Article
Pharmacology & Pharmacy
Leyi Yao, Yali Hao, Guanmei Wen, Qingzhong Xiao, Penglong Wu, Jinheng Wang, Jinbao Liu
Summary: The study revealed an important regulatory role for the HO-1 pathway in immune cell regulation and atherosclerosis, suggesting that modulating HO-1 signaling represents a potential therapeutic strategy against atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joseana de Oliveira, Marina B. Denadai, Diego L. Costa
Summary: Heme oxygenase-1 (HO-1) plays a crucial role in iron metabolism and has the potential to modulate immunity and inflammation through regulating cellular oxidation reactions and the expression of inflammation-related proteins.
Article
Biochemistry & Molecular Biology
Seung Hyeon Kim, Su-Jung Kim, Jeongmin Park, Yeonsoo Joe, So Eui Lee, Soma Saeidi, Xiancai Zhong, Seong Hoon Kim, Sin-Aye Park, Hye-Kyung Na, Hun Taeg Chung, Young-Joon Surh
Summary: Tumor-associated macrophages (TAMs) are important components of the tumor microenvironment and exhibit heterogeneity in phenotype, playing crucial roles in tumor development and progression. During chemotherapy, the phagocytic engulfment of tumor cell debris by TAMs may reduce the efficacy of chemotherapy.
Article
Biochemistry & Molecular Biology
Natasha M. Nesbitt, Lisa E. Malone, Zhaoyan Liu, Alexander Jares, Dmitri V. Gnatenko, Yupo Ma, Wei Zhu, Wadie F. Bahou
Summary: The cytoprotective functions of heme oxygenases involve the generation of carbon monoxide, ferrous iron, and bilirubin, with downstream biliverdin reductases playing a key role in cellular protection, especially in stress hematopoiesis. Blvrb is identified as a crucial driver in stress cytoprotection and redox-regulated lineage partitioning in erythroid/megakaryocyte lineage speciation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Sara Magri, Beatrice Musca, Laura Pinton, Elena Orecchini, Maria Laura Belladonna, Ciriana Orabona, Camilla Bonaudo, Francesco Volpin, Pietro Ciccarino, Valentina Baro, Alessandro Della Puppa, Susanna Mandruzzato
Summary: This study investigates the immune-suppressive activity of tumor-associated macrophages (TAMs) in the glioblastoma tumor microenvironment (TME). Researchers found that sustained iron metabolism and immune-suppressive activity in TAMs were correlated. They also discovered that blocking the central enzyme heme oxygenase-1 (HO-1) could reverse the tolerogenic activity of TAMs. Additionally, the activation status of T cells affected the expression of PD-L1 and the activity of IDO1, with both being upregulated in the presence of activated T cells. These findings highlight the crucial role of HO-1 in TAMs' immune-suppressive activity and suggest the feasibility of reprogramming TAMs for immune surveillance restoration.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Food Science & Technology
Yen-Chang Chen, Yu-Kai Cheng, Jia-Hong Chen, Cheng-Fang Tsai, Tsung-Kai Wang, Chen-Yun Wu, Pei-Chun Chang, Wei-Lan Yeh
Summary: This research investigates the effects of cardamonin on pulmonary inflammation. The results suggest that cardamonin has anti-inflammatory and anti-oxidative properties against PMA-induced pulmonary inflammation. It activates the Nrf2/HO-1 axis and reduces pro-inflammatory responses in alveolar macrophages.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Physiology
Marta Martinez-Casales, Raquel Hernanz, Maria J. Alonso
Summary: Hypertension is considered an inflammatory disease with elevated cytokine levels and oxidative stress. In hypertension, the polarization of macrophages to the M1 phenotype plays a key role in producing inflammatory cytokines and oxidative stress.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yi-Hsuan Wu, Hsi-Lung Hsieh
Summary: The heme oxygenase system, particularly HO-1 and HO-2, plays an important role in the nervous system. Dysregulation of HO-1 is associated with neurodegenerative diseases.
Article
Pharmacology & Pharmacy
Enric Pouso-Vazquez, Xue Bai, Gerard Batalle, Gerard Roch, Olga Pol
Summary: Painful diabetic neuropathy is a common complication of diabetes, and current treatments have limitations. This study investigated the effects of a HO-1 inducer, CoPP, on a mouse model of type 2 diabetes. The results showed that CoPP has antihyperglycemic and antiallodynic effects, as well as potent antioxidant, antinociceptive, anti-inflammatory, and antiapoptotic properties in the central nervous system of type 2 diabetic mice.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eman Y. Gohar, Rawan N. Almutlaq, Chunlan Fan, Rohan S. Balkawade, Maryam K. Butt, Lisa M. Curtis
Summary: This study suggests that G protein-coupled estrogen receptor 1 (GPER1) does not play a significant role in cisplatin-induced acute kidney injury (AKI), but its deletion exacerbates renal apoptosis and diminishes heme oxygenase-1 (HO-1) induction, indicating potentially important cytoprotective and anti-apoptotic actions of GPER1 in AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maria G. Detsika, Elias A. Lianos
Summary: Heme oxygenase-1 has a new cytoprotective role by regulating the complement control protein, which helps prevent kidney injury. Targeting HO-1 induction in specific cells could be a novel approach to attenuate complement-dependent kidney diseases.
Review
Biochemistry & Molecular Biology
Valeria Consoli, Valeria Sorrenti, Salvo Grosso, Luca Vanella
Summary: Heme-oxygenase (HO-1) plays a crucial role in maintaining cellular oxidative damage and has implications in cancer research and antioxidant activity.
Article
Hematology
Louise L. Dunn, Stephanie M. Y. Kong, Sergey Tumanov, Weiyu Chen, James Cantley, Anita Ayer, Ghassan J. Maghzal, Robyn G. Midwinter, Kim H. Chan, Martin K. C. Ng, Roland Stocker
Summary: The stress-induced enzyme Hmox1 plays a protective role against cardiovascular diseases and ischemic injury by interacting with HIF-1 alpha and regulating cellular metabolism. Lack of Hmox1 leads to impaired blood flow recovery, tissue necrosis, and autoamputation, highlighting its crucial role in ischemic injury protection.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yuki Kata, Yu Hara, Yoichi Tagami, Aya Yabe, Kota Murohashi, Ryo Nagasawa, Kentaro Nakashima, Hiroaki Fujii, Yusuke Saigusa, Masafumi Shiida, Keisuke Watanabe, Nobuyuki Horita, Nobuaki Kobayashi, Takeshi Kaneko
Summary: The present study aimed to evaluate the utility of serum heme oxygenase (HO)-1 as a blood biomarker for diagnosing acute exacerbations (AEs) of idiopathic interstitial pneumonia (IIP) and secondary interstitial pneumonia (SIP). The study found that patients with AEs had significantly higher levels of serum HO-1 compared to those without AEs. Serum HO-1 showed good diagnostic accuracy in detecting AEs in both IIP and SIP patients.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Virginia Athanassiadou, Stella Plavoukou, Eirini Grapsa, Maria G. Detsika
Summary: The protein heme oxygenase-1 plays a key role in kidney disease and affects immune pathways and responses, as demonstrated by animal models and patient studies.
Review
Biochemistry & Molecular Biology
Nunziata Maio, Anshika Jain, Tracey A. Rouault
CURRENT OPINION IN CHEMICAL BIOLOGY
(2020)
Editorial Material
Biochemistry & Molecular Biology
Tracey A. Rouault, Nunziata Maio
Article
Biochemistry & Molecular Biology
Anshika Jain, Anamika Singh, Nunziata Maio, Tracey A. Rouault
HUMAN MOLECULAR GENETICS
(2020)
Article
Hematology
Manik C. Ghosh, De-Liang Zhang, Wade H. Ollivierre, Audrey Noguchi, Danielle A. Springer, W. Marston Linehan, Tracey A. Rouault
Summary: The study demonstrates that treatment with the HIF-2 alpha inhibitor MK-6482 is effective in reversing polycythemia and mitigating pulmonary hypertension, cardiac fibrosis, and pulmonary fibrosis by reducing the expression of HIF-2 alpha and its target genes.
Article
Biochemistry & Molecular Biology
Daniel R. Crooks, Nunziata Maio, Martin Lang, Christopher J. Ricketts, Cathy D. Vocke, Sandeep Gurram, Sevilay Turan, Yun-Young Kim, G. Mariah Cawthon, Ferri Sohelian, Natalia De Val, Ruth M. Pfeiffer, Parthav Jailwala, Mayank Tandon, Bao Tran, Teresa W-M Fan, Andrew N. Lane, Thomas Ried, Darawalee Wangsa, Ashkan A. Malayeri, Maria J. Merino, Youfeng Yang, Jordan L. Meier, Mark W. Ball, Tracey A. Rouault, Ramaprasad Srinivasan, W. Marston Linehan
Summary: Understanding the mechanism of Warburg shift to aerobic glycolysis is essential for defining the metabolic basis of cancer. HLRCC, an aggressive cancer, is characterized by impaired mitochondrial respiratory chain, loss of expression of mtDNA-encoded subunits, and accumulation of fumarate, leading to the promotion of aerobic glycolysis and disease progression. Accumulation of fumarate in HLRCC tumors disrupts mtDNA replication and proofreading, causing loss of respiratory chain components.
Article
Multidisciplinary Sciences
Nunziata Maio, Bernard A. P. Lafont, Debangsu Sil, Yan Li, J. Martin Bollinger, Carsten Krebs, Theodore C. Pierson, W. Marston Linehan, Tracey A. Rouault
Summary: Research has shown that the catalytic subunit nsp12 of the SARS-CoV-2 RdRp complex ligates two iron-sulfur metal cofactors which are essential for viral replication and interaction with the viral helicase. Oxidation of these clusters by TEMPOL inhibits RdRp activity and blocks SARS-CoV-2 replication in cell culture, indicating that these iron-sulfur clusters could be targeted for therapy of COVID-19.
Article
Hematology
Nunziata Maio, De-Liang Zhang, Manik C. Ghosh, Anshika Jain, Anna M. SantaMaria, Tracey A. Rouault
Summary: Humans and other vertebrates have evolved effective mechanisms to maintain iron balance through the regulation of iron concentration and utilization at the cellular and systemic levels, involving iron-regulatory hormone hepcidin and iron regulatory proteins.
SEMINARS IN HEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nunziata Maio, Tracey A. Rouault
Article
Biochemistry & Molecular Biology
Nunziata Maio, Tracey A. Rouault
Article
Multidisciplinary Sciences
Forson Chan, Simon Lai, Marcus Pieterman, Lisa Richardson, Amanda Singh, Jocelynn Peters, Alex Toy, Caroline Piccininni, Taiysa Rouault, Kristie Wong, James K. Quong, Adrienne T. Wakabayashi, Anna Pawelec-Brzychczy
Summary: A new prototype symptom checker was developed and tested for safety and accuracy in real patient scenarios. The study found that the prototype outperformed patients in deciding the most appropriate treatment setting for medical issues. Compliance with the symptom checker recommendations could significantly reduce unnecessary hospital visits while maintaining accuracy and safety outcomes.
Article
Multidisciplinary Sciences
Jin-Seon Yook, Mikyoung You, Jiyoung Kim, Ashley M. Toney, Rong Fan, Bhanwar Lal Puniya, Tomas Helikar, Sophie Vaulont, Jean-Christophe Deschemin, Meshail Okla, Liwei Xie, Manik C. Ghosh, Tracey A. Rouault, Jaekwon Lee, Soonkyu Chung
Summary: This study investigates the iron-regulatory network underlying beige adipogenesis, showing that thermogenic stimulus leads to redistribution of iron into beige fat through interplay between adipocyte iron demands and systemic iron liberation. Disruption of systemic iron homeostasis impairs beige fat development, suggesting coordinated interplay between renal hypoxia and hepcidin down-regulation as a key mechanism for activating adaptive thermogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Christina A. Porras, Tracey A. Rouault
Summary: This review provides an overview of the role of iron homeostasis disruption in various neurological disorders, discussing the consequences of both iron accumulation and deficiency. It also examines the history of animal models and presents a comparison of patients with a newly discovered neurodegenerative disorder caused by mutations in iron regulatory protein 2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Nunziata Maio, Sara Cherry, David C. Schultz, Brett L. Hurst, W. Marston Linehan, Tracey A. Rouault
Summary: TEMPOL has been shown to inhibit the RNA-dependent RNA polymerase of SARS-CoV-2 and effectively block viral replication in the Syrian hamster model. These findings support the potential application of TEMPOL as a highly efficacious antiviral against COVID-19 in humans.
Article
Multidisciplinary Sciences
Wing-Hang Tong, Hayden Ollivierre, Audrey Noguchi, Manik C. Ghosh, Danielle A. Springer, Tracey A. Rouault
Summary: Cardiomyopathy is a primary cause of death in Friedreich ataxia patients with defective iron-sulfur cluster biogenesis. The mTOR and AKT signaling cascades play crucial roles in regulating cardiovascular growth and homeostasis, with mTOR and AKT hyperactivations possibly as part of the metabolic stress response to ISC deficiencies.
Article
Clinical Neurology
Nunziata Maio, Russell P. Saneto, Richard Steet, Marcio A. Sotero de Menezes, Cindy Skinner, Tracey A. Rouault
Summary: Altered brain iron homeostasis can contribute to neurodegeneration. Mutations in the IREB2 gene can cause a newly characterized type of early onset progressive neurodegenerative disease, impacting iron metabolism regulation.
BRAIN COMMUNICATIONS
(2022)