A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

PIM1 Protein Kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

(2010) Fengxue Zhang et al.   CANCER BIOLOGY & THERAPY

Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia

(2009) J. Tamburini et al.   BLOOD

Combined Inhibition of MEK and Mammalian Target of Rapamycin Abolishes Phosphorylation of Cyclin-Dependent Kinase 4 in Glioblastoma Cell Lines and Prevents Their Proliferation

(2009) S. Paternot et al.   CANCER RESEARCH

Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells

(2009) Z. Beharry et al.   MOLECULAR CANCER THERAPEUTICS

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH

Potential roles for the PIM1 kinase in human cancer – A molecular and therapeutic appraisal

(2008) Nilesh Shah et al.   EUROPEAN JOURNAL OF CANCER

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases

(2008) Zuping Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study

(2008) Eric D. Hsi et al.   LEUKEMIA & LYMPHOMA