Article
Biochemistry & Molecular Biology
Su Jung Hwang, Bum Ju Ahn, Min-Wook Shin, Ye-Seul Song, Youngbin Choi, Goo Taeg Oh, Kyu-Won Kim, Hyo-Jong Lee
Summary: Ninj1 plays a critical role in maintaining vascular integrity, while miR-125a-5p acts as a novel regulator in inflammatory diseases and diabetic retinopathy.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Gastroenterology & Hepatology
Yi Xu, Kaiming Leng, Yue Yao, Pengcheng Kang, Guanqun Liao, Yi Han, Guangjun Shi, Daolin Ji, Peng Huang, Wangyang Zheng, Zhenglong Li, Jinglin Li, Lining Huang, Liang Yu, Yongxu Zhou, Xingming Jiang, Hao Wang, Chunlong Li, Zhilei Su, Sheng Tai, Xiangyu Zhong, Zhidong Wang, Yunfu Cui
Summary: The study revealed that circ-CCAC1 is upregulated in cholangiocarcinoma (CCA) cells and extracellular vesicles (EVs), and plays a crucial role in promoting CCA tumorigenesis and metastasis through various mechanisms.
Article
Biochemistry & Molecular Biology
Chiou-Mei Lee, Ming-Ling Chang, Ren-Hao Chen, Fan-Wen Chen, Jo-Chuan Liu, Shun-Li Kuo, Hsin-Hsin Peng
Summary: This study demonstrates that thrombin-activated platelets (TAPLT) can protect endothelial cells against tumor-related pro-inflammatory changes, inhibiting angiogenesis and metastasis. The protection is likely mediated by VCAM-1-mediated endothelial cell linkage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Ruiqi Zheng, Feifan Li, Fengcen Li, Aihua Gong
Summary: Tumor recurrence often results from an abnormal microenvironment, such as the presence of pro-angiogenic factors and lack of pro-maturation factors in the tumor microenvironment. The coexistence of perfusion and hypoxic zones, as well as uneven blood vessel distribution, profoundly influence tumor development. Vascular normalization therapy can improve tumor oxygenation and substance transport, leading to better treatment outcomes and fewer side effects.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Ophthalmology
Yamei Cui, Ruyuan Liu, Yiwen Hong, Yishen Wang, Yanjie Zhu, Tao Wen, Jing Lu, Shudi Mao, Xiao Wang, Jianying Pan, Yan Luo
Summary: The study aimed to investigate the effects and mechanism of miR-92a-3p in retinal angiogenesis. The results showed that overexpression of miR-92a-3p inhibited retinal vascular development and targeted the SGK3 pathway. These findings have important implications for understanding the pathogenesis of retinal vascular diseases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Biochemical Research Methods
Yoshikazu Kameda, Surachada Chuaychob, Miwa Tanaka, Yang Liu, Ryu Okada, Kazuya Fujimoto, Takuro Nakamura, Ryuji Yokokawa
Summary: This study proposes a new method for culturing 3D tissues directly on an 'on-chip vascular bed', overcoming the limitations in size, culture period, and maturity. The method utilizes a removable membrane and a preformed vascular bed to enable the direct settling of the tissue. This in vitro system offers a new technique for evaluating the effects of vasculature on 3D tissues.
Article
Pediatrics
Lu Jiang, Xiaohan Hu, Yajun Feng, Zhen Wang, Hanyun Tang, Qiang Lin, Yunyan Shen, Yun Zhu, Qinying Xu, Xiaozhong Li
Summary: The study demonstrates that an agonistic Tie2 monoclonal antibody can exert vascular protective effects and ameliorate RIF by inhibiting vascular inflammation, apoptosis, and fibrosis. This suggests that Tie2 may be a potential target for the treatment of tubulointerstitial fibrosis.
PEDIATRIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Lauriane Cornuault, Francois-Xavier Herion, Celia Bourguignon, Paul Rouault, Ninon Foussard, Philippe Alzieu, Candice Chapouly, Alain-Pierre Gadeau, Thierry Couffinhal, Marie-Ange Renault
Summary: This study aims to investigate the consequences of partial pericyte depletion in the heart. The results demonstrate that pericyte dysfunction may contribute to the occurrence of cardiac diseases.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biotechnology & Applied Microbiology
Zhongyan Zhao, Chanji Wu, Xiangying He, Eryi Zhao, Shijun Hu, Yeguang Han, Ting Wang, Yanquan Chen, Tao Liu, Shixiong Huang
Summary: The study reveals that miR-152-3p exacerbates vascular endothelial cell dysfunction under hypoxia by targeting DDX6. Inhibition of miR-152-3p can reverse hypoxia-induced cell injury and increased angiogenesis, as well as endothelial cell permeability. These findings suggest a potential therapeutic target for stroke patients through modulation of miR-152-3p and DDX6.
Article
Cell Biology
Hua Zhang, Yongyuan Ma, Xinying Cheng, Dongbo Wu, Xingming Huang, Bin Chen, Yafeng Ren, Wei Jiang, Xiaoqiang Tang, Ting Bai, Yutian Chen, Yilin Zhao, Chunxue Zhang, Xia Xiao, Jing Liu, Yue Deng, Tinghong Ye, Lu Chen, Han-Min Liu, Scott L. Friedman, Liping Chen, Bi-Sen Ding, Zhongwei Cao
Summary: The study revealed that epigenetically reprogrammed vascular adaptation contributes to liver fibrosis by enriching fibrogenic T(H)17 cells in the liver in NASH patients and animal models. Targeting HDAC2 and DNMT1 with pharmacological agents alleviated fibrosis in a minipig NASH model.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Yixiong Chen, Junlong Dang, Xiaorong Lin, Manli Wang, Yan Liu, Jingrong Chen, Ye Chen, Xiqing Luo, Zuoyu Hu, Weizhen Weng, Xiaoyi Shi, Xuan Bi, Yan Lu, Yunfeng Pan
Summary: This study found that EVs derived from RA FLSs can promote angiogenesis in ECs, primarily through the miR-1972 targeting of the p53/mTOR signaling pathway. This research provides a promising strategy for the treatment of RA patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Mingxiang Cai, Huizhen Peng, Minyi Liu, Maohua Huang, Wen Zheng, Guilan Zhang, Wenjia Lai, Chufang Liao, Lizhao Cai, Dongmei Zhang, Xiangning Liu
Summary: The study reveals a significant correlation between pericytes and age-related bone resorption, with conditional deletion of pericytes leading to bone resorption and osteopenia. Pericyte-derived exosomes (PC-EVs) inhibit osteoclast development and bone resorption by suppressing the NF-kappa B pathway through Traf3. This suggests a potential novel strategy for developing anti-bone resorption therapies through targeting pericytes.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Xiao-yu Dai, Li-jun Ren, Lang Yan, Ji-qian-zhu Zhang, Yi-fan Dong, Tao-lin Qing, Wen-jing Shi, Jin-feng Li, Fang-yuan Gao, Xiao-fang Zhang, Yi-jun Tian, Yu-ping Zhu, Jiang-bo Zhu, Ji-kuai Chen
Summary: This study demonstrated that MWCNTs can affect endothelial cell activity, disrupt tube formation and cell migration ability, subsequently affecting angiogenesis. Furthermore, the VEGF-Akt-eNOS axis plays a crucial role in MWCNT-induced endothelial cell injury.
Review
Biochemistry & Molecular Biology
Lucio Diaz-Flores, Ricardo Gutierrez, Maria Pino Garcia, Miriam Gonzalez-Gomez, Lucio Diaz-Flores, Jose Luis Carrasco, Juan Francisco Madrid, Aixa Rodriguez Bello
Summary: Perivascular cells, including pericytes and CD34+ stromal cells/telocytes, play an important role in angiogenesis. The behavior and changes of these cells differ depending on the type of angiogenesis, involving various cell-to-cell interactions and signaling pathways. Perivascular cells and CD34+ stromal cells/telocytes have important functions in vessel development and tissue repair, while their involvement in intussusceptive angiogenesis is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Rina Hashimoto, Junya Takahashi, Keisuke Shirakura, Risa Funatsu, Kaori Kosugi, Sayaka Deguchi, Masaki Yamamoto, Yugo Tsunoda, Maaya Morita, Kosuke Muraoka, Masato Tanaka, Tomoaki Kanbara, Shota Tanaka, Shigeyuki Tamiya, Nagisa Tokunoh, Atsushi Kawai, Masahito Ikawa, Chikako Ono, Keisuke Tachibana, Masuo Kondoh, Masanori Obana, Yoshiharu Matsuura, Akihiro Ohsumi, Takeshi Noda, Takuya Yamamoto, Yasuo Yoshioka, Yu-Suke Torisawa, Hiroshi Date, Yasushi Fujio, Miki Nagao, Kazuo Takayama, Yoshiaki Okada
Summary: This study found that SARS-CoV-2 decreases the expression of Claudin-5 (CLDN5), a tight junction protein, and disrupts vascular endothelial cadherin-mediated adherens junctions, thereby leading to the disruption of the endothelial barrier in respiratory organs. The down-regulation of CLDN5 expression was observed in the lungs of a COVID-19 patient. The overexpression of CLDN5 or treatment with Fluvastatin rescued the SARS-CoV-2-induced respiratory endothelial barrier disruption. Inducing CLDN5 expression is identified as a therapeutic strategy against COVID-19.
Article
Hematology
Biljana Culjkovic-Kraljacic, Tharu M. Fernando, Rossella Marullo, Nieves Calvo-Vidal, Akanksha Verma, ShaoNing Yang, Fabrizio Tabbo, Marcello Gaudiano, Hiba Zahreddine, Rebecca L. Goldstein, Jayeshkumar Patel, Tony Taldone, Gabriela Chiosis, Marco Ladetto, Paola Ghione, Rodolfo Machiorlatti, Olivier Elemento, Giorgio Inghirami, Ari Melnick, Katherine L. B. Borden, Leandro Cerchietti
Letter
Oncology
Daphne Dupere-Richer, Mena Kinal, Filippa Pettersson, Audrey Emond, M. Nieves Calvo-Vidal, Jessica N. Nichol, Cynthia Guilbert, Dany Plourde, Kathleen Klein Oros, Torsten H. Nielsen, Teresa Ezponda, Jonathan D. Licht, Nathalie A. Johnson, Sarit Assouline, Leandro Cerchietti, Wilson H. Miller, Koren K. Mann
LEUKEMIA & LYMPHOMA
(2017)
Article
Engineering, Biomedical
F. N. U. Apoorva, Ye F. Tian, Timothy M. Pierpont, David M. Bassen, Leandro Cerchietti, Jonathan T. Butcher, Robert S. Weiss, Ankur Singh
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2017)
Editorial Material
Oncology
Leandro Cerchietti, Ari Melnick
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Letter
Oncology
Sarah C. Rutherford, Eric N. Stewart, Zhengming Chen, Amy Chadburn, Natasha E. Wehrli, Koen van Besien, Peter Martin, Richard R. Furman, John P. Leonard, Leandro Cerchietti
LEUKEMIA & LYMPHOMA
(2018)
Article
Genetics & Heredity
Ly P. Vu, Camila Prieto, Elianna M. Amin, Sagar Chhangawala, Andrei Krivtsov, M. Nieves Calvo-Vidal, Timothy Chou, Arthur Chow, Gerard Minuesa, Sun Mi Park, Trevor S. Barlowe, James Taggart, Patrick Tivnan, Raquel P. Deering, Lisa P. Chu, Jeong-Ah Kwon, Cem Meydan, Javier Perales-Paton, Arora Arshi, Mithat Gonen, Christopher Famulare, Minal Patel, Elisabeth Paietta, Martin S. Tallman, Yuheng Lu, Jacob Glass, Francine E. Garret-Bakelman, Ari Melnick, Ross Levine, Fatima Al-Shahrour, Marcus Jaras, Nir Hacohen, Alexia Hwang, Ralph Garippa, Christopher J. Lengner, Scott A. Armstrong, Leandro Cerchietti, Glenn S. Cowley, David Root, John Doench, Christina Leslie, Benjamin L. Ebert, Michael G. Kharas
Article
Multidisciplinary Sciences
Florencia Cayrol, Pannee Praditsuktavorn, Tharu M. Fernando, Nicholas Kwiatkowski, Rosella Marullo, M. Nieves Calvo-Vidal, Jude Phillip, Benet Pera, Shao Ning Yang, Kaipol Takpradit, Lidia Roman, Marcello Gaudiano, Ramona Crescenzo, Jia Ruan, Giorgio Inghirami, Tinghu Zhang, Graciela Cremaschi, Nathanael S. Gray, Leandro Cerchietti
NATURE COMMUNICATIONS
(2017)
Article
Oncology
Ester Valls, Camille Lobry, Huimin Geng, Ling Wang, Mariano Cardenas, Martin Rivas, Leandro Cerchietti, Philmo Oh, Shao Ning Yang, Erin Oswald, Camille W. Graham, Yanwen Jiang, Katerina Hatzi, Xabier Agirre, Eric Perkey, Zhuoning Li, Wayne Tam, Kamala Bhatt, John P. Leonard, Patrick A. Zweidler-McKay, Ivan Maillard, Olivier Elemento, Weimin Ci, Iannis Aifantis, Ari Melnick
Article
Oncology
Danilo Fiore, Luca Vincenzo Cappelli, Paul Zumbo, Jude M. Phillips, Zhaoqi Liu, Shuhua Cheng, Liron Yoffe, Paola Ghione, Federica Di Maggio, Ahmet Dogan, Inna Khodos, Elisa de Stanchina, Joseph Casano, Clarisse Kayembe, Wayne Tam, Doron Betel, Robin Foa, Leandro Cerchietti, Raul Rabadan, Steven Horwitz, David M. Weinstock, Giorgio Inghirami
Article
Multidisciplinary Sciences
Biljana Culjkovic-Kraljacic, Lucy Skrabanek, Maria V. Revuelta, Jadwiga Gasiorek, Victoria H. Cowling, Leandro Cerchietti, Katherine L. B. Borden
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biology
Daniel P. Gomari, Annalise Schweickart, Leandro Cerchietti, Elisabeth Paietta, Hugo Fernandez, Hassen Al-Amin, Karsten Suhre, Jan Krumsiek
Summary: Variable autoencoders offer a powerful method for learning biologically meaningful, non-linear, and transferable latent representations of metabolomics data.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mehdi Ghram, Gavin Morris, Biljana Culjkovic-Kraljacic, Jean-Clement Mars, Patrick Gendron, Lucy Skrabanek, Maria Victoria Revuelta, Leandro Cerchietti, Monica L. Guzman, Katherine L. B. Borden
Summary: Aberrant splicing, a known contributor to malignancies, is usually attributed to splice-factor mutation. This study, however, discovered a mutation-independent mechanism for extensively reprogramming alternative splicing (AS) in acute myeloid leukemia (AML). The dysregulated expression of eukaryotic translation initiation factor eIF4E was found to increase selective splice-factor production, thereby affecting multiple spliceosome complexes and generating a splicing landscape that supported altered splice-site selection for hundreds of transcripts in AML patients with high-eIF4E expression.
Article
Oncology
Meng Li, Matthew R. Teater, Jun Young Hong, Noel R. Park, Cihangir Duy, Hao Shen, Ling Wang, Zhengming Chen, Leandro Cerchietti, Shawn M. Davidson, Hening Lin, Ari M. Melnick
Summary: This study reveals the link between SIRT3 and ATF4 in DLBCL cells, connecting lymphoma amino acid metabolism with ATF4 translation via metabolic stress signals. The SIRT3-ATF4 axis is required in DLBCL cells regardless of subtype, indicating a common metabolic vulnerability in DLBCLs and can serve as a therapeutic target.
BLOOD CANCER DISCOVERY
(2022)
Article
Oncology
Dhruba Deb, Satwik Rajaram, Jill E. Larsen, Patrick D. Dospoy, Rossella Marullo, Long Shan Li, Kimberley Avila, Fengtian Xue, Leandro Cerchietti, John D. Minna, Steven J. Altschuler, Lani F. Wu
Article
Oncology
Wei Du, Rebecca Goldstein, Yanwen Jiang, Omar Aly, Leandro Cerchietti, Ari Melnick, Olivier Elemento