Review
Microbiology
Marina A. Senchukova
Summary: H. pylori plays a role in the development of gastric cancer through interactions with pattern-recognition receptors on immune and epithelial cells. In addition to induction, H. pylori may also affect the mechanisms of gastric cancer progression.
CURRENT MICROBIOLOGY
(2022)
Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Oncology
Michelle C. C. Lim, Phatcharida Jantaree, Michael Naumann
Summary: Helicobacter pylori is a pathogenic bacterium that resides in the stomach lining and causes inflammation called type B gastritis. The chronic inflammation induced by H. pylori and other factors may lead to the development of stomach neoplasms and adenocarcinoma. Dysregulation of cellular processes in the stomach lining and microenvironment is a characteristic of H. pylori infection. In this review, we discuss the contradictory role of H. pylori in promoting or suppressing apoptosis in gastric epithelial cells and highlight the key processes in the microenvironment that contribute to apoptosis and gastric carcinogenesis.
Article
Cell Biology
Duanrui Liu, Jingyu Zhu, Xiaoli Ma, Lulu Zhang, Yufei Wu, Wenshuai Zhu, Yuanxin Xing, Yanfei Jia, Yunshan Wang
Summary: The study revealed the influence of HP infection on metabolic patterns in GC, with low metabolic scores associated with poor survival. The expression of MRGs was correlated with HP infection and patient survival, providing potential targets for treatment of HP-induced GC. These findings suggest a crosstalk between metabolism and immune promotion during HP infection.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Microbiology
Victor E. Reyes
Summary: Helicobacter pylori infection is a major risk factor for gastric cancer and is associated with chronic inflammation and DNA damage. Understanding the mechanisms of H. pylori-induced carcinogenesis and immune evasion is crucial for preventing gastric cancer and reducing the burden of this disease.
Review
Biotechnology & Applied Microbiology
Linqi Zhu, Yue Huang, Hong Li, Shihe Shao
Summary: Infection with Helicobacter pylori may promote the occurrence and progression of gastric cancer by influencing the tumor microenvironment (TME).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Cell Biology
Beatrice Messina, Federica Lo Sardo, Stefano Scalera, Lorenzo Memeo, Cristina Colarossi, Marzia Mare, Giovanni Blandino, Gennaro Ciliberto, Marcello Maugeri-Sacca, Giulia Bon
Summary: The Hippo pathway is a critical regulator of tissue homeostasis, balancing cellular proliferation and differentiation. Dysregulation of this pathway is commonly observed in gastric cancer and Helicobacter pylori-induced infection, suggesting its important role in disease onset and progression. This review provides an overview of the architecture and regulation of the Hippo pathway, discusses its dysregulation in gastric cancer, and explores the crosstalk with other oncogenic signaling pathways. Furthermore, therapeutic approaches targeting aberrant YAP/TAZ activation are highlighted, along with their clinical perspectives and challenges.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Haigang Geng, Zhongyi Dong, Linmeng Zhang, Chen Yang, Tingting Li, Yuxuan Lin, Shouyu Ke, Xiang Xia, Zizhen Zhang, Gang Zhao, Chunchao Zhu
Summary: HP infection is the greatest risk factor for GC, and tumor immune microenvironment plays a critical role in the prognosis and therapeutic efficacy of HP+ GC patients. The IRSHG signature can predict the prognosis and immunotherapy efficacy of HP+ GC patients, providing new insights for personalized treatment.
Article
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, and its development is influenced by genetic predisposition, environmental factors, and Helicobacter pylori infection. Matrix metalloproteinases (MMPs) play an active role in the progression of gastric cancer, with bacterial dependence being less significant in later stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Surinder M. Soond, Andrey A. Zamyatnin
Summary: The relationship between pathogens and the increased risk of cancer has attracted significant attention, particularly the contribution of Helicobacter pylori infection to the risk of developing gastric cancer. Research is increasingly focusing on the mechanisms by which the microorganism affects host cells and the importance of the host immune system in disease progression.
Article
Oncology
Zhuoyuan Xin, Luping Zhang, Mingqing Liu, Yachen Wang, Yingli Zhang, Weidan Zhao, Yongxiao Sun, Lei Shi, Na Xu, Nan Zhang, Hong Xu
Summary: The study revealed the association between H. pylori infection and the condition of gastric cancer patients, suggesting the regulatory role of lncRNAs may affect patients' prognosis. A prognostic signature related to H. pylori infection based on lncRNAs was established and showed a strong correlation with the prognosis of patients infected with H. pylori.
FRONTIERS IN ONCOLOGY
(2021)