Article
Immunology
Julia Castillo-Gonzalez, Jose Luis Ruiz, Ignacio Serrano-Martinez, Irene Forte-Lago, Ana Ubago-Rodriguez, Marta Caro, Jesus Miguel Perez-Gomez, Alejandro Benitez-Troncoso, Eduardo Andres-Leon, Macarena Sanchez-Navarro, Raul M. Luque, Elena Gonzalez-Rey
Summary: This study aimed to investigate the potential function of endogenous and therapeutic cortistatin in regulating brain endothelium dysfunction in a neuroinflammatory/neurodegenerative environment. The results demonstrated that cortistatin plays a key role in maintaining cerebral microvasculature physiology, and its presence is crucial for a balanced response to damage and the repair of barrier integrity. Cortistatin-based therapies could emerge as a novel strategy to ameliorate neuroinflammatory/neurodegenerative disorders with disrupted BBB.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Andrea E. Toth, Hans C. Helms, Andras Harazin, Kasper B. Johnsen, Charlotte Goldeman, Annette Burkhart, Maj S. Thomsen, Paul J. Kempen, Adrian Klepe, Dora V. Lipka, Peter L. Moller, Thomas L. Andresen, Mette Nyegaard, Torben Moos, Birger Brodin, Morten S. Nielsen
Summary: Sortilin acts as a crucial regulatory protein for maintaining the tightness of the blood-brain barrier (BBB). Lack of sortilin results in BBB leakage, potentially due to alterations in signalling pathways, leading to compromised connections between brain endothelial cells.
Article
Neurosciences
Si-yi Xu, Hui-jie Bian, Shu Shu, Sheng-nan Xia, Yue Gu, Mei-juan Zhang, Yun Xu, Xiang Cao
Summary: Inhibiting AIM2 appears to preserve BBB integrity after ischemic stroke by modulating STAT3 activation, suggesting that AIM2 may be a promising therapeutic target for cerebral ischemic stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Editorial Material
Pharmacology & Pharmacy
Jessica I. Griffith, Jann N. Sarkaria, William F. Elmquist
Summary: Although apparent blood-brain barrier disruption is common in glioblastoma, it has not resulted in improved drug delivery efficacy. Recent studies have shown that efflux transporters play a significant role in limiting drug delivery, leading to ineffective drug delivery to brain tumor cells.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Chemistry, Analytical
Maider Badiola-Mateos, Davide Di Giuseppe, Roberto Paoli, Maria Jose Lopez-Martinez, Arianna Mencattini, Josep Samitier, Eugenio Martinelli
Summary: The study aims to overcome limitations of current techniques for measuring barrier integrity by using a multi-layer microfluidic platform with integrated electrodes and MTEER, in conjunction with machine learning algorithms. The platform can detect barrier formation, opening, and regeneration, and has the potential to aid in understanding barrier responses to different drug treatments.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Pharmacology & Pharmacy
Seph M. Palomino, Aidan A. Levine, Jared Wahl, Erika Liktor-Busa, John M. Streicher, Tally M. Largent-Milnes
Summary: This study investigated the role of heat shock protein HSP90 in blood-brain barrier leak associated with cortical spreading depression (CSD). The results showed that inhibition of HSP90 reduced CSD-induced blood-brain barrier leak, suggesting a potential therapeutic approach for headache disorders targeting HSP90.
Review
Biochemistry & Molecular Biology
Ruicheng Yang, Jundan Wang, Fen Wang, Huipeng Zhang, Chen Tan, Huanchun Chen, Xiangru Wang
Summary: Despite advances in treatment, bacterial meningitis remains a serious infection that poses a risk to life. The blood-brain barrier plays an important role in the pathogenesis of bacterial meningitis through increased permeability. Recent studies have shown that targeting the factors contributing to enhanced blood-brain barrier permeability is an effective complement to antimicrobial therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Peina Wang, Qianqian Ren, Mengtong Shi, Yuanyuan Liu, Huiyuan Bai, Yan-Zhong Chang
Summary: Blood-brain barrier (BBB) breakdown is a common feature of ischemic stroke. This study reveals that overexpression of mitochondrial ferritin (FtMt) can attenuate BBB disruption in an ischemia-reperfusion (I/R) injury model by inhibiting iron dysregulation and reactive oxygen species accumulation. These findings provide novel insights into the protective role of FtMt in maintaining BBB integrity during ischemic stroke.
Article
Biochemistry & Molecular Biology
Typhaine Anquetil, Romain Solinhac, Aude Jaffre, Gaetan Chicanne, Julien Viaud, Jean Darcourt, Cyrille Orset, Eva Geuss, Christoph Kleinschnitz, Bart Vanhaesebroeck, Denis Vivien, Karim Hnia, Vincent Larrue, Bernard Payrastre, Marie-Pierre Gratacap
Summary: Protecting endothelial cells is critical in preventing the impact of vascular leakage and edema on pathological conditions. PI3KC2 beta could be a potential new therapeutic target for treating aggravating lesions following ischemic stroke.
Article
Medicine, General & Internal
Kristy Nguyen, Pierre Juillard, Simon Hawke, Georges E. Grau, Felix Marsh-Wakefield
Summary: The breakdown of the blood-brain barrier and the migration of lymphocytes play important roles in the development of multiple sclerosis. Treatment with alemtuzumab can inhibit inflammation in the central nervous system, but its effect on T cell migration needs more study.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Yanzhao Zhou, Feng Yan, Xue Han, Xin Huang, Xiang Cheng, Yanan Geng, Xiufang Jiang, Ying Han, Ming Zhao, Lingling Zhu
Summary: NB-3 plays an important role in neural development and injury recovery. It maintains the integrity of the blood brain barrier under high-altitude cerebral edema conditions. Deficiency of NB-3 leads to BBB leakage and downregulation of tight junction proteins, while overexpression or supplementation with NB-3 can alleviate endothelial barrier injuries.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Doryssa Hermans, Evelien Houben, Paulien Baeten, Helena Slaets, Kris Janssens, Cindy Hoeks, Baharak Hosseinkhani, Gayel Duran, Seppe Bormans, Elizabeth Gowing, Chloe Hoornaert, Lien Beckers, Wing Ka Fung, Horst Schroten, Hiroshi Ishikawa, Judith Fraussen, Ronald Thoelen, Helga E. de Vries, Gijs Kooij, Stephanie Zandee, Alexandre Prat, Niels Hellings, Bieke Broux
Summary: OSM plays an important role in neuro-inflammatory diseases, including MS, where it increases the responsiveness of lymphocytes and is produced by activated myeloid cells and astrocytes. In a preclinical model of MS, OSMR beta-deficient mice show milder symptoms, reduced Th17 cell infiltration, and BBB leakage. In vitro, OSM reduces BBB integrity, promotes CCL20 secretion by inflamed BBB-endothelial cells and astrocytes, and enhances Th17 cell adhesion.
ACTA NEUROPATHOLOGICA
(2022)
Review
Biochemistry & Molecular Biology
Evelyne Gozal, Rekha Jagadapillai, Jun Cai, Gregory N. Barnes
Summary: This review discusses the role of the Sonic Hedgehog/Wingless-related integration site (Shh/Wnt) pathways in neurodevelopment, neuroinflammation, and blood-brain barrier (BBB) development, revealing their crucial implications in the pathophysiology of Autism Spectrum Disorder.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biotechnology & Applied Microbiology
Juntao Wang, Fang Xu, Xiaoming Zhu, Xianghua Li, Yankun Li, Jia Li
Summary: The blood-brain barrier (BBB) is a specialized neurovascular unit that protects the brain from harmful substances and facilitates the exchange of essential nutrients vital for brain homeostasis. Disrupted BBB integrity is often associated with brain diseases, highlighting the importance of understanding the mechanisms underlying BBB regulation. MicroRNAs (miRNA) have emerged as important regulators of BBB integrity, presenting potential therapeutic targets for brain diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chenglong Gao, Yazhou Xu, Zhuangzhuang Liang, Yunjie Wang, Qinghong Shang, Shengbin Zhang, Cunfang Wang, Mingmin Ni, Dalei Wu, Zhangjian Huang, Tao Pang
Summary: LFHP-1c, as a direct PGAM5 inhibitor, has been shown to prevent blood-brain barrier disruption after ischemic stroke by inhibiting PGAM5 phosphatase activity and reducing interaction with NRF2, leading to nuclear translocation of NRF2 and protection against BBB disruption. Additionally, LFHP-1c administration targeting PGAM5 has shown promise in reducing infarct volume, brain edema, and neurological deficits in a nonhuman primate model with tMCAO, suggesting a potential therapeutic for brain ischemic stroke.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Cardiac & Cardiovascular Systems
Helene David, Aurore Ughetto, Philippe Gaudard, Maelle Plawecki, Nitchawat Paiyabhroma, Emma Zub, Pascal Colson, Sylvain Richard, Nicola Marchi, Pierre Sicard
Summary: The study utilized in vivo photoacoustic imaging to track changes in vascular oxygen saturation in multiple organs and the brain post-myocardial infarction. Results showed a correlation between LV sO(2) and cardiac dysfunction, with global hypoxia observed in the brain, kidney, and liver shortly after MI, but returning to pre-MI levels after 7 days.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Environmental Sciences
Isabel Forner-Piquer, Adele Faucherre, Julia Byram, Marine Blaquiere, Frederic de Bock, Laurence Gamet-Payrastre, Sandrine Ellero-Simatos, Etienne Audinat, Chris Jopling, Nicola Marchi
Summary: In zebrafish larvae, exposure to high concentrations of glyphosate leads to behavioral and neurophysiological defects, while cellular and transcript signatures can be detected in response to low doses.
Article
Clinical Neurology
Damir Janigro, Damian M. Bailey, Sylvain Lehmann, Jerome Badaut, Robin O'Flynn, Christophe Hirtz, Nicola Marchi
Summary: The blood-brain barrier in the neurovascular unit plays a critical role in isolating the brain parenchyma from peripheral blood, and increased permeability of the barrier can contribute to the onset of CNS diseases. Biomarkers from glial, neuronal, and pericyte cells can exit the brain and appear in peripheral body fluids, such as saliva or urine, in various temporal trajectories under pathological conditions.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Fabien Boux, Florence Forbes, Nora Collomb, Emma Zub, Lucile Maziere, Frederic de Bock, Marine Blaquiere, Vasile Stupar, Antoine Depaulis, Nicola Marchi, Emmanuel L. Barbier
Summary: The study aims to improve the identification of the epileptogenic zone and associated seizure-spreading regions using multi-parametric MRI analysis. The results show that combining multiple cellular and cerebrovascular MRI read-outs can effectively differentiate epileptogenic from seizure-spreading areas in an experimental model of mesial temporal lobe epilepsy. The potential clinical value of these findings is discussed.
Article
Environmental Sciences
Isabel Forner-Piquer, Wendy Klement, Giuseppe Gangarossa, Emma Zub, Frederic de Bock, Marine Blaquiere, Tangui Maurice, Etienne Audinat, Adele Faucherre, Frederic Lasserre, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre, Chris Jopling, Nicola Marchi
Summary: The study found that male offspring of mice exposed to a pesticide cocktail exhibited anxiety-like behavior, while zebrafish larvae exposed to the pesticide cocktail during development showed alterations in motor behaviors.
ENVIRONMENTAL POLLUTION
(2021)
Article
Endocrinology & Metabolism
Damian M. Bailey, Anthony R. Bain, Ryan L. Hoiland, Otto F. Barak, Ivan Drvis, Christophe Hirtz, Sylvain Lehmann, Nicola Marchi, Damir Janigro, David B. MacLeod, Philip N. Ainslie, Zeljko Dujic
Summary: In this study, it was found that prolonged apnea duration during voluntary asphyxia leads to increased cerebral blood flow and blood-brain barrier permeability. The study highlights the critical role of hypoxemia and hypercapnia in BBB disruption.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Geoffrey Canet, Charleine Zussy, Celia Hernandez, Nathalie Chevallier, Nicola Marchi, Catherine Desrumaux, Laurent Givalois
Summary: This study reveals that chronic corticosterone (CORT) consumption is a main risk factor for Alzheimer's disease (AD) and suggests that glucocorticoid-based therapies should be prescribed with caution in populations with AD risk.
NEUROENDOCRINOLOGY
(2022)
Review
Clinical Neurology
Erwin A. van Vliet, Nicola Marchi
Summary: The neurovascular unit (NVU) is a complex network involving different cells in the brain, including specialized brain endothelium, glial and mural cells, and neurons. Research suggests that dysfunction of the NVU is a common mechanism underlying late-onset seizures or epilepsy, neurological and neurodegenerative disorders associated with aging. Further studies also indicate that seizure activity may contribute to brain aging by causing regional NVU dysfunction, while cerebrovascular pathology may be linked to comorbidities. Diagnostic approaches tailored to seizure conditions in the elderly and disease-modifying strategies focusing on NVU restoration and control of inflammation are being explored. However, there are still knowledge gaps and clinical challenges in understanding seizure onset and conditions in an aging population.
Article
Clinical Neurology
Geoffrey Canet, Emma Zub, Charleine Zussy, Celia Hernandez, Marine Blaquiere, Valentin Garcia, Mathieu Vitalis, Frederic DeBock, Maria Moreno-Montano, Etienne Audinat, Catherine Desrumaux, Emmanuel Planel, Laurent Givalois, Nicola Marchi
Article
Critical Care Medicine
Charlotte Oris, Julie Durif, Marion Rouzaire, Bruno Pereira, Damien Bouvier, Samy Kahouadji, Mathieu Abbot, Marina Brailova, Sylvain Lehmann, Christophe Hirtz, Philippe Decq, Bernard Dusfour, Nicola Marchi, Vincent Sapin
Summary: This study evaluated the use of seven blood biomarkers for sport-related concussions. Only S100B and GFAP remained stable over the course of a season. The individual percentage change of S100B and NFL concentrations measured 36 hours after concussion was significantly different between non-resolutive and resolutive cases.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
N. Cresto, A. Janvier, N. Marchi
Summary: While seizures involve neuronal events, other brain cells also play a significant role in synaptic transmission. The blood-brain barrier and neuro-glio-vascular unit regulate the brain's homeostasis by maintaining the composition of the interstitial fluid. Damage to the blood-brain barrier and neuroinflammation are mechanisms that sustain abnormal neuronal discharges, which are associated with various pathological conditions. The understanding of the role of the blood-brain barrier and neuroinflammation in epilepsy could lead to the development of biomarkers for predicting disease progression and the discovery of new diagnostic and therapeutic approaches.
REVUE NEUROLOGIQUE
(2023)
Article
Environmental Sciences
Sophie Sakkaki, Noemie Cresto, Raphael Chancel, Emma Zub, Pierre Sicard, Tangui Maurice, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre, Nicola Marchi, Julie Perroy
Summary: This study investigates the risk of continuous exposure to glyphosate from prenatal to adulthood and the impact of Shank3 synaptic gene mutation on neurological adaptations. The results show that prenatal exposure to glyphosate increases embryonic mortality rate and leads to neuroinflammation and behavioral adaptations in progenies of Shank3(Delta C/+) mice.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Neurosciences
Valentin Garcia, Marine Blaquiere, Alicia Janvier, Noemie Cresto, Carla Lana, Athenais Genin, Helene Hirbec, Etienne Audinat, Adele Faucherre, Emmanuel L. Barbier, Sophie Hamelin, Philippe Kahane, Chris Jopling, Nicola Marchi
Summary: This study reveals the association between mechanosensitive channel PIEZO1 and inflammatory responses in the central nervous system, particularly in the context of epilepsy. The expression of PIEZO1 is increased in epileptogenic regions of the brain and correlates with pro-inflammatory biomarkers. Additionally, TNF alpha is identified as a direct regulator of PIEZO1 expression. These findings highlight the potential significance of PIEZO1 in neuro-inflammatory processes.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cell Biology
Fabiana Oliviero, Wendy Klement, Lucile Mary, Yannick Dauwe, Yannick Lippi, Claire Naylies, Veronique Gayrard, Nicola Marchi, Laila Mselli-Lakhal
Summary: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common chronic liver disease, especially in obese individuals. This study suggests that the nuclear receptor CAR may play a role in the pathogenesis of NAFLD and could be a potential therapeutic target. In mice, deletion of CAR led to a NASH-like hepatic transcriptomic signature and astrogliosis in the hypothalamus of female mice.
Article
Immunology
Anais Virenque, Hennariikka Koivisto, Salli Antila, Emma Zub, Erin Jane Rooney, Diana Miszczuk, Adrian Mueller, Enija Stoka, Nicola Marchi, Kari Alitalo, Heikki Tanila, Francesco Mattia Noe
Summary: Understanding the pathological mechanisms of chronic traumatic brain injury (TBI) could lead to new therapeutic approaches. This study examined the role of meningeal lymphatic vessel dysfunction in modifying post-TBI pathology. The results showed that preexisting dysfunction of meningeal lymphatic vessels did not impact the structural brain damage and post-TBI behavior, but was associated with increased activation of microglia over time.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2022)