Review
Oncology
Ciro Novaes Rosa Lino, Sujal Ghosh
Summary: Epstein-Barr Virus (EBV) is a common virus that infects over 90% of the world's population, usually without causing symptoms in healthy individuals. However, patients with certain genetic immune deficiencies are at a higher risk of developing malignancies and lymphoproliferative diseases due to EBV infection.
Article
Microbiology
Archana Panikkar, Katie E. Lineburg, Jyothy Raju, Keng Yih Chew, George R. Ambalathingal, Sweera Rehan, Srividhya Swaminathan, Pauline Crooks, Laetitia Le Texier, Leone Beagley, Shannon Best, Matthew Solomon, Katherine K. Matthews, Sriganesh Srihari, Michelle A. Neller, Kirsty R. Short, Rajiv Khanna, Corey Smith
Summary: Adoptive T-cell immunotherapy has shown promising results in treating viral complications, especially in immunocompromised patients. Expanding T cells from healthy individuals provides a new approach to antiviral immunotherapy with rapid and customized treatment options. Recent research indicates that SARS-CoV-2-specific T cells play a crucial role in protecting against COVID-19, suggesting the potential of using HLA-matched virus-specific T cells for treating active COVID-19 or at-risk patients.
Review
Oncology
Miriam Verdu-Bou, Gustavo Tapia, Agueda Hernandez-Rodriguez, Jose-Tomas Navarro
Summary: Epstein-Barr virus (EBV) plays a role in lymphomagenesis, particularly in populations with immunodeficiencies like people living with HIV (PLWH). The presence of EBV in these lymphomas affects their epidemiological, pathological, and clinical characteristics, as well as their prognosis. EBV, along with cooperation with HIV, mediates the pathogenic roles in lymphomas arising in PLWH.
Article
Biology
Wesley Soo I. Hoo, Kaylie Higa, Alison A. McCormick
Summary: This study successfully developed a mouse B cell line expressing latent membrane protein 1 and demonstrated that vaccination protected mice against B cell tumors expressing latent membrane protein 1. This research provides a potential for studying vaccine immunotherapy in cancer patients.
Article
Biochemistry & Molecular Biology
Lih-Tsern Lin, Yi-Shan Lu, Hsiang-Hung Huang, Hao Chen, Shih-Wei Hsu, Li-Kwan Chang
Summary: In this study, researchers found that TRIM5 alpha can interact with and induce the degradation of EBV capsid protein BORF1. TRIM5 alpha promotes BORF1 ubiquitination and destabilizes BORF1 via direct recognition of its substrate. These findings reveal the antiviral impact of TRIM5 alpha beyond retroviruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Victor Omoboyede, Ochapa Ibrahim, Haruna Isiyaku Umar, Taye Bello, Ayodeji Adeola Adedeji, Aqsa Khalid, Emmanuel Sunday Fayojegbe, Adunola Blessing Ayomide, Prosper Obed Chukwuemeka
Summary: The study aimed to develop a multiepitope-based polyvalent vaccine against EBV-associated tumors using an immunoinformatics approach. Thirty viable B-cell and T-cell epitopes were selected and conjugated to form the vaccine construct, showing desirable properties based on in silico evaluation.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yoshimi Enose-Akahata, Limin Wang, Fahad Almsned, Kory R. Johnson, Yair Mina, Joan Ohayon, Xin Wei Wang, Steven Jacobson
Summary: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), and the cause of MS remains unknown. This study investigated the antibody responses against various viruses in the cerebrospinal fluid (CSF) and serum of MS patients, and found significant differences compared to healthy volunteers, as well as a pattern of antibody responses against multiple viruses, including Epstein-Barr virus. These findings indicate that virus-specific antibody signatures might reflect the disease-associated inflammatory milieu in the CSF of patients with neuroinflammatory diseases.
Review
Biochemistry & Molecular Biology
Leila Sawada, Antonio Carlos Rosario Vallinoto, Igor Brasil-Costa
Summary: EBV is an oncovirus associated with various types of cancer, with the reason for cancer development in only some infected individuals still unknown. EBV-associated cancers are more aggressive and resistant to treatment compared to EBV-negative cancers, making monoclonal antibodies targeting immune checkpoints a potential therapy.
Article
Hematology
Julie Brault, Taylor Liu, Ezekiel Bello, Siyuan Liu, Colin L. Sweeney, Ronald J. Meis, Sherry Koontz, Cristina Corsino, Uimook Choi, Guillaume Vayssiere, Marita Bosticardo, Kennichi Dowdell, Cicera R. Lazzarotto, Aaron B. Clark, Luigi D. Notarangelo, Juan C. Ravell, Michael J. Lenardo, Benjamin P. Kleinstiver, Shengdar Q. Tsai, Xiaolin Wu, Gary A. Dahl, Harry L. Malech, Suk See De Ravin
Summary: XMEN disease, a primary immunodeficiency, can potentially be treated with a developed targeted gene therapy using CRISPR/Cas9 AAV, offering two efficient therapeutic options. However, current treatment methods carry certain risks.
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yin-Feng Kang, Xiao Zhang, Xiao-Hui Yu, Qingbing Zheng, Zhe Liu, Jiang-Ping Li, Cong Sun, Xiang-Wei Kong, Qian-Ying Zhu, Hai-Wen Chen, Yang Huang, Miao Xu, Qian Zhong, Yi-Xin Zeng, Mu-Sheng Zeng
Summary: This study utilized self-assembled nanoparticles presenting copies of gp350 to design a promising EBV vaccine candidate that could induce higher neutralizing antibody titers compared to monomeric gp350 vaccines. Results from animal experiments showed that this vaccine design could effectively trigger neutralizing antibody production, and in nonhuman primate models, it demonstrated potential protection against EBV infection.
Article
Environmental Sciences
Mengmeng Li, Wen-Jie Chen, Jun Yang, Hadrien Charvat, Shang-Hang Xie, Tong Li, Wei Ling, Yu-Qiang Lu, Qing Liu, Ming-Huang Hong, Su-Mei Cao
Summary: This study investigated the association between solid fuel use and Epstein-Barr virus (EBV) seropositivity, as well as EBV activation related to nasopharyngeal carcinoma (NPC). The results showed that solid fuel use was associated with a higher risk of EBV seropositivity and NPC-related EBV activation. The findings have important implications for understanding the etiology of NPC and public health, particularly in low resource settings.
ENVIRONMENTAL POLLUTION
(2022)
Article
Hematology
Hannes Vietzen, Philippe L. Furlano, Jan J. Cornelissen, Georg A. Boehmig, Peter Jaksch, Elisabeth Puchhammer-Stoeckl
Summary: This study found that nonclassic human leukocyte antigen E (HLA-E)-restricted immune responses have a significant impact on the development of Epstein-Barr virus (EBV) diseases in the individual host. The highly expressed HLA-E*0103/0103 genotype is protective against infectious mononucleosis (IM) by inducing potent EBV BZLF1-specific HLA-E-restricted CD8(+) T-cell responses. Variations in the inhibitory NKG2A/LMP-1/HLA-E axis are associated with the risk of symptomatic EBV reactivations in both immunocompetent individuals and immunocompromised transplant recipients.
Article
Immunology
Zhicheng Ye, Luxi Chen, Huaqing Zhong, Lingfeng Cao, Pan Fu, Jin Xu
Summary: This study investigated the epidemiology and infectious characteristics of Epstein-Barr virus (EBV) infection among children in Shanghai, China from 2017 to 2022. The results showed that EBV was prevalent among children, and coinfection with bacteria or other viruses increased the viral loads of EBV. The primary EBV-related diseases were systemic lupus erythematosus (SLE), immunodeficiency, and infectious mononucleosis (IM).
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Nina Brauer, Yuto Maruta, Miriam Lisci, Katharina Strege, Ilske Oschlies, Hikari Nakamura, Svea Boehm, Kai Lehmberg, Leon Brandhoff, Stephan Ehl, Nima Parvaneh, Wolfram Klapper, Mitsunori Fukuda, Gillian M. Griffiths, Hans Christian Hennies, Tim Niehues, Sandra Ammann
Summary: In this study, a unique consanguineous family with impaired immune system and susceptibility to infections was described. The family members showed varying levels of impairment in NK cell and cytotoxic T cell function. Whole exome sequencing revealed homozygous variants in RAB27A, FBP1, and ACAD9, which might aggravate the clinical and immune phenotype and affect CD8 T cell function.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Adrienne G. Randolph, Wai-Ki Yip, Emma Kaitlynn Allen, Carrie M. Rosenberger, Anna A. Agan, Stephanie A. Ash, Yu Zhang, Tushar R. Bhangale, David Finkelstein, Natalie Z. Cvijanovich, Peter M. Mourani, Mark W. Hall, Helen C. Su, Paul G. Thomas
JOURNAL OF INFECTIOUS DISEASES
(2017)
Article
Medicine, General & Internal
Ahmet Ozen, William A. Comrie, Rico C. Ardy, Cecilia Dominguez Conde, Buket Dalgic, Omer F. Beser, Aaron R. Morawski, Elif Karakoc-Aydiner, Engin Tutar, Safa Baris, Figen Ozcay, Nina K. Serwas, Yu Zhang, Helen F. Matthews, Stefania Pittaluga, Les R. Folio, Aysel Unlusoy Aksu, Joshua J. McElwee, Ana Krolo, Ayca Kiykim, Zeren Baris, Meltem Gulsan, Ismail Ogulur, Scott B. Snapper, Roderick H. J. Houwen, Helen L. Leavis, Deniz Ertem, Renate Kain, Sinan Sari, Tulay Erkan, Helen C. Su, Kaan Boztug, Michael J. Lenardo
NEW ENGLAND JOURNAL OF MEDICINE
(2017)
Article
Rheumatology
Angeliki Giannelou, Hongying Wang, Qing Zhou, Yong Hwan Park, Mones S. Abu-Asab, Kris Ylaya, Deborah L. Stone, Anna Sediva, Rola Sleiman, Lucie Sramkova, Deepika Bhatla, Elisavet Serti, Wanxia Li Tsai, Dan Yang, Kevin Bishop, Blake Carrington, Wuhong Pei, Natalie Deuitch, Stephen Brooks, Jehad H. Edwan, Sarita Joshi, Seraina Prader, Daniela Kaiser, William C. Owen, Abdullah Al Sonbul, Yu Zhang, Julie E. Niemela, Shawn M. Burgess, Manfred Boehm, Barbara Rehermann, JaeJin Chae, Martha M. Quezado, Amanda K. Ombrello, Rebecca H. Buckley, Alexi A. Grom, Elaine F. Remmers, Jana M. Pachlopnik, Helen C. Su, Gustavo Gutierrez-Cruz, Stephen M. Hewitt, Raman Sood, Kimberly Risma, Katherine R. Calvo, Sergio D. Rosenzweig, Massimo Gadina, Markus Hafner, Hong-Wei Sun, Daniel L. Kastner, Ivona Aksentijevich
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Article
Allergy
William A. Comrie, Aiman J. Faruqi, Susan Price, Yu Zhang, V. Koneti Rao, Helen C. Su, Michael J. Lenardo
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Review
Immunology
Swadhinya Arjunaraja, Pamela Angelus, Helen C. Su, Andrew L. Snow
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Genetics & Heredity
Julie C. Sapp, Jennifer J. Johnston, Kate Driscoll, Alexis R. Heidlebaugh, Ane Miren Sagardia, D. Nadine Dogbe, Kendall L. Umstead, Erin Turbitt, Ilias Alevizos, Jeffrey Baron, Carsten Bonnemann, Brian Brooks, Sandra Donkervoort, Youn Hee Jee, W. Marston Linehan, Francis J. McMahon, Joel Moss, James C. Mullikin, Deborah Nielsen, Eileen Pelayo, Alan T. Remaley, Richard Siegel, Helen Su, Carlos Zarate, Teri A. Manolio, Barbara B. Biesecker, Leslie G. Biesecker
AMERICAN JOURNAL OF HUMAN GENETICS
(2018)
Article
Immunology
Nicholas Hernandez, Isabelle Melki, Huie Jing, Tanwir Habib, Susie S. Y. Huang, Jeffrey Danielson, Tomasz Kula, Scott Drutman, Serkan Belkaya, Vimel Rattina, Lazaro Lorenzo-Diaz, Anais Boulai, Yoann Rose, Naoki Kitabayashi, Mathieu P. Rodero, Cecile Dumaine, Stephane Blanche, Marie-Noelle Lebras, Man Chun Leung, Lisa Sara Mathew, Bertrand Boisson, Shen-Ying Zhang, Stephanie Boisson-Dupuis, Silvia Giliani, Damien Chaussabel, Luigi D. Notarangelo, Stephen J. Elledge, Michael J. Ciancanelli, Laurent Abel, Qian Zhang, Nico Marr, Yanick J. Crow, Helen C. Su, Jean-Laurent Casanova
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Review
Immunology
Helen C. Su, Huie Jing, Pam Angelus, Alexandra F. Freeman
IMMUNOLOGICAL REVIEWS
(2019)
Review
Genetics & Heredity
Ian T. Lamborn, Helen C. Su
Article
Medicine, Research & Experimental
Juan C. Ravell, Mami Matsuda-Lennikov, Samuel D. Chauvin, Juan Zou, Matthew Biancalana, Sally J. Deeb, Susan Price, Helen C. Su, Giulia Notarangelo, Ping Jiang, Aaron Morawski, Chrysi Kanellopoulou, Kyle Binder, Ratnadeep Mukherjee, James T. Anibal, Brian Sellers, Lixin Zheng, Tingyan He, Alex B. George, Stefania Pittaluga, Astin Powers, David E. Kleiner, Devika Kapuria, Marc Ghany, Sally Hunsberger, Jeffrey I. Cohen, Gulbu Uzel, Jenna Bergerson, Lynne Wolfe, Camilo Toro, William Gahl, Les R. Folio, Helen Matthews, Pam Angelus, Ivan K. Chinn, Jordan S. Orange, Claudia M. Trujillo-Vargas, Jose Luis Franco, Julio Orrego-Arango, Sebastian Gutierrez-Hincapie, Niraj Chandrakant Patel, Kimiyo Raymond, Turkan Patiroglu, Ekrem Unal, Musa Karakukcu, Alexandre G. R. Day, Pankaj Mehta, Evan Masutani, Suk S. De Ravin, Harry L. Malech, Gregoire Altan-Bonnet, V. Koneti Rao, Matthias Mann, Michael J. Lenardo
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Review
Immunology
Luigi D. Notarangelo, Rosa Bacchetta, Jean Laurent Casanova, Helen C. Su
SCIENCE IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Matthew K. Schindler, Stefania Pittaluga, Yoshimi Enose-Akahata, Helen C. Su, V. Koneti Rao, Amy Rump, Steven Jacobson, Irene Cortese, Daniel S. Reich, Gulbu Uzel
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Allergy
Saliha Esenboga, Hande Ucler, Sevil Oskay Halacli, Cagman Tan, Nergis Kendirci, Yu Zhang, Helen Su, Deniz Cagdas, Ilhan Tezcan
Summary: Patients with X-linked agammaglobulinemia (XLA) are susceptible to bacterial infections, but fungal infections are rare. This report describes a case of a 17-month-old boy with absent BTK protein expression caused by a novel de-novo variant of the BTK gene, who presented with neutropenic fever and sepsis caused by Candida and Pseudomonas aeruginosa.
ASTIM ALLERJI IMMUNOLOJI
(2022)
Letter
Medicine, Research & Experimental
Ines Ambite, Ulrich Dobrindt, Catharina Svanborg
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Letter
Medicine, Research & Experimental
Qian Zhang, Aurelie Cobat, Paul Bastard, Luigi D. Notarangelo, Helen C. Su, Laurent Abel, Jean-Laurent Casanova
JOURNAL OF CLINICAL INVESTIGATION
(2021)