Review
Immunology
Mengyao Yu, Yuexinzi Jin, Shichang Zhang, Jian Xu, Jiexin Zhang
Summary: This narrative review focuses on the interaction and molecular mechanisms between Human cytomegalovirus (HCMV) and host immune cells, with a specific emphasis on HCMV-encoded miRNAs. The review highlights the importance of HCMV infection and explores the potential of miRNA-targeted therapies and alternative vaccines.
Article
Medicine, Research & Experimental
Amir Hossein Saeidian, Leila Youssefian, Charles Y. Huang, Fahimeh Palizban, Mahtab Naji, Zahra Saffarian, Hamidreza Mahmoudi, Azadeh Goodarzi, Soheila Sotoudeh, Fatemeh Vahidnezhad, Maliheh Amani, Narjes Tavakoli, Ali Ajami, Samaneh Mozafarpoor, Mehrdad Teimoorian, Saeed Dorgaleleh, Sima Shokri, Mohammad Shenagari, Nima Abedi, Sirous Zeinali, Paolo Fortina, Vivien Beziat, Emmanuelle Jouanguy, Jean-Laurent Casanova, Jouni Uitto, Hassan Vahidnezhad
Summary: This study presents a whole-transcriptome sequencing-based method that can simultaneously identify the cutaneous virome and the underlying inborn errors of immunity (IEI) genes by RNA-Seq on a single skin biopsy. The method allows for rapid and accurate diagnosis of patients with viral skin infections and potential genetic defects, providing guidance for further treatment.
Review
Multidisciplinary Sciences
Qian Zhang, Paul Bastard, Aurelie Cobat, Jean-Laurent Casanova
Summary: SARS-CoV-2 infection is generally mild, but in around 10% of cases, it can lead to severe pneumonia and potentially death. Genetic factors, such as inborn errors of type I interferons, and pre-existing auto-antibodies can increase the risk of critical illness. The production of type I interferons is essential for host defense against the virus.
Review
Allergy
Stuart G. Tangye, Anne Puel
Summary: Chronic mucocutaneous candidiasis (CMC) is recognized as a primary immunodeficiency, and recent studies have identified the genetic etiology of CMC linked to impaired IL-17-mediated immunity. The IL-17 axis plays a crucial role in mucocutaneous immunity to Candida spp and Staphylococcus aureus in humans, while it seems to be redundant against other common microbes. This review provides an overview of the current understanding of IL-17A/F-mediated immunity and its relevance in human immunity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Immunology
Anthony Bosco
Summary: Respiratory syncytial virus (RSV) and Rhinovirus (RV) infections are major triggers of severe lower respiratory illnesses (sLRI) in infants and children and are strongly associated with the subsequent development of asthma. Recent findings highlight novel aspects of the interferon response in sLRI pathogenesis and provide new directions for mechanistic studies and drug development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Rocky Lai, Diana N. Gong, Travis Williams, Abiola F. Ogunsola, Kelly Cavallo, Cecilia S. Lindestam Arlehamn, Sarah Acolatse, Gillian L. Beamer, Martin T. Ferris, Christopher M. Sassetti, Douglas A. Lauffenburger, Samuel M. Behar
Summary: In this study, we investigated the influence of host genetics on Bacillus Calmette Guerin-induced immunity against Mycobacterium tuberculosis in 24 collaborative cross (CC) mouse strains. We found that host genetics plays a major role in BCG-induced immunity against M. tuberculosis infection, which poses a barrier to vaccine-mediated protection. Furthermore, BCG efficacy is independent of inherent susceptibility to tuberculosis, and the composition of T cells in the lung after infection is mainly determined by host genetics rather than BCG vaccination.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Infectious Diseases
Sherif A. El-Kafrawy, Salma M. Alsayed, Thamir A. Alandijany, Leena H. Bajrai, Arwa A. Faizo, Hessa A. Al-Sharif, Ahmed M. Hassan, Khalid M. Alquthami, Jaffar A. Al-Tawfiq, Alimuddin Zumla, Esam Azhar
Summary: This study investigated the genetic diversity of human rhinoviruses (HRVs) among pilgrims with respiratory symptoms during the Hajj pilgrimage in 2019. The results showed a high diversity of HRV genotypes circulating among pilgrims and emphasized the need for further clinical and sequencing studies in larger cohorts of overseas and local pilgrims.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Cell Biology
Beatriz Beamud, Neris Garcia-Gonzalez, Mar Gomez-Ortega, Fernando Gonzalez-Candelas, Pilar Domingo-Calap, Rafael Sanjuan
Summary: Bacteriophages play key roles in bacterial ecology and evolution and are potential antimicrobials. However, the determinants of phage-host specificity remain elusive. In this study, 46 phages were isolated and tested against 138 clinical isolates of Klebsiella pneumoniae, revealing a narrow host range for most phages. Bacterial capsule diversity was found to be the main factor limiting phage host range, while phage-encoded depolymerases and their sequence types were associated with the ability to infect specific capsular types.
Review
Nanoscience & Nanotechnology
Xiaodong Zhang, Xiaokai Chen, Yanli Zhao
Summary: Artificial nanosystems have the ability to modulate immune responses and can be used in vaccine development and treatment of bacterial infections and diseases. This review discusses the recent advances of nanosystems in vaccine development and immune activation, as well as the application of immune-suppressive nanosystems.
ACS APPLIED NANO MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Rosanna Capparelli, Domenico Iannelli
Summary: Genetic diversity plays a significant role in protection against Helicobacter pylori infection, and different Hp strains require different research approaches. Selecting genes from the same family and extending the analysis to metabolism enhance the reliability and effectiveness of the study. MyD88, TIRAP, and IL1RL1 have been shown to play a protective role against Hp infection in this combined approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jae-Min Yuk, Eun-Jin Park, In Soo Kim, Eun-Kyeong Jo
Summary: Itaconate is an important immunometabolite with anti-infective and anti-inflammatory properties. Its derivatives and isomers have potential as drugs for inflammation and infection. However, the exact mechanisms of action and the therapeutic potential of Itaconate are not fully understood due to contradictory results and a lack of clinical data. Further research is needed to understand how itaconate exerts its effects and to explore its therapeutic applications.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Veronica Marrella, Amanda Facoetti, Barbara Cassani
Summary: Cellular senescence is an irreversible cell cycle arrest and inflammatory secretion phenomenon that affects various tissues, including lymphoid tissue, leading to chronic inflammation and immune dysfunction. Persistent microbial challenge or pathogenic microorganisms may accelerate cellular aging and premature senescence of immune cells. Therapeutic strategies targeting cellular senescence may improve immune dysfunctions in the elderly and reduce susceptibility to infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Mihai G. Netea, Jorge Dominguez-Andres, Frank L. van de Veerdonk, Reinout van Crevel, Bali Pulendran, Jos W. M. van der Meer
Summary: Individuals exposed to SARS-CoV-2 may exhibit natural resistance to infection, with variability in susceptibility observed. Factors contributing to natural resistance include host genetic variants, viral interference, and innate immune responses. Understanding natural resistance can assist in developing better preventive and therapeutic measures for future pandemics.
TRENDS IN IMMUNOLOGY
(2022)
Article
Orthopedics
Yu Wang, Dustin Dikeman, Jeffrey Zhang, Nicole Ackerman, Sophia Kim, Martin P. Alphonse, Roger Ortines, Haiyun Liu, Daniel P. Joyce, Carly A. Dillen, John M. Thompson, Abigail A. Thomas, Roger D. Plaut, Lloyd S. Miller, Nathan K. Archer
Summary: CCR2 plays a crucial role in host defense during orthopedic implant-associated infections, by increasing immune cell infiltrates in the draining lymph nodes to contain and prevent the spread of infection.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Review
Immunology
Shamala Devi Sekaran, Amni Adilah Ismail, Gaythri Thergarajan, Samudi Chandramathi, S. K. Hanan Rahman, Ravishankar Ram Mani, Felicita Fedelis Jusof, Yvonne A. L. Lim, Rishya Manikam
Summary: Dengue and Zika viruses are major public health concerns, affecting millions of people worldwide. The similarities and differences in disease transmission and immune responses between these two viruses are crucial for understanding and tackling these infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Ian T. Lamborn, Huie Jing, Yu Zhang, Scott B. Drutman, Jordan K. Abbott, Shirin Munir, Sangeeta Bade, Heardley M. Murdock, Celia P. Santos, Linda G. Brock, Evan Masutani, Emmanuel Y. Fordjour, Joshua J. McElwee, Jason D. Hughes, Dave P. Nichols, Aziz Belkadi, Andrew J. Oler, Corinne S. Happel, Helen F. Matthews, Laurent Abel, Peter L. Collins, Kanta Subbarao, Erwin W. Gelfand, Michael J. Ciancanelli, Jean-Laurent Casanova, Helen C. Su
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Rheumatology
Angeliki Giannelou, Hongying Wang, Qing Zhou, Yong Hwan Park, Mones S. Abu-Asab, Kris Ylaya, Deborah L. Stone, Anna Sediva, Rola Sleiman, Lucie Sramkova, Deepika Bhatla, Elisavet Serti, Wanxia Li Tsai, Dan Yang, Kevin Bishop, Blake Carrington, Wuhong Pei, Natalie Deuitch, Stephen Brooks, Jehad H. Edwan, Sarita Joshi, Seraina Prader, Daniela Kaiser, William C. Owen, Abdullah Al Sonbul, Yu Zhang, Julie E. Niemela, Shawn M. Burgess, Manfred Boehm, Barbara Rehermann, JaeJin Chae, Martha M. Quezado, Amanda K. Ombrello, Rebecca H. Buckley, Alexi A. Grom, Elaine F. Remmers, Jana M. Pachlopnik, Helen C. Su, Gustavo Gutierrez-Cruz, Stephen M. Hewitt, Raman Sood, Kimberly Risma, Katherine R. Calvo, Sergio D. Rosenzweig, Massimo Gadina, Markus Hafner, Hong-Wei Sun, Daniel L. Kastner, Ivona Aksentijevich
ANNALS OF THE RHEUMATIC DISEASES
(2018)
Article
Allergy
William A. Comrie, Aiman J. Faruqi, Susan Price, Yu Zhang, V. Koneti Rao, Helen C. Su, Michael J. Lenardo
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Review
Immunology
Swadhinya Arjunaraja, Pamela Angelus, Helen C. Su, Andrew L. Snow
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Genetics & Heredity
Julie C. Sapp, Jennifer J. Johnston, Kate Driscoll, Alexis R. Heidlebaugh, Ane Miren Sagardia, D. Nadine Dogbe, Kendall L. Umstead, Erin Turbitt, Ilias Alevizos, Jeffrey Baron, Carsten Bonnemann, Brian Brooks, Sandra Donkervoort, Youn Hee Jee, W. Marston Linehan, Francis J. McMahon, Joel Moss, James C. Mullikin, Deborah Nielsen, Eileen Pelayo, Alan T. Remaley, Richard Siegel, Helen Su, Carlos Zarate, Teri A. Manolio, Barbara B. Biesecker, Leslie G. Biesecker
AMERICAN JOURNAL OF HUMAN GENETICS
(2018)
Article
Immunology
Nicholas Hernandez, Isabelle Melki, Huie Jing, Tanwir Habib, Susie S. Y. Huang, Jeffrey Danielson, Tomasz Kula, Scott Drutman, Serkan Belkaya, Vimel Rattina, Lazaro Lorenzo-Diaz, Anais Boulai, Yoann Rose, Naoki Kitabayashi, Mathieu P. Rodero, Cecile Dumaine, Stephane Blanche, Marie-Noelle Lebras, Man Chun Leung, Lisa Sara Mathew, Bertrand Boisson, Shen-Ying Zhang, Stephanie Boisson-Dupuis, Silvia Giliani, Damien Chaussabel, Luigi D. Notarangelo, Stephen J. Elledge, Michael J. Ciancanelli, Laurent Abel, Qian Zhang, Nico Marr, Yanick J. Crow, Helen C. Su, Jean-Laurent Casanova
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Review
Immunology
Helen C. Su, Huie Jing, Pam Angelus, Alexandra F. Freeman
IMMUNOLOGICAL REVIEWS
(2019)
Article
Medicine, Research & Experimental
Juan C. Ravell, Mami Matsuda-Lennikov, Samuel D. Chauvin, Juan Zou, Matthew Biancalana, Sally J. Deeb, Susan Price, Helen C. Su, Giulia Notarangelo, Ping Jiang, Aaron Morawski, Chrysi Kanellopoulou, Kyle Binder, Ratnadeep Mukherjee, James T. Anibal, Brian Sellers, Lixin Zheng, Tingyan He, Alex B. George, Stefania Pittaluga, Astin Powers, David E. Kleiner, Devika Kapuria, Marc Ghany, Sally Hunsberger, Jeffrey I. Cohen, Gulbu Uzel, Jenna Bergerson, Lynne Wolfe, Camilo Toro, William Gahl, Les R. Folio, Helen Matthews, Pam Angelus, Ivan K. Chinn, Jordan S. Orange, Claudia M. Trujillo-Vargas, Jose Luis Franco, Julio Orrego-Arango, Sebastian Gutierrez-Hincapie, Niraj Chandrakant Patel, Kimiyo Raymond, Turkan Patiroglu, Ekrem Unal, Musa Karakukcu, Alexandre G. R. Day, Pankaj Mehta, Evan Masutani, Suk S. De Ravin, Harry L. Malech, Gregoire Altan-Bonnet, V. Koneti Rao, Matthias Mann, Michael J. Lenardo
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Review
Immunology
Luigi D. Notarangelo, Rosa Bacchetta, Jean Laurent Casanova, Helen C. Su
SCIENCE IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Matthew K. Schindler, Stefania Pittaluga, Yoshimi Enose-Akahata, Helen C. Su, V. Koneti Rao, Amy Rump, Steven Jacobson, Irene Cortese, Daniel S. Reich, Gulbu Uzel
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Allergy
Saliha Esenboga, Hande Ucler, Sevil Oskay Halacli, Cagman Tan, Nergis Kendirci, Yu Zhang, Helen Su, Deniz Cagdas, Ilhan Tezcan
Summary: Patients with X-linked agammaglobulinemia (XLA) are susceptible to bacterial infections, but fungal infections are rare. This report describes a case of a 17-month-old boy with absent BTK protein expression caused by a novel de-novo variant of the BTK gene, who presented with neutropenic fever and sepsis caused by Candida and Pseudomonas aeruginosa.
ASTIM ALLERJI IMMUNOLOJI
(2022)
Letter
Medicine, Research & Experimental
Ines Ambite, Ulrich Dobrindt, Catharina Svanborg
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Letter
Medicine, Research & Experimental
Qian Zhang, Aurelie Cobat, Paul Bastard, Luigi D. Notarangelo, Helen C. Su, Laurent Abel, Jean-Laurent Casanova
JOURNAL OF CLINICAL INVESTIGATION
(2021)
