Article
Engineering, Electrical & Electronic
Hamza Landari, Jean-Christophe Blais, Younes Messaddeq, Amine Miled
Summary: This study proposes a new method for continuous monitoring and grading of maple syrup degrees Brix and color based on multiple sensing methods including electrochemical sensing, electrical impedance, and optical sensing. Experimental results show that the electrochemical sensor is impacted by temperature, the electrical impedance method can establish a fitting relationship between impedance and degrees Brix, and the optical sensor using a green LED is most suitable for maple syrup grade detection.
IEEE SENSORS JOURNAL
(2021)
Article
Engineering, Electrical & Electronic
Niccolo Biasi, Andrea Gargano, Lucia Arcarisi, Nicola Carbonaro, Alessandro Tognetti
Summary: This work presents an innovative framework for the practical implementation of tactile sensors based on electrical impedance tomography. The framework involves the use of a physics-based general purpose FEM software for the implementation of the forward model, and an artificial neural network (ANN) model for the inverse problem solution. The results demonstrate that the ANN approach outperforms standard linear reconstruction methods in terms of accuracy, both on simulated data and with a physical prototype for touch position detection.
IEEE SENSORS JOURNAL
(2022)
Article
Engineering, Biomedical
Gerwin Dijk, Romanos Poulkouras, Rodney P. OConnor
Summary: In this study, an all-in-one microchip with stimulation electrodes and low impedance micro-scale sensing electrodes was developed for highly sensitive impedance monitoring. The results showed that coated electrodes with PEDOT:PSS exhibited more pronounced impedance changes and improved spatial resolution and sensitivity.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Allergy
Arturo O. Rinaldi, Manru Li, Elena Barletta, Paolo D'Avino, Duygu Yazici, Yagiz Pat, Siobhan Ward, Daniel Burla, Ge Tan, Nima Askary, Rasmus Larsson, Jeremy Bost, Huseyn Babayev, Raja Dhir, Nicolas Gaudenzio, Mubeccel Akdis, Kari Nadeau, Cezmi A. Akdis, Yasutaka Mitamura
Summary: The study demonstrated that household laundry detergents and SDS impaired the epidermal barrier in both in vivo and ex vivo human skin models. Daily exposure to detergents may lead to skin barrier disruption and contribute to the development of atopic diseases. Laundry detergents caused reduced electrical impedance, disrupted major pathways involved in skin barrier integrity, and induced inflammation.
Article
Nanoscience & Nanotechnology
Marian Baah, Afifa Rahman, Sarah Sibilia, Gianmarco Trezza, Luigi Ferrigno, Laura Micheli, Antonio Maffucci, Ekaterina Soboleva, Yuri Svirko, Polina Kuzhir
Summary: This paper proposes an original approach for real-time detection of industrial organic pollutants in water based on the time evolution monitoring of the electrical impedance of low-cost graphitic nanomembranes. The approach utilizes the high sensitivity of 2D graphene-related materials to adsorbents. The study examines the sensitivity of nanomembranes based on pyrolyzed photoresist, pyrolytic carbon (PyC), and multilayer graphene films, and demonstrates the correlation between the sensitivity of electric impedance to adsorbents and the structure of the nanomembranes. The results reveal that amorphous PyC, being the most homogeneous and adhesive to the SiO2 substrate, shows the most promising integration capability into industrial pollutants sensors.
Article
Biochemistry & Molecular Biology
Andrew S. Mason, Claire L. Varley, Olivia M. Foody, Xiang Li, Katie Skinner, Dawn Walker, Tony R. Larson, Daisuke Wakamatsu, Simon C. Baker, Jennifer Southgate
Summary: Urothelium is a specialized epithelium that lines the lower urinary tract and plays a crucial role in maintaining barrier function. This study explored the role of glycerophospholipids in urothelial barrier function and demonstrated the importance of lipid mediators in tissue homeostasis. Transcriptomic analysis revealed metabolic changes during urothelial differentiation, and knocking down the LPCAT4 gene significantly affected cell proliferation and barrier function recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Electrical & Electronic
Junwei Li, Kok-Meng Lee
Summary: This article proposes an impedance sensing method using conductivity changes during muscle contraction to estimate muscle-driven joint torques through a convolutional neural network (CNN). The effects of different image formats on CNN performance are experimentally studied on human forearms. The findings show that the impedance-based method can accurately estimate joint torques and data sharing among similar groups can reduce training time for CNN on new subjects.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Akshata Anchan, Graeme Finlay, Catherine E. Angel, James J. W. Hucklesby, Scott E. Graham
Summary: Previous studies have shown that human melanoma cells can weaken the brain endothelial barrier, but the expression of MMPs and proteases released by melanoma cells may not directly contribute to the initial disruption of the brain endothelium.
Article
Engineering, Electrical & Electronic
Goran M. Stojanovic, Tijana Kojic, Mitar Simic, Aleksandra Jovanovic-Galovic, Bojan Pavlovic, Amaia Zurutuza, Luca Anzi, Roman Sordan
Summary: A compact microfluidic platform for selective detection of ascorbic acid was presented in this paper, with the application of graphene improving response linearity and reducing detection and quantification limits compared to the reference structure.
IEEE SENSORS JOURNAL
(2021)
Article
Allergy
Arturo O. Rinaldi, Angelica Korsfeldt, Siobhan Ward, Daniel Burla, Anita Dreher, Marja Gautschi, Britta Stolpe, Ge Tan, Eugen Bersuch, David Melin, Nima Askary Lord, Simon Grant, Per Svedenhag, Kristina Tsekova, Peter Schmid-Grendelmeier, Matthias Mohrenschlager, Ellen D. Renner, Cezmi A. Akdis
Summary: This study successfully established a method to directly assess the in vivo status of the epithelial barrier using electrical impedance spectroscopy, demonstrating its usefulness in patients with atopic dermatitis. Electrical impedance spectroscopy showed a significant negative correlation with transepidermal water loss, and a higher sensitivity in discriminating between lesional and non-lesional skin in patients with atopic dermatitis.
Article
Allergy
Mari Sasaki, Mathilda Sundberg, Remo Frei, Ruth Ferstl, Kristina N. Heye, Erik P. Willems, Cezmi A. Akdis, Roger Lauener, Caroline Roduit
Summary: This study investigates the use of electrical impedance spectroscopy to detect skin barrier dysfunction in children with AD. Based on the EIS/AD score, EIS algorithm is able to clearly differentiate healthy skin and clinically unaffected skin of 4 months to 3-year-old children with active AD. EIS/AD score is also different between healthy skin, skin of children with non-active AD (before onset or after onset of AD but without active symptoms) and active AD.
Article
Computer Science, Software Engineering
Junxiao Shen, John Dudley, George Mo, Per Ola Kristensson
Summary: This paper examines the task of key gesture spotting and proposes a key gesture spotting architecture to address the challenges of accuracy and activation lag. The architecture achieved high recognition accuracy with early detection and can be efficiently used by developers through a graphical user interface and an application programming interface.
IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS
(2022)
Article
Engineering, Multidisciplinary
Yuan Yang, Wenbo Zhou, Xuyang Chen, Jinhua Ye, Haibin Wu
Summary: The new non-array flexible touching sensor based on variation of electrical impedance distribution (VEID) is proposed for detecting position and pressure of external touching, utilizing the SVM algorithm for modeling the relation between different touching and monitoring electrode signals with high accuracy.
Article
Environmental Sciences
Rinku Basak, Khan A. Wahid
Summary: Plant phenotyping is crucial for enhancing crop yields by evaluating plant traits through image reconstruction. In this study, an electrical impedance tomography (EIT) system is developed to non-destructively reconstruct and evaluate plant inhomogeneities. The system utilizes a high-precision electrode array sensor and impedance imaging technique to assess and calibrate the reconstructed results. The performance and accuracy of the EIT system are evaluated using low-cost impedance spectroscopy tools and a finite element method (FEM) modeling.
Article
Engineering, Mechanical
Ling Zhu, Yishou Wang, Weixuan Zhang, Xiangwen Xiao, Yuan Liu, Wendong Xue
Summary: This paper presents an online wear particles cluster imaging method based on tdEIT and Unet. Key issues are solved and the proposed system successfully images the clustering zone of wear particles in lubricating oil.
TRIBOLOGY INTERNATIONAL
(2023)
Article
Chemistry, Analytical
Roberto Paoli, Davide Di Giuseppe, Maider Badiola-Mateos, Eugenio Martinelli, Maria Jose Lopez-Martinez, Josep Samitier
Summary: This paper discusses the application of digital manufacturing and rapid prototyping technologies in Organ-on-a-Chip applications, as well as the main thermoplastic material choices and manufacturing methods, and investigates the limitations of the PDMS soft lithography strategy.
Article
Multidisciplinary Sciences
Valeria Rizzuto, Arianna Mencattini, Begona Alvarez-Gonzalez, Davide Di Giuseppe, Eugenio Martinelli, David Beneitez-Pastor, Maria del Mar Manu-Pereira, Maria Jose Lopez-Martinez, Josep Samitier
Summary: The combination of microfluidics technology with machine learning allows for massive quantitative cell behavior studies and the development of intelligent decision-making systems. By adapting the physiological spleen filtering strategy for in vitro study using a microfluidic device, RBC shape analysis in blood diseases can be effectively monitored. The proposed platform shows high efficiency in discriminating healthy controls and patients, as well as distinguishing between RHHA subtypes.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Nuria Blanco-Cabra, Maria Jose Lopez-Martinez, Betsy Veronica Arevalo-Jaimes, Maria Teresa Martin-Gomez, Josep Samitier, Eduard Torrents
Summary: The management of bacterial infections is currently threatened by increasing antimicrobial resistance, chronic biofilm-associated infections, and lack of appropriate treatment approaches. This study introduces a microfluidic platform called BiofilmChip, which provides a straightforward tool for antimicrobial biofilm susceptibility testing, suitable for use in routine clinical laboratories.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Biochemical Research Methods
Sara Tombelli, Cosimo Trono, Simone Berneschi, Chiara Berrettoni, Ambra Giannetti, Romeo Bernini, Gianluca Persichetti, Genni Testa, Guillermo Orellana, Francesca Salis, Susanne Weber, Peter B. Luppa, Giampiero Porro, Giovanna Quarto, Markus Schubert, Marcel Berner, Paulo P. Freitas, Susana Cardoso, Fernando Franco, Vania Silverio, Maria Lopez-Martinez, Urs Hilbig, Kathrin Freudenberger, Gunter Gauglitz, Holger Becker, Claudia Gartner, Mark T. O'Connell, Francesco Baldini
Summary: This paper describes a compact point of care optical device for therapeutic drug monitoring, utilizing immunoassays in disposable plastic chips to detect multiple analytes simultaneously with high efficiency. The device is equipped with a microfluidic system and thin film amorphous silicon photodiodes for fluorescence detection, improving the speed and sensitivity of the assay.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Monica Mir, Sujey Palma-Florez, Anna Lagunas, Maria Jose Lopez-Martinez, Josep Samitier
Summary: In recent decades, there has been a growing interest in developing new biological platforms to study disease progression and drug efficacy, especially in neurodegenerative diseases. The blood-brain barrier (BBB), as an organ-on-a-chip platform, provides a valuable tool for understanding neurodegenerative diseases and testing drug permeability for new treatments. The integration of detection systems in BBB-oC technology allows continuous monitoring of biomarkers and automated analysis of drug permeability, making it more efficient for commercialization.
Article
Polymer Science
Francesc Subirada, Roberto Paoli, Jessica Sierra-Agudelo, Anna Lagunas, Romen Rodriguez-Trujillo, Josep Samitier
Summary: The combination of microfluidics and stereolithography (SLA) has great potential in areas like biological analysis and chemical detection. In this article, microfluidic devices were manufactured using different methods, and significant results were achieved for 3D printing with commercial resins.
Article
Multidisciplinary Sciences
Maider Badiola-Mateos, Tatsuya Osaki, Roger Dale Kamm, Josep Samitier
Summary: Proprioceptive sensory neurons (pSN) are an essential and undervalued component of the neuromuscular circuit. Differentiating human neural stem cells (hNSC) into pSN and comparing their genetic profile with motor neurons (MN) provide insights into the role of pSN in the development and progression of amyotrophic lateral sclerosis (ALS).
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Ines Pereira, Maria J. Lopez-Martinez, Aranzazu Villasante, Clelia Introna, Daniel Tornero, Josep M. Canals, Josep Samitier
Summary: In this study, a composite biomaterial consisting of GelMA, AlgMA, and HA was developed to mimic the ECM of the brain and support the long-term differentiation of NPCs. The biomaterial exhibited desired physical properties for printing defined structures and maintained high cell viability throughout the culture. The NPCs cultured in this biomaterial showed increased maturation and functional properties, as demonstrated by the formation of a neuronal network and spontaneous activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Marina Llenas, Roberto Paoli, Natalia Feiner-Gracia, Lorenzo Albertazzi, Josep Samitier, David Caballero
Summary: Tumor vessel-on-a-chip systems can accurately recapitulate the features of tumor-derived vascular networks, but face challenges in treating rare conditions such as massive thrombi and bleeding. Replicating these pathophysiological events can provide insights into vascular tumors and may have applications in vascular-related diseases.
BIOENGINEERING-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Roberto Paoli, Maria Bulwan, Oscar Castano, Elisabeth Engel, J. C. Rodriguez-Cabello, Antoni Homs-Corbera, Josep Samitier
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)