Article
Public, Environmental & Occupational Health
Stephen W. Farrell, Kristen J. Meyer, David Leonard, Kerem Shuval, Carolyn E. Barlow, Andjelka Pavlovic, Laura DeFina, William L. Haskell
Summary: This study found that levels of physical activity are positively associated with 25(OH)D levels and negatively associated with measures of adiposity. Higher levels of physical activity attenuate the association between adiposity and 25(OH)D.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Nutrition & Dietetics
Julia Sanguesa, Sandra Marquez, Mariona Bustamante, Jordi Sunyer, Carmen Iniguez, Jesus Vioque, Loreto Santa-Marina Rodriguez, Alba Jimeno-Romero, Matias Torrent, Maribel Casas, Martine Vrijheid
Summary: This study examines the association between prenatal vitamin D levels and growth and adiposity in late childhood. The results suggest a sex-specific programming effect of early pregnancy vitamin D levels on offspring body composition, which is observed in boys but not in girls.
Article
Gastroenterology & Hepatology
Sunyoung Lee, Kyoung Won Kim, Jeongjin Lee, Taeyong Park, Seungwoo Khang, Heeryeol Jeong, Gi-Won Song, Sung-Gyu Lee
Summary: The severity of non-alcoholic fatty liver was positively correlated with visceral fat accumulation in a lean Asian population. Visceral adiposity may be a risk factor for lean NAFLD in potential living liver donors.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Endocrinology & Metabolism
Fatme AlAnouti, Amar Sabri Ahmad, Laila Abdel Wareth, Ayesha Al Dhaheri, Abderrahim Oulhaj, Abdulla Al Junaibi, Abdullah Al Naeemi, Aisha Al Hamiz, Ayesha Al Hosani, Eiman Al Zaabi, Fatima Mezhal, Fatma Al Maskari, Habiba Alsafar, Jamila Yaaqoub, Marina Al Bastaki, Mohammed Al Houqani, Naima Oumeziane, Nirmin F. Juber, Scott Sherman, Syed M. Shah, Teeb Alsharid, Thekra Al Zaabi, Tom Loney, Wael Al Mahmeed, Abdishakur Abdulle, Raghib Ali
Summary: This study analyzed the data from UAE Healthy Future Study to investigate the association between serum vitamin D levels and body fat composition as well as BMI among Emiratis. The results showed a significant negative association between serum vitamin D levels and body fat composition at intermediate percentiles, and a negative association between serum vitamin D levels and BMI at the median.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Pang Yao, Andri Iona, Christiana Kartsonaki, Saredo Said, Neil Wright, Kuang Lin, Alfred Pozarickij, Iona Millwood, Hannah Fry, Mohsen Mazidi, Yiping Chen, Huaidong Du, Derrick Bennett, Daniel Avery, Dan Schmidt, Pei Pei, Jun Lv, Canqing Yu, Michael Hill, Junshi Chen, Richard Peto, Robin Walters, Rory Collins, Liming Li, Robert Clarke, Zhengming Chen
Summary: We investigated the associations between adiposity and plasma levels of 1463 proteins in 3977 Chinese adults using measured and genetically-instrumented BMI. The study revealed significant associations between adiposity and 1096 proteins, with these proteins involved in multiple disease mechanisms such as atherosclerosis, lipid metabolism, tumor progression, and inflammation. Bi-directional MR analyses identified 8 proteins that significantly affect BMI levels. These findings provide insights into the pathways linking adiposity with disease risks and potential targets for obesity treatment.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Biology
Zihao Yao, Weizhong Qi, Hongbo Zhang, Zhicheng Zhang, Liangliang Liu, Yan Shao, Hua Zeng, Jianbin Yin, Haoyan Pan, Xiongtian Guo, Anling Liu, Daozhang Cai, Xiaochun Bai, Haiyan Zhang
Summary: Obesity is a significant risk factor in the progression of osteoarthritis (OA), but the mechanism of obesity-related inflammation in OA synovitis is not fully understood. This study found that synovial macrophages infiltrated and polarized in the obesity microenvironment and identified the important role of M1 macrophages in impaired macrophage efferocytosis. The study revealed that obese OA patients and Apoe(-/-) mice showed more severe synovitis and increased macrophage infiltration, accompanied by dominant M1 macrophage polarization.
Article
Dermatology
Julie De Smedt, Sofie Van Kelst, Laudine Janssen, Vivien Marasigan, Veerle Boecxstaens, Marguerite Stas, Dirk Vanderschueren, Ipek Guler, Kris Bogaerts, Katleen Vandenberghe, Oliver Bechter, Jaak Billen, Arjen Nikkels, Tine Strobbe, Gabriella Emri, Diether Lambrechts, Marjan Garmyn
Summary: This study aimed to confirm the well-known determinants and assess new determinants for 25-hydroxyvitamin D levels in a cutaneous melanoma population. The results showed that body mass index, seasonal time of blood sampling, vitamin D supplementation, and a specific subtype of skin and hair color had a significant effect on vitamin D status.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Oncology
Hannah Oh, Lusine Yaghjyan, Rebecca J. Austin-Datta, Yujing J. Heng, Gabrielle M. Baker, Korsuk Sirinukunwattana, Adithya D. Vellal, Laura C. Collins, Divya Murthy, A. Heather Eliassen, Bernard A. Rosner, Rulla M. Tamimi
Summary: The study indicates that childhood body fatness and BMI in adulthood are associated with the proportions of adipose and fibrous stromal tissue in breast tissue, suggesting a long-term impact of body fatness on breast tissue composition.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Gastroenterology & Hepatology
Yu-Ming Cheng, Jia-Horng Kao, Chia-Chi Wang
Summary: The study revealed that 16.5% of MAFLD patients were identified as lean MAFLD, with a higher proportion in older age and female subjects. Compared to lean healthy controls, lean MAFLD patients exhibited distinct metabolic characteristics and body composition differences compared to non-lean MAFLD patients.
HEPATOLOGY INTERNATIONAL
(2021)
Review
Nutrition & Dietetics
Azizah Ugusman, Syarifah Amirah Syed Shahrin, Nurul Hana Azizan, Siva Balan Pillai, Khamini Krishnan, Norizam Salamt, Amilia Aminuddin, Adila A. Hamid, Jaya Kumar, Mohd Helmy Mokhtar
Summary: The study systematically reviewed the effects of honey on obesity, finding that honey showed anti-obesity effects in animal studies but had conflicting results in clinical trials. While honey supplementation did not show significant weight reduction in some trials, there was also no evidence that it increased body weight.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Bartosz Hudzik, Justyna Nowak, Janusz Szkodzinski, Aleksander Danikiewicz, Ilona Korzonek-Szlacheta, Barbara Zubelewicz-Szkodzinska
Summary: There is a substantial rate of misclassification of weight status between BMI and BAI in elderly patients with stable CAD. BMI tends to overestimate weight status, while BAI underestimates it. Despite some correlations between BMI and BAI, they exhibit discrepancies in assessing weight status.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Katherine A. Kentistou, Jian'an Luan, Laura B. L. Wittemans, Catherine Hambly, Lucija Klaric, Zoltan Kutalik, John R. Speakman, Nicholas J. Wareham, Timothy J. Kendall, Claudia Langenberg, James F. Wilson, Peter K. Joshi, Nicholas M. Morton
Summary: Our understanding of the genetic contribution to human adiposity is incomplete, as few studies measure adiposity directly. In this study, the authors used whole-body imaging adiposity phenotypes in large biobanks to enhance their ability to discover genes driving human adiposity, and investigated one such gene using a mouse model.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Paivi E. Korhonen, Tuija Mikkola, Hannu Kautiainen, Johan G. Eriksson
Summary: This study found that both fat mass and lean mass index are positively associated with blood pressure levels, independently of other factors. Lean body mass is shown to be an important determinant of blood pressure levels, with a magnitude similar to fat mass. Excess muscle mass may not be beneficial to cardiovascular health.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Qinqiu Wang, Xiaoying Shi, Jinghua Wang, Juanwen Zhang, Chengfu Xu
Summary: This study found that a low serum vitamin D level is associated with NAFLD in obese participants but not in lean participants. Obese individuals with NAFLD had lower levels of serum vitamin D compared to obese individuals without NAFLD. Serum vitamin D level was negatively correlated with NAFLD prevalence in obese participants, and independently associated with NAFLD risk in this group.
Article
Geriatrics & Gerontology
Lucas Baptistella Barbieri, Marco Aurelio Costa da Silva, Fabiana de Souza Orlandi, Ariene Angelini dos Santos-Orlandi, Sofia Cristina Iost Pavarini, Karina Gramani-Say, Grace Angelica de Oliveira Gomes, Marisa S. Zazzetta, Henrique Pott-Junior
Summary: This study investigated the interaction between a set of factors commonly associated with vitamin D production and nutritional intake and serum 25(OH)D levels among older adults. The results showed that gender and BMI were independent adjustment measures for serum 25(OH)D levels, while other factors were not significantly associated.
Article
Pharmacology & Pharmacy
Zareen M. Farukhi, Olga Demler, Michael P. Caulfield, Krishnaji Kulkarni, Jay Wohlgemuth, Michael Cobble, Heike Luttmann-Gibson, Chunying Li, John R. Nelson, Nancy R. Cook, Julie E. Buring, Ronald M. Krauss, JoAnn E. Manson, Samia Mora
JOURNAL OF CLINICAL LIPIDOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Brendan M. Everett, M. V. Moorthy, Jani T. Tikkanen, Nancy R. Cook, Christine M. Albert
Article
Endocrinology & Metabolism
Meryl S. LeBoff, Elle M. Murata, Nancy R. Cook, Peggy Cawthon, Sharon H. Chou, Gregory Kotler, Vadim Bubes, Julie E. Buring, JoAnn E. Manson
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Rheumatology
Lindsey A. MacFarlane, Nancy R. Cook, Eunjung Kim, I-Min Lee, Maura D. Iversen, David Gordon, Julie E. Buring, Jeffrey N. Katz, JoAnn E. Manson, Karen H. Costenbader
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Kathryn Foti, Randi E. Foraker, Pamela Martyn-Nemeth, Cheryl A. M. Anderson, Nancy R. Cook, Alice H. Lichtenstein, Sarah D. de Ferranti, Deborah Rohm Young, Marie-France Hivert, Robert Ross, Prakash Deedwania, Laurie P. Whitsel, Lawrence J. Appel
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2020)
Article
Medicine, General & Internal
Pamela M. Rist, Julie E. Buring, Nancy R. Cook, JoAnn E. Manson, Tobias Kurth
Summary: The study concluded that supplementation of vitamin D and marine omega-3 fatty acids did not reduce the frequency or severity of migraines in middle-aged or older adults, compared to a placebo.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Rikuta Hamaya, Samia Mora, Patrick R. Lawler, Nancy R. Cook, Paul M. Ridker, Julie E. Buring, I-Min Lee, JoAnn E. Manson, Deirdre K. Tobias
Summary: The study found that higher plasma BCAA concentrations are associated with adverse profiles of biomarkers of inflammation and dyslipidemia, reflecting poorer cardiometabolic health.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2021)
Article
Obstetrics & Gynecology
Alayne D. Markland, Camille Vaughan, Alison Huang, Eunjung Kim, Vadim Y. Bubes, Vin Tangpricha, Julie Buring, I-Min Lee, Nancy Cook, JoAnn E. Manson, Francine Grodstein
Summary: This study found that vitamin D supplementation did not have a significant effect on the prevalence, incidence, or progression of urinary incontinence in older women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Baris Gencer, Luc Djousse, Omar T. Al-Ramady, Nancy R. Cook, JoAnn E. Manson, Christine M. Albert
Summary: In randomized controlled trials examining cardiovascular outcomes, supplementation of marine -3 fatty acids was associated with an increased risk of atrial fibrillation (AF). The risk appeared to be greater in trials testing >1 g/d.
Article
Cardiac & Cardiovascular Systems
Rosangela A. Hoshi, Yanyan Liu, Heike Luttmann-Gibson, Saumya Tiwari, Franco Giulianini, Allen M. Andres, Jeramie D. Watrous, Nancy R. Cook, Karen H. Costenbader, Olivia Okereke, Paul M. Ridker, JoAnn E. Manson, I-Min Lee, Manickavasagar Vinayagamoorthy, Susan Cheng, Trisha Copeland, Mohit Jain, Daniel Chasman, Olga Demler, Samia Mora
Summary: This study identified a profile of bioactive lipids associated with physical activity, and 12 of these lipids were found to have opposite associations with incident cardiovascular disease events.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Alvin Chandra, Michael H. Picard, Shi Huang, Deepak K. Gupta, Kartik Agusala, Julie E. Buring, I-Min Lee, Nancy R. Cook, JoAnn E. Manson, Ravi Thadhani, Thomas J. Wang
Summary: In a study lasting 2 years, supplementation with vitamin D3 and n-3 fatty acids did not have significant effects on cardiac structure and function in middle-aged/older individuals.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Nutrition & Dietetics
Yanbin Dong, Haidong Zhu, Li Chen, Ying Huang, William Christen, Nancy R. Cook, Trisha Copeland, Samia Mora, Julie E. Buring, I-Min Lee, Karen H. Costenbader, JoAnn E. Manson
Summary: In the VITAL study, vitamin D-3 supplementation reduced hs-CRP levels at year 2, but had no significant effects on other inflammatory biomarkers. Marine n-3 FAs supplementation did not significantly affect these biomarkers at either time point.
Article
Urology & Nephrology
Christine P. Limonte, Leila R. Zelnick, Andrew N. Hoofnagle, Ravi Thadhani, Michal L. Melamed, Samia Mora, Nancy R. Cook, Heike Luttmann-Gibson, Howard D. Sesso, I-Min Lee, Julie E. Buring, JoAnn E. Manson, Ian H. de Boer
Summary: Based on the results of the Vitamin D and Omega-3 Trial (VITAL), there is no difference in the effects of vitamin D3 supplementation on cardiovascular and cancer outcomes based on baseline estimated glomerular filtration rate (eGFR). The effects on serum 25(OH)D and parathyroid hormone (PTH) concentrations also did not differ at different eGFR levels.
Article
Cardiac & Cardiovascular Systems
Neal A. Chatterjee, Jani T. Tikkanen, Gopi K. Panicker, Dhiraj Narula, Daniel C. Lee, Tuomas Kentta, Juhani M. Junttila, Nancy R. Cook, Alan Kadish, Jeffrey J. Goldberger, Heikki Huikuri, Christine M. Albert
EUROPEAN HEART JOURNAL
(2020)