu, Zhishan Chen, Jirong Long, Xingyi Guo, Yaohua Yang, Conghui Qu, Yoon-Ok Ahn, Qiuyin Cai, Graham Casey, Stephen B. Gruber, Jeroen R. Huyghe, Sun Ha Jee, Mark A. Jenkins, Wei-Hua Jia, Keum Ji Jung, Yoichiro Kamatani, Dong-Hyun Kim, Jeongseon Kim, Sun-Seog Kweon, Loic Le Marchand, Koichi Matsuda, Keitaro Matsuo, Polly A. Newcomb, Jae Hwan Oh, Jennifer Ose, Isao Oze, Rish K. Pai, Zhi-Zhong Pan, Paul D. P. Pharoah, Mary C. Playdon, Ze-Fang Ren, Robert E. Schoen, Aesun Shin, Min-Ho Shin, Xiao-Ou Shu, Xiaohui Sun, Catherine M. Tangen, Chizu Tanikawa, Cornelia M. Ulrich, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Alicja Wolk, Michael O. Woods, Anna H. Wu, Ulrike Peters, Wei Zheng
Summary: This study identified potential novel risk biomarkers for colorectal cancer by integrating genetics and circulating metabolomics data. The results highlight the importance of lipids, especially certain glycerophospholipids and triacylglycerols, in the etiology of colorectal cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Jie Ping, Yaohua Yang, Wanqing Wen, Sun-Seog Kweon, Koichi Matsuda, Wei-Hua Jia, Aesun Shin, Yu-Tang Gao, Keitaro Matsuo, Jeongseon Kim, Dong-Hyun Kim, Sun Ha Jee, Qiuyin Cai, Zhishan Chen, Ran Tao, Min-Ho Shin, Chizu Tanikawa, Zhi-Zhong Pan, Jae Hwan Oh, Isao Oze, Yoon-Ok Ahn, Keum Ji Jung, Zefang Ren, Xiao-Ou Shu, Jirong Long, Wei Zheng
Summary: PRS constructed using East Asian-specific data showed better performance in predicting colorectal cancer risk compared to PRS constructed using European descendants data. Individuals in the highest 5% risk group had a 2.52-fold elevated risk of colorectal cancer compared to the medium risk group.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Hye Won Yun, Keum Ji Jung, Sun Ha Jee, Heejin Kimm
Summary: This study aimed to analyze smoking cessation among healthy adult triple users of conventional cigarettes, e-cigarettes, and heated tobacco products. The majority of ever triple users continued to use these tobacco products instead of quitting. Age, gender, hyperlipidemia, and marital status were significantly associated with overall quit.
Article
Environmental Sciences
SuHyun Lee, YoungWook Lim, YounSeok Kang, KeumJi Jung, SunHa Jee
Summary: This study aimed to examine the association between blood concentration of dioxin-like polychlorinated biphenyls (DL-PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/DFs) and the risk of type 2 diabetes mellitus (T2DM) and thyroid cancer. The results showed a significant positive association between PCDD/DFs concentrations and both T2DM and thyroid cancer.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Dong-Hyuk Park, Seon Young Goo, Sung Hyun Hong, Ji-hee Min, Ji Yong Byeon, Mi-Kyung Lee, Hae Dong Lee, Byoung Wook Ahn, Heejin Kimm, Sun Ha Jee, Dong Hoon Lee, Yong-ho Lee, Eun Seok Kang, Justin Y. Jeon
Summary: This study aimed to investigate the association between resting heart rate (RHR) and the prevalence of undiagnosed diabetes. The results showed that participants with higher RHR had a significantly higher prevalence of undiagnosed diabetes, and this association was stronger among younger and leaner individuals. Therefore, RHR can be used as an indicator to identify and prevent undiagnosed diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Medicine, General & Internal
Hanbit Mun, Jae-Yong Shim, Heejin Kimm, Hee-Cheol Kang
Summary: This study examined the association between cardiovascular risk and cognitive function, and found that individuals with high cardiovascular risk had poorer cognitive function, especially older women. Therefore, the management of cardiovascular risk factors should be emphasized to promote healthy mental aging in elderly individuals.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Genetics & Heredity
Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Bien, Virginia Diez-Obrero, Li Li, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Harris, Victoria Svinti, Kevin McDonnell, Susan Farrington, James Studd, Peter Vaughan-Shaw, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Xingyi Guo, Yingchang Lu, Peter Scacheri, James Studd, Jeroen Huyghe, Tabitha Harrison, David Shibata, Christopher Haiman, Mathew Devall, Fredrick Schumacher, Marilena Melas, Gad Rennert, Mireia Obon-Santacana, Vicente Martin-Sanchez, Ferran Moratalla-Navarro, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John Potter, Mark Jenkins, Aung Ko Win, Rish Pai, Jane Figueiredo, Robert Haile, Steven Gallinger, Michael Woods, Polly Newcomb, David Shibata, Jeremy Cheadle, Richard Kaplan, Timothy Maughan, Rachel Kerr, David Kerr, Iva Kirac, Jan Boehm, Lukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri Aaltonen, Harri Rissanen, Eero Pukkala, Johan Eriksson, Tatiana Cajuso, Ulrika Hanninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Brent Zanke, Satu Mannisto, Demetrius Albanes, Stephanie Weinstein, Edward Ruiz-Narvaez, Julie Palmer, Daniel Buchanan, Elizabeth Platz, Kala Visvanathan, Cornelia Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha Slattery, John Potter, Konstantinos Tsilidis, Matthias Schulze, Marc Gunter, Neil Murphy, Antoni Castells, Sergi Castellvi-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, Mariana Stern, Bens Pardamean, Timothy Bishop, Graham Giles, Melissa Southey, Gregory Idos, Kevin McDonnell, Zomoroda Abu-Ful, Joel Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope Keku, Bethany van Guelpen, Thomas Hudson, Heather Hampel, Rachel Pearlman, Sonja Berndt, Richard Hayes, Marie Elena Martinez, Sushma Thomas, Douglas Corley, Paul Pharoah, Susanna Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly Doheny, Elizabeth Pugh, Tameka Shelford, Andrew Chan, Marcia Cruz-Correa, Annika Lindblom, David Shibata, Amit Joshi, Clemens Schafmayer, Peter Scacheri, Anshul Kundaje, Deborah Nickerson, Robert Schoen, Jochen Hampe, Zsofia Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Nickolas Papadopoulos, Chistopher Edlund, William Gauderman, Duncan Thomas, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen Gruber, Franzel van Duijnhoven, Edith Feskens, Lori Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie Bien, Charles Kooperberg, Christopher Li, Yi Lin, Ross Prentice, Conghui Qu, Stephane Bezieau, Catherine Tangen, Elaine Mardis, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Christopher Haiman, Loic Le Marchand, Anna Wu, Chenxu Qu, Caroline McNeil, Gerhard Coetzee, Caroline Hayward, Ian Deary, Sarah Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters
Summary: This study identified 205 independent risk associations for colorectal cancer through a genome-wide association study meta-analysis. Transcriptome and methylome analysis further revealed 53 risk associations. These findings provide insights into the genetic and molecular mechanisms of colorectal oncogenesis and suggest potential targets for new treatment and prevention strategies.
Article
Substance Abuse
Ju Sam Hwang, Kiheon Lee, Choon-Young Kim, Heejin Kim, Sungroul Kim, Cheol M. Lee
Summary: This study examined the factors influencing the selection of JUUL among adult tobacco users in South Korea, as well as the changes in electronic cigarette (EC) usage patterns before and after the launch of JUUL. The results showed a significant increase in the proportion of EC and JUUL users, as well as triple users, after 4 months of JUUL's debut. The intention to quit EC decreased, particularly among concurrent JUUL users. Logistic regression analysis revealed that JUUL use was associated with male sex, young and middle age, and metropolitan residency status.
TOBACCO INDUCED DISEASES
(2023)
Article
Multidisciplinary Sciences
Seong Gyu Choi, Minsuk Oh, Dong-Hyuk Park, Byeongchan Lee, Yong-ho Lee, Sun Ha Jee, Justin Y. Jeon
Summary: This study compares the prediction performance of machine learning-based undiagnosed diabetes prediction models and traditional statistics-based prediction models. The results show that the machine learning-based models have higher AUC values when using features such as sex, age, and waist circumference. Similarly, when additional features including family history of diabetes, hypertension, alcohol consumption, and smoking status are included, the machine learning-based models still outperform the traditional statistics-based models. The study concludes that machine learning-based prediction models using anthropometric and lifestyle measurements may be more accurate in predicting undiagnosed diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Youngmin Han, Hye Jin Yoo, Sun Ha Jee, Jong Ho Lee
Summary: Monitoring metabolic biomarkers could be used as an effective tool for the early detection of gastric cancer risk. This study discovered that changes in serum levels of l-carnitine and citric acid are associated with gastric cancer occurrence, and may serve as predictive serum biomarkers for gastric cancer.
Article
Gastroenterology & Hepatology
Hyun-Soo Zhang, Yeunsoo Yang, Sunmi Lee, Sohee Park, Chung Mo Nam, Sun Ha Jee
Summary: This study employs three statistical methods to avoid immortal time bias and compares their results with a naive time-fixed analysis, concluding that metformin use is not associated with colorectal cancer incidence.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)