Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

The potential role of Aurora kinase inhibitors in haematological malignancies

(2011) Sherif S. Farag   BRITISH JOURNAL OF HAEMATOLOGY

Aurora B Regulates Formin mDia3 in Achieving Metaphase Chromosome Alignment

(2011) Lina Cheng et al.   DEVELOPMENTAL CELL

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction

(2011) Stefano Santaguida et al.   EMBO JOURNAL

Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient

(2011) Enxiu Wang et al.   JOURNAL OF CELL BIOLOGY

Polar actomyosin contractility destabilizes the position of the cytokinetic furrow

(2011) Jakub Sedzinski et al.   NATURE

Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation

(2011) Maria Maldonado et al.   NATURE CELL BIOLOGY

The bidirectional depolymerizer MCAK generates force by disassembling both microtubule ends

(2011) Yusuke Oguchi et al.   NATURE CELL BIOLOGY

External forces control mitotic spindle positioning

(2011) Jenny Fink et al.   NATURE CELL BIOLOGY

Defects in nuclear pore assembly lead to activation of an Aurora B–mediated abscission checkpoint

(2010) Douglas R. Mackay et al.   JOURNAL OF CELL BIOLOGY

Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal

(2010) Thomas J. Maresca et al.   JOURNAL OF CELL SCIENCE

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

(2010) Lisa S. Westerberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

Live cell imaging of micronucleus formation and development

(2010) Manabu Yasui et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Centromere tension: a divisive issue

(2010) Alexey Khodjakov et al.   NATURE CELL BIOLOGY

Emergence of Micronuclei and Their Effects on the Fate of Cells under Replication Stress

(2010) Koh-ichi Utani et al.   PLoS One

Still entangled: Assembly of the central spindle by multiple microtubule modulators

(2010) Max E. Douglas et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Sensing centromere tension: Aurora B and the regulation of kinetochore function

(2010) Michael A. Lampson et al.   TRENDS IN CELL BIOLOGY

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

(2009) Patrick Steigemann et al.   CELL

Kinetochore stretching inactivates the spindle assembly checkpoint

(2009) Kazuhiko S.K. Uchida et al.   JOURNAL OF CELL BIOLOGY

Intrakinetochore stretch is associated with changes in kinetochore phosphorylation and spindle assembly checkpoint activity

(2009) Thomas J. Maresca et al.   JOURNAL OF CELL BIOLOGY

Ipl1-dependent phosphorylation of Dam1 is reduced by tension applied on kinetochores

(2009) P. Keating et al.   JOURNAL OF CELL SCIENCE

Aurora B Kinase Regulates the Postmitotic Endoreduplication Checkpoint via Phosphorylation of the Retinoblastoma Protein at Serine 780

(2009) Jayasree S. Nair et al.   MOLECULAR BIOLOGY OF THE CELL

Characterization of two classes of small molecule inhibitors of Arp2/3 complex

(2009) B. J. Nolen et al.   NATURE

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene

(2008) Karolien Beel et al.   BRITISH JOURNAL OF HAEMATOLOGY

Moesin Controls Cortical Rigidity, Cell Rounding, and Spindle Morphogenesis during Mitosis

(2008) Patricia Kunda et al.   CURRENT BIOLOGY

Multiple origins of spontaneously arising micronuclei in HeLa cells: Direct evidence from long-term live cell imaging

(2008) Xiaotang Rao et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS