Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity

Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6

(2011) Victoria E. Ahn et al.   DEVELOPMENTAL CELL

Novel mutations affecting LRP5 splicing in patients with osteoporosis-pseudoglioma syndrome (OPPG)

(2011) C M Laine et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Lrp5 functions in bone to regulate bone mass

(2011) Yajun Cui et al.   NATURE MEDICINE

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

(2011) Zhihong Cheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

(2011) Eric Bourhis et al.   STRUCTURE

Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B

(2010) Bing Wang et al.   HUMAN MOLECULAR GENETICS

First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function

(2010) Elke Piters et al.   HUMAN MUTATION

Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

(2010) Eric Bourhis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MUC1 as a Discriminator between Endometrium from Fertile and Infertile Patients with PCOS and Endometriosis

(2010) L. Margarit et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genetic and clinical peculiarities in a new family with hereditary hypophosphatemic rickets with hypercalciuria: a case report

(2010) Natalia Mejia-Gaviria et al.   Orphanet Journal of Rare Diseases

Dkk1 Stabilizes Wnt Co-Receptor LRP6: Implication for Wnt Ligand-Induced LRP6 Down-Regulation

(2010) Yonghe Li et al.   PLoS One

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

(2010) S. A. Ettenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emerging role of serotonin (5-hydroxytryptamine) in the skeleton and its mediation of the skeletal effects of low-density lipoprotein receptor-related protein 5 (LRP5)

(2009) Stuart J. Warden et al.   BONE

Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia

(2009) Anne Saarinen et al.   CLINICAL ENDOCRINOLOGY

A1330V Variant of the Low-density Lipoprotein Receptorrelated Protein 5 (LRP5) Gene Decreases Wnt Signaling and Affects the Total Body Bone Mineral Density in Japanese Women

(2009) Tomohiko URANO et al.   ENDOCRINE JOURNAL

Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1

(2008) Banghyun Lee et al.   BIOLOGY OF REPRODUCTION

The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations

(2008) Wendy Balemans et al.   CALCIFIED TISSUE INTERNATIONAL

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

(2008) Vijay K. Yadav et al.   CELL

Gene Expression Profiles of Luteal Phase Fallopian Tube Epithelium from BRCA Mutation Carriers Resemble High-Grade Serous Carcinoma

(2008) A. A. Tone et al.   CLINICAL CANCER RESEARCH

Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma

(2007) Ya-Wei Qiang et al.   BONE

Deficient Bone Formation in Idiopathic Juvenile Osteoporosis: A Histomorphometric Study of Cancellous Iliac Bone

(2006) Frank Rauch et al.   JOURNAL OF BONE AND MINERAL RESEARCH