CLEC-2 expression is maintained on activated platelets and on platelet microparticles

Amplification of bacteria-induced platelet activation is triggered by Fc RIIA, integrin  IIb 3, and platelet factor 4

(2014) M. Arman et al.   BLOOD

CLEC-2 is required for development and maintenance of lymph nodes

(2014) C. Benezech et al.   BLOOD

Clinicopathological Correlations of Podoplanin (gp38) Expression in Rheumatoid Synovium and Its Potential Contribution to Fibroblast Platelet Crosstalk

(2014) Manuel J. Del Rey et al.   PLoS One

Combined In Vivo Depletion of Glycoprotein VI and C-Type Lectin-Like Receptor 2 Severely Compromises Hemostasis and Abrogates Arterial Thrombosis in Mice

(2013) Markus Bender et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A novel and essential role for Fc RIIa in cancer cell-induced platelet activation

(2013) A. Mitrugno et al.   BLOOD

Platelet ITAM signaling

(2013) Wolfgang Bergmeier et al.   CURRENT OPINION IN HEMATOLOGY

Patient autoantibodies induce platelet destruction signals via raft-associated glycoprotein Ib  and Fc RIIa in immune thrombocytopenia

(2013) R. T. Urbanus et al.   HAEMATOLOGICA

Glycoprotein Ibα and FcγRIIa play key roles in platelet activation by the colonizing bacterium,Streptococcus oralis

(2013) D. O. Tilley et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Podoplanin is an inflammatory protein upregulated in Th17 cells in SKG arthritic joints

(2013) Yoshiaki Miyamoto et al.   MOLECULAR IMMUNOLOGY

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

(2013) Brett H. Herzog et al.   NATURE

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

(2012) J. M. Burkhart et al.   BLOOD

Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

(2012) Sophie E. Acton et al.   IMMUNITY

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

(2011) B. A. Finney et al.   BLOOD

CalDAG-GEFI deficiency protects mice in a novel model of Fc RIIA-mediated thrombosis and thrombocytopenia

(2011) M. Stolla et al.   BLOOD

Platelets at work in primary hemostasis

(2011) Katleen Broos et al.   BLOOD REVIEWS

CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses

(2011) Diego Mourão-Sá et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

Essential in vivo roles of the platelet activation receptor CLEC-2 in tumour metastasis, lymphangiogenesis and thrombus formation

(2011) Katsue Suzuki-Inoue   JOURNAL OF BIOCHEMISTRY

Laboratory testing for heparin-induced thrombocytopenia: a conceptual framework and implications for diagnosis

(2011) T. E. WARKENTIN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The association between platelet activation and FcγRIIa proteolysis

(2011) I. NAZI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2

(2011) A. M. KERRIGAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Arterial thrombosis—insidious, unpredictable and deadly

(2011) Shaun P Jackson   NATURE MEDICINE

Platelets

(2010) Cara C. Bertozzi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases

(2010) M. Bender et al.   BLOOD

Platelets Play an Essential Role in Separating the Blood and Lymphatic Vasculatures During Embryonic Angiogenesis

(2010) Laura Carramolino et al.   CIRCULATION RESEARCH

A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis

(2010) Tie Zheng Hou et al.   FEBS LETTERS

Essentialin VivoRoles of the C-type Lectin Receptor CLEC-2

(2010) Katsue Suzuki-Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel mechanism of cytokine release in phagocytes induced by aggretin, a snake venom C-type lectin protein, through CLEC-2 ligation

(2010) C.-H. CHANG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

CLEC-2 is not required for platelet aggregation at arteriolar shear

(2010) C. E. HUGHES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Cellular origin of platelet-derived microparticles in vivo

(2010) Andreas Rank et al.   THROMBOSIS RESEARCH

Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation

(2010) Kevin N. Couper et al.   PLoS Pathogens

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

(2009) F. May et al.   BLOOD

CLEC-2 Is a Phagocytic Activation Receptor Expressed on Murine Peripheral Blood Neutrophils

(2009) A. M. Kerrigan et al.   JOURNAL OF IMMUNOLOGY

Renal cells activate the platelet receptor CLEC-2 through podoplanin

(2008) Charita M. Christou et al.   BIOCHEMICAL JOURNAL

Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles

(2008) R. Flaumenhaft et al.   BLOOD

G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2

(2008) Jun Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Plasma (TRAIL), TNFR-2, Fas Ligand, and Plasma Microparticles after Human Immunodeficiency Virus Type 1 (HIV-1) Transmission: Implications for HIV-1 Vaccine Design

(2008) N. Gasper-Smith et al.   JOURNAL OF VIROLOGY