Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators

Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial

(2014) David Michelson et al.   LANCET NEUROLOGY

The effects of repeated zolpidem treatment on tolerance, withdrawal-like symptoms, and GABAA receptor mRNAs profile expression in mice: Comparison with diazepam

(2014) Brittany T. Wright et al.   PSYCHOPHARMACOLOGY

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

(2013) Anthony L Gotter et al.   BMC NEUROSCIENCE

Discovery and development of orexin receptor antagonists as therapeutics for insomnia

(2013) C J Winrow et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sleep deprivation and neurobehavioral dynamics

(2013) Mathias Basner et al.   CURRENT OPINION IN NEUROBIOLOGY

Quantitative Electroencephalography Within Sleep/Wake States Differentiates GABAA Modulators Eszopiclone and Zolpidem From Dual Orexin Receptor Antagonists in Rats

(2013) Steven V Fox et al.   NEUROPSYCHOPHARMACOLOGY

Orexin receptor antagonism for treatment of insomnia: A randomized clinical trial of suvorexant

(2012) W. J. Herring et al.   NEUROLOGY

Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep and EEG Power Spectra in a Model of Situational Insomnia

(2012) Paolo Bettica et al.   NEUROPSYCHOPHARMACOLOGY

Insomnia Pharmacotherapy

(2012) Timothy Roehrs et al.   Neurotherapeutics

Sleep Deprivation Impairs Consolidation of Cued Fear Memory in Rats

(2012) Tankesh Kumar et al.   PLoS One

Benzodiazepines revisited-will we ever learn?

(2011) Malcolm Lader   ADDICTION

Orexin Receptors: Pharmacology and Therapeutic Opportunities

(2011) Thomas E. Scammell et al.   Annual Review of Pharmacology and Toxicology

Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

(2011) Christopher J. Winrow et al.   JOURNAL OF NEUROGENETICS

Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia

(2011) Christopher J. Winrow et al.   NEUROPHARMACOLOGY

British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders

(2010) SJ Wilson et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Zolpidem-induced changes in activity, metabolism, and anxiety in rats

(2010) Helen M. Murphy et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics

(2009) David J Nutt et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Sleep deprivation impairs cAMP signalling in the hippocampus

(2009) Christopher G. Vecsey et al.   NATURE