Article
Gastroenterology & Hepatology
S. Coughlan, A. Das, E. O'Herlihy, F. Shanahan, P. W. O'Toole, I. B. Jeffery
Summary: The study conducted metagenomic sequencing of fecal Virus-Like Particles (VLPs) from 55 patients with IBS and 51 control individuals. It found significantly lower alpha diversity of viral clusters in IBS, identified core viromes in both IBS and control groups, and noted no significant covariation between the virome and the bacteriome, IBS clinical subtype, or Bile Acid Malabsorption status.
Article
Gastroenterology & Hepatology
Sawangpong Jandee, Suppana Chuensakul, Suppasil Maneerat
Summary: In this study, there were no significant differences in fecal microbiota between Thai IBS-D patients and healthy controls. Probiotics showed some effects on symptom and fecal characteristic changes, particularly in reducing diarrhea frequency and mucus stool. No significant changes were observed in fecal microbiota after probiotic intervention, except for an increase in the proportion of B. bifidum.
Review
Gastroenterology & Hepatology
Xuehong Deng, Lin Xiao, Mei Luo, Peiwei Xie, Lishou Xiong
Summary: Irritable bowel syndrome (IBS) is a common gastrointestinal disease caused by disturbances in intestinal bacteria. The interactions between bile acids, gut microbiota, and the host play a crucial role in regulating immune and metabolic homeostasis. Recent studies have shown that the bile acid-gut microbiota axis is important in the development of IBS. This literature review examines the role of bile acids in IBS pathogenesis and its potential clinical implications. The interaction between bile acids and gut microbiota in the intestines leads to compositional and functional changes seen in IBS, including gut microbial dysbiosis, disrupted bile acid pathways, and altered microbial metabolites. The alterations of farnesoid-X receptor and G protein-coupled receptor contribute to the pathogenesis of IBS. Diagnostic markers and treatments targeting bile acids and its receptor show promise for the management of IBS. Bile acids and gut microbiota are key factors in the development of IBS and may serve as attractive biomarkers for treatments. Individualized therapy targeting bile acids and its receptor could have significant diagnostic implications and requires further investigation.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Microbiology
Jose F. Garcia-Mazcorro, Mercedes Amieva-Balmori, Arturo Triana-Romero, Bridgette Wilson, Leanne Smith, Job Reyes-Huerta, Megan Rossi, Kevin Whelan, Jose M. Remes-Troche
Summary: Increasing evidence suggests a microbial pathogenesis in irritable bowel syndrome (IBS), and this study found differences in the fecal microbiota between different IBS subtypes, and even within the same subtype depending on geographical location.
Article
Immunology
Jun-Jie Hou, Xin Wang, Ying Li, Shuai Su, Yu-Ming Wang, Bang-Mao Wang
Summary: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disease that is closely related to the imbalance of intestinal microecology and proteolytic activity (PA). Research has shown changes in gut microbiota and increased PA in IBS patients, highlighting the pivotal roles of gut microbiota and PA in IBS.
MICROBIAL PATHOGENESIS
(2021)
Article
Gastroenterology & Hepatology
Chengjiao Yao, Yilin Li, Lihong Luo, Fengjiao Xie, Qin Xiong, Tinglin Li, Chunrong Yang, Pei-min Feng
Summary: The study identified significant differences in gut microbiota between IBS-D patients of Han nationality in Southwest China and healthy individuals, suggesting that these differences may be related to environmental factors such as eating habits, living habits, and mental and psychological factors.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Nutrition & Dietetics
Annamaria Altomare, Federica Del Chierico, Giulia Rocchi, Sara Emerenziani, Chiara Nuglio, Lorenza Putignani, Silvia Angeletti, Alessandra Lo Presti, Massimo Ciccozzi, Alessandra Russo, Silvia Cocca, Mentore Ribolsi, Maurizio Muscaritoli, Michele Cicala, Michele Pier Luca Guarino
Summary: This study revealed an association between nutrient intake, adherence to Mediterranean diet, IBS symptoms, and gut microbiota in IBS patients. Lower adherence to Mediterranean diet was correlated with severe abdominal pain and higher flatulence in IBS patients, indicating a potential connection between dietary patterns and gut microbial biomarkers in IBS.
Article
Immunology
Jie Wu, Liang Lv, Chunlian Wang
Summary: The meta-analysis examined the efficacy of fecal microbiota transplantation (FMT) in irritable bowel syndrome (IBS) and found inconsistent results. FMT administered via colonoscopy or gastroscope may benefit IBS patients and improve their quality of life. However, the quality of evidence supporting the use of FMT in IBS is very low.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yangfan Hou, Lei Dong, Xiaolan Lu, Haitao Shi, Bing Xu, Wenting Zhong, Lin Ma, Shuhui Wang, Caifeng Yang, Xinyi He, Yidi Zhao, Shenhao Wang
Summary: Changes in intestinal microbiota are associated with the pathogenesis and clinical manifestations of irritable bowel syndrome (IBS).
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Naghmeh Salarieh, Armitasadat Emami Meibodi, Samira Alipour, Masoumeh Azimirad, Mehdi Azizmohammad Looha, Hamid Asadzadeh Aghdaei, Abbas Yadegar, Shabnam Shahrokh, Mohammad Reza Zali
Summary: This study aimed to compare the composition of mucosal microbiota in IBS + NLH patients, IBS patients, and healthy controls. The results showed the presence of various pathogens in IBS + NLH patients and differences in microbiota composition compared to IBS patients and healthy controls.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Immunology
Lin Xiao, Qin Liu, Mei Luo, Lishou Xiong
Summary: Research has identified the significant roles that microbiota-derived metabolites play in the development of IBS symptoms in patients, shedding light on the complex interplay between gut microbiota and IBS.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Nutrition & Dietetics
Chiara Ricci, Fernando Rizzello, Maria Chiara Valerii, Enzo Spisni, Paolo Gionchetti, Silvia Turroni, Marco Candela, Federica D'Amico, Renato Spigarelli, Irene Bellocchio, Giovanni Marasco, Giovanni Barbara
Summary: Geraniol, an acyclic monoterpene alcohol, has demonstrated anti-inflammatory and antimicrobial properties and positive effects on gut microbiota in IBS patients. In this study, IBS patients treated with a low-absorbable geraniol food supplement (LAGS) showed a significant reduction in IBS symptoms severity score compared to placebo. Geraniol administration also resulted in changes in gut microbiota composition, with a decrease in Oscillospira and an increase in Faecalibacterium. The findings suggest that LAGS is effective in treating overall IBS symptoms and improving gut microbiota profile, particularly in the IBS mixed subtype.
Article
Biochemistry & Molecular Biology
Qian Chen, Hua Zhang, Chang-Yue Sun, Qing-Ying He, Rui-Rong Zhang, Bin-Fei Luo, Zi-Hao Zhou, Xiao-Fan Chen
Summary: An animal model that mimics the pathological state of diarrhea symptoms, visceral hypersensitivity, reduced intestinal mucosal barrier permeability, immune regulatory dysfunction, and dysbiosis in IBS-D patients was constructed through restraint stress and chemical stimulation. However, herbs with antibacterial effects such as rhubarb and senna are not suitable for chemical stimulation, as they may alter the intestinal flora imbalance, and restraint stress may be a key factor in modeling.
MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Binbin Tang, Yunlian Hu, Jianhui Chen, Chengxia Su, Qian Zhang, Chaoqun Huang
Summary: This study investigated the characteristics and correlation between oral (tongue coating) and fecal microbiota in patients with diarrheal irritable bowel syndrome (IBS-D). The microbial richness of tongue coating in IBS-D patients was lower than that in the normal control group. The oral and fecal microbiotas of IBS-D patients differ from those of the control group.
Article
Microbiology
Celine Nourrisson, Julien Scanzi, Julie Brunet, Frederic Delbac, Michel Dapoigny, Philippe Poirier
Summary: The study investigated the differences in microbiota between IBS-C patients and healthy individuals, revealing significant changes in certain microbial phyla when Blastocystis was present in IBS-C patients, notably an increase in Tenericutes phylum and Ruminococcaceae family. Colonization with Blastocystis was also associated with subtle changes in the microbial eukaryome, particularly in the Fungi taxa. The mycobiota changes varied depending on the patient group, with potentially more deleterious effects in the IBS-C group.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
A. Dlugosz, P. Nowak, M. D'Amato, G. Mohammadian Kermani, J. Nystrom, S. Abdurahman, G. Lindberg
NEUROGASTROENTEROLOGY AND MOTILITY
(2015)
Article
Gastroenterology & Hepatology
Kenneth K. Wang, David L. Carr-Locke, Satish K. Singh, Helmut Neumann, Helga Bertani, Jean-Paul Galmiche, Razvan I. Arsenescu, Fabrice Caillol, Kenneth J. Chang, Stanislas Chaussade, Emmanuel Coron, Guido Costamagna, Aldona Dlugosz, S. Ian Gan, Marc Giovannini, Frank G. Gress, Oleh Haluszka, Khek Y. Ho, Michel Kahaleh, Vani J. Konda, Frederic Prat, Raj J. Shah, Prateek Sharma, Adam Slivka, Herbert C. Wolfsen, Alvin Zfass
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2015)
Article
Gastroenterology & Hepatology
Kotryna Truskaite, Aldona Dlugosz
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2016)
Article
Biotechnology & Applied Microbiology
Aldona Dlugosz, Katherina Zakikhany, Nathalie Acevedo, Mauro D'Amato, Greger Lindberg
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Hematology
Mats Remberger, Malin Ackefors, Sofia Berglund, Ola Blennow, Goran Dahllof, Aldona Dlugosz, Karin Garming-Legert, Jens Gertow, Britt Gustafsson, Moustapha Hassan, Zuzana Hassan, Dan Hauzenberger, Hans Hagglund, Helen Karlsson, Lena Klingspor, Gunilla Kumlien, Katarina Le Blanc, Per Ljungman, Maciej Machaczka, Karl-Johan Malmberg, Hanns-Ulrich Marschall, Jonas Mattsson, Richard Olsson, Brigitta Omazic, Darius Sairafi, Marie Schaffer, Britt-Marie Svahn, Petter Svenberg, Lisa Swartling, Attila Szakos, Michael Uhlin, Mehmet Uzunel, Emma Watz, Annika Wernerson, Agneta Wikman, Ann-Charlotte Wikstrom, Jacek Winiarski, Olle Ringden
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2011)
Article
Gastroenterology & Hepatology
Aldona Dlugosz, Hans Tornblom, Ghazaleh Mohammadian, Gareth Morgan, Bela Veress, Benjamin Edvinsson, Gunnar Sandstrom, Greger Lindberg
BMC GASTROENTEROLOGY
(2010)
Article
Gastroenterology & Hepatology
Arthur Beyder, Amelia Mazzone, Peter R. Strege, David J. Tester, Yuri A. Saito, Cheryl E. Bernard, Felicity T. Enders, Weronica E. Ek, Peter T. Schmidt, Aldona Dlugosz, Greger Lindberg, Pontus Karling, Bodil Ohlsson, Maria Gazouli, Gerardo Nardone, Rosario Cuomo, Paolo Usai-Satta, Francesca Galeazzi, Matteo Neri, Piero Portincasa, Massimo Bellini, Giovanni Barbara, Michael Camilleri, G. Richard Locke, Nicholas J. Talley, Mauro D'Amato, Michael J. Ackerman, Gianrico Farrugia
Article
Gastroenterology & Hepatology
Kyosuke Tanaka, Carlos A. Rubio, Aldona Dlugosz, Kotryna Truskaite, Ragnar Befrits, Greger Lindberg, Peter T. Schmidt
GASTROINTESTINAL ENDOSCOPY
(2013)
Article
Gastroenterology & Hepatology
Marco Zucchelli, Michael Camilleri, Anna Nixon Andreasson, Francesca Bresso, Aldona Dlugosz, Jonas Halfvarson, Leif Torkvist, Peter T. Schmidt, Pontus Karling, Bodil Ohlsson, Richard H. Duerr, Magnus Simren, Greger Lindberg, Lars Agreus, Paula Carlson, Alan R. Zinsmeister, Mauro D'Amato
Article
Gastroenterology & Hepatology
Weronica E. Ek, Anna Reznichenko, Stephan Ripke, Beate Niesler, Marco Zucchelli, Natalia V. Rivera, Peter T. Schmidt, Nancy L. Pedersen, Patrik Magnusson, Nicholas J. Talley, Elizabeth G. Holliday, Lesley Houghton, Maria Gazouli, George Karamanolis, Gudrun Rappold, Barbara Burwinkel, Harald Surowy, Joseph Rafter, Ghazaleh Assadi, Ling Li, Evangelia Papadaki, Dario Gambaccini, Santino Marchi, Rocchina Colucci, Corrado Blandizzi, Raffaella Barbaro, Pontus Karling, Susanna Walter, Bodil Ohlsson, Hans Tornblom, Francesca Bresso, Anna Andreasson, Aldona Dlugosz, Magnus Simren, Lars Agreus, Greger Lindberg, Guy Boeckxstaens, Massimo Bellini, Vincenzo Stanghellini, Giovanni Barbara, Mark J. Daly, Michael Camilleri, Mira M. Wouters, Mauro D'Amato
Article
Gastroenterology & Hepatology
A. Dlugosz, K. Zakikhany, S. Muschiol, K. Hultenby, G. Lindberg
NEUROGASTROENTEROLOGY AND MOTILITY
(2011)
Article
Gastroenterology & Hepatology
Julia Liu, Aldona Dlugosz, Helmut Neumann
WORLD JOURNAL OF GASTROENTEROLOGY
(2013)
Article
Gastroenterology & Hepatology
Aldona Dlugosz, Sandra Muschiol, Katherina Zakikhany, Ghazaleh Assadi, Mauro D'Amato, Greger Lindberg
Article
Gastroenterology & Hepatology
Aldona Dlugosz, Ammar Mohkles Barakat, Niklas K. Bjorkstrom, Ake Ost, Annika Bergquist
ENDOSCOPY INTERNATIONAL OPEN
(2016)