Low Cost Tuberculosis Vaccine Antigens in Capsules: Expression in Chloroplasts, Bio-Encapsulation, Stability and Functional Evaluation In Vitro

A chloroplast-derivedToxoplasma gondiiGRA4 antigen used as an oral vaccine protects against toxoplasmosis in mice

(2012) María del L. Yácono et al.   PLANT BIOTECHNOLOGY JOURNAL

Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells

(2012) Kwang-Chul Kwon et al.   PLANT BIOTECHNOLOGY JOURNAL

A chloroplast-derived C4V3 polypeptide from the human immunodeficiency virus (HIV) is orally immunogenic in mice

(2012) Néstor Rubio-Infante et al.   PLANT MOLECULAR BIOLOGY

Preclinical evidence for implementing a prime-boost vaccine strategy for tuberculosis

(2012) Michael J. Brennan et al.   VACCINE

Production of foreign proteins using plastid transformation

(2011) Nunzia Scotti et al.   BIOTECHNOLOGY ADVANCES

A synthetic gene increases TGFβ3 accumulation by 75-fold in tobacco chloroplasts enabling rapid purification and folding into a biologically active molecule

(2011) Martin F. Gisby et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant-made vaccines in support of the Millennium Development Goals

(2011) Claire A. Penney et al.   PLANT CELL REPORTS

A Booster Vaccine Expressing a Latency-Associated Antigen Augments BCG Induced Immunity and Confers Enhanced Protection against Tuberculosis

(2011) Bappaditya Dey et al.   PLoS One

Taking a New Shot At a TB Vaccine

(2011) K. Kupferschmidt   SCIENCE

Development of vaccines against tuberculosis

(2011) Anil K. Tyagi et al.   TUBERCULOSIS

Loss of anti-mycobacterial efficacy in mice over time following vaccination with Mycobacterium bovis bacillus Calmette-Guérin

(2011) Yuriko Ozeki et al.   VACCINE

Advances in plant molecular farming

(2010) Olawole O. Obembe et al.   BIOTECHNOLOGY ADVANCES

Low-dose oral immunization with lyophilized tissue of herbicide-resistant lettuce expressing hepatitis B surface antigen for prototype plant-derived vaccine tablet formulation

(2010) Tomasz Pniewski et al.   JOURNAL OF APPLIED GENETICS

Low-cost production of proinsulin in tobacco and lettuce chloroplasts for injectable or oral delivery of functional insulin and C-peptide

(2010) Diane Boyhan et al.   PLANT BIOTECHNOLOGY JOURNAL

Chloroplast transformation of rapeseed (Brassica napus) by particle bombardment of cotyledons

(2010) Lin Cheng et al.   PLANT CELL REPORTS

The Role of Heterologous Chloroplast Sequence Elements in Transgene Integration and Expression

(2010) T. Ruhlman et al.   PLANT PHYSIOLOGY

Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice

(2010) D. Verma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ag85B–ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers

(2010) Jaap T. van Dissel et al.   VACCINE

What Role Does the Route of Immunization Play in the Generation of Protective Immunity against Mucosal Pathogens?

(2009) I. M. Belyakov et al.   JOURNAL OF IMMUNOLOGY

Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery

(2009) Abdoreza Davoodi-Semiromi et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression of a multi-epitope DPT fusion protein in transplastomic tobacco plants retains both antigenicity and immunogenicity of all three components of the functional oligomer

(2009) Ruth Elena Soria-Guerra et al.   PLANTA

Plant-made vaccine antigens and biopharmaceuticals

(2009) Henry Daniell et al.   TRENDS IN PLANT SCIENCE

Immune response to Mycobacterium tuberculosis specific antigen ESAT-6 among south Indians

(2009) Madhan Kumar et al.   TUBERCULOSIS

Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole

(2008) J. Smith et al.   INFECTION AND IMMUNITY

Effective Plague Vaccination via Oral Delivery of Plant Cells Expressing F1-V Antigens in Chloroplasts

(2008) P. A. Arlen et al.   INFECTION AND IMMUNITY

A protocol for expression of foreign genes in chloroplasts

(2008) Dheeraj Verma et al.   Nature Protocols

Exhaustion of the chloroplast protein synthesis capacity by massive expression of a highly stable protein antibiotic

(2008) Melanie Oey et al.   PLANT JOURNAL

Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning

(2008) Rhea N. Coler et al.   VACCINE