Review
Cell Biology
Wei Li, Rongqun Guo, Yongping Song, Zhongxin Jiang
Summary: Erythroblastic islands (EBIs) are specialized microenvironments for erythropoiesis, consisting of a central macrophage and developing erythroid cells. EBI macrophages play a crucial role in supporting erythropoiesis, and dysfunction may lead to certain erythroid hematological disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Physiology
Sanja Vignjevic Petrinovic, Aleksandra Jaukovic, Maja Milosevic, Diana Bugarski, Mirela Budec
Summary: Cancer-related anemia (CRA) is a common disorder that negatively affects the quality of life and prognosis in cancer patients. Stress erythropoiesis (SE) plays a pivotal role in CRA, but chronic SE may lead to ineffective erythropoiesis, worsening the condition. Therefore, there is an urgent need to control ineffective erythropoiesis in cancer patients and develop personalized treatment strategies for CRA management.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Emine Gulturk, Deniz Yilmaz, Gulru Birce Sonmezoz, Ezgi Simge Yildirim
Summary: This study compared the biochemical and clinical features of PV patients diagnosed using the 2016 WHO criteria with those missed by the 2008 criteria, and evaluated the impact of lowered thresholds on PV diagnosis. The number of PV diagnoses significantly increased with the introduction of the 2016 criteria, with higher red blood cell and lactate dehydrogenase values and lower lymphocyte counts in the newly diagnosed patients. These findings provide support for the diagnostic value of the 2016 WHO criteria and the lowered thresholds.
Article
Cell & Tissue Engineering
Sudjit Luanpitpong, Xing Kang, Montira Janan, Kanjana Thumanu, Jingting Li, Pakpoom Kheolamai, Surapol Issaragrisil
Summary: This study demonstrated the regulatory role of the O-GlcNAc/BCL11A axis in erythroid differentiation, maturation, and globin production. O-GlcNAcylation promotes HSCs toward erythroid differentiation and enucleation, and affects globin production. BCL11A is identified as a key mediator of O-GlcNAc-driven erythroid differentiation and β- and α-globin production. Metabolic reprogramming also plays a role in this process, as indicated by the unique metabolic fingerprints observed upon OGA inhibition.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Hematology
Min Jung Kim, Seong Soon Kwon, Young Sok Ji, Min-Young Lee, Kyoung Ha Kim, Namsu Lee, Sung Kyu Park, Jong-Ho Won, Seug Yun Yoon
Summary: The role of inflammation in the pathophysiology of polycythemia vera (PV) is important. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are markers of inflammation. This study found that NLR and PLR were significantly higher in PV patients compared to secondary polycythemia (SP) patients, and had better diagnostic value than serum erythropoietin (EPO) levels.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Article
Hematology
Kristell Mahe, Francis Couturaud, Helene Kerspern, Aurelie Chauveau, Jean-Christophe Ianotto
Summary: The study analyzed the relevance of B2m levels, EPO levels, and tobacco exposure in patients with polycythemia, finding that increased B2m levels, low EPO levels, and no tobacco exposure were predictive of PV, while normal B2m and EPO levels, along with tobacco exposure, were predictive of SP. These simple and inexpensive parameters can assist in rapidly differentiating between PV and SP cases.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2021)
Review
Hematology
Pu Tang, Huaquan Wang
Summary: Erythropoiesis is a complex process involving the transfer of cells from the yolk sac to the fetal hepar and then to the bone marrow. Erythroid progenitor cells in the bone marrow undergo stages of development to produce reticulocytes that enter the bloodstream. Various factors, including erythropoietin and hepcidin, regulate erythropoiesis. Disruptions in these factors can lead to abnormal red blood cell production and function. Understanding erythropoiesis is important for diagnosing and treating hematological disorders.
Article
Medicine, Research & Experimental
Michela Simbula, Maria Francesca Manchinu, Maura Mingoia, Mauro Pala, Isadora Asunis, Cristian Antonio Caria, Lucia Perseu, Manan Shah, Merlin Crossley, Paolo Moi, Maria Serafina Ristaldi
Summary: This study identified a crucial BCL11A/miR-365-3p/SOX6 pathway in the regulation of HbF, providing new insights and potential therapeutic targets for treating 0-hemoglobinopathies.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Hematology
Abdellatif Ismail, Elmustafa Abdalla, Ali Aqel, Abdalla Fadul, Ashraf Ahmed, Ahmed Alsayed, Muzamil Musa, Mohamed A. Yassin
Summary: Although polycythemia vera (PV) is usually associated with low erythropoietin (EPO) levels, elevated EPO levels do not exclude this diagnosis. Workup for PV should include testing for JAK2 mutation and bone marrow biopsy.
Article
Hematology
Heimo Mairbaurl, Samuel Kilian, Svenja Seide, Martina U. Muckenthaler, Max Gassmann, Rukundo K. Benedict
Summary: To compensate for decreased oxygen partial pressure, high-altitude residents increase hemoglobin concentrations [Hb]. The currently used altitude adjustments (World Health Organization [WHO]) do not account for regional differences. Our analysis found that the patterns of [Hb] change with altitude vary among residents from different world regions, indicating that a region-independent correction factor for altitude may not be applicable for diagnosing abnormal [Hb]. We provide regression coefficients and reference-tables specific for different world regions and altitude ranges to improve diagnosing abnormal [Hb].
Article
Hematology
Barbora Kralova, Lucie Sochorcova, Jihyun Song, Ondrej Jahoda, Katarina Hlusickova Kapralova, Josef T. Prchal, Vladimir Divoky, Monika Horvathova
Summary: Iron availability for erythropoiesis is controlled by the iron-regulatory hormone hepcidin. In this study, the researchers investigated the mechanisms coordinating erythropoietic activity with iron homeostasis in mtHEPOR mice. They found that in the prenatal and perinatal period, mtHEPOR mice had increased Erfe transcripts, reduced hepcidin, and iron deficiency. However, postnatally, hepcidin increased in mtHEPOR mice, accompanied by low Erfe induction and iron accumulation. Aging also had an impact on erythropoiesis and iron deposition in these mice.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Hematology
Zollie White, Alejandro A. Gru, Adam N. Goldfarb
Summary: This study investigates the role of LKB1 in erythropoiesis using in vivo and ex vivo experiments. The results suggest that LKB1 deficiency leads to increased serum Epo and accelerated erythroid maturation. These findings highlight the importance of LKB1 in erythropoiesis and maturation control.
BLOOD CELLS MOLECULES AND DISEASES
(2022)
Article
Medicine, General & Internal
James C. Barton, Barrett P. Cary, Robert M. Frederickson
Summary: This article reports a case of a 71-year-old woman who was diagnosed with polycythemia rubra vera and asymptomatic sporadic bilateral renal angiomyolipomas. Phlebotomy and hydroxyurea were used for the treatment of polycythemia rubra vera, while surveillance was conducted for the renal angiomyolipomas.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Louisa Liu, Neil Dudheker, Lhara M. Sumarriva Lezama, Sameer Shah, Maureen Nwaokoro, Vishal Ranpura
Summary: Pure erythroid leukemia (PEL) is an aggressive and rare form of acute leukemia characterized by neoplastic proliferation of immature cells committed to the erythroid lineage. Cases of PEL associated with polycythemia vera, radiation therapy, or chemotherapeutic alkylating agents have been reported. This study presents a rare case of polycythemia vera patient undergoing leukemic transformation to PEL after treatment with phlebotomy and hydroxyurea.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Hematology
Angela Bozza, Martina Bernardi, Daniela Catanzaro, Katia Chieregato, Anna Merlo, Giuseppe Astori
Summary: Polycythemia Vera (PV) is a myeloproliferative neoplasm characterized by the overproduction of red blood cells. ACE inhibition has been shown to reduce erythroid precursor frequency, suggesting that ACE inhibitors and AT1R antagonists could effectively manage erythrocytosis in PV, even in the presence of JAK2 mutation.
Article
Genetics & Heredity
Vladimir Divoky, Jihyun Song, Monika Horvathova, Barbora Kralova, Hana Votavova, Josef T. Prchal, Donghoon Yoon
JOURNAL OF MOLECULAR MEDICINE-JMM
(2016)
Article
Hematology
M. Monika Belickova, Michaela Dostalova Merkerova, Hana Votavova, Jan Valka, Jitka Vesela, Barbora Pejsova, Hana Hajkova, Jiri Klema, Jaroslav Cermak, Anna Jonasova
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2016)
Article
Oncology
Monika Belickova, Jitka Vesela, Anna Jonasova, Barbora Pejsova, Hana Votavova, Michaela Dostalova Merkerova, Zuzana Zemanova, Jana Brezinova, Dana Mikulenkova, Marie Lauermannova, Jan Valka, Kyra Michalova, Radana Neuwirtova, Jaroslav Cermak
Article
Hematology
Jan Valka, Jitka Vesela, Hana Votavova, Michaela Dostalova-Merkerova, Zuzana Horakova, Vit Campr, Jana Brezinova, Zuzana Zemanova, Anna Jonasova, Jaroslav Cermak, Monika Belickova
EUROPEAN JOURNAL OF HAEMATOLOGY
(2017)
Article
Oncology
Zdenek Krejcik, Monika Belickova, Andrea Hrustincova, Hana Votavova, Anna Jonasova, Jaroslav Cermak, Jan E. Dyr, Michaela Dostalova Merkerova
Article
Oncology
Monika Belickova, Jaroslav Cermak, Michaela Dostalova Merkerova, Jitka Vesela, Zdenek Krejcik, Eliska Cechova, Zuzana Zemanova, Kyra Michalova, Hana Votavova, Miroslav Caniga, Radana Neuwirtova, Anna Jonasova
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2012)
Article
Public, Environmental & Occupational Health
Radim J. Sram, Blanka Binkova, Miroslav Dostal, Michaela Merkerova-Dostalova, Helena Libalova, Alena Milcova, Pavel Rossner, Andrea Rossnerova, Jana Schmuczerova, Vlasta Svecova, Jan Topinka, Hana Votavova
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2013)
Article
Oncology
Hana Votavova, Martina Grmanova, Michaela Dostalova Merkerova, Monika Belickova, Alzbeta Vasikova, Radana Neuwirtova, Jaroslav Cermak
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2011)
Article
Substance Abuse
Hana Votavova, Michaela Dostalova Merkerova, Zdenek Krejcik, Kamila Fejglova, Alzbeta Vasikova, Anna Pastorkova, Nana Tabashidze, Jan Topinka, Ivan Balascak, Radim J. Sram, Radim Brdicka
NICOTINE & TOBACCO RESEARCH
(2012)
Article
Developmental Biology
H. Votavova, M. Dostalova Merkerova, K. Fejglova, A. Vasikova, Z. Krejcik, A. Pastorkova, N. Tabashidze, J. Topinka, M. Veleminsky, R. J. Sram, R. Brdicka
Article
Oncology
Jan Valka, Jitka Vesela, Hana Votavova, Michaela Dostalova-Merkerova, Zuzana Urbanova, Anna Jonasova, Jaroslav Cermak, Monika Belickova
ONCOLOGY RESEARCH AND TREATMENT
(2019)
Review
Oncology
Hana Votavova, Monika Belickova
Summary: The translated article discusses the differences between hypoplastic myelodysplastic syndrome (hMDS) and aplastic anemia (AA), highlighting the importance of molecular testing.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Monika Kaisrlikova, Jitka Vesela, David Kundrat, Hana Votavova, Michaela Dostalova Merkerova, Zdenek Krejcik, Vladimir Divoky, Marek Jedlicka, Jan Fric, Jiri Klema, Dana Mikulenkova, Marketa Stastna Markova, Marie Lauermannova, Jolana Mertova, Jacqueline Soukupova Maaloufova, Anna Jonasova, Jaroslav Cermak, Monika Belickova
Summary: This study found that the RUNX1 mutation is the main predictor of rapid progression in LR-MDS patients. Comparison of gene expression profiles between patients with and without RUNX1 mutations suggests that RUNX1 mutations may trigger malignant transformation. Dysregulation of DDR and cellular senescence was also observed. Additionally, the expression profiles of RUNX1-mutated LR-MDS resemble those of higher-risk MDS.
Article
Oncology
M. Dostalova Merkerova, A. Hrustincova, Z. Krejcik, H. Votavova, E. Ratajova, J. Cermak, M. Belickova
Review
Biochemistry & Molecular Biology
A. Hrustincova, H. Votavova, M. Dostalova Merkerova
Article
Hematology
Fanbi Meng, Shuang Chen, Chunliang Liu, Muhammad Shoaib Khan, Yan Yan, Jun Wan, Yue Xia, Chenglin Sun, Mengnan Yang, Renping Hu, Kesheng Dai
Summary: PKC plays a critical role in regulating megakaryocyte development and platelet production in thrombocytopenia. The inhibition of PKC activation delays and reduces radiation-induced megakaryocyte apoptosis, leading to improved platelet count recovery. This study provides a potential therapeutic target for treating thrombocytopenia.
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Article
Hematology
Xia Chen, Fang Liu, Yuanyuan Ren, Luyang Zhang, Yang Wan, Wenyu Yang, Xiaojuan Chen, Li Zhang, Yao Zou, Yumei Chen, Xiaofan Zhu, Ye Guo
Summary: Unrelated umbilical cord blood transplantation (UCBT) is an effective alternative treatment for pediatric patients with bone marrow failure. The use of the TBI/BU + FLU + CY conditioning regimen ensures a high engraftment rate for UCBT and overcomes the challenge of graft failure. Secondary salvage use of cord blood transplantation may still be useful for patients who have failed after other transplantation.
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Article
Hematology
Chithra D. Palani, Xingguo Zhu, Manickam Alagar, Otis C. Attucks, Betty S. Pace
Summary: This study evaluated the ability of a novel Bach1 inhibitor, HPP-D, to induce HbF in KU812 cells and primary sickle erythroid progenitors. The results showed that HPP-D increased HbF levels and decreased Bach1 protein levels in both cell types. Furthermore, it enhanced NRF2 binding to the gamma-globin promoter antioxidant response elements, leading to an open chromatin configuration and increased gamma-globin transcription.
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Letter
Hematology
Marcos Borato Viana, Erica Louback Oliveira, Andre Rolim Belisario
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Article
Hematology
Ke Zhang, Longying Ye, Yanhui Jin, Yuan Chen, Shuting Jiang, Haixiao Xie, Lihong Yang, Mingshan Wang
Summary: This study investigated two pedigrees with FV deficiency and identified three mutations that may have deleterious effects on the function and structure of FV.
BLOOD CELLS MOLECULES AND DISEASES
(2024)