Article
Medicine, Research & Experimental
Lianxia Guo, Haobin Cen, Jiaxian Weng, Yiting He, Xiaocao Guo, Di He, Kaisheng Liu, Shuyi Duan, Jing Yang, Xiaojian Zhang, Zifei Qin, Yong Wan, Zhiyong Chen, Baojian Wu
Summary: This study investigates the role of circadian clock in the development of pituitary adenomas. Altered expression of pituitary clock genes, especially PER2, is found in patients with pituitary adenomas. Jetlagged mice with PER2 upregulation show accelerated tumor growth, while loss of Per2 protects mice against estrogen-induced pituitary adenoma. Mechanistically, PER2 regulates the transcription of cell cycle genes to promote pituitary tumorigenesis. These findings advance our understanding of the relationship between circadian clock and pituitary adenomas, highlighting the relevance of clock-based approaches in disease management.
Review
Hematology
Serge Mbiandjeu, Alessandra Balduini, Alessandro Malara
Summary: Thrombopoiesis is governed by the response of megakaryocyte cytoskeleton to various stimuli, supporting platelet shedding. New cytoskeleton regulators have emerged as critical components in the dynamic protein network that supports platelet production.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Jiansong Huang, Shujuan Huang, Zhixin Ma, Xiangjie Lin, Xia Li, Xin Huang, Jinghan Wang, Wenle Ye, Yang Li, Daqiang He, Min Yang, Jiajia Pan, Qing Ling, Fenglin Li, Shihui Mao, Huafeng Wang, Yungui Wang, Jie Jin
Summary: Ibrutinib can inhibit early megakaryopoiesis, leading to transient thrombocytopenia, while promoting late-stage megakaryopoiesis with enhanced differentiation and platelet formation. Additionally, this drug impairs integrin alpha IIb beta 3 outside-in signaling in megakaryocytes.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Cecilia Karlstrom, Gunilla Gryfelt, Laurent Schmied, Stephan Meinke, Petter Hoglund
Summary: Prophylactic platelet transfusion is common in severely thrombocytopenic patients, but responses are variable and difficult to predict. This study found that corrected count increment (CCI) varied greatly among patients, and factors like time since last transfusion and storage time of PLT products affected transfusion response. Furthermore, the study suggests that the thrombocytopenic environment or disease-associated factors may hinder platelet responsiveness.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Pediatrics
Qi Wang, Jia Wei, Xi Jia, Xiao Feng, Zhenghua Ji, Xueqiang Ji, Xuejun Shao
Summary: This study aimed to investigate the roles and mechanisms of ADAM17 in pediatric immune thrombocytopenia (ITP). It was found that ADAM17 was significantly downregulated in megakaryocytes and platelets of children with ITP, and related markers were altered. Further research suggested that the loss of ADAM17 may contribute to inefficient platelet production.
Article
Multidisciplinary Sciences
Shen Y. Y. Heazlewood, Tanveer Ahmad, Benjamin Cao, Huimin Cao, Melanie Domingues, Xuan Sun, Chad K. K. Heazlewood, Songhui Li, Brenda Williams, Madeline Fulton, Jacinta F. F. White, Tom Nebl, Christian M. M. Nefzger, Jose M. M. Polo, Benjamin T. T. Kile, Felix Kraus, Michael T. T. Ryan, Yu B. B. Sun, Peter F. M. Choong, Sarah L. L. Ellis, Minna-Liisa Anko, Susan K. K. Nilsson
Summary: Different sub-populations of megakaryocytes play important roles in generating platelets and regulating blood stem cells, and they are conserved in humans.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Juan Alfonso Redondo, Romain Bibes, Alizee Vercauteren Drubbel, Benjamin Dassy, Xavier Bisteau, Eleonore Maury, Benjamin Beck
Summary: The study focused on the oscillations of the clock-related gene PER2 in esophageal cancer cells and found that chemotherapy is more effective when PER2 expression is low. This suggests that chronotherapy could enhance the impact of current chemotherapy regimens for esophageal cancer. The results indicate that understanding and utilizing the circadian rhythm in cancer treatment may lead to improved therapeutic outcomes.
Article
Cell Biology
Rong Yan, Xinxin Ge, Ningbo Pang, Honglei Ye, Liuxia Yuan, Bin Cheng, Kangxi Zhou, Mengnan Yang, Yueyue Sun, Suqin Zhang, Zhongren Ding, Jincai Luo, Changgeng Ruan, Kesheng Dai
Summary: In this study, we found that zyxin deficiency leads to severe macrothrombocytopenia, likely by affecting MK maturation, demarcation membrane system formation, and proplatelet generation. The protein GPIb-IX associated with macrothrombocytopenia was significantly reduced in zyxin-deficient platelets. Additionally, the colocalization of zyxin with VASP may regulate GPIb-IX surface expression through VASP-mediated cytoskeleton reorganization.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Svetlana Safiullina, Natalia G. Evtugina, Izabella A. Andrianova, Rafael R. Khismatullin, Olga A. Kravtsova, Alina Khabirova, Chandrasekaran Nagaswami, Amina G. Daminova, Alina D. Peshkova, Rustem Litvinov, John W. Weisel
Summary: Mutations in the MYH9 gene can result in macrothrombocytopenia and hemorrhagic symptoms. This study found that a specific heterozygous mutation (R1933X) in the MYH9 gene is associated with not only thrombocytopenia, but also structural and functional defects in platelets. These defects include impaired platelet contractility, which may contribute to a hemorrhagic phenotype in patients with MYH9 gene mutations.
SCIENTIFIC REPORTS
(2022)
Article
Hematology
Abdullah O. Khan, Alexandre Slater, Annabel Maclachlan, Phillip L. R. Nicolson, Jeremy A. Pike, Jasmeet S. Reyat, Jack Yule, Rachel Stapley, Julie Rayes, Steven G. Thomas, Neil Morgan
Summary: This study investigates the role of specific tubulin isoforms and post-translational modifications in platelet production and function. The research reveals distinct patterns of polymodification in megakaryocytes and platelets, which are regulated by specific enzymes. These findings provide insights into the spatial regulation of motor proteins and cytoskeletal reorganization in platelet formation and thrombus formation.
Review
Hematology
Emma C. Josefsson
Summary: This review focuses on the molecular regulation of intrinsic apoptosis in platelets, conditions associated with enhanced platelet death, ex vivo storage of platelets, and caveats related to the assessment of platelet apoptosis.
THROMBOSIS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qin Huang, Meng Jiang, Zhong-Yuan Xia, Shaoqing Lei, Bo Zhao, Zhen Qiu
Summary: The study revealed that diabetes can affect cardiac PER2 and CK1ε signaling, uncovering the potential mechanism between them. Diabetes prolonged PER period, upregulated CK1ε and phosphorylated PER2 expression, and inhibiting CK1ε and PER2 can reduce myocardial injuries under high glucose conditions.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Hematology
Alicia Veninga, Constance C. F. M. J. Baaten, Ilaria De Simone, Bibian M. E. Tullemans, Marijke J. E. Kuijpers, Johan W. M. Heemskerk, Paola E. J. van der Meijden
Summary: Platelets from healthy donors exhibit heterogeneity in response to agonists, with activation thresholds controlled by various bioactive molecules. Elevated levels of priming substances like adenosine and succinate have been associated with hypercoagulability in patients with ischaemic heart disease. An improved flow cytometry methodology was employed to analyze platelet populations following activation and priming, revealing distinct responses based on the type of agonist used. The study identified five platelet populations post-activation, each with different characteristics depending on the agonist utilized, highlighting the complex and dynamic nature of platelet activation.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cell Biology
Jaturawat Pawinwongchai, Ponthip Mekchay, Nungruthai Nilsri, Nipan Israsena, Ponlapat Rojnuckarin
Summary: Researchers investigated the pathogenesis of macrothrombocytopenia caused by GP Ib deficiency or hyper-function in humans using a human induced pluripotent stem cell (hiPSC) model. They found that both loss- and gain-of-function mutations reduced MAPK/ERK activation but enhanced ROCK/MLC2 phosphorylation, leading to dysregulated platelet generation.
Review
Biochemistry & Molecular Biology
Joanna Sikora, Aleksandra Karczmarska-Wodzka, Joanna Bugieda, Przemyslaw Sobczak
Summary: The Total Thrombus Formation Analysis System is a device used for studying blood clotting disorders by identifying abnormalities in blood platelets. Recent studies suggest that this system plays an important role in diagnosing issues, monitoring therapy, and predicting bleeding events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qi Sun, Yue Zhao, Yunxia Yang, Xiao Yang, Minghui Li, Xi Xu, Dan Wen, Junsong Wang, Jianfa Zhang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Gastroenterology & Hepatology
Yue Zhao, Timothy Wai Ho Shuen, Tan Boon Toh, Xue Ying Chan, Min Liu, Sue Yee Tan, Yong Fan, Hechuan Yang, Shridhar Ganpathi Lyer, Glenn Kunnath Bonney, Eva Loh, Kenneth Tou En Chang, Thiam Chye Tan, Weiwei Zhai, Jerry Kok Yen Chan, Edward Kai-Hua Chow, Cheng Ean Chee, Guan Huei Lee, Yock Young Dan, Pierce Kah-Hoe Chow, Han Chong Toh, Seng Gee Lim, Qingfeng Chen
Article
Physiology
Emily S. Hartman, Elena C. Brindley, Julien Papoin, Steven L. Ciciotte, Yue Zhao, Luanne L. Peters, Lionel Blanc
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Pathology
Peng Chen, Chunying Li, Wenqaing Pang, Yue Zhao, Wei Dong, Shiming Wang, Jianfa Zhang
AMERICAN JOURNAL OF PATHOLOGY
(2009)
Article
Endocrinology & Metabolism
Ying Zhang, Zhongqiu Wang, Yue Zhao, Ming Zhao, Shiming Wang, Zichun Hua, Jianfa Zhang
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2012)
Article
Gastroenterology & Hepatology
Mengyi Zhou, Ping Jia, Jinping Chen, Aihui Xiu, Yue Zhao, Yibei Zhan, Peng Chen, Jianfa Zhang
BMC GASTROENTEROLOGY
(2013)
Article
Biochemistry & Molecular Biology
Yue Zhao, Ying Zhang, Mengyi Zhou, Shiming Wang, Zichun Hua, Jianfa Zhang
Review
Oncology
Qingfeng Chen, Jiaxu Wang, Wai Nam Liu, Yue Zhao
TRANSLATIONAL ONCOLOGY
(2019)
Article
Genetics & Heredity
Raymond F. Robledo, Steven L. Ciciotte, Joel H. Graber, Yue Zhao, Amy J. Lambert, Babette Gwynn, Nathaniel J. Maki, Elena C. Brindley, Emily Hartman, Lionel Blanc, Luanne L. Peters
Article
Gastroenterology & Hepatology
Yue Zhao, Jiaxu Wang, Wai Nam Liu, Shin Yie Fong, Timothy Wai Ho Shuen, Min Liu, Sarah Harden, Sue Yee Tan, Jia Ying Cheng, Wilson Wei Sheng Tan, Jerry Kok Yen Chan, Cheng Ean Chee, Guan Huei Lee, Han Chong Toh, Seng Gee Lim, Yue Wan, Qingfeng Chen
Summary: This study established humanized-immune-system HCC mouse models for testing combinational therapies, showing that triple-combination therapy had superior anti-HCC effects compared to single or dual treatments. It was found that human immune cells in the tumor microenvironment were strongly modulated by HCC, promoting HCC proliferation and angiogenesis through specific signaling pathways.
Article
Biochemistry & Molecular Biology
Yang Zhao, Rui Cheng, Yue Zhao, Wenhao Ge, Yunxia Yang, Zhao Ding, Xi Xu, Zhongqiu Wang, Zhenguo Wu, Jianfa Zhang
Summary: The research shows that type 2 diabetic mice spontaneously enter a hibernation-like suspended animation state in cold temperatures, and injection of ATP in nondiabetic mice can mimic this severe hypothermia seen in diabetic mice.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Junhao Liu, Yang Zhao, Zhao Ding, Yue Zhao, Tingting Chen, Wenhao Ge, Jianfa Zhang
Summary: Iron accumulation with age can affect metabolic patterns and the circadian clock. Both high-iron diet and advanced age alter gene expression in mice, including pathways related to oxidative stress response and the circadian clock. Phlebotomy can decrease iron accumulation in old mice, partially restoring the oscillatory expression of clock genes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Shijun Ma, Yue Zhao, Wee Chyan Lee, Li-Teng Ong, Puay Leng Lee, Zemin Jiang, Gokce Oguz, Zhitong Niu, Min Liu, Jian Yuan Goh, Wenyu Wang, Matias A. Bustos, Sidse Ehmsen, Adaikalavan Ramasamy, Dave S. B. Hoon, Henrik J. Ditzel, Ern Yu Tan, Qingfeng Chen, Qiang Yu
Summary: This study reveals that hypoxia-induced epigenetic suppression of effector gene expression leads to dysfunction of T and NK cells, resulting in resistance to anti-PD1 blockade in triple negative breast cancer. Targeting hypoxia and the associated epigenetic machinery can reverse immune effector dysfunction and overcome immune resistance.
NATURE COMMUNICATIONS
(2022)
Article
Hematology
Yue Zhao, Min Liu, Xue Ying Chan, Sue Yee Tan, Sharrada Subramaniam, Yong Fan, Eva Loh, Kenneth Tou En Chang, Thiam Chye Tan, Qingfeng Chen
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)