Suppression of inhibitor formation against FVIII in a murine model of hemophilia A by oral delivery of antigens bioencapsulated in plant cells

The diversity of the immune response to the A2 domain of human factor VIII

(2013) R. C. Markovitz et al.   BLOOD

Progress toward inducing immunologic tolerance to factor VIII

(2013) D. W. Scott et al.   BLOOD

Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies

(2013) David M. Markusic et al.   EMBO Molecular Medicine

Oral Delivery of Bioencapsulated Proteins Across Blood–Brain and Blood–Retinal Barriers

(2013) Neha Kohli et al.   MOLECULAR THERAPY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

Low Cost Tuberculosis Vaccine Antigens in Capsules: Expression in Chloroplasts, Bio-Encapsulation, Stability and Functional Evaluation In Vitro

(2013) Priya Saikumar Lakshmi et al.   PLoS One

Mechanism of oral tolerance induction to therapeutic proteins

(2012) Xiaomei Wang et al.   ADVANCED DRUG DELIVERY REVIEWS

Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells

(2012) Kwang-Chul Kwon et al.   ADVANCED DRUG DELIVERY REVIEWS

CD4+ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice

(2012) K. N. Steinitz et al.   BLOOD

Immune tolerance in haemophilia: the long journey to the fork in the road

(2012) Donna M. DiMichele   BRITISH JOURNAL OF HAEMATOLOGY

Inhibitory antibodies in hemophilia A

(2012) Kathleen P. Pratt   CURRENT OPINION IN HEMATOLOGY

Dangerous liaisons: how the immune system deals with factor VIII

(2012) A. WROBLEWSKA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Modern haemophilia care

(2012) Erik Berntorp et al.   LANCET

Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells

(2012) Kwang-Chul Kwon et al.   PLANT BIOTECHNOLOGY JOURNAL

Transient B Cell Depletion or Improved Transgene Expression by Codon Optimization Promote Tolerance to Factor VIII in Gene Therapy

(2012) Brandon K. Sack et al.   PLoS One

Oral tolerance

(2011) Howard L. Weiner et al.   IMMUNOLOGICAL REVIEWS

Induction of tolerance to factor VIII by transient co-administration with rapamycin

(2011) B. MOGHIMI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts

(2011) Shashi Kumar et al.   METABOLIC ENGINEERING

Nonredundant Roles of IL-10 and TGF-β in Suppression of Immune Responses to Hepatic AAV-Factor IX Gene Transfer

(2011) Brad E Hoffman et al.   MOLECULAR THERAPY

Plastid biotechnology for crop production: present status and future perspectives

(2011) Jihong Liu Clarke et al.   PLANT MOLECULAR BIOLOGY

Immunoglobulin isotypes and functional anti-FVIII antibodies in response to FVIII treatment in Balb/c and C57BL/6 haemophilia A mice

(2010) M. QADURA et al.   HAEMOPHILIA

Low-cost production of proinsulin in tobacco and lettuce chloroplasts for injectable or oral delivery of functional insulin and C-peptide

(2010) Diane Boyhan et al.   PLANT BIOTECHNOLOGY JOURNAL

The Role of Heterologous Chloroplast Sequence Elements in Transgene Integration and Expression

(2010) T. Ruhlman et al.   PLANT PHYSIOLOGY

Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice

(2010) D. Verma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomodulation for inhibitors in hemophilia A: the important role of Treg cells

(2010) Carol H Miao   Expert Review of Hematology

B-Cell and T-Cell Epitopes in Anti-factor VIII Immune Responses

(2009) Kathleen P. Pratt et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Functional roles of the factor VIII B domain

(2009) S. W. PIPE   HAEMOPHILIA

Impact of the Underlying Mutation and the Route of Vector Administration on Immune Responses to Factor IX in Gene Therapy for Hemophilia B

(2009) Ou Cao et al.   MOLECULAR THERAPY

Plant-made vaccine antigens and biopharmaceuticals

(2009) Henry Daniell et al.   TRENDS IN PLANT SCIENCE

A protocol for expression of foreign genes in chloroplasts

(2008) Dheeraj Verma et al.   Nature Protocols