Article
Immunology
Shih-Hsiu Chou, Tsai-Wen Wan, Chung-Wai Shiau, Ling -Han Chen, Hsueh-Chun Lin, Hao-Chieh Chiu
Summary: In this study, it was found that the tyrosine kinase inhibitor nilotinib has antibacterial activity against intracellular Salmonella enterica. The aim was to exploit the antibacterial activity of nilotinib and understand its mechanism of action.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Review
Medicine, Research & Experimental
Guangli Lu, Zhen Wu, Jia Shang, Zhenxing Xie, Chaoran Chen, Chuning Zhang
Summary: Metformin is the first-line option for treating diabetic patients and has various pharmacological actions, including antitumor, anti-aging, and ovarian protection effects. Recent research has shown that autophagy is a crucial mechanism through which metformin exerts its pharmacological actions, although the effects on autophagy remain inconsistent.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ram Hari Pokhrel, Suman Acharya, Jae-Hee Ahn, Ye Gu, Mahesh Pandit, Jong-Oh Kim, Yun-Yong Park, Ben Kang, Hyun-Jeong Ko, Jae-Hoon Chang
Summary: In this study, it was found that AMP-activated protein kinase (AMPK) plays a regulatory role in the expression of PD-1 through the HMGCR/p38 MAPK/GSK3 beta signaling pathway in regulatory T cells (Tregs). This suggests that AMPK activators may have synergistic antitumor effects in murine tumor models when combined with other treatments.
Review
Pharmacology & Pharmacy
Wang Liao, Jiaxin Xu, Bo Li, Yuting Ruan, Tian Li, Jun Liu
Summary: Alzheimer's disease is a prevalent neurodegenerative disease with no effective treatment. Metformin, a medication for Type 2 Diabetes Mellitus, has shown beneficial effects on cognitive function, but current evidence remains ambiguous and conflicting.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mohamed Z. Elhussiny, Phuong Tran, Ying Wang, Yoshimitsu Ouchi, Shogo Haraguchi, Elizabeth R. Gilbert, Mark A. Cline, Takashi Bungo, Mitsuhiro Furuse, Vishwajit S. Chowdhury
Summary: The study found that central injection of taurine can rapidly change the concentrations of free amino acids in the brain and plasma, which may play a role in thermoregulation, food intake, and stress response in chicks.
Review
Pharmacology & Pharmacy
Yanhong Song, Ziyi Wu, Ping Zhao
Summary: This article discusses the potential of using metformin in the treatment of osteoarthritis, highlighting its benefits in inhibiting inflammation, modulating autophagy, antagonizing oxidative stress, and reducing pain levels for patients. Metformin, with its anti-inflammatory and anti-aging properties, has the potential to be an effective drug for treating osteoarthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Reproductive Biology
Xing Zhang, Song-Mao Guo, Da-Wei Zhu, Yu Li, Fei Wen, Ming Xian, Zhang-Tao Hu, Qian-Long Zou, Li-Kun Zhang, Yu-Lin Chen, Jian-Hong Hu
Summary: This study investigated the effect of metformin on sheep semen cryopreservation and identified the most effective concentration as 1.0 mmol/L. The results demonstrated that metformin significantly improved sperm quality, reduced oxidative stress, and enhanced sperm mitochondrial function and fertilization capacity through the AMPK pathway.
Article
Neurosciences
Pingping Ning, Anling Luo, Xin Mu, Yanming Xu, Tian Li
Summary: Alzheimer's disease is the most common neurodegenerative disease characterized by the deposition of amyloid beta plaques and neurofibrillary tangles in the brain. Research has shown a significant association between Type 2 diabetes and AD, suggesting common pathophysiological mechanisms.
Article
Multidisciplinary Sciences
Lorea Zubiaga, Olivier Briand, Florent Auger, Veronique Touche, Thomas Hubert, Julien Thevenet, Camille Marciniak, Audrey Quenon, Caroline Bonner, Simon Peschard, Violeta Raverdy, Mehdi Daoudi, Julie Kerr-Conte, Gianni Pasquetti, Hermann Koepsell, Daniela Zdzieblo, Markus Muhlemann, Bernard Thorens, Nathalie D. Delzenne, Laure B. Bindels, Benoit Deprez, Marie C. Vantyghem, Blandine Laferrere, Bart Staels, Damien Huglo, Sophie Lestavel, Francois Pattou
Summary: Metformin (MET) is a commonly prescribed antidiabetic drug, and recent data suggests that its main mechanism of action is through the gut. It reduces the expression of sodium-glucose transporter 1 (SGLT1) in enterocytes, leading to decreased glucose absorption and transiently lowering post-prandial glucose response.
Article
Oncology
Siyuan Yan, Dongdong Yuan, Qianqian Li, Shi Li, Fan Zhang
Summary: Numerous studies have shown the importance of PFKFB3 in glycolysis regulation. PFK-15 inhibitor induces cell death and affects autophagy and protein degradation pathways. AICAR can restore AMPK activity and autophagy while enhancing cell death caused by PFK-15. Additionally, AICAR attenuates the inhibitory effect of PFK-15 on the AKT-mTORC1 signaling pathway.
Article
Cell Biology
Carolina Silva, Ilda Rodrigues, Sara Andrade, Raquel Costa, Raquel Soares
Summary: The study demonstrates that metformin can prevent vessel assembly in human microvascular endothelial cells through an AMPK-independent mechanism. It has an impact on the expression of key genes related to angiogenesis, while showing no significant effects on cell proliferation and invasion.
Article
Oncology
Aleksei Viktorovich Novik, Svetlana Anatolievna Protsenko, Irina Alexandrovna Baldueva, Lev Michailovich Berstein, Vladimir Nikolaevich Anisimov, Irina Nikolaevna Zhuk, Anna Igorevna Semenova, Dilorom Khamidovna Latipova, Elena Viktorovna Tkachenko, Tatiana Yurievna Semiglazova
Summary: There was no evidence to suggest that melatonin and metformin could increase the efficacy of systemic chemotherapy in melanoma. Combination therapy with these two drugs did not show more benefit than monotherapy with dacarbazine. Delayed responses were observed in patients receiving the combination therapy, indicating potential involvement of the immune system in clinical activity.
Review
Cardiac & Cardiovascular Systems
Manrose Singh, Akito T. Nicol, Jaclyn DelPozzo, Jia Wei, Mandeep Singh, Tony Nguyen, Satoru Kobayashi, Qiangrong Liang
Summary: Current research suggests that metformin (MET) may reduce the cardiotoxicity of doxorubicin (DOX) and enhance its anticancer effects through the activation of AMP-activated protein kinase (AMPK). However, further studies are needed to fully understand the role and mechanism of the MET-AMPK axis in DOX cardiotoxicity and antitumor efficacy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Chemistry, Medicinal
Wei Mu, Guoqiang Liang, Yue Feng, Yunyun Jiang, Falin Qu
Summary: Metformin, a widely-used anti-diabetic drug, has shown potential in treating bone metabolic disorders in addition to its efficacy in lowering blood glucose levels. It has been found to regulate bone formation and prevent bone fragility through various mechanisms, including activating AMPK and inhibiting mitochondrial respiratory chain complex I. Adequate glycemic control is important in preventing bone tissue alterations in diabetic patients. Overall, metformin is considered a promising adjunct therapy for bone metabolic disorders.
Review
Biochemistry & Molecular Biology
Mehdi Sanati, Samaneh Aminyavari, Hamid Mollazadeh, Ali Motamed-Sanaye, Bahram Bibak, Elmira Mohtashami, Yong Teng, Amir R. R. Afshari, Amirhossein Sahebkar
Summary: This research reviewed the literature to assess the connection between metformin's anticancer properties and the development of glioblastoma multiforme (GBM). The comprehensive review found that metformin not only inhibits tumor growth by activating the AMPK pathway, but also induces cell apoptosis, inhibits cell proliferation and metastasis, and enhances chemo-radio-sensitizing behavior against GBM through other mechanisms. Further research is needed to explore the potential of metformin-based therapeutics for GBM and the challenges they may face.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Rex John Scaramuzzi, Nesrine Zouaidi, Jean-Baptiste Menassol, Joelle Dupont
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2015)
Article
Reproductive Biology
L. Falchi, R. J. Scaramuzzi
Article
Agriculture, Dairy & Animal Science
J. Dupont, R. J. Scaramuzzi, M. Reverchon
Article
Reproductive Biology
Jean-Baptiste Menassol, Armelle Collet, Didier Chesneau, Benoit Malpaux, Rex J. Scaramuzzi
BIOLOGY OF REPRODUCTION
(2012)
Article
Developmental Biology
A. Somchit-Assavacheep, B. K. Campbell, M. Khalid, N. R. Kendall, R. J. Scaramuzzi
Article
Developmental Biology
H. M. Brown, C. Fabre Nys, J. Cognie, R. J. Scaramuzzi
Review
Developmental Biology
R. J. Scaramuzzi, D. T. Baird, B. K. Campbell, M. -A. Driancourt, J. Dupont, J. E. Fortune, R. B. Gilchrist, G. B. Martin, K. P. McNatty, A. S. McNeilly, P. Monget, D. Monniaux, C. Vinoles, R. Webb
REPRODUCTION FERTILITY AND DEVELOPMENT
(2011)
Article
Developmental Biology
B. K. Campbell, N. R. Kendall, V. Onions, L. Guo, R. J. Scaramuzzi
REPRODUCTION FERTILITY AND DEVELOPMENT
(2014)
Article
Developmental Biology
R. J. Scaramuzzi, L. Oujagir, J-B. Menassol, S. Freret, A. Piezel, H. M. Brown, J. Cognie, C. Fabre Nys
REPRODUCTION FERTILITY AND DEVELOPMENT
(2014)
Article
Agriculture, Dairy & Animal Science
S. Leethongdee, M. Khalid, R. J. Scaramuzzi
REPRODUCTION IN DOMESTIC ANIMALS
(2014)
Article
Reproductive Biology
L. Falchi, M. Taema, S. La Clanche, R. J. Scaramuzzi
Article
Reproductive Biology
L. Falchi, R. J. Scaramuzzi
Article
Agriculture, Dairy & Animal Science
Fabio De Rensis, Roberta Saleri, Irina Garcia-Ispierto, Rex Scaramuzzi, Fernando Lopez-Gatius
Summary: Environmentally induced hyperthermia, or heat stress (HS), has negative effects on reproductive physiology in mammals, particularly altering oocyte quality and follicular growth dynamics. Dairy cows, under metabolic stress from high milk production, serve as a good model for studying the impact of HS on ovarian function. Heat stress may impair ovulation, fertilization, and early embryo development, with evidence of long-lasting effects on oogenesis and final follicular maturation.
Article
Developmental Biology
Claude Fabre-Nys, Audrey Chanvallon, Nathalie Debus, Dominique Francois, Frederic Bouvier, Joelle Dupont, Lionel Lardic, Didier Lomet, Christelle Rame, Rex J. Scaramuzzi