Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia
出版年份 2010 全文链接
标题
Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia
作者
关键词
-
出版物
BLOOD
Volume 116, Issue 1, Pages 71-80
出版商
American Society of Hematology
发表日期
2010-04-20
DOI
10.1182/blood-2010-01-261628
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Nutlin kills cancer cells via mitochondrial p53
- (2011) Eugenia Morselli et al. CELL CYCLE
- The transcription-independent mitochondrial p53 program is a major contributor to Nutlin-induced apoptosis in tumor cells
- (2011) Angelina V. Vaseva et al. CELL CYCLE
- The p53 mRNA-Mdm2 interaction
- (2011) Nadia Naski et al. CELL CYCLE
- Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism
- (2009) P. Secchiero et al. BLOOD
- MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53
- (2009) Martin Enge et al. CANCER CELL
- Blinded by the Light: The Growing Complexity of p53
- (2009) Karen H. Vousden et al. CELL
- Modes of p53 Regulation
- (2009) Jan-Philipp Kruse et al. CELL
- Nutlin-3 Affects Expression and Function of Retinoblastoma Protein
- (2009) Wei Du et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia
- (2009) H Seifert et al. LEUKEMIA
- Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axis
- (2009) K Kojima et al. LEUKEMIA
- Targeting the MDM2-p53 Interaction for Cancer Therapy
- (2008) S. Shangary et al. CLINICAL CANCER RESEARCH
- The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML
- (2008) K Kojima et al. LEUKEMIA
- Skp2 Suppresses p53-Dependent Apoptosis by Inhibiting p300
- (2008) Mayumi Kitagawa et al. MOLECULAR CELL
- Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26
- (2008) Yaara Ofir-Rosenfeld et al. MOLECULAR CELL
- A complex barcode underlies the heterogeneous response of p53 to stress
- (2008) Fiona Murray-Zmijewski et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines
- (2008) M Kitagawa et al. ONCOGENE
- Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
- (2008) S. Shangary et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations
- (2008) A. W. MacInnes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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