Article
Chemistry, Physical
Magali F. Scocozza, Francisco Vieyra, Fernando Battaglini, Ligia O. O. Martins, Daniel H. H. Murgida
Summary: In this study, it was found that the performance of DyP enzyme from Bacillus subtilis can be greatly enhanced by electrochemical activation in the absence of externally added H2O2. The enzyme shows higher specific activities towards different substrates and broader pH activity profiles under these conditions.
Review
Biochemistry & Molecular Biology
Kaori Kanemaru, Yoshikazu Nakamura
Summary: Phospholipase C (PLC) metabolizes phosphatidylinositol 4,5-bisphosphate in the plasma membrane and generates inositol 1,4,5-trisphosphate and diacylglycerol, which regulate cellular functions. Mammalian PLC consists of six typical classes and one atypical class, and dysregulation of PLC activity is associated with various diseases. Therefore, the review focuses on the structure, activation mechanisms, and physiological functions of mammalian PLC.
Review
Biotechnology & Applied Microbiology
Diogo Silva, Carolina F. Rodrigues, Constanca Lorena, Patricia T. Borges, Ligia O. Martins
Summary: Dye-decolorizing Peroxidases (DyPs) are heme-containing enzymes that catalyze the reduction of hydrogen peroxide and oxidation of various substrates. Understanding DyPs has provided new insights into peroxidases, while their physiological role and catalytic mechanisms remain to be fully understood. DyPs have a unique fold and specific binding sites for substrates and hydrogen peroxide. The engineering of DyPs has been focused on applications such as textile effluent treatment and lignin degradation. The study of DyP-type peroxidases has implications for environmental sustainability and the development of bio-based products.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Biology
Kristina Zahonova, Gordon Lax, Savar D. Sinha, Guy Leonard, Thomas A. Richards, Julius Lukes, Jeremy G. Wideman
Summary: The study sequenced and assembled 20 euglenozoan single-cell amplified genomes, identifying three in kinetoplastids, 14 in diplonemids, one in euglenids, and two potentially branching as early-branching euglenozoans. Notably, two of the genomes contained unique features such as full-length rns and rnl genes, multiple mitoribosomal genes, and nad11, suggesting ancestral mitochondrial characteristics.
Article
Biochemistry & Molecular Biology
Eric Olo Ndela, Francois Enault, Ariane Toussaint
Summary: By searching for potential transposable prophages in Leptospiraceae genomes, 236 predicted transposable prophages were discovered, especially abundant in the most pathogenic leptospiral clade, potentially involved in acquiring virulent traits. These prophages, distantly related to known transposable phages, are organized into six groups with structural and transposition proteins showing different relationship reconstructions, suggesting ancestral recombinations. Despite high divergence, all prophages exhibit conserved size and genomic organization, with similarities to non-transposable phages infecting L. biflexa, indicating gene transfer between different Caudovirales inside the leptospiral host.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Monica R. Cesinger, Nicole H. Schwardt, Cortney R. Halsey, Maureen K. Thomason, Michelle L. Reniere
Summary: The study revealed that L. monocytogenes utilizes a diverse set of peroxidase enzymes to defend against peroxide toxicity during infection of mammalian cells, with fri being essential for cytosolic growth.
MICROBIOLOGY SPECTRUM
(2021)
Review
Chemistry, Inorganic & Nuclear
Yuma Shisaka, Osami Shoji
Summary: The haem-acquisition system protein A (HasA) has the ability to accommodate a variety of synthetic metal complexes and opens up biological applications for these previously incompatible complexes.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Jun-Tong Chen, Magnus Liden, Xian-Han Huang, Liang Zhang, Xin-Jian Zhang, Tian-Hui Kuang, Jacob B. Landis, Dong Wang, Tao Deng, Hang Sun
Summary: A systematic study of Corydalis with 530 species revealed three subgenera, 25 sections, and one series as monophyletic, and proposed a new classification with four subgenera, 39 sections, including 16 consistent with previous classification, 16 recircumscribed, one reinstated, and six newly established sections.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Thomas L. Poulos, Jenny S. Kim, Vidhi C. Murarka
Summary: This paper examines the energetic differences in Trp radical stabilization in three different peroxidases, using thermodynamic integration and multistate Bennett acceptance ratio methods for analysis. The results show that the local solvent structure near the redox active Trp plays a significant role in stabilizing the cationic Trp radical.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Lin Zhang, Xinxin Zhu, Yiyong Zhao, Jing Guo, Taikui Zhang, Weichen Huang, Jie Huang, Yi Hu, Chien-Hsun Huang, Hong Ma
Summary: The adaptation of Pooideae to cool climates has been influenced by gene duplications and regulatory mechanisms. Pooideae originated in the late Cretaceous and underwent divergences under cooling conditions. During the Eocene-Oligocene transition, Pooideae species experienced significant gene duplications and regulatory changes, promoting their adaptation to cold habitats.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Review
Cell Biology
Huiwen Zhou, Juan Hua, Hongdi Li, Xinyu Song, Shihong Luo
Summary: Maize, originating from southern Mexico, has been bred into various hybrid varieties during domestication. It contains specialized plant metabolites (SPMs) that enable it to resist stresses and pathogens. A wide range of compounds, including terpenoids, phenolics, alkaloids, and others, have been identified in maize. These SPMs have diverse chemical structures and exhibit broad-spectrum biological activities, providing valuable insights for breeding and promoting the maize industry.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dhruv C. Rathod, Sonali M. Vaidya, Marie-T. Hopp, Toni Kuehl, Diana Imhof
Summary: Heme plays a dual role in biological processes, functioning as a prosthetic group of hemoproteins and also regulating biochemical pathways through transient association with proteins. However, the mechanisms of heme recognition and complex formation with target proteins are poorly understood. This report focuses on evaluating mammalian heme-regulated proteins and their heme-binding motifs (HBMs), particularly the Cys-Pro dipeptide motifs. This analysis provides insights into the sequence and structural anomalies observed during transient heme binding and protein regulation.
Article
Biology
Paul M. Oliver, Deborah S. Bower, Peter J. McDonald, Fred Kraus, Jennifer Luedtke, Kelsey Neam, Louise Hobin, Alienor L. M. Chauvenet, Allen Allison, Evy Arida, Simon Clulow, Rainer Gunther, Elizah Nagombi, Burhan Tjaturadi, Scott L. Travers, Stephen J. Richards
Summary: Melanesia in the Pacific, centered around the island of New Guinea, is home to the world's most diverse and intact insular frog fauna. It has over 97% of globally recognized frog species, with nearly 7% of them found in less than 0.7% of the world's land area. This exceptional biodiverse region offers valuable insights and opportunities for conservation efforts.
COMMUNICATIONS BIOLOGY
(2022)
Article
Microbiology
Daniel Cadar, Jonas Schmidt-Chanasit, Dennis Tappe
Summary: Research on VSBV-1 reveals that its genetic diversity is primarily shaped by in situ evolution, with evidence of adaptive evolution in the G and L genes. The main mechanism of virus spread is through animal trade, leading to local micro-evolution in zoos and holdings.
Article
Integrative & Complementary Medicine
Wang You-Xu, Cao Ning, Guan Hui-Da, Cheng Xue-Mei, Wang Chang-Hong
Summary: This study found that heme peroxidases catalyze the oxidative reaction of harmaline and revealed the metabolic pathway of harmaline in blood. The findings are of great significance for understanding the metabolism of carboline compounds and pharmacokinetic studies.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Biochemistry & Molecular Biology
Andrew E. Webb, Z. Nevin Gerek, Claire C. Morgan, Thomas A. Walsh, Christine E. Loscher, Scott V. Edwards, Mary J. O'Connell
MOLECULAR BIOLOGY AND EVOLUTION
(2015)
Article
Chemistry, Physical
Long Ye, Yuan Xiong, Huifeng Yao, Abay Gadisa, Hao Zhang, Sunsun Li, Masoud Ghasemi, Nrup Balar, Adrian Hunt, Brendan T. O'Connor, Jianhui Hou, Harald Ade
CHEMISTRY OF MATERIALS
(2016)
Article
Evolutionary Biology
James E. Tarver, Mario dos Reis, Siavash Mirarab, Raymond J. Moran, Sean Parker, Joseph E. O'Reilly, Benjamin L. King, Mary J. O'Connell, Robert J. Asher, Tandy Warnow, Kevin J. Peterson, Philip C. J. Donoghue, Davide Pisani
GENOME BIOLOGY AND EVOLUTION
(2016)
Article
Polymer Science
Bingxiao Zhao, Omar Awartani, Brendan O'Connor, Mohammed A. Zikry
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
(2016)
Article
Chemistry, Physical
Emerson R. Silva, Gary Cooney, Ian W. Hamley, Wendel A. Alves, Shannon Lee, Brendan F. O'Connor, Mehedi Reza, Janne Ruokolainen, Dermot Walls
Article
Parasitology
Kathryn M. Mcrae, Barbara Good, James P. Hanrahan, Matthew S. McCabe, Paul Cormican, Torres Sweeney, Mary J. O'Connell, Orla M. Keane
VETERINARY PARASITOLOGY
(2016)
Editorial Material
Multidisciplinary Sciences
James O. McInerney, Mary J. O'Connell
Letter
Microbiology
James O. McInerney, Alan McNally, Mary J. O'Connell
NATURE MICROBIOLOGY
(2017)
Article
Microbiology
James O. McInerney, Alan McNally, Mary J. O'Connell
NATURE MICROBIOLOGY
(2017)
Article
Multidisciplinary Sciences
Nicole M. Foley, Graham M. Hughes, Zixia Huang, Michael Clarke, David Jebb, Conor V. Whelan, Eric J. Petit, Frederic Touzalin, Olivier Farcy, Gareth Jones, Roger D. Ransome, Joanna Kacprzyk, Mary J. O'Connell, Gerald Kerth, Hugo Rebelo, Luisa Rodrigues, Sebastien J. Puechmaille, Emma C. Teeling
Article
Biochemistry & Molecular Biology
Joseph J. B. Cockburn, Sophie J. Hesketh, Peter Mulhair, Maren Thomsen, Mary J. O'Connel, Michael Way
Article
Biochemistry & Molecular Biology
Haidee Tinning, Alysha Taylor, Dapeng Wang, Bede Constantinides, Ruth Sutton, Georgios Oikonomou, Miguel A. Velazquez, Paul Thompson, Achim Treumann, Mary J. O'Connell, Niamh Forde
Article
Biochemistry & Molecular Biology
Peter O. Mulhair, Charley G. P. McCarthy, Karen Siu-Ting, Christopher J. Creevey, Mary J. O'Connell
Summary: Conflicting studies have placed the Xenacoelomorpha in two different positions within the animal tree, either as the primary emerging bilaterian phylum or within Deuterostomia. Recent studies also question the monophyly of Deuterostomia. Hidden paralogy and low phylogenetic signal are challenges in reconstructing species phylogenies.
Article
Computer Science, Artificial Intelligence
Andrew E. Webb, Thomas A. Walsh, Mary J. O'Connell
PEERJ COMPUTER SCIENCE
(2017)
Article
Veterinary Sciences
L. Gunn, P. J. Collins, M. J. O'Connell, H. O'Shea
IRISH VETERINARY JOURNAL
(2015)