Review
Microbiology
Tarek Mazzawi
Summary: Research suggests that manipulating gut microbiota can improve symptoms of irritable bowel syndrome (IBS), with dietary management and other approaches showing promise in changing gut composition and alleviating IBS symptoms. However, more research is needed to identify the exact mixture of beneficial bacteria.
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Medicine, General & Internal
Grace L. Burns, Nicholas J. Talley, Simon Keely
Summary: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by chronic abdominal pain and altered defaecation. Research has found that small intestinal mechanosensation, altered barrier functions, and microbial imbalance are associated with IBS. The current literature suggests that the pathogenesis of IBS may involve dysfunction of the entire intestinal tract.
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Review
Gastroenterology & Hepatology
Arjun Gandhi, Ayesha Shah, Michael P. Jones, Natasha Koloski, Nicholas J. Talley, Mark Morrison, Gerald Holtmann
Summary: The systematic review and meta-analysis indicated that methane-positive SIBO is more prevalent in IBS, particularly in IBS-C, compared to controls, while it is less common in patients with IBD. In patients with IBD, methane-positive SIBO was significantly lower in Crohn's disease compared to ulcerative colitis. More studies are needed to establish a causal relationship due to the low quality of evidence and clinical heterogeneity in the current studies.
Article
Gastroenterology & Hepatology
Magdy El-Salhy, Tanisa Patcharatrakul, Sutep Gonlachanvit
Summary: Irritable bowel syndrome (IBS) affects about 12% of the global population, with the etiology still unclear but intestinal microbiota playing a pivotal role in its pathophysiology. Fecal microbiota transplantation (FMT) has shown positive effects in some randomized controlled trials (RCTs), but further research is needed to determine the optimal treatment approach.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Medicine, General & Internal
Mihaela Fadgyas Stanculete, Abdulrahman Ismaiel, Stefan-Lucian Popa, Octavia Oana Capatina
Summary: Irritable bowel syndrome (IBS) is a disorder characterized by altered gut-brain interaction and dysfunction of the brain-gut-microbiota axis. Prior studies have shown significant impairments in the health-related quality of life of patients with IBS. Resilience, as a psychosocial ability, plays a crucial role in promoting health and enhancing stress response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Tarek Mazzawi, Trygve Hausken, Magdy El-Salhy
Summary: This study aimed to investigate the effect of fecal microbiota transplantation (FMT) on colonic enteroendocrine cells densities in patients with irritable bowel syndrome (IBS). The results showed significant changes in colonic enteroendocrine cells densities in the group of responders who received donor-FMT. However, the mechanisms behind the interaction between gut microbiota and colonic enteroendocrine cells still need further investigation.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Juan J. Sebastian Domingo
Summary: Irritable bowel syndrome is a common functional bowel disorder with significant impact on patients' daily lives and society's economy. It is characterized by abdominal pain, bloating, and altered bowel movements, and its etiology and pathophysiological mechanism are still unknown.
Article
Biochemistry & Molecular Biology
Sholpan Omarova, Karem Awad, Verena Moos, Christoph Puening, Greta Goelz, Jorg-Dieter Schulzke, Roland Buecker
Summary: This study observed patients with persistent PI-IBS symptoms after C. jejuni infection and found that the epithelial resistance of the colon epithelium was unaltered, but the permeability of HRP increased and some inflammation-related markers were elevated. Therefore, targeting these mechanisms caused by the infection may help reduce sequelae such as PI-IBS.
Article
Multidisciplinary Sciences
A. Das, E. O'Herlihy, F. Shanahan, P. W. O'Toole, I. B. Jeffery
Summary: Alterations in the gut mycobiome were found to be significantly different between patients with Irritable Bowel Syndrome (IBS) and control subjects, but not among clinical subtypes of IBS. The mycobiome changes were significantly associated with alterations in the bacteriome and metabolome, but did not show a link with dietary habits. Despite co-variation with bacterial components, the mycobiome presents limited therapeutic and diagnostic potential for IBS.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Qi Su, Hein M. Tun, Qin Liu, Yun Kit Yeoh, Joyce Wing Yan Mak, Francis K. L. Chan, Siew C. Ng
Summary: This study examined the association between gut microbiota and Irritable bowel syndrome (IBS) subtypes, and found that there are distinct differences in microbiota composition among different IBS subtypes. The microbial diversity is significantly reduced in IBS-D and IBS-U, but not in IBS-C. The study also identified microbial signatures associated with depression in IBS patients. Factors such as gender, age, and dietary patterns have significant effects on gut microbiota in different IBS subtypes. These findings emphasize the importance of personalized gut microbiome modulation approaches for optimal therapeutic effects in different subtypes of IBS.
Review
Immunology
Ying Gao, Peilun Ding, Junmin Wang, Caiyun Zhang, Guang Ji, Tao Wu
Summary: "Application of Metabolomics in Irritable Bowel Syndrome: A Review" provides an updated overview of metabolomics studies related to irritable bowel syndrome (IBS) in the past 5 years, including clinical studies, animal studies, and traditional Chinese medicine interventions. The review highlights the potential of metabolomics in the diagnosis and treatment of IBS, as well as the role of traditional Chinese medicine in improving IBS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Robin Spiller
Summary: IBS is strongly influenced by diet, but identifying specific food intolerances is difficult due to the complexities of diet. Rapidly fermented carbohydrates and gut-specific mast cell activation may cause symptoms in IBS patients. More research is needed to fully understand the mechanisms of food intolerances and improve personalized medicine approaches to diet in IBS.
Review
Immunology
Lin Xiao, Qin Liu, Mei Luo, Lishou Xiong
Summary: Research has identified the significant roles that microbiota-derived metabolites play in the development of IBS symptoms in patients, shedding light on the complex interplay between gut microbiota and IBS.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
A. Dlugosz, P. Nowak, M. D'Amato, G. Mohammadian Kermani, J. Nystrom, S. Abdurahman, G. Lindberg
NEUROGASTROENTEROLOGY AND MOTILITY
(2015)
Article
Gastroenterology & Hepatology
Kenneth K. Wang, David L. Carr-Locke, Satish K. Singh, Helmut Neumann, Helga Bertani, Jean-Paul Galmiche, Razvan I. Arsenescu, Fabrice Caillol, Kenneth J. Chang, Stanislas Chaussade, Emmanuel Coron, Guido Costamagna, Aldona Dlugosz, S. Ian Gan, Marc Giovannini, Frank G. Gress, Oleh Haluszka, Khek Y. Ho, Michel Kahaleh, Vani J. Konda, Frederic Prat, Raj J. Shah, Prateek Sharma, Adam Slivka, Herbert C. Wolfsen, Alvin Zfass
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2015)
Article
Gastroenterology & Hepatology
Kotryna Truskaite, Aldona Dlugosz
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2016)
Article
Biotechnology & Applied Microbiology
Aldona Dlugosz, Katherina Zakikhany, Nathalie Acevedo, Mauro D'Amato, Greger Lindberg
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Hematology
Mats Remberger, Malin Ackefors, Sofia Berglund, Ola Blennow, Goran Dahllof, Aldona Dlugosz, Karin Garming-Legert, Jens Gertow, Britt Gustafsson, Moustapha Hassan, Zuzana Hassan, Dan Hauzenberger, Hans Hagglund, Helen Karlsson, Lena Klingspor, Gunilla Kumlien, Katarina Le Blanc, Per Ljungman, Maciej Machaczka, Karl-Johan Malmberg, Hanns-Ulrich Marschall, Jonas Mattsson, Richard Olsson, Brigitta Omazic, Darius Sairafi, Marie Schaffer, Britt-Marie Svahn, Petter Svenberg, Lisa Swartling, Attila Szakos, Michael Uhlin, Mehmet Uzunel, Emma Watz, Annika Wernerson, Agneta Wikman, Ann-Charlotte Wikstrom, Jacek Winiarski, Olle Ringden
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2011)
Article
Gastroenterology & Hepatology
Arthur Beyder, Amelia Mazzone, Peter R. Strege, David J. Tester, Yuri A. Saito, Cheryl E. Bernard, Felicity T. Enders, Weronica E. Ek, Peter T. Schmidt, Aldona Dlugosz, Greger Lindberg, Pontus Karling, Bodil Ohlsson, Maria Gazouli, Gerardo Nardone, Rosario Cuomo, Paolo Usai-Satta, Francesca Galeazzi, Matteo Neri, Piero Portincasa, Massimo Bellini, Giovanni Barbara, Michael Camilleri, G. Richard Locke, Nicholas J. Talley, Mauro D'Amato, Michael J. Ackerman, Gianrico Farrugia
Article
Gastroenterology & Hepatology
Kyosuke Tanaka, Carlos A. Rubio, Aldona Dlugosz, Kotryna Truskaite, Ragnar Befrits, Greger Lindberg, Peter T. Schmidt
GASTROINTESTINAL ENDOSCOPY
(2013)
Article
Gastroenterology & Hepatology
Marco Zucchelli, Michael Camilleri, Anna Nixon Andreasson, Francesca Bresso, Aldona Dlugosz, Jonas Halfvarson, Leif Torkvist, Peter T. Schmidt, Pontus Karling, Bodil Ohlsson, Richard H. Duerr, Magnus Simren, Greger Lindberg, Lars Agreus, Paula Carlson, Alan R. Zinsmeister, Mauro D'Amato
Article
Gastroenterology & Hepatology
Weronica E. Ek, Anna Reznichenko, Stephan Ripke, Beate Niesler, Marco Zucchelli, Natalia V. Rivera, Peter T. Schmidt, Nancy L. Pedersen, Patrik Magnusson, Nicholas J. Talley, Elizabeth G. Holliday, Lesley Houghton, Maria Gazouli, George Karamanolis, Gudrun Rappold, Barbara Burwinkel, Harald Surowy, Joseph Rafter, Ghazaleh Assadi, Ling Li, Evangelia Papadaki, Dario Gambaccini, Santino Marchi, Rocchina Colucci, Corrado Blandizzi, Raffaella Barbaro, Pontus Karling, Susanna Walter, Bodil Ohlsson, Hans Tornblom, Francesca Bresso, Anna Andreasson, Aldona Dlugosz, Magnus Simren, Lars Agreus, Greger Lindberg, Guy Boeckxstaens, Massimo Bellini, Vincenzo Stanghellini, Giovanni Barbara, Mark J. Daly, Michael Camilleri, Mira M. Wouters, Mauro D'Amato
Article
Gastroenterology & Hepatology
A. Dlugosz, K. Zakikhany, S. Muschiol, K. Hultenby, G. Lindberg
NEUROGASTROENTEROLOGY AND MOTILITY
(2011)
Article
Gastroenterology & Hepatology
Julia Liu, Aldona Dlugosz, Helmut Neumann
WORLD JOURNAL OF GASTROENTEROLOGY
(2013)
Article
Gastroenterology & Hepatology
Aldona Dlugosz, Sandra Muschiol, Katherina Zakikhany, Ghazaleh Assadi, Mauro D'Amato, Greger Lindberg
Article
Multidisciplinary Sciences
Aldona Dlugosz, Bjorn Winckler, Elin Lundin, Katherina Zakikhany, Gunnar Sandstrom, Weimin Ye, Lars Engstrand, Greger Lindberg
SCIENTIFIC REPORTS
(2015)
Article
Gastroenterology & Hepatology
Aldona Dlugosz, Ammar Mohkles Barakat, Niklas K. Bjorkstrom, Ake Ost, Annika Bergquist
ENDOSCOPY INTERNATIONAL OPEN
(2016)