期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 21, 期 9, 页码 899-908出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2010.08.005
关键词
Central spindle; Microtubule bundle; MKLP1; CYK4; PRC1
资金
- Cancer Research UK [C19769/A6356]
- BBSRC
The central spindle is a microtubule-based structure that assembles during anaphase of mitosis in animal cells and is essential for multiple steps of cytokinesis. Central spindle assembly occurs by the cooperative action of multiple microtubule motors and modulators. Here, we review the mechanism by which the central spindle is formed, the role of several key proteins in this process and how central spindle assembly is temporally and spatially coordinated with mitosis. (C) 2010 Elsevier Ltd. All rights reserved.
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