Article
Pharmacology & Pharmacy
Xiaoyu Zhang, Junping Zheng, Nan Jiang, Guangjun Sun, Xinkun Bao, Mingwang Kong, Xue Cheng, Aizhen Lin, Hongtao Liu
Summary: This study demonstrates that lactulose can accelerate intestinal motility, suppress inflammatory responses, protect gut barrier, and improve constipation by repairing gut microbiota and enhancing the generation of intestinal metabolites.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Immunology
Mengqi Hao, Jing Song, Xiaohu Zhai, Nuo Cheng, Cong Xu, Shuangying Gui, Juan Chen
Summary: The study found that Platycodon grandiflorum polysaccharides (PGP) have a therapeutic effect on intestinal motility disorder and can relieve constipation symptoms. PGP increases the secretion of motility-related hormones and regulates the level of serotonin (5-HT) by interacting with the gut microbiota and the intestinal neuro-endocrine system, thereby improving constipation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yifan Hu, Xiaoyu Gao, Yan Zhao, Shuangfeng Liu, Kailian Luo, Xiang Fu, Jiayi Li, Jun Sheng, Yang Tian, Yuanhong Fan
Summary: Amomum tsaoko (AT) is a dietary botanical with laxative properties, and its active components and mechanisms are still unknown. The study found that the ethanol-soluble part of AT aqueous extract (ATES), particularly the total flavonoids (ATTF), promoted defecation in constipated mice by altering the gut microbiota and serotonergic synaptic pathway. ATTF increased the abundance of Lactobacillus and Bacillus while reducing Lachnospiraceae, and it also affected gut metabolites and the expression of genes involved in the serotonergic synaptic pathway. The study suggests that ATTF has the potential for the development of laxative drugs by regulating gut microbiota and serotonergic synaptic pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Yujin Wang, Hua Jiang, Lijun Wang, Huiping Gan, Xinchun Xiao, Liangwu Huang, Wenxin Li, Zongrun Li
Summary: Luteolin, a flavone compound, has been found to enhance colonic function and alleviate functional constipation, suggesting its potential as a therapeutic option for this condition.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Yu Wei, Na Huang, Xinyu Ye, Meng Liu, Meilian Wei, Yali Huang
Summary: This study aimed to investigate the effects and mechanisms of postbiotic of hawthorn-probiotic on loperamide modeled old KM mice. The results showed that postbiotic of hawthorn-probiotic improved intestinal movement and pathomorphology, elevated AQP3, Enac-?, and mucin-2 expression, accompanied by decreased serum TNF-a and cell apoptosis, but increased proliferation. Furthermore, it modified the gut microbiota of constipated mice, featured by upregulation of Lactobacillaceae.
FRONTIERS IN NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Li Ma, Zhiqiang Qu, Luo Xu, Lei Han, Qingfang Han, Juan He, Xiao Luan, Bingxiang Wang, Yongye Sun, Baoguo He
Summary: The study suggests that 7,8-DHF may regulate colonic motility possibly via a TrkB/Akt/M3 pathway and could be applicable for alleviating constipation.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mao Chai, Linlin Wang, Xinping Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: Constipation is a widespread condition globally, and Bifidobacterium bifidum has been shown to have a relieving effect on constipation. This study found that different strains of B. bifidum can modify levels of gastrointestinal active peptides and promote intestinal peristalsis, suggesting significant intraspecific differences in the remission mechanism. The results provide a theoretical basis for population experiments and personalized treatment for constipation.
Article
Nutrition & Dietetics
Ying Chen, Rong Zhang, Jialiang Xu, Qing Ren
Summary: Millet porridge prevents constipation by improving intestinal motility and regulating the proportions of intestinal flora.
FRONTIERS IN NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Paul T. Heitmann, Lauren Keightley, Lukasz Wiklendt, David A. Wattchow, Simon S. J. Brookes, Nicholas J. Spencer, Marcello Costa, Phil G. Dinning
Summary: This study aimed to describe the effects of loperamide on neuromuscular function in the human colon. The findings suggest that loperamide primarily alters colonic function by acting on inhibitory motor neurons or alternative non-opioid receptor pathways.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Chemistry, Medicinal
Fatma Arrari, Mohamed-Amine Jabri, Imen Hammami, Hichem Sebai
Summary: This study evaluated the laxative effects of orange peel pectin extract (OPPE) in rats. The results showed that OPPE significantly increased stool moistening, stool weight, and frequency of defecation. OPPE also increased intestinal motility and gastric emptying. OPPE treatment attenuated the reduction in intestinal secretion and oxidative stress caused by loperamide.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Biochemistry & Molecular Biology
Rong Li, Sheng Xu, Bei Li, Bo Zhang, Weihua Chen, Die Dai, Zhi Liu
Summary: Refractory constipation is a severe form of constipation with unknown etiology. Accumulating studies have shown significant dysbiosis of the gut microbiota in constipation patients. This study analyzed the gut microbiota composition of fresh and accumulated feces of refractory constipation patients and found a significant difference between them.
Article
Biochemistry & Molecular Biology
Yan Zhao, Chengcheng Zhang, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai
Summary: This study investigated the protective effects of five strains of L. fermentum on constipation in mice. The results showed that L. fermentum YN54 relieved constipation by regulating gastrointestinal peptides and increasing the amount of intestinal short-chain fatty acids. Comparative genomic analysis revealed that L. fermentum YN54 possessed specific functional genes associated with its probiotic effect.
Article
Microbiology
Xiaoyu Gao, Yifan Hu, Yafei Tao, Shuangfeng Liu, Haowen Chen, Jiayi Li, Yan Zhao, Jun Sheng, Yang Tian, Yuanhong Fan
Summary: The aqueous extract of Cymbopogon citratus has laxative effects by modulating gastrointestinal motility factors, intestinal inflammation, gut barrier, and gut microbiota, resulting in shortened defecation time and improved gastrointestinal transit rate.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu Gu, Xiali Qin, Guoqiong Zhou, Chen Wang, Chenlu Mu, Xiang Liu, Weilong Zhong, Xin Xu, Bangmao Wang, Kui Jiang, Jinghua Liu, Hailong Cao
Summary: In this study, it was found that LGGs upregulated the expression of 5-HT4R, promoting the production of MUC2 and regulating the gut microbiota. These findings provide new evidence for the application of LGG in relieving gastrointestinal motility disorders.
Article
Food Science & Technology
Wei-Feng Cai, Song-Xia Lin, Pan-Yu Ma, Chun-Yan Shen
Summary: This study demonstrates that Semen Pruni oil can treat constipation by regulating neurotransmitters, oxidative stress, and inflammatory responses to alleviate constipation symptoms.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Qi Sun, Yue Zhao, Yunxia Yang, Xiao Yang, Minghui Li, Xi Xu, Dan Wen, Junsong Wang, Jianfa Zhang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Gastroenterology & Hepatology
Yue Zhao, Timothy Wai Ho Shuen, Tan Boon Toh, Xue Ying Chan, Min Liu, Sue Yee Tan, Yong Fan, Hechuan Yang, Shridhar Ganpathi Lyer, Glenn Kunnath Bonney, Eva Loh, Kenneth Tou En Chang, Thiam Chye Tan, Weiwei Zhai, Jerry Kok Yen Chan, Edward Kai-Hua Chow, Cheng Ean Chee, Guan Huei Lee, Yock Young Dan, Pierce Kah-Hoe Chow, Han Chong Toh, Seng Gee Lim, Qingfeng Chen
Article
Physiology
Emily S. Hartman, Elena C. Brindley, Julien Papoin, Steven L. Ciciotte, Yue Zhao, Luanne L. Peters, Lionel Blanc
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Pathology
Peng Chen, Chunying Li, Wenqaing Pang, Yue Zhao, Wei Dong, Shiming Wang, Jianfa Zhang
AMERICAN JOURNAL OF PATHOLOGY
(2009)
Article
Endocrinology & Metabolism
Ying Zhang, Zhongqiu Wang, Yue Zhao, Ming Zhao, Shiming Wang, Zichun Hua, Jianfa Zhang
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2012)
Article
Biochemistry & Molecular Biology
Yue Zhao, Ying Zhang, Mengyi Zhou, Shiming Wang, Zichun Hua, Jianfa Zhang
Article
Hematology
Yue Zhao, Ying Zhang, Shiming Wang, Zichun Hua, Jianfa Zhang
THROMBOSIS RESEARCH
(2011)
Review
Oncology
Qingfeng Chen, Jiaxu Wang, Wai Nam Liu, Yue Zhao
TRANSLATIONAL ONCOLOGY
(2019)
Article
Genetics & Heredity
Raymond F. Robledo, Steven L. Ciciotte, Joel H. Graber, Yue Zhao, Amy J. Lambert, Babette Gwynn, Nathaniel J. Maki, Elena C. Brindley, Emily Hartman, Lionel Blanc, Luanne L. Peters
Article
Gastroenterology & Hepatology
Yue Zhao, Jiaxu Wang, Wai Nam Liu, Shin Yie Fong, Timothy Wai Ho Shuen, Min Liu, Sarah Harden, Sue Yee Tan, Jia Ying Cheng, Wilson Wei Sheng Tan, Jerry Kok Yen Chan, Cheng Ean Chee, Guan Huei Lee, Han Chong Toh, Seng Gee Lim, Yue Wan, Qingfeng Chen
Summary: This study established humanized-immune-system HCC mouse models for testing combinational therapies, showing that triple-combination therapy had superior anti-HCC effects compared to single or dual treatments. It was found that human immune cells in the tumor microenvironment were strongly modulated by HCC, promoting HCC proliferation and angiogenesis through specific signaling pathways.
Article
Biochemistry & Molecular Biology
Yang Zhao, Rui Cheng, Yue Zhao, Wenhao Ge, Yunxia Yang, Zhao Ding, Xi Xu, Zhongqiu Wang, Zhenguo Wu, Jianfa Zhang
Summary: The research shows that type 2 diabetic mice spontaneously enter a hibernation-like suspended animation state in cold temperatures, and injection of ATP in nondiabetic mice can mimic this severe hypothermia seen in diabetic mice.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Junhao Liu, Yang Zhao, Zhao Ding, Yue Zhao, Tingting Chen, Wenhao Ge, Jianfa Zhang
Summary: Iron accumulation with age can affect metabolic patterns and the circadian clock. Both high-iron diet and advanced age alter gene expression in mice, including pathways related to oxidative stress response and the circadian clock. Phlebotomy can decrease iron accumulation in old mice, partially restoring the oscillatory expression of clock genes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Shijun Ma, Yue Zhao, Wee Chyan Lee, Li-Teng Ong, Puay Leng Lee, Zemin Jiang, Gokce Oguz, Zhitong Niu, Min Liu, Jian Yuan Goh, Wenyu Wang, Matias A. Bustos, Sidse Ehmsen, Adaikalavan Ramasamy, Dave S. B. Hoon, Henrik J. Ditzel, Ern Yu Tan, Qingfeng Chen, Qiang Yu
Summary: This study reveals that hypoxia-induced epigenetic suppression of effector gene expression leads to dysfunction of T and NK cells, resulting in resistance to anti-PD1 blockade in triple negative breast cancer. Targeting hypoxia and the associated epigenetic machinery can reverse immune effector dysfunction and overcome immune resistance.
NATURE COMMUNICATIONS
(2022)
Article
Hematology
Yue Zhao, Min Liu, Xue Ying Chan, Sue Yee Tan, Sharrada Subramaniam, Yong Fan, Eva Loh, Kenneth Tou En Chang, Thiam Chye Tan, Qingfeng Chen