Article
Plant Sciences
Andres V. Reyes, Ruben Shrestha, Peter R. Baker, Robert J. Chalkley, Shou-Ling Xu
Summary: Accurate relative quantification is crucial in proteomic studies. Incorporating stable isotope N-15 to plant-expressed proteins in vivo is a powerful tool for accurate quantification, but it faces challenges such as incomplete labeling and contamination. This study demonstrates the use of parallel reaction monitoring (PRM) on a high-resolution mass spectrometer to achieve reliable quantification, even for low abundance proteins.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Qingyun Yang, Yingxiao Gao, Xia Liu, Yihang Xiao, Mingxuan Wu
Summary: A new method for editing the N-tail of histone H3 using sortase mediated metathesis (SMM) is reported. This method expands the application scope of sortase and offers a strategy for precise editing of PTMs of cellular histone H3.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Chemical
Alexander Chernonosov, Liliya Aksenova, Vladimir Koval
Summary: This study aimed to develop and validate a rapid, sensitive, and robust LC-HRMS method for the quantification of apixaban in DPSs. Validation results showed good accuracy and precision, demonstrating the method's selectivity and robustness.
Article
Engineering, Chemical
Liliya Aksenova, Vladimir V. Koval, Alexander A. Chernonosov
Summary: In this study, a rapid and sensitive method for quantifying atenolol in dried plasma spots (DPS) using liquid chromatography with high-resolution mass spectrometry (LC-HRMS) was developed and validated. The method showed good selectivity and stability, and was suitable for atenolol quantification in DPS.
Article
Multidisciplinary Sciences
Xinmin Hu, Yalu Han, Yong Wang, Xiaopei Zhang, Lizhi Du
Summary: The accumulation of municipal solid waste in landfills can cause serious pollution to the geological environment and groundwater. Monitoring the seepage path and migration law of leachate is crucial for determining the pollution range of the landfill site.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Xinran Li, Jiaqi Zhou, Wenjuan Zhao, Qing Wen, Weijie Wang, Huipai Peng, Yuan Gao, Kelly J. Bouchonville, Steven M. Offer, Kuiming Chan, Zhiquan Wang, Nan Li, Haiyun Gan
Summary: AMAPEX is a new method that identifies proteins near modified histones using antibody-mediated protein labeling, overcoming limitations of current approaches. This method utilizes biotin labeling to mark nearby proteins, which are then identified by mass spectrometry, demonstrating its utility in studying proximal protein modifications.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Biochemical Research Methods
Ziqing Yu, Lei Xu, Weiyuan Lyu, Feng Shen
Summary: Digital biological analysis compartmentalizes targets of interest and performs detection and investigation. This study presents a parallel multistep digital analysis SlipChip, which enables the manipulation of a large number of droplets for digital biological analysis. The SlipChip utilizes a self-partitioning droplet formation mechanism and can perform digital loop-mediated isothermal amplification and digital CRISPR detection in parallel.
Review
Biochemistry & Molecular Biology
Xiufei Chen, Haiqi Xu, Xiao Shu, Chun-Xiao Song
Summary: The concept of epigenetics was first proposed in 1942. Chemical modifications on histones, DNA, and RNA have been identified as three key components of epigenetic modifications. These modifications play a crucial role in various biological processes and diseases, including cancer. With the advancement of sequencing technologies, scientists are now able to accurately map and quantify different types of epigenetic modifications in histones, DNA, and RNA, providing insights into gene regulation.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Neurosciences
Marta Maleszewska, Aleksandra Steranka, Magdalena Smiech, Beata Kaza, Paulina Pilanc, Michal Dabrowski, Bozena Kaminska
Summary: Microglia pre-exposed to glioma-conditioned medium acquire a transcriptional memory and display reduced expression of inflammatory genes after re-stimulation. Epigenetic mechanisms contribute to glioma-induced transcriptional memory in microglia, resulting in a tumor-supportive phenotype. GCM induces distinct histone modifications in microglia, with Hdac inhibitors blocking these changes and restoring inflammatory responses.
Review
Environmental Sciences
Arijit Chakraborty, Soma Ghosh, Bratisha Biswas, Sreemanta Pramanik, Jerome Nriagu, Subhamoy Bhowmick
Summary: Arsenic exposure can cause harmful epigenetic alterations, leading to various health complications. This review summarizes the mechanisms underlying arsenic-induced epigenetic changes and proposes therapeutic strategies to alleviate the global burden of arsenic poisoning.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Medicine, General & Internal
Elena Camporesi, Johanna Nilsson, Agathe Vrillon, Emmanuel Cognat, Claire Hourregue, Henrik Zetterberg, Kaj Blennow, Bruno Becker, Ann Brinkmalm, Claire Paquet, Gunnar Brinkmalm
Summary: The synaptic proteins NRXN and Nlgn are not suitable biomarkers for synaptic pathology in Alzheimer's disease, as they show weak correlation with core biomarkers and reflect different pathogenic processes at the synapse.
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Article
Chemistry, Analytical
Xiao-Dong Pan, Jian-Long Han, Xiao-Min Xu
Summary: This study presents a method for analyzing 37 glucocorticoids in chicken muscle using UHPLC-Q-Orbitrap MS with PRM. The results demonstrated satisfactory sensitivity and recovery rates, indicating the potential of this method as a routine quantification approach for multiple glucocorticoid residues in chicken samples.
ANALYTICAL METHODS
(2023)
Article
Urology & Nephrology
Yuan Li, Ying Zhang, Xinjin Zhou, Xinli Xue, Muxi Wang, Dedong Kang, Yali Zhou, Ruimin Hu, Songxia Quan, Guolan Xing, Jinghua Yang
Summary: The study developed a PRM-based targeted proteomics method for the early diagnosis and typing of renal amyloidosis, which showed high sensitivity and reliability.
Article
Biochemistry & Molecular Biology
Anca-Roxana Petrovici, Mihaela Silion, Natalia Simionescu, Rami Kallala, Mariana Pinteala, Stelian S. Maier
Summary: This study describes the identification of ZA-calcium complexes in calcium-rich environments and proposes a new method for quantification of low ZA amounts. The method avoids compound derivatization and utilizes high-performance liquid chromatography and electrospray ionization mass spectrometry. It can accurately quantify low concentrations of ZA in the blood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Social Work
In Young Park, Anamika Barman-Adhikari, Hsun-Ta Hsu, Sarah C. Narendorf, Diane Santa Maria, Jama Shelton, Kristin M. Ferguson, Kimberly Bender, Robin Petering
Summary: This study found that discrimination was significantly related to perceived stress among YAEH, and online health information-seeking behavior played a moderating role in this relationship. Therefore, providing digital access and creating online informational resources are important engagement strategies for YAEH.
JOURNAL OF TECHNOLOGY IN HUMAN SERVICES
(2022)
Article
Biochemistry & Molecular Biology
Mate Marosi, Miroslav N. Nenov, Jessica Di Re, Nolan M. Dvorak, Musaad Alshammari, Fernanda Laezza
Summary: In this study, it was found that Akt inhibition enhances peak transient Na+ current density through Na(v)1.6 channels and increases action potential firing in CA1 pyramidal neurons, accompanied by a decrease in action potential current threshold. Complementary confocal analysis revealed that Akt inhibition is associated with the lengthening of Na(v)1.6 fluorescent intensity along the axonal initial segment, providing a mechanism for augmented neuronal excitability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mate Marosi, Parsa Arman, Giuseppe Aceto, Marcello D'Ascenzo, Fernanda Laezza
Summary: GSK3 beta is a multifunctional kinase expressed in all eukaryotic cells, with a central role in intracellular signaling. It phosphorylates voltage-gated ion channels, affecting neuronal excitability, plasticity, and behavior. Imbalanced GSK3 beta activity may increase vulnerability of neuronal circuitry and the risk for neuropsychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Instruments & Instrumentation
Joo-Hee Lee, Soo-Hwan Byun, Sang-Min Yi, In-Young Park, Byoung-Eun Yang, Hye-Lim Lee
Summary: This study aimed to evaluate the potential for improving dentition imaging with CBCT scans using an intraoral scanner instead of a plaster model. The results showed that the intraoral scanners satisfactorily complemented the CBCT, especially for patients and surgeons who have difficulty in scanning the complete arch at once.
Article
Biology
You Na Lim, Byoung-Eun Yang, Soo-Hwan Byun, Sang-Min Yi, Sung-Woon On, In-Young Park
Summary: This study investigated the relationship between skeletal and soft tissue changes after incisor retraction in patients with Angle Class I bimaxillary dentoalveolar protrusion. The results showed a significant correlation between skeletal point A and soft tissue point A on the anteroposterior axis. However, changes in incisor tip, apex, and inclination did not significantly affect the position of skeletal points A and B. It is important to consider both hard and soft tissue analysis in treatment planning for malocclusion.
Article
Family Studies
In Young Park, Rachel Speer, Darren L. Whitfield, Leo Kattari, Eugene N. Walls, Candace Christensen
Summary: Using multivariate logistic regression, this study analyzed data from the 2015 Healthy Kids Colorado Survey to explore the relationship between the intersection of race/ethnicity and gender identity with mental and behavioral health-related risks. The findings suggest that youth with multiple marginalized identities, particularly those who identify as both Bi/Multi-racial or Latino and as transgender/non-binary, have higher levels of depression and suicidal ideation compared to cisgender White youth. Intersectional approaches are important in designing risk prevention and response interventions for racial/ethnic minority youth who are also transgender/non-binary.
CHILDREN AND YOUTH SERVICES REVIEW
(2022)
Article
Multidisciplinary Sciences
Eun-Ji Chung, Byoung-Eun Yang, In-Young Park, Sangmin Yi, Sung-Woon On, Young-Hee Kim, Sam-Hee Kang, Soo-Hwan Byun
Summary: Lateral cephalograms and related analysis are representative methods for orthodontic treatment, but inaccuracies may be produced when quantitative evaluation is required. Cone-beam computed tomography (CBCT) provides high-resolution three-dimensional images at a relatively low dose and cost, and using artificial intelligence analysis programs for lateral cephalogram generation from CBCT has proven to be efficient and consistent for orthodontic diagnosis and planning.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Sung-Woon On, Sang-Min Yi, In-Young Park, Soo-Hwan Byun, Byoung-Eun Yang
Summary: The aim of this study was to compare the mechanical behaviors of three dental implant fixtures with different abutment connection designs. The results of the static compression to fracture tests and fatigue tests showed that all three implants had suitable mechanical properties for intraoral use. Fracture patterns may vary due to differences in the fixture design or abutment connection.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Family Studies
Jangmin Kim, Jin Yao Kwan, Stephanie Rachel Speer, In Young Park, Jennifer L. Bellamy, Aaron Banman, Justin S. Harty, Neil B. Guterman
Summary: This study examines the influence of parental characteristics on parent-worker relationships in home visiting, finding that immigrant status is an important predictor for both mothers and fathers, while ethnicity is only significant for fathers. Additionally, the study reveals that U.S.-born Hispanic/Latinx fathers face greater challenges in building positive worker relationships. These findings underscore the importance of developing gender-specific and culturally responsive strategies to enhance parent-worker relationships.
FAMILIES IN SOCIETY-THE JOURNAL OF CONTEMPORARY SOCIAL SERVICES
(2023)
Article
Biotechnology & Applied Microbiology
Ran-Yeong Cho, Soo-Hwan Byun, Sang-Min Yi, Hee-Ju Ahn, Yoo-Sung Nam, In-Young Park, Sung-Woon On, Jong-Cheol Kim, Byoung-Eun Yang
Summary: Comparative analysis of facial images obtained from three different facial scanners showed that all scanners achieved acceptable results, with scanner 3 performing the best. Each scanner had its own strengths and weaknesses due to differences in scanning methods. The findings from this study can be utilized in creating digital twins, selecting and merging data, and developing new scanners to overcome limitations.
BIOENGINEERING-BASEL
(2023)
Review
Biology
Timothy J. Baumgartner, Zahra Haghighijoo, Nana A. Goode, Nolan M. Dvorak, Parsa Arman, Fernanda Laezza
Summary: Alzheimer's disease is characterized by two major histopathological abnormalities: extracellular plaques composed of amyloid beta and intracellular hyperphosphorylated tau. Attenuation of hippocampal hyperactivity, which is linked to dysfunction of voltage-gated Na+ channels, has emerged as a promising therapeutic strategy for early-stage AD. This review explores the role of Nav channels in neuronal function, their connections to AD pathology, and their potential as therapeutic targets.
Article
Family Studies
Pari Shah Thibodeau, In Young Park, Annie Zean Dunbar, Amy He
Summary: A positive organizational culture, including a supportive learning culture, is crucial for a healthy child welfare workforce. This study explores the relationship between preparation and training, ongoing professional development, and learning culture among child welfare caseworkers. The findings indicate that preparation for work and professional development are positively associated with learning culture, highlighting the importance of providing relevant opportunities for growth within child welfare settings. The implications for child welfare education, training, and practice applications are discussed.
CHILDREN AND YOUTH SERVICES REVIEW
(2023)
Article
Social Work
In Young Park, N. Eugene Walls, Brittanie Atteberry-Ash, Leo Kattari
Summary: This study examines the relationships between school bullying, online bullying, and suicide attempts among young adults, and the protective role of supportive adults. Results show that both types of bullying are associated with suicide attempts, and only parental support moderates this relationship.
JOURNAL OF THE SOCIETY FOR SOCIAL WORK AND RESEARCH
(2023)
Meeting Abstract
Oncology
Y. -C. Kim, I. -J. Oh, C. -K. Park, H. -J. Oh, I. Y. Park, S. -C. Bae
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Psychology, Clinical
Johnny S. Kim, Jody Brook, Kiley W. Liming, In Young Park, Becci A. Akin, Cynthia Franklin
Summary: This study examines whether parents involved in the child welfare system, due to substance abuse, who receive solution-focused brief therapy (SFBT) counseling experience more hope and positive emotions than those receiving treatment-as-usual counseling services. The results suggest that SFBT may help increase positive emotions and hope in parents through a solution-building approach, but more research is needed.
INTERNATIONAL JOURNAL OF SYSTEMIC THERAPY
(2022)
