Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells

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Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia

(2011) L. S. Chen et al.   BLOOD

In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells

(2011) Dharminder Chauhan et al.   CLINICAL CANCER RESEARCH

Abnormal MicroRNA Expression in Ts65Dn Hippocampus and Whole Blood: Contributions to Down Syndrome Phenotypes

(2011) Jennifer Keck-Wherley et al.   DEVELOPMENTAL NEUROSCIENCE

RNAi-mediated silencing of VEGF-C inhibits non-small cell lung cancer progression by simultaneously down-regulating the CXCR4, CCR7, VEGFR-2 and VEGFR-3-dependent axes-induced ERK, p38 and AKT signalling pathways

(2011) Yukuan Feng et al.   EUROPEAN JOURNAL OF CANCER

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

(2011) Katey J. Rayner et al.   NATURE

miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response

(2011) Bogdan Mateescu et al.   NATURE MEDICINE

microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma

(2010) J.-J. Zhao et al.   BLOOD

Epigenetics and MicroRNAs Combine to Modulate the MDM2/p53 Axis in Myeloma

(2010) Marta Chesi et al.   CANCER CELL

Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

(2010) Flavia Pichiorri et al.   CANCER CELL

MicroRNAs and Metastasis: Little RNAs Go a Long Way

(2010) D. M. Dykxhoorn   CANCER RESEARCH

Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer

(2010) E. Kupperman et al.   CANCER RESEARCH

MicroRNAs: From Decay to Decoy

(2010) Michaela Beitzinger et al.   CELL

miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts

(2010) Anna M. Eiring et al.   CELL

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

(2010) L. Brault et al.   HAEMATOLOGICA

MicroRNA-155Regulates Cell Survival, Growth, and Chemosensitivity by TargetingFOXO3ain Breast Cancer

(2010) William Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pim protein kinases regulate energy metabolism and cell growth

(2010) Z. Beharry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo

(2010) T. Horie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis

(2010) S. H. Najafi-Shoushtari et al.   SCIENCE

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

(2009) Y.-W. Lin et al.   BLOOD

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

(2009) L. S. Chen et al.   BLOOD

Identification of microRNA expression patterns and definition of a microRNA/mRNA regulatory network in distinct molecular groups of multiple myeloma

(2009) M. Lionetti et al.   BLOOD

MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma

(2009) A. M. Roccaro et al.   BLOOD

Pim-1 expression and monoclonal antibody targeting in human leukemia cell lines

(2009) Jie Li et al.   EXPERIMENTAL HEMATOLOGY

Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration

(2009) Rebekka Grundler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-221/222 Negatively Regulates Estrogen Receptorα and Is Associated with Tamoxifen Resistance in Breast Cancer

(2008) Jian-Jun Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis

(2008) F. Pichiorri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA