Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B

Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning

(2010) Hai Song et al.   NATURE

Planar polarization of node cells determines the rotational axis of node cilia

(2010) Masakazu Hashimoto et al.   NATURE CELL BIOLOGY

Planar Cell Polarity Enables Posterior Localization of Nodal Cilia and Left-Right Axis Determination during Mouse and Xenopus Embryogenesis

(2010) Dragana Antic et al.   PLoS One

The Role of Spatially Controlled Cell Proliferation in Limb Bud Morphogenesis

(2010) Bernd Boehm et al.   PLOS BIOLOGY

A BMP-Shh negative-feedback loop restricts Shh expression during limb development

(2009) M. F. Bastida et al.   DEVELOPMENT

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

(2009) K. N. Retting et al.   DEVELOPMENT

Noncanonical frizzled signaling regulates cell polarity of growth plate chondrocytes

(2009) Y. Li et al.   DEVELOPMENT

A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes

(2009) Wibke Schwarzer et al.   HUMAN MOLECULAR GENETICS

A Self-Regulatory System of Interlinked Signaling Feedback Loops Controls Mouse Limb Patterning

(2009) J.-D. Benazet et al.   SCIENCE

Vertebrate Limb Development: Moving from Classical Morphogen Gradients to an Integrated 4-Dimensional Patterning System

(2009) J.-D. Benazet et al.   Cold Spring Harbor Perspectives in Biology

Sfrp Controls Apicobasal Polarity and Oriented Cell Division in Developing Gut Epithelium

(2009) Makoto Matsuyama et al.   PLoS Genetics

The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome

(2008) R. Raz et al.   DEVELOPMENT

Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development

(2008) F. He et al.   DEVELOPMENT

Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development

(2008) D. ten Berge et al.   DEVELOPMENT

Wnt5a is essential for intestinal elongation in mice

(2008) Sara Cervantes et al.   DEVELOPMENTAL BIOLOGY

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

(2008) Jianjian Zhu et al.   DEVELOPMENTAL CELL

Cooperation of polarized cell intercalations drives convergence and extension of presomitic mesoderm during zebrafish gastrulation

(2008) Chunyue Yin et al.   JOURNAL OF CELL BIOLOGY

Genetic evidence that FGFs have an instructive role in limb proximal–distal patterning

(2008) Francesca V. Mariani et al.   NATURE

An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth

(2008) Jamie M. Verheyden et al.   NATURE

Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles

(2008) Danelle Devenport et al.   NATURE CELL BIOLOGY

The Deleted in Brachydactyly B Domain of ROR2 Is Required for Receptor Activation by Recruitment of Src

(2008) Shiva Akbarzadeh et al.   PLoS One

Genetic interaction between members of the Vangl family causes neural tube defects in mice

(2008) E. Torban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt5a Control of Cell Polarity and Directional Movement by Polarized Redistribution of Adhesion Receptors

(2008) E. S. Witze et al.   SCIENCE

FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis

(2007) K. Yu et al.   DEVELOPMENT