Article
Multidisciplinary Sciences
Mirren Charnley, Amr H. Allam, Lucas M. Newton, Patrick O. Humbert, Sarah M. Russell
Summary: A critical stage in T cell development is beta-selection, where the T cell receptor beta (TCR beta) chain is generated and the T cell starts to acquire antigenic specificity. This study identifies E-cadherin as a critical cue within the developing T cell niche that facilitates T cell development. E-cadherin mediates cell-cell interactions and plays a role in the formation of the immunological synapse and alignment of the mitotic spindle during division, ultimately coordinating the beta-selection stage of T cell development.
Article
Cell & Tissue Engineering
Boya Li, Yixiao Xing, Yehua Gan, Jing He, Hong Hua
Summary: The study showed that LGMSCs or LGMSC-Exos have potential therapeutic effects against Sjogren's syndrome (SS), reducing inflammatory infiltration in salivary glands and restoring secretory function. They were also found to inhibit Th17 cell differentiation, promote Treg cell induction, decrease levels of IL-17, interferon gamma, and IL-6, and increase secretion of transforming growth factor beta and IL-10. These findings suggest that LGMSCs are promising for MSCs-based therapy and LGMSC-Exos could be used for a new cell-free therapy for SS.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Hui Li, Dexiao Kong, Yi Zhao, Xia Liu, Fang Xiao, Xiaoyan Li, Jianting Hu, Yingjie Chen, Shengli Li, Baozhu Wang, Yuan Chen, Yang Jiang, Xiaoli Liu, Xiumei Feng, Yanan Guo, Xiaoli Feng, Jing Ren, Fang Wang, Ying Han, William Donelan, Lijun Yang, Dawei Xu, Dongqi Tang, Chengyun Zheng
Summary: This study investigates the therapeutic effect of irisin in an AA mouse model. The results show that irisin plays a role in the pathogenesis of AA and can protect HPSC through stimulation of proliferation and regulation of mitochondria function, providing evidence for the application of irisin in AA therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Anke Schmidt, Melissa Muehl, Walison Augusto da Silva Brito, Debora Singer, Sander Bekeschus
Summary: Polystyrene nano- and micro-sized plastic particles (NMP) are common pollutants in the environment, water, and oceans. They can be absorbed by the body through various routes and have been shown to cause oxidative stress and affect cellular responses. In this study, we exposed murine lung cells to NMP of different sizes and observed significant correlations between cellular consequences and particle size. Our findings highlight the potential hazards of plastic contamination and uptake in lung cells.
Article
Oncology
Alexandra Berger, Sarah J. Colpitts, Morgan Zych, Christopher J. Paige
Summary: We explored the use of IL-21 cell-based anti-leukemia treatment in a mouse model of acute lymphoblastic leukemia. Injection of IL-21-secreting 70Z/3 leukemia cells induced a strong anti-leukemia response and led to 100% survival rate. IL-21 secretion correlated with improved survival and the expansion of IL-21-secreting cells. The delivery of IL-21 showed the potential to induce a potent immune response and long-term immunity, making it an attractive candidate for cancer immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Veronica Dave, Laura E. Richert-Spuhler, Tanvi Arkatkar, Lakshmi Warrier, Thepthara Pholsena, Christine Johnston, Joshua T. Schiffer, Martin Prlic, Jennifer M. Lund
Summary: The immune cell compartment in genital skin expands and contracts following HSV-2 reactivation, and includes cells recruited from circulation and proliferating cells. Despite frequent antigen exposure, tissue T cell number and phenotype remain stable in the long-term, likely driven by regulatory mechanisms. It remains unclear if periodic viral reactivation can induce T cell dysfunction in a localized infection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Cell & Tissue Engineering
Chinwe Okeke, Ufele Silas, Chinedu Okeke, Chiedozie Chikwendu
Summary: Advancements in technology and genetics have led to the discovery of new types of hemopoietic stem cells, challenging the traditional belief that all blood cells are derived from HSC. The heterogeneity and evolving knowledge of HSC have improved its therapeutic applications for various blood disorders. With the potential for reprogramming non-hematopoietic cells and evolving sequencing technologies, there is a paradigm shift in HSC transplantation donor selection towards haploidentical HCT.
CURRENT STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Shaima Jabbar, Parker Mathews, Xiaobei Wang, Pasupathi Sundaramoorthy, Emily Chu, Sadhna O. Piryani, Shengli Ding, Xiling Shen, Phuong L. Doan, Yubin Kang
Summary: This study reveals that the thioredoxin-1 (TXN1)-TP53 axis plays a regulatory role in the biological functions of hematopoietic stem/progenitor cells (HSPCs). Deletion of TXN1 activates the TP53 signaling pathway and impairs the capacity of HSPCs to reconstitute hematopoiesis. Moreover, knockout of TXN1 renders HSPCs more sensitive to radiation, while treatment with recombinant TXN1 promotes the proliferation and expansion of HSPCs.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Hematology
Rochelle E. Fletcher, Natalia S. Nunes, Michael T. Patterson, Natasha Vinod, Shanzay M. Khan, Suresh K. Mendu, Xianghong Li, Alessandra de Paula Pohl, Lucas P. Wachsmuth, Hyoyoung Choo-Wosoba, Michael A. Eckhaus, David J. Venzon, Christopher G. Kanakry
Summary: Posttransplantation cyclophosphamide (PTCy) reduces graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT), but its mechanism is not fully understood. This study showed that Tregs were necessary for controlling GVHD induced by new donor cells but PTCy's impact on Tregs was indirect. The study also suggested that myeloid-derived suppressor cells (MDSCs) played a complementary role in GVHD prevention and their percentages increased after PTCy administration.
Article
Biology
David C. Klein, Santana M. Lardo, Kurtis N. McCannell, Sarah J. Hainer
Summary: The FACT complex maintains cellular pluripotency by regulating nucleosome positioning and transcription activity. FACT interacts with genes such as OCT4, SOX2, and NANOG, binding to both promoter and enhancer elements, and regulates their transcription and expression, thereby influencing cell fate decisions.
Article
Immunology
Chorong Yang, Dong-il Kwon, Mingyu Kim, Sin-Hyeog Im, You Jeong Lee
Summary: The study found that commensal bacteria can promote PM-induced neutrophilia in the lung via T gamma delta 17 cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Ozge Karabiyik Acar, Gulcin Delal Nozhatzadeh, Alperen Tuncer, Gamze Torun Kose, Ezgi Hacihasanoglu, Fikrettin Sahin, Erhan Aysan
Summary: This study successfully differentiated thyroid stem/progenitor cells into parathyroid-like cells using Activin A and sonic hedgehog proteins in a co-culture environment. It presents a potentially effective novel method for cell differentiation.
Article
Cell & Tissue Engineering
Ziyang Liang, Guoyang Zhang, Guangting Gan, Duolan Naren, Xiaoyan Liu, Hongyun Liu, Jiani Mo, Shengqin Lu, Danian Nie, Liping Ma
Summary: The safety of human bone marrow-derived MSCs was investigated on mice, and it was found that there were no significant abnormalities or immune responses observed. The results suggest that MSCs are a safe and promising therapy.
CELL TRANSPLANTATION
(2023)
Article
Cell Biology
Jiao Lin, Jiahui Zeng, Wencui Sun, Kun Liu, Myagmartsend Enkhbat, Danying Yi, Javad Harati, Jiaxin Liu, Peter Kingshott, Bo Chen, Feng Ma, Peng-Yuan Wang
Summary: The study demonstrates that the use of a new artificial extracellular matrix cSAP can enhance the hematopoietic potential of human embryonic stem cells, leading to the generation of more blood-like cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Michael Chamo, Omri Koren, Oron Goldstein, Nir Bujanover, Nurit Keinan, Ye'ela Scharff, Roi Gazit
Summary: This study successfully identified and characterized leukemia stem cells in a murine model, providing insights into their molecular mechanisms and whole transcriptome analysis. The discovery of these cells and their potential therapeutic targets is a critical advancement in leukemia research in immunocompetent animals.
Review
Hematology
Allison J. Li, Laura M. Calvi
EXPERIMENTAL HEMATOLOGY
(2017)
Article
Immunology
D. Oleksyn, J. Zhao, A. Vosoughi, J. C. Zhao, R. Misra, A. P. Pentland, D. Ryan, J. Anolik, C. Ritchlin, J. Looney, A. P. Anandarajah, G. Schwartz, L. M. Calvi, M. Georger, C. Mohan, I. Sanz, L. Chen
IMMUNOLOGY LETTERS
(2017)
Article
Multidisciplinary Sciences
Julia J. Mack, Thiago S. Mosqueiro, Brian J. Archer, William M. Jones, Hannah Sunshine, Guido C. Faas, Anais Briot, Raquel L. Aragon, Trent Su, Milagros C. Romay, Austin I. McDonald, Cheng-Hsiang Kuo, Carlos O. Lizama, Timothy F. Lane, Ann C. Zovein, Yun Fang, Elizabeth J. Tarling, Thomas Q. de Aguiar Vallim, Mohamad Navab, Alan M. Fogelman, Louis S. Bouchard, M. Luisa Iruela-Arispe
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Susanne Roser-Page, Tatyana Vikulina, Daiana Weiss, Mark M. Habib, George R. Beck, Roberto Pacifici, Timothy F. Lane, M. Neale Weitzmann
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2018)
Review
Endocrinology & Metabolism
Corey M. Hoffman, Jimin Han, Laura M. Calvi
Article
Multidisciplinary Sciences
Rhonda J. Staversky, Daniel K. Byun, Mary A. Georger, Brandon J. Zaffuto, Alexandra Goodman, Michael W. Becker, Laura M. Calvi, Benjamin J. Frisch
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Edward Ayoub, Michael P. Wilson, Kathleen E. McGrath, Allison J. Li, Benjamin J. Frisch, James Palis, Laura M. Calvi, Yi Zhang, Archibald S. Perkins
NATURE COMMUNICATIONS
(2018)
Review
Hematology
Titas Banerjee, Laura M. Calvi, Michael W. Becker, Jane L. Liesveld
Editorial Material
Endocrinology & Metabolism
Laura M. Calvi, Lorenz C. Hofbauer
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Article
Biology
Laura M. Calvi, Benjamin J. Frisch, Paul D. Kingsley, Anne D. Koniski, Tanzy M. Love, Jacqueline P. Williams, James Palis
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Article
Oncology
Mitra Azadniv, Jason R. Myers, Helene R. McMurray, Naxin Guo, Phil Rock, Myra L. Coppage, John Ashton, Michael W. Becker, Laura M. Calvi, Jane L. Liesveld
Editorial Material
Endocrinology & Metabolism
Laura M. Calvi
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Editorial Material
Hematology
Laura M. Calvi
Summary: This study highlights the novel role of FGF-23 in G-CSF-stimulated mobilization of HSPCs, shedding light on the connection between phosphate metabolism and hematopoietic stem cells.
Article
Oncology
Allison N. Seyfried, Amanda McCabe, Julianne N. P. Smith, Laura M. Calvi, Katherine C. MacNamara
Summary: Our research has identified CCR5 signaling as a key axis promoting the development of IFN gamma-dependent bone marrow failure, particularly relevant in aging where Ccr5 expression is elevated.
Article
Medicine, Research & Experimental
Benjamin J. Frisch, Corey M. Hoffman, Sarah E. Latchney, Mark W. LaMere, Jason Myers, John Ashton, Allison J. Li, Jerry Saunders, James Palis, Archibald S. Perkins, Amanda McCabe, Julianne N. P. Smith, Kathleen E. McGrath, Fatima Rivera-Escalera, Andrew McDavid, Jane L. Liesveld, Vyacheslav A. Korshunov, Michael R. Elliott, Katherine C. MacNamara, Michael W. Becker, Laura M. Calvi