Article
Nutrition & Dietetics
Dana A. A. Bader, Anas Abed, Beisan A. A. Mohammad, Ahmad Aljaberi, Ahmad Sundookah, Maha Habash, Ahmad R. R. Alsayed, Mohammad Abusamak, Sami Al-Shakhshir, Mahmoud Abu-Samak
Summary: This research evaluated the effects of high-dose cholecalciferol supplements on selected circulating cytokines associated with cytokine storms in adults with vitamin D deficiency. The results showed that the supplementation significantly increased the levels of certain cytokines. However, further trials are needed to clarify the potential benefits of the supplementation during cytokine storms.
Article
Nutrition & Dietetics
Aasiya Bano, Saida Abrar, Elisa Brilli, Germano Tarantino, Ali Akbar Bugti, Marco Fabbrini, Gabriele Conti, Silvia Turroni, Mahroo Bugti, Fauzia Afridi, Shah Mureed, Hakeem Zada, Ikram Din Ujjan, Saadia Ashraf, Aamir Ghafoor, Saeed Khan, Amjad Khan
Summary: This study compared the absorption of an innovative phospholipids-sucrester matrix biodelivery vehicle-based Vit D3 preparation with a reference chewable tablet and soft gel capsule Vit D3 formulations in Vit D-deficient healthy adults. The results showed that the phospholipids-sucrester matrix Vit D3 preparation was efficiently absorbed in the gastrointestinal system, achieving higher and sustained circulatory Vit D levels, and can effectively contribute to the body's protection against Vit D deficiency-associated health conditions.
FRONTIERS IN NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Khaled M. Abdelrahman, Kevin V. Hackshaw
Summary: Neuropathic pain affects a significant portion of the population and is often treated ineffectively, leading patients to turn to nonpharmacologic treatments such as nutritional supplements. While patients commonly use vitamins, minerals, and herbal remedies for pain relief, there is limited evidence on the efficacy and mechanisms of these supplements in neuropathic pain, necessitating further exploration through large randomized controlled trials.
Article
Biochemistry & Molecular Biology
Cristian Sandoval, Jorge Farias, Mauricio Zamorano, Christian Herrera
Summary: The present review examined the relationship between vitamin deficiency and chronic liver disease. It was found that alcohol patients have low blood vitamin levels and that antioxidant mechanisms can prevent alcohol-induced liver damage. However, the effectiveness of antioxidants remains uncertain. Deficiencies in nutritional vitamins can rapidly develop during chronic liver disease.
Article
Endocrinology & Metabolism
Sharon H. Chou, Elle M. Murata, Cindy Yu, Jacqueline Danik, Gregory Kotler, Nancy R. Cook, Vadim Bubes, Samia Mora, Paulette D. Chandler, Deirdre K. Tobias, Trisha Copeland, Julie E. Buring, JoAnn E. Manson, Meryl S. LeBoff
Summary: This study aimed to investigate the effects of vitamin D-3 supplementation on weight and body composition, and the results showed that there were no significant effects on weight, BMI, or measures of adiposity and lean tissue. However, it did slightly improve body fat percentage in participants with normal BMI at baseline, indicating a potential benefit for individuals with normal weight.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Geriatrics & Gerontology
Jennifer A. Schrack, Yurun Cai, Jacek K. Urbanek, Amal A. Wanigatunga, Christine M. Mitchell, Edgar R. Miller III, Jack M. Guralnik, Stephen P. Juraschek, Erin D. Michos, David L. Roth, Lawrence J. Appel
Summary: This study aimed to assess whether vitamin D-3 supplementation could attenuate the decline in daily physical activity in low-functioning older adults. The results showed that supplementation with 1000 IU/day or higher of vitamin D-3 did not attenuate the decline in physical activity compared to 200 IU/day. Individuals with baseline serum 25(OH)D levels < 20 ng/mL experienced accelerated declines in physical activity.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Psychiatry
Chirag M. Vyas, David Mischoulon, Grace Chang, Charles F. Reynolds, Nancy R. Cook, Alison Weinberg, Trisha Copeland, Vadim Bubes, Gary Bradwin, I-Min Lee, Julie E. Buring, Samia Mora, Nader Rifai, JoAnn E. Manson, Olivia I. Okereke
Summary: This study examined the relationship between serum brain-derived neurotrophic factor (BDNF) and late-life depression (LLD) both cross-sectionally and longitudinally. It also investigated the effects of vitamin D3 and omega-3s on changes in BDNF and explored the role of BDNF in the effects of these supplements on LLD. The results showed significant cross-sectional associations between serum BDNF levels and LLD, but no longitudinal associations. Neither vitamin D3 nor omega-3s had an effect on serum BDNF levels over a 2-year period.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Malgorzata Starek, Pawel Gumulka, Monika Dabrowska
Summary: Nowadays, the quality of dietary supplements is of utmost importance due to reports of insufficient content or absence of ingredients. This study developed optimal conditions for analyzing the content of vitamins D-2, D-3, and K-2 in various dietary supplements. The results showed that the methodology developed was reliable and met analytical requirements. The amount of vitamin D-3 in the analyzed products matched the manufacturer's declaration, while the content of vitamin K-2 varied.
Article
Medical Laboratory Technology
Jun-Il Yoo, Hye Jin Chung, Bo Gyu Kim, Youn-Kwan Jung, Kyung-Wan Baek, Myung-Geun Song, Min-Chul Cho
Summary: The levels of bioavailable 25(OH)D were found to be significantly decreased in sarcopenic patients. Using serum bioavailable 25(OH)D levels to diagnose sarcopenia, a cutoff point of 1.70 ng/ml was identified. The incidence of sarcopenia increased by 3.3 times in individuals with bioavailable 25(OH)D levels below 1.70 ng/ml.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Nutrition & Dietetics
Rudolf Aschauer, Sandra Unterberger, Patrick A. Zoehrer, Agnes Draxler, Bernhard Franzke, Eva-Maria Strasser, Karl-Heinz Wagner, Barbara Wessner
Summary: Vitamin D3 supplementation does not have additive effects on muscle strength and performance in older adults during resistance training. However, it can improve vitamin D status. Resistance training positively affects muscle endurance and arm curl test.
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Nutrition & Dietetics
Christopher T. Sempos, Ramon A. Durazo-Arvizu, Philip R. Fischer, Craig F. Munns, John M. Pettifor, Tom D. Thacher
Summary: The study found a significant association between serum 25(OH)D and nutritional rickets in Nigerian children, and showed that the vitamin D requirement to prevent nutritional rickets varies inversely with calcium intake. The use of multivariable modeling is essential in defining vitamin D requirements.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Pramod B. Umarji, Pankaj Verma, Vivek Garg, Marian Schini, Richard Eastell
Summary: This study conducted a 6-month randomized controlled trial on young Indian women aged 25 to 44, with the results showing favorable changes in bone metabolism and calcium homeostasis, indicating potential improvements in bone health.
Review
Nutrition & Dietetics
Rakesh Balachandar, Raghu Pullakhandam, Bharati Kulkarni, Harshpal Singh Sachdev
Summary: This study found that cholecalciferol was more effective than ergocalciferol in improving vitamin D status and regulating PTH levels, regardless of participant demographics, dosage, and vehicle of supplementation.
Article
Health Care Sciences & Services
Vito Fiore, Andrea De Vito, Paola Bagella, Elija Princic, Anna Antonella Mariani, Lucia Denti, Alessandro Giuseppe Fois, Giordano Madeddu, Sergio Babudieri, Ivana Maida
Summary: This study evaluated the usefulness of Vitamin D3 among patients hospitalized for COVID-19. The findings showed that patients receiving Vitamin D3 had better survival rates, lower likelihood of needing non-invasive ventilation, and improvement in inflammatory parameters. Therefore, Vitamin D3 level is considered as a useful prognostic marker for the clinical course of COVID-19.
