Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery

Comparative genomics reveals selective distribution and domain organization of FYVE and PX domain proteins across eukaryotic lineages

(2010) Sumana Banerjee et al.   BMC GENOMICS

Drugging the PI3 Kinome: From Chemical Tools to Drugs in the Clinic

(2010) P. Workman et al.   CANCER RESEARCH

Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

(2010) Nai-Yun Hsu et al.   CELL

Molecular Evolutionary Analysis of Cancer Cell Lines

(2010) Y. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Activity of any class IA PI3K isoform can sustain cell proliferation and survival

(2010) L. C. Foukas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collaborative actions in anti-trypanosomatid chemotherapy with partners from disease endemic areas

(2010) Jean-Claude Dujardin et al.   TRENDS IN PARASITOLOGY

Plasmodium falciparum Drug Resistance in Madagascar: Facing the Spread of Unusual pfdhfr and pfmdr-1 Haplotypes and the Decrease of Dihydroartemisinin Susceptibility

(2009) V. Andriantsoanirina et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The TryPIKinome of five human pathogenic trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi, Leishmania major, Leishmania braziliensis and Leishmania infantum – New tools for designing specific inhibitors

(2009) Diana Bahia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication

(2009) Andrew W. Tai et al.   Cell Host & Microbe

Phosphoinositide 3-kinases and their role in inflammation: potential clinical targets in atherosclerosis?

(2009) Anne Fougerat et al.   CLINICAL SCIENCE

Changes in the Treatment Responses to Artesunate-Mefloquine on the Northwestern Border of Thailand during 13 Years of Continuous Deployment

(2009) Verena Ilona Carrara et al.   PLoS One

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

(2008) Beth Apsel et al.   Nature Chemical Biology

Inositol derivatives: evolution and functions

(2008) Robert H. Michell   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PtdIns5P regulation through evolution: roles in membrane trafficking?

(2008) Odile Lecompte et al.   TRENDS IN BIOCHEMICAL SCIENCES

Drugging the Plasmodium kinome: the benefits of academia–industry synergy

(2008) Didier Leroy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES