Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia

Targeting human Rad51 by specific DNA aptamers induces inhibition of homologous recombination

(2010) Susan F. Martinez et al.   BIOCHIMIE

Chronic myeloid leukemia: mechanisms of blastic transformation

(2010) Danilo Perrotti et al.   JOURNAL OF CLINICAL INVESTIGATION

From Strand Exchange to Branch Migration; Bypassing of Non-homologous Sequences by Human Rad51 and Rad54

(2010) Damian E. Urena et al.   JOURNAL OF MOLECULAR BIOLOGY

BCR–ABL: a multi-faceted promoter of DNA mutation in chronic myelogeneous leukemia

(2010) B A Burke et al.   LEUKEMIA

Non random distribution of genomic features in breakpoint regions involved in chronic myeloid leukemia cases with variant t(9;22) or additional chromosomal rearrangements

(2010) Francesco Albano et al.   Molecular Cancer

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

(2010) Mary Ellen Moynahan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single-molecule imaging brings Rad51 nucleoprotein filaments into focus

(2010) Anthony L. Forget et al.   TRENDS IN CELL BIOLOGY

c-ABL tyrosine kinase stabilizes RAD51 chromatin association

(2009) Hiroko Shimizu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair

(2009) M. S. Fernandes et al.   BLOOD

Detection of c-Abl kinase-promoted phosphorylation of Rad51 by specific antibodies reveals that Y54 phosphorylation is dependent on that of Y315

(2009) Milena Popova et al.   FEBS LETTERS

DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange

(2009) Takako Ishida et al.   NUCLEIC ACIDS RESEARCH

JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders

(2008) I. Plo et al.   BLOOD

BCR/ABL Inhibits Mismatch Repair to Protect from Apoptosis and Induce Point Mutations

(2008) T. Stoklosa et al.   CANCER RESEARCH

Coupling of Mutated Met Variants to DNA Repair via Abl and Rad51

(2008) S. S. Ganapathipillai et al.   CANCER RESEARCH

BCR/ABL and Other Kinases from Chronic Myeloproliferative Disorders Stimulate Single-Strand Annealing, an Unfaithful DNA Double-Strand Break Repair

(2008) K. Cramer et al.   CANCER RESEARCH

Effects of Dasatinib on Src Kinase Activity and Downstream Intracellular Signaling in Primitive Chronic Myelogenous Leukemia Hematopoietic Cells

(2008) H. Konig et al.   CANCER RESEARCH

Cancer induction by restriction of oncogene expression to the stem cell compartment

(2008) María Pérez-Caro et al.   EMBO JOURNAL

The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer

(2008) Jen-Chung Ko et al.   EXPERIMENTAL CELL RESEARCH

Inhibition of filament formation of human Rad51 protein by a small peptide derived from the BRC-motif of the BRCA2 protein

(2008) Julian Nomme et al.   GENES TO CELLS

BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold

(2008) J Dierov et al.   LEUKEMIA

BCR/ABL promotes accumulation of chromosomal aberrations induced by oxidative and genotoxic stress

(2008) M Koptyra et al.   LEUKEMIA

Multiple sub-microscopic genomic lesions are a universal feature of chronic myeloid leukaemia at diagnosis

(2008) J S Khorashad et al.   LEUKEMIA