Article
Geriatrics & Gerontology
Jiacheng Chen, Ning Guo, Yuting Ruan, Yingren Mai, Wang Liao, Yanqing Feng
Summary: This study found that isoniazid administration can effectively improve cognitive performance, clear Aβ plaques, protect dendritic synapses, and reduce innate immune cells around the Aβ plaques in a transgenic mouse model of Alzheimer's disease. These results suggest that isoniazid could be a potential drug for AD treatment.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Man Xu, Xiaoya Wang, Luyi Wang, Shali Wang, Jing Deng, Yan Wang, Yingbo Li, Sen Pan, Ailing Liao, Yihao Tao, Shujiang Tan
Summary: This study investigates the effects of chronic sleep restriction on wild-type and CTNND2 knockout mice. It finds that chronic sleep restriction impairs social ability and cognition, and increases repetitive behaviors in CTNND2 knockout mice. This research has implications for understanding the relationship between disrupted sleep and neurodevelopmental disorders in CTNND2 gene-related autism.
BRAIN AND BEHAVIOR
(2023)
Article
Pharmacology & Pharmacy
Sara Badesso, Paz Cartas-Cejudo, Maria Espelosin, Enrique Santamaria, Mar Cuadrado-Tejedor, Ana Garcia-Osta
Summary: DHA, as the most abundant polyunsaturated fatty acid in the brain, is essential for successful aging and may lower the risk for developing Alzheimer's disease. DHA enhances memory function through promoting synapse formation and has potential for dietary supplement for AD dementia prevention.
Article
Biochemistry & Molecular Biology
Ying Han, Le Chen, Jingyun Liu, Jie Chen, Chunyang Wang, Yu Guo, Xuebin Yu, Chenghong Zhang, Haiying Chu, Haiying Ma
Summary: Alzheimer's disease is a neurodegenerative disease that seriously affects the health of older people. This study found that HDACs are involved in the synaptic defects in AD models, and the HDAC inhibitor BG45 can repair synaptic damage and loss of hippocampal neurons by specifically inhibiting HDAC1, HDAC2, and HDAC3, thus enhancing the function of excitatory synapses.
Article
Geriatrics & Gerontology
Benke Xu, Yun He, Lian Liu, Guosheng Ye, Lulu Chen, Qingning Wang, Michael Chen, Yuncai Chen, Dahong Long
Summary: Memory loss is a key symptom of Alzheimer's disease. This study investigated the effects of prolonged physical running on spatial memory in a rodent model of AD. The results showed that running improved hippocampal-dependent spatial memory in AD mice by preventing the loss of synaptic contacts and slowing down amyloid pathology.
Article
Cell Biology
Sudhir Kshirsagar, Rainier Vladlen Alvir, Ashly Hindle, Subodh Kumar, Murali Vijayan, Jangampalli Adi Pradeepkiran, Arubala P. Reddy, Bhagavathi Ramasubramanian, P. Hemachandra Reddy
Summary: The purpose of this study is to investigate the early cellular, molecular, morphological, and behavioral changes in humanized amyloid-beta-knock-in (hAbKI) mice. The findings suggest that amyloid-beta is sufficient to cause behavioral, mitochondrial, synaptic, and ultrastructural changes in mice.
Article
Anatomy & Morphology
E. Aloni, S. Verbitsky, L. Kushnireva, E. Korkotian, M. Segal
Summary: Research indicates that Synaptopodin (SP) plays a key role in the spine apparatus of central excitatory neurons and the axon initial segment. Lack of SP in SPKO mice results in cognitive deficiencies, increased excitability in hippocampal cells, and higher expression of arc staining.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Neurosciences
Weiwei Cui, Chunhui Chen, Liya Gong, Junyan Wen, Shanshan Yang, Min Zheng, Baogui Gao, Junxiong You, Xuecong Lin, Yanyu Hao, Zhimin Chen, Ziqi Wu, Liaoming Gao, Jiayu Tang, Zhen Yuan, Xuegang Sun, Linlin Jing, Ge Wen
Summary: Our study found that deficiency of PGAM5 leads to depressive-like behaviors by reducing the number of neuronal spines in the prefrontal cortex (PFC). We also showed that ATP administration can rescue these behavioral and neuronal phenotypes.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Sandra Schilling, Ajay Pradhan, Amelie Heesch, Andrea Helbig, Kaj Blennow, Christian Koch, Lea Bertgen, Edward H. Koo, Gunnar Brinkmalm, Henrik Zetterberg, Stefan Kins, Simone Eggert
Summary: This study compares the effects of different APP genetic mutations on their processing and pathogenic mechanisms in Alzheimer's disease. The results show significant differences in the underlying mechanisms for familial AD mutations located at the alpha-, beta-, and gamma-secretase cleavage sites. Different mutations have different effects on APP processing and the generation of A β peptides.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Clinical Neurology
Leticia Peris, Julie Parato, Xiaoyi Qu, Jean-Marc Soleilhac, Fabien Lante, Atul Kumar, Maria Elena Pero, Jose Martinez-Hernandez, Charlotte Corrao, Giulia Falivelli, Floriane Payet, Sylvie Gory-Faure, Christophe Bosc, Marian Blanca Ramirez, Andrew Sproul, Jacques Brocard, Benjamin Di Cara, Philippe Delagrange, Alain Buisson, Yves Goldberg, Marie-Jo Moutin, Francesca Bartolini, Annie Andrieux
Summary: Microtubules are important for neuronal processes, synaptic function, and plasticity. The balance between tubulin tyrosination and detyrosination is crucial for maintaining microtubule dynamics and neuronal homeostasis. This study reveals that decreased tubulin tyrosine ligase expression is associated with Alzheimer's disease and leads to memory impairment and reduced synaptic integrity. Restoring microtubule entry into dendritic spines through tubulin retyrosination can protect against amyloid-beta peptide-induced synaptic damage.
Article
Biochemistry & Molecular Biology
Xingxing Wang, Qinfang Shi, Arpit Kumar Pradhan, Laura Ziegon, Martin Schlegel, Gerhard Rammes
Summary: This study found that inhalative anesthetics can enhance the activity of BACE, increase the aggregation of Aβ(1-42), and modulate dendritic spine dynamics. Sevoflurane treatment leads to a decrease in dendritic spine density and nectin-3 expression in the hippocampus, while isoflurane treatment decreases spine density and attenuates LTP. Xenon does not alter dendritic spine remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Madhumathi Gnanaprakash, Agnieszka Staniszewski, Hong Zhang, Rose Pitstick, Michael P. Kavanaugh, Ottavio Arancio, Russell E. Nicholls
Summary: The study demonstrated that overexpression of PP2A methyltransferase LCMT-1 prevented cognitive and electrophysiological impairments caused by chronically elevated Aβ levels, while overexpression of PME-1 showed some negative effects.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Cell Biology
Grant Pfundstein, Alexander G. Nikonenko, Vladimir Sytnyk
Summary: This review examines the interactions of cell adhesion molecules with APP and Aβ, and analyzes the critical role these proteins play in regulating APP metabolism and physiological function, as well as Aβ toxicity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liana Marengo, Fred Armbrust, Caroline Schoenherr, Steffen E. Storck, Ulrich Schmitt, Silvia Zampar, Oliver Wirths, Hermann Altmeppen, Markus Glatzel, Christoph Kaether, Sascha Weggen, Christoph Becker-Pauly, Claus U. Pietrzik
Summary: This study reports the generation of a transgenic mouse model of AD lacking the functional Mep1b gene (APP/lon x Mep1b(-/-)). The results showed that when meprin beta is absent, the levels of A beta 1-40 and 1-42 are reduced in APP/lon mice, and the deposition of N-terminally truncated A beta 2-x peptide is also decreased. Importantly, the loss of meprin beta improved cognitive abilities in APP/lon mice.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Geriatrics & Gerontology
Carmen Freire-Cobo, Emily S. Rothwell, Merina Varghese, Melise Edwards, William G. M. Janssen, Agnes Lacreuse, Patrick R. Hof
Summary: The investigation focuses on the neurobiological and neuropathological changes in synapses and their impact on the vulnerability of the aging brain to Alzheimer's disease. Cellular characteristics in the cerebral cortex of behaviorally characterized marmosets were studied, revealing increased astrogliosis, heightened phagocytic activity of microglial cells, and differences in microglial cell phenotypes between cognitively impaired and non-impaired marmosets. Additionally, age-related changes in dendritic spines were observed in cortical areas associated with cognition. These findings suggest an accelerated aging process and neurodegeneration contributing to neuronal vulnerability in cognitively impaired aged marmosets.
NEUROBIOLOGY OF AGING
(2023)
