Article
Agriculture, Multidisciplinary
Mengyao Liu, Xin Gao, Shan Shan, Yongzhi Li, Jiaping Wang, Weihong Lu
Summary: Eleutheroside E can regulate intestinal lipid metabolism in Caenorhabditis elegans through neuroendocrine signals, reducing fat storage.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Review
Nutrition & Dietetics
Alyssa S. Zembroski, Changting Xiao, Kimberly K. Buhman
Summary: The formation of cytoplasmic lipid droplets in enterocytes is crucial for the absorption of dietary fat, and recent studies have identified various factors that regulate this process, such as compartmentalization of different lipid pools, gut microbiome, liver X receptor, and obesity.
ANNUAL REVIEW OF NUTRITION, VOL 41, 2021
(2021)
Article
Food Science & Technology
Ting Gong, Yujing Zhou, Lei Zhang, Haizhu Wang, Min Zhang, Xiong Liu
Summary: The combination of capsaicin and dietary fibers can effectively improve obesity and metabolic diseases, reduce blood lipids, and increase beneficial gut bacteria.
FOOD SCIENCE & NUTRITION
(2023)
Article
Immunology
Yixin Gu, Wenjie Wang, Yu Zhan, Xiaoyan Wei, Yanyan Shi, Dandan Cui, Tingting Peng, Jian Han, Xuejie Li, Yan Chen, Zhuang Xue, Wei Wang
Summary: This study investigated the effects and potential mechanisms of artemisinin on intestinal immune disease (IID) in marine fish. The results showed that artemisinin has immunoprotective effects by regulating the HIF-1 signaling pathway. In addition, artemisinin improved resistance to bacterial infection, enhanced antioxidant capacity, and optimized intestinal structure in vivo.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Colin R. Lickwar, James M. Davison, Cecelia Kelly, Gilberto Padilla Mercado, Jia Wen, Briana R. Davis, Matthew C. Tillman, Ivana Semova, Sarah F. Andres, Goncalo Vale, Jeffrey G. McDonald, John F. Rawls
Summary: This study reveals that the combination of microbiota and high-fat diet may suppress the expression of hepatocyte nuclear factor 4 alpha, leading to the preferential activation of intestinal epithelial cell proliferation programs, which in turn affects intestinal lipid absorption, epithelial cell renewal, and systemic energy balance.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ying Lan, Chi Wang, Cheng Zhang, Pengju Li, Jinding Zhang, Hong Ji, Haibo Yu
Summary: This study investigated the beneficial effects of sea buckthorn polysaccharide (SP) on lipid metabolism, liver, and intestinal health in zebrafish fed with high-fat diet. The results showed that adding 2 and 4 g/kg of SP in the high-fat diet significantly improved the survival rate of zebrafish, reduced the levels of serum triglyceride, total cholesterol, aspartate aminotransferase, and alanine transaminase, and alleviated the lipid accumulation in the liver. Furthermore, SP enhanced the antioxidant capacity of liver and intestine, alleviated liver and intestinal inflammation, and normalized the imbalance of intestinal microbiota caused by high-fat diet, resulting in improved survival rate of zebrafish.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Food Science & Technology
Zixin Guo, Yixiang Liu, Yangchao Luo
Summary: This paper explores the role of dietary lipids in the absorption and utilization of carotenoids, discussing the mechanisms of intestinal absorption, regulation of lipid transporters and intracellular metabolizing enzymes, and the efflux process of chyle particles. It emphasizes the importance of selecting appropriate dietary lipids for the absorption and utilization of different carotenoids.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Medicine, Research & Experimental
Min Jia, Tongcheng Xu, Yong-Jiang Xu, Yuanfa Liu
Summary: Brown adipose tissue (BAT) and beige fat have the potential to fight obesity and chronic diseases by rapidly consuming fatty acids and dissipating energy. This review summarizes the effects of dietary fatty acids on thermogenic adipose tissue, including activation and deactivation of BAT and beige fat.
Article
Multidisciplinary Sciences
Fangjun Yu, Zhigang Wang, Tianpeng Zhang, Xun Chen, Haiman Xu, Fei Wang, Lianxia Guo, Min Chen, Kaisheng Liu, Baojian Wu
Summary: The intestinal circadian clock functions as an accelerator in dietary fat absorption, protecting against obesity and related abnormalities induced by a high-fat diet. Targeting intestinal BMAL1 to regulate dietary fat absorption may be a promising approach for managing metabolic diseases caused by excess fat intake.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Swagata Goswami, Qiming Zhang, Cigdem Elif Celik, Ethan M. Reich, Omer H. Yilmaz
Summary: Metabolic reprogramming and the utilization of lipids play a crucial role in cancer initiation, progression, and metastasis. The complex interactions within the tumor microenvironment influence how cancer cells utilize lipids. Obesity is associated with multiple cancer types, while diets like calorie restriction and fasting have been shown to improve health and delay cancer. Cancer cells interact with immune and stromal components within the heterogeneous microenvironment, and there is a complex metabolic crosstalk between these compartments. Understanding lipid metabolism and signaling pathways is therefore important for developing therapeutic strategies for cancer treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Chemistry, Physical
Asma El Aoud, Emmanuelle Reboul, Aurelien Dupont, Cristelle Meriadec, Franck Artzner, Sebastien Marze
Summary: This study investigated structural transitions in intestinal assemblies containing bile components, dietary fat, and fat-soluble vitamins. Results showed that increasing dietary lipid concentration led to a transition from core-shell micelles to unilamellar vesicles, while increasing fat-soluble vitamin concentration induced various structural transitions in the assemblies. SAXS data was used to propose ideal molecular organizations for the assemblies with and without alpha-tocopherol.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Neurosciences
Min Liu, Ling Shen, Qing Yang, Andromeda M. Nauli, Madison Bingamon, David Q-H Wang, Yvonne M. Ulrich-Lai, Patrick Tso
Summary: The study revealed significant differences in intestinal lipid absorption and lymphatic transport between female and male animals. Estrogen treatment in ovariectomized rats significantly reduced lymphatic output of [H-3]triacylglycerol (TAG) by suppressing TAG transport, associated with enhanced vegfa gene expression in the intestine. Progesterone treatment decreased lymphatic output of [C-14]cholesterol by inhibiting cholesterol absorption in ovariectomized rats. Estrogen treatment also increased lymphatic output of apolipoprotein A-I in ovariectomized rats, potentially contributing to the reduced risk of atherosclerosis in females.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Agriculture, Dairy & Animal Science
Peng Li, Mingkun Gao, Jiahuan Fu, Shaojia Yan, Yongfa Liu, Tahir Mahmood, Zengpeng Lv, Yuming Guo
Summary: This study showed that dietary supplementation of 50 mg/kg SS improved lipid metabolism, immune function, and intestinal flora of laying hens, while 500 mg/kg SS had negative effects.
Article
Biochemistry & Molecular Biology
Julia Schipke, Dagmar Juette, Christina Brandenberger, Chiara Autilio, Jesus Perez-Gil, Wolfgang Bernhard, Matthias Ochs, Christian Muehlfeld
Summary: The study found that different dietary patterns have a significant impact on lung function and pulmonary surfactant, with high-fat diets significantly affecting pulmonary surfactant function, and high-carbohydrate diets potentially leading to changes in phospholipid species. This provides new research directions for investigating pulmonary complications associated with obesity and type 2 diabetes.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Applied
Zhi-Yong Zhang, Samwel M. Limbu, Si-Han Zhao, Li-Qiao Chen, Yuan Luo, Mei-Ling Zhang, Fang Qiao, Zhen-Yu Du
Summary: The wide use of high-fat diet negatively affects flesh quality in farmed fish. However, the addition of L-carnitine can alleviate these negative effects.
Article
Gastroenterology & Hepatology
Sei Higuchi, Tiara R. Ahmad, Donovan A. Argueta, Pedro A. Perez, Chen Zhao, Gary J. Schwartz, Nicholas DiPatrizio, Rebecca A. Haeusler
Meeting Abstract
Biochemistry & Molecular Biology
Margaret Schmill, Zoe Thompson, Nicholas DiPatrizio, Theodore Garland
Article
Nutrition & Dietetics
Bryant Avalos, Donovan A. Argueta, Pedro A. Perez, Mark Wiley, Courtney Wood, Nicholas DiPatrizio
Article
Multidisciplinary Sciences
Elena Kozlova, Bhuvaneswari D. Chinthirla, Pedro A. Perez, Nicholas DiPatrizio, Donovan A. Argueta, Allison L. Phillips, Heather M. Stapleton, Gwendolyn M. Gonzalez, Julia M. Krum, Valeria Carrillo, Anthony E. Bishay, Karthik R. Basappa, Margarita C. Curras-Collazo
SCIENTIFIC REPORTS
(2020)
Review
Medicine, General & Internal
Donovan A. Argueta, Anupam Aich, Fjolla Muqolli, Hemanth Cherukury, Varun Sagi, Nicholas DiPatrizio, Kalpna Gupta
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Nutrition & Dietetics
Nicholas DiPatrizio
Summary: The gut-brain signaling system, particularly the endocannabinoid system in the upper gastrointestinal tract, plays a crucial role in controlling food intake and the dysregulation of this system is associated with obesity. Direct and indirect interactions between endocannabinoids and vagal afferent neurons are key mechanisms in this control, with a focus on how diet-induced obesity impacts these pathways.
Article
Biochemistry & Molecular Biology
Arzu Ulu, Abigail Burr, Art J. Heires, Jacqueline Pavlik, Tricia Larsen, Pedro A. Perez, Carissa Bravo, Nicholas DiPatrizio, Michelle Baack, Debra J. Romberger, Tara M. Nordgren
Summary: Agricultural workers, especially those working in swine confinement facilities, are at higher risk of developing pulmonary diseases due to exposures to fumes, vapors, and organic dust. Chronic exposure to agricultural dust leads to unresolved inflammation, while diet also plays a significant role in inflammation and disease progression.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mark B. Wiley, Nicholas DiPatrizio
Summary: The gut barrier is compromised in diet-induced obesity, and the dysregulated endocannabinoid system in the gut may play a role in this dysfunction. This study found that mice lacking cannabinoid receptor subtype-1 (CB1R) in intestinal epithelial cells had worsened gut barrier dysfunction when fed a high-fat/sucrose diet. The mice also showed reduced levels of endocannabinoids and altered gene expression for gut barrier components and inflammatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Courtney P. Wood, Bryant Avalos, Camila Alvarez, Nicholas V. DiPatrizio
Summary: The genetic deletion of CB1Rs in the intestinal epithelium is associated with an anxiolytic phenotype in a sex-dependent manner, with male mice showing reduced anxiety-like behaviors but no significant effects observed in female mice.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Mark B. Wiley, Sarah D. Bobardt, Tara M. Nordgren, Meera G. Nair, Nicholas V. DiPatrizio
Summary: The study revealed that the levels of endocannabinoids increase during infection, indicating a potential immunomodulatory role. Additionally, it was found that CB(1) receptors are involved in resolving Th2 inflammatory responses, while CB2 receptors do not play a role in this process.
CANNABIS AND CANNABINOID RESEARCH
(2021)
Article
Urology & Nephrology
Alex Y. Pai, Cachet Wenziger, Elani Streja, Donovan A. Argueta, Nicholas DiPatrizio, Connie M. Rhee, Nosratola D. Vaziri, Kamyar Kalantar-Zadeh, Daniele Piomelli, Hamid Moradi
Summary: In patients on maintenance hemodialysis, serum levels of OEA and PEA are significantly correlated with variables related to lipid metabolism and body mass, with higher levels of PEA associated with mortality risk. Future studies are needed to explore the mechanisms behind these findings and their clinical implications.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Meeting Abstract
Hematology
Donovan A. Argueta, Hanan Chweih, Bryant Avalos, Huy Tran, Aithanh Nguyen, Anupam Aich, Nicholas V. DiPatrizio, Kalpna Gupta
Meeting Abstract
Medicine, Research & Experimental
Mahyar Khazaeli, Nazli Farahanchi, Yitong Zhao, Han Liu, Ane Nunes, Donovan Argueta, Mahziar Khazaali, Nicholas DiPatrizio, Daniele Piomelli, Ted Farzaneh, Nosratola Vaziri, Hamid Moradi
LABORATORY INVESTIGATION
(2020)
Meeting Abstract
Pathology
Mahyar Khazaeli, Nazli Farahanchi, Yitong Zhao, Han Liu, Ane Nunes, Donovan Argueta, Mahziar Khazaali, Nicholas DiPatrizio, Daniele Piomelli, Ted Farzaneh, Nosratola Vaziri, Hamid Moradi
Article
Urology & Nephrology
Hamid Moradi, Christina Park, Elani Streja, Donovan A. Argueta, Nicholas V. DiPatrizio, Amy S. You, Connie M. Rhee, Nosratola D. Vaziri, Kamyar Kalantar-Zadeh, Daniele Piomelli
AMERICAN JOURNAL OF NEPHROLOGY
(2020)