Article
Veterinary Sciences
Yanbin Bai, Xupeng Li, Zongchang Chen, Jingsheng Li, Hongshan Tian, Yong Ma, Sayed Haidar Abbas Raza, Bingang Shi, Xiangmin Han, Yuzhu Luo, Jiang Hu, Jiqing Wang, Xiu Liu, Shaobin Li, Zhidong Zhao
Summary: The study found that lncRNA and mRNA play a crucial role in regulating UFA synthesis in bovine adipocytes, with some lncRNAs being essential for UFA synthesis.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Zhidong Zhao, Yanbin Bai, Hongshan Tian, Bingang Shi, Xupeng Li, Yuzhu Luo, Jiqing Wang, Jiang Hu, Sayed Haidar Abbas Raza
Summary: "Through RNA-Seq analysis, circRNAs were found to regulate the expression of the ACSL1 gene and other genes related to UFA synthesis in bovine adipocytes, providing insights into the molecular mechanisms involved in circRNA-mediated regulation of UFA synthesis."
Article
Nutrition & Dietetics
Mengyang Su, Xuanrui Zhang, Wei Hu, Zhenxiao Yang, Danyu Chen, Yingdi Yang, Keliang Xie, Yuming Chen, Zheqing Zhang
Summary: This study investigated the longitudinal relationship between erythrocyte membrane PUFAs concentrations and age-related changes in skeletal muscle mass in a Chinese middle-aged and older adult population. The study found that the associations between different individual PUFAs and age-related muscle loss may differ, with high concentrations of n-6 PUFAs being correlated with less muscle mass loss, while extremely high concentrations of n-3 PUFAs being correlated with more muscle loss.
CLINICAL NUTRITION
(2023)
Article
Genetics & Heredity
Xupeng Li, Yanbin Bai, Jingsheng Li, Zongchang Chen, Yong Ma, Bingang Shi, Xiangmin Han, Yuzhu Luo, Jiang Hu, Jiqing Wang, Xiu Liu, Shaobin Li, Zhidong Zhao
Summary: This study investigates the miRNA regulation of unsaturated fatty acid synthesis in bovine adipocytes by transfecting si-ACSL1 and NC-ACSL1 in bovine preadipocytes. The results indicate that the differentially expressed miRNAs target genes involved in biological regulation and metabolic processes. Moreover, these miRNAs are enriched in metabolic pathways, fatty acid metabolism, and other related pathways.
FRONTIERS IN GENETICS
(2022)
Article
Nutrition & Dietetics
Shanshan Peng, Zhicheng Du, Yannan He, Feng Zhao, Yujing Chen, Shengchi Wu, Yuantao Hao, Li Cai
Summary: This study investigated the association between maternal erythrocyte PUFA levels and offspring allergies in the Chinese population. The findings revealed that higher levels of total PUFA, particularly arachidonic acid and n-3 PUFA, were associated with a reduced risk of offspring allergies. The associations were stronger in children with a maternal allergy history.
Article
Geriatrics & Gerontology
Permal Deo, Varinderpal S. Dhillon, Philip Thomas, Michael Fenech
Summary: The study found a negative association between saturated fatty acids and a blood biomarker of AGE, while unsaturated fatty acids showed a positive association with it. However, these associations weakened after adjusting for age, BMI, and gender.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Oncology
Iman Moussa, Rena S. Day, Ruosha Li, Ahmed Kaseb, Prasun K. Jalal, Carrie Daniel-MacDougall, Rikita I. Hatia, Ahmed Abdelhakeem, Asif Rashid, Yun Shin Chun, Donghui Li, Manal M. Hassan
Summary: This study found an inverse association between monounsaturated fatty acid intake and hepatocellular carcinoma (HCC) risk, and a direct association between total polyunsaturated fatty acid intake and HCC risk. Omega-6 PUFA intake was directly associated with HCC risk, while long-chain omega-3 PUFA intake was inversely associated with HCC risk. No significant association was observed for saturated fat and HCC risk.
Article
Biochemistry & Molecular Biology
Pablo E. Morales, Matias Monsalves-Alvarez, Satya Murthy Tadinada, Matthew P. Harris, Andrea Ramirez-Sagredo, Jafet Ortiz-Quintero, Mayarling Francisca Troncoso, Nicole De Gregorio, Ximena Calle, Renata O. Pereira, Vitor A. Lira, Alejandra Espinosa, E. Dale Abel, Sergio Lavandero
Summary: The study found that high-fat diet induced differential regulation of autophagy and mitochondrial activity in different skeletal muscles of mice. After high-fat diet feeding, oxidative soleus muscle showed increased OXPHOS subunits and mitochondrial DNA content, while gastrocnemius muscle exhibited an increase in mitochondrial mass only after 40 weeks. Defects in autophagy may alter mitochondrial respiratory activity in response to obesogenic diet.
Article
Nutrition & Dietetics
Ze-Bin Fang, Gao-Xiang Wang, Gui-Zhang Cai, Peng-Xiang Zhang, De-Liang Liu, Shu-Fang Chu, Hui-Lin Li, Hing-Xia Zhao
Summary: This study investigates the relationship between fatty acid intake and bone mineral density (BMD) in adults aged 20-59. The results reveal a significant positive correlation between the consumption of saturated fatty acids, monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids and BMD.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, Research & Experimental
Xin Wang, Rui Ma, Rongcan Shi, Hui Qin, Wenjuan Chen, Zengyang Yu, Yangfeng Ding, Chen Peng, Yuling Shi
Summary: Sex differences exist in both disease severity and plasma PUFAs levels. The association between PUFAs and psoriasis severity varies between males and females, and should be taken into consideration in future studies on the clinical application of PUFAs in psoriasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ailma O. da Paixao, Anaysa Paola Bolin, Joao G. Silvestre, Alice Cristina Rodrigues
Summary: The saturated fatty acid palmitic acid negatively affects muscle tube diameter, fusion, and metabolism, which may be related to miR-206.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Kathleen A. Lee-Sarwar, Kasper Fischer-Rasmussen, Klaus Bonnelykke, Hans Bisgaard, Bo Chawes, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Leonard B. Bacharier, Vincent J. Carey, Nancy Laranjo, Augusto A. Litonjua, Scott T. Weiss
Summary: The association between omega-3 fatty acids (n-3) and allergic diseases varies due to genetic variation. This study aimed to identify and validate genetic variants that modify the relationship between n-3 and childhood asthma or atopy. Results showed that certain SNPs in the DPP10 region interacted with n-3 levels in plasma or diet and were associated with atopy in early childhood and at age 6.
Article
Medicine, Research & Experimental
Francois Pelletier, Erwann Durand, Jatuporn Chaiyut, Clemence Bronstein, Laurence Pessemesse, Laurent Vaysse, Siriluck Liengprayoon, Sylvie Gaillet, Thomas Brioche, Christelle Bertrand-Gaday, Charles Coudray, Ariane Sultan, Christine Feillet-Coudray, Francois Casas
Summary: Skeletal muscle is essential for locomotion and energy homeostasis, and it is regulated by nutrition, genetics, physical activity, and hormones. Research has shown that a dietary supplement of furan fatty acid can reduce metabolic disorders. This study demonstrated that FuFA-F2 extracted from Hevea brasiliensis latex can stimulate muscle protein synthesis and increase muscle mass in vitro and in mice, resembling the effects of physical activity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nutrition & Dietetics
Mohsen Mazidi, Andre P. Kengne, Mario Siervo, Richard Kirwan
Summary: The study suggests that higher dietary intake of polyunsaturated fatty acids (PUFAs) is associated with improved renal function and lower risk of chronic kidney disease (CKD), while there is no significant association between monounsaturated fatty acids (MUFAs) intake and renal function or CKD risk. Genetically determined serum levels of PUFAs and MUFAs also do not show significant association with renal function and CKD risk.
Article
Nutrition & Dietetics
Huimin Tian, Haitao Yu, Yiqi Lin, Yueting Li, Wenhui Xu, Yiru Chen, Guoliang Liu, Lin Xie
Summary: This study found significant differences in the content of n-6 PUFA in breast milk based on the transcription levels of the FADS1 gene, highlighting the importance of developing new methods and diets to optimize infant feeding.
Article
Multidisciplinary Sciences
Wietje Nolte, Georg Thaller, Christa Kuehn
Article
Multidisciplinary Sciences
Franziska Koch, Ulrike Thom, Elke Albrecht, Rosemarie Weikard, Wietje Nolte, Bjoern Kuhla, Christa Kuehn
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Annie Robic, Thomas Faraut, Sarah Djebali, Rosemarie Weikard, Katia Feve, Sarah Maman, Christa Kuehn
Article
Veterinary Sciences
A. Heimes, J. Brodhagen, R. Weikard, H. M. Hammon, M. M. Meyerholz, W. Petzl, H. Zerbe, S. Engelmann, M. Schmicke, M. Hoedemaker, H. -J. Schuberth, C. Kuehn
BMC VETERINARY RESEARCH
(2019)
Article
Multidisciplinary Sciences
Yinuo Liu, Elke Albrecht, Dirk Dannenberger, Harald M. Hammon, Christa Kuehn, Helga Sauerwein, Runjun Yang, Zhihui Zhao, Steffen Maak
SCIENTIFIC REPORTS
(2019)
Correction
Veterinary Sciences
A. Heimes, J. Brodhagen, R. Weikard, H. M. Hammon, M. M. Meyerholz, W. Petzl, H. Zerbe, S. Engelmann, M. Schmicke, M. Hoedemaker, H. -J. Schuberth, C. Kuehn
BMC VETERINARY RESEARCH
(2019)
Article
Veterinary Sciences
L. Rohmeier, W. Petzl, M. Koy, T. Eickhoff, A. Huelsebusch, S. Jander, L. Macias, A. Heimes, S. Engelmann, M. Hoedemaker, H. M. Seyfert, C. Kuehn, H. J. Schuberth, H. Zerbe, M. M. Meyerholz
BMC VETERINARY RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Wietje Nolte, Rosemarie Weikard, Ronald M. Brunner, Elke Albrecht, Harald M. Hammon, Antonio Reverter, Christa Kuehn
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Genetics & Heredity
Bilal Ahmad Mir, Henry Reyer, Katrin Komolka, Siriluck Ponsuksili, Christa Kuehn, Steffen Maak
Article
Genetics & Heredity
Jacqueline Knaust, Rosemarie Weikard, Elke Albrecht, Ronald M. Brunner, Juliane Guenther, Christa Kuehn
Article
Cell Biology
Annie Robic, Julie Demars, Christa Kuehn
Article
Genetics & Heredity
Annie Robic, Christa Kuehn
Article
Multidisciplinary Sciences
Doreen Becker, Rosemarie Weikard, Frieder Hadlich, Christa Kuehn
Summary: The analysis of single-cell RNA datasets from bovine milk cells and pbMECs revealed distinct clusters within each population, indicating heterogeneity between the populations. These datasets provide a molecular cell atlas for future studies of milk cell composition and gene expression.
Article
Biotechnology & Applied Microbiology
Wietje Nolte, Hatem Alkhoder, Mirell Wobbe, Kathrin F. Stock, Ernst Kalm, Sarah Vosgerau, Nina Krattenmacher, Georg Thaller, Jens Tetens, Christa Kuehn
Summary: This study aimed to impute the microsatellite (MS) genotypes required for parentage control in German warmblood horses using a medium-density SNP panel. The results showed that MS markers with high genotyping rate perform well in cross-breeding imputation, and the method is suitable for routine implementation.
JOURNAL OF APPLIED GENETICS
(2022)
Article
Agriculture, Dairy & Animal Science
Doreen Becker, Rosemarie Weikard, Christoph Schulze, Peter Wohlsein, Christa Kuehn
GENETICS SELECTION EVOLUTION
(2020)