期刊
BLOOD REVIEWS
卷 26, 期 2, 页码 81-95出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.blre.2011.11.002
关键词
Ex-vivo generated erythroblasts; Red blood cell transfusion; Glucocorticoids; Growth factors
类别
资金
- NY-STAR Foundation [C-06066]
- Centro Nazionale Sangue, Rome, Italy
- Mount Sinai School of Medicine
- Istituto Superiore Sanita, Italy
Blood transfusion is indispensable for modern medicine. In developed countries, the blood supply is adequate and safe but blood for alloimmunized patients is often unavailable. Concerns are increasing that donations may become inadequate in the future as the population ages prompting a search for alternative transfusion products. Improvements in culture conditions and proof-of-principle studies in animal models have suggested that ex-vivo expanded red cells may represent such a product Compared to other cell therapies transfusion poses the unique challenge of requiring great cell doses (2.5 x 10(12) cells vs 10(7) cells). Although production of such cell numbers is theoretically possible. current technologies generate red cells in numbers sufficient only for safety studies. It is conceived that by the time these studies will be completed, technical barriers to mass cell production will have been eliminated making transfusion with ex-vivo generated red cells a reality. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据