Article
Oncology
Csilla Kriston, Mark Hernadfoi, Mark Plander, Agnes Mark, Ferenc Takacs, Agnes Czeti, Gabor Szaloki, Orsolya Szabo, Andras Matolcsy, Gabor Barna
Summary: Lenalidomide has limited effect on BMSCs, increases apoptosis of CLL cells, decreases interaction with microenvironment, and enhances expression of certain cell molecules.
HEMATOLOGICAL ONCOLOGY
(2021)
Article
Genetics & Heredity
Binyamin A. Knisbacher, Ziao Lin, Cynthia K. Hahn, Ferran Nadeu, Marti Duran-Ferrer, Kristen E. Stevenson, Eugen Tausch, Julio Delgado, Alex Barbera-Mourelle, Amaro Taylor-Weiner, Pablo Bousquets-Munoz, Ander Diaz-Navarro, Andrew Dunford, Shankara Anand, Helene Kretzmer, Jesus Gutierrez-Abril, Sara Lopez-Tamargo, Stacey M. Fernandes, Clare Sun, Mariela Sivina, Laura Z. Rassenti, Christof Schneider, Shuqiang Li, Laxmi Parida, Alexander Meissner, Francois Aguet, Jan A. Burger, Adrian Wiestner, Thomas J. Kipps, Jennifer R. Brown, Michael Hallek, Chip Stewart, Donna S. Neuberg, Jose Martin-Subero, Xose S. Puente, Stephan Stilgenbauer, Catherine J. Wu, Elias Campo, Gad Getz
Summary: This study identifies genetic drivers and molecular subtypes associated with clinical outcomes in chronic lymphocytic leukemia (CLL) through genomic, transcriptomic, and epigenomic analysis. The findings provide fresh insights into the oncogenesis and prognostication of CLL.
Article
Hematology
Vaclav Seda, Eva Vojackova, Laura Ondrisova, Lenka Kostalova, Sonali Sharma, Tomas Loja, Gabriela Mladonicka Pavlasova, Daniel Zicha, Marie Kudlickova Peskova, Jan Krivanek, Kvetoslava Liskova, Leos Kren, Vladimir Benes, Katerina Musilova Litzmanova, Marek Borsky, Jan Oppelt, Jan Verner, Sarka Pospisilova, Yvona Brychtova, Anna Panovska, Zhi Tan, Shuxing Zhang, Michael Doubek, Katerina Amruz Cerna, Jiri Mayer, Marek Mraz
Summary: The migration and survival of CLL cells are influenced by GAB1, which can be targeted for therapeutic purposes, especially in combination with BTK inhibitors.
Review
Cell Biology
Kevin Woods, Borhane Guezguez
Summary: Mesenchymal stromal cells (MSCs) are a diverse cell population known for their nutrient-producing and immunomodulatory functions, crucial in regulating hematopoietic stem cells (HSC) in the bone marrow for blood production and immunity. MSCs contribute to bone integrity and hormone supply by differentiating into osteoblasts and adipocytes, playing a key role in the complex interactions of the HSC niche.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Kevin Woods, Borhane Guezguez
Summary: MSCs are a heterogeneous cell population found in various tissues in the body, with important regulatory functions, especially in the bone marrow where they play a critical role in regulating HSCs. They contribute to maintaining bone integrity and hormonal nutrition supply, as well as regulating the homeostasis and differentiation of the HSC niche through differentiation into different cell types. Research on MSCs helps understand their role in regulating cell interactions and homeostasis in the body.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kristan V. Piroeva, Charlotte Mcdonald, Charalampos Xanthopoulos, Chelsea Fox, Christopher T. Clarkson, Jan-Philipp Mallm, Yevhen Vainshtein, Luminita Ruje, Lara C. Klett, Stephan Stilgenbauer, Daniel Mertens, Efterpi Kostareli, Karsten Rippe, Vladimir B. Teif
Summary: This study compared the nucleosome positions in chronic lymphocytic leukemia (CLL) patients and healthy individuals, and found significant changes in nucleosome positioning in CLL. The spacing between nucleosomes was shortened, and changes in nucleosome occupancy were linked to chromatin remodeling and reduced DNA methylation. Nucleosome positioning can be used to classify CLL subtypes and monitor disease progression.
Article
Cell & Tissue Engineering
Elmira Jalilian, Hamed Massoumi, Bianca Bigit, Sohil Amin, Eitan A. Katz, Victor H. Guaiquil, Khandaker N. Anwar, Peiman Hematti, Mark Rosenblatt, Ali R. Djalilian
Summary: This study compares the differences in neuro-regenerative properties of MSC-derived EVs generated in 2D and 3D culture systems. The findings show that 3D culture system produces EVs with higher concentration, more heterogeneous phenotype, and enhanced ability to promote neurite growth and elongation. This has important implications for the scalable production of MSC-derived EVs and their therapeutic applications.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Madhan Jeyaraman, Shiva Kumar Bingi, Sathish Muthu, Naveen Jeyaraman, Rathinavelpandian Perunchezhian Packkyarathinam, Rajni Ranjan, Shilpa Sharma, Saurabh Kumar Jha, Manish Khanna, Sree Naga Sowndary Rajendran, Ramya Lakshmi Rajendran, Prakash Gangadaran
Summary: Human bone marrow is a promising source of mesenchymal stromal cells (MSCs) for regenerative procedures involving cartilage and bone. However, the low proportion of MSCs in the bone marrow requires careful harvesting and processing techniques. There is currently a lack of consensus regarding the variables in the harvesting and processing technique of bone marrow aspiration concentrate (BMAC) and their impact on MSC yield.
BIOENGINEERING-BASEL
(2022)
Article
Medicine, General & Internal
Barbara Eichhorst, Carsten U. Niemann, Arnon P. Kater, Moritz Fuerstenau, Julia von Tresckow, Can Zhang, Sandra Robrecht, Michael Gregor, Gunnar Juliusson, Patrick Thornton, Philipp B. Staber, Tamar Tadmor, Vesa Lindstrom, Caspar da Cunha-Bang, Christof Schneider, Christian B. Poulsen, Thomas Illmer, Bjoern Schoettker, Thomas Noesslinger, Ann Janssens, Ilse Christiansen, Michael Baumann, Henrik Frederiksen, Marjolein van der Klift, Ulrich Jaeger, Maria B. L. Leys, Mels Hoogendoorn, Kourosh Lotfi, Holger Hebart, Tobias Gaska, Harry Koene, Lisbeth Enggaard, Jereon Goede, Josien C. Regelink, Anouk Widmer, Florian Simon, Nisha De Silva, Anna-Maria Fink, Jasmin Bahlo, Kirsten Fischer, Clemens-Martin Wendtner, Karl A. Kreuzer, Matthias Ritgen, Monika Brueggemann, Eugen Tausch, Mark-David Levin, Marinus van Oers, Christian Geisler, Stephan Stilgenbauer, Michael Hallek
Summary: In fit patients with CLL, venetoclax-obinutuzumab, with or without ibrutinib, showed superior results compared to chemoimmunotherapy as a first-line treatment, with higher rates of undetectable minimal residual disease and progression-free survival.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Xun Wu, J. Ernesto Fajardo-Despaigne, Christine Zhang, Vishala Neppalli, Versha Banerji, James B. Johnston, Spencer B. Gibson, Aaron J. Marshall
Summary: In chronic lymphocytic leukemia (CLL), follicular helper T cells (T-FH) are increased and exhibit abnormal phenotypes with elevated levels of PD-1, TIGIT, CD40L, IFN gamma, and IL-21. Treatment with ibrutinib can normalize T-FH frequencies and phenotype. CLL development is associated with expansion of abnormal T-FH populations that produce elevated levels of cytokines and costimulatory molecules which may help support CLL proliferation.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Billy Michael Chelliah Jebaraj, Stephan Stilgenbauer
Summary: Telomeres play a crucial role in chronic lymphocytic leukemia (CLL), with their dysfunction shaping the disease progression. Members of the shelterin complex and TERT activation are closely associated with CLL cell survival and proliferation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Hematology
Freda K. Stevenson, Francesco Forconi, Thomas J. Kipps
Summary: Research into chronic lymphocytic leukemia has led to significant improvements in the assessment and treatment of patients, with designer drugs now successfully targeting tumor cells based on their biology. Classifying CLL into unmutated (U) and mutated (M) diseases based on the mutational status of IGHV sequences reveals distinct origins, biology, and clinical behaviors for each. Despite advances, challenges such as cell-escape strategies and immunosuppression remain, necessitating continued research into CLL biology.
Article
Hematology
Fabienne Meier-Abt, Junyan Lu, Ester Cannizzaro, Marcel F. Pohly, Sandra Kummer, Sibylle Pfammatter, Laura Kunz, Ben C. Collins, Ferran Nadeu, Kwang Seok Lee, Peng Xue, Myriam Gwerder, Michael Roiss, Jennifer Huellein, Sebastian Scheinost, Sascha Dietrich, Elias Campo, Wolfgang Huber, Ruedi Aebersold, Thorsten Zenz
Summary: This study uncovered mutations affecting protein expression in CLL and identified signaling pathways associated with trisomy 12. STAT2 protein expression was linked to specific drug responses, providing a protein expression reference map for CLL.
Review
Medicine, General & Internal
Alon Bnaya, Chezi Ganzel, Linda Shavit
Summary: Pseudohyperkalemia refers to falsely elevated serum potassium levels due to in vitro potassium release from cells. It has been reported in patients with thrombocytosis, leukocytosis, and hematologic malignancies, particularly chronic lymphocytic leukemia (CLL). Various factors contribute to pseudohyperkalemia in CLL, including leukocyte fragility, high leukocyte counts, mechanical stress, higher cell membrane permeability, and metabolite depletion. The prevalence of pseudohyperkalemia is up to 40%, especially in cases with high leukocyte count (>50 x 10(9)/L). The diagnosis of pseudohyperkalemia is often missed, leading to unnecessary and potentially harmful treatment. Whole blood testing and point-of-care blood gas analysis, combined with thorough clinical evaluation, can help differentiate between true and pseudohyperkalemic episodes.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Oncology
David Allard, Pavel Chrobak, Yacine Bareche, Bertrand Allard, Priscilla Tessier, Marjorie A. Bergeron, Nathalie A. Johnson, John Stagg
Summary: Our study identified CD73 as a pro-leukemic immune checkpoint in CLL and uncovered a previously unknown sex bias for the CD73-adenosine pathway. The therapeutic potential of targeting CD73 in CLL was investigated using genetically engineered mice, revealing a pro-leukemic role for CD73 in an autochthonous mouse model of CLL. Our findings suggest that targeting CD73 in CLL in combination with anti-PD-1/PD-L1 immunotherapies may be beneficial, with sex potentially contributing to responses to adenosine-targeting agents.
Article
Oncology
Jiao-jiao Yu, Dan-dan Zhou, Bing Cui, Cheng Zhang, Feng-wei Tan, Shan Chang, Ke Li, Xiao-xi Lv, Xiao-wei Zhang, Shuang Shang, Yu-Jin Xiang, Fei Chen, Jin-mei Yu, Shan-shan Liu, Feng Wang, Zhuo-Wei Hu, Fang Hua
Article
Multidisciplinary Sciences
Jiao-jiao Yu, Dan-dan Zhou, Xiao-xiao Yang, Bing Cui, Feng-wei Tan, Junjian Wang, Ke Li, Shuang Shang, Cheng Zhang, Xiao-xi Lv, Xiao-wei Zhang, Shan-shan Liu, Jin-mei Yu, Feng Wang, Bo Huang, Fang Hua, Zhuo-Wei Hu
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Ke Li, Feng Wang, Zhao-na Yang, Ting-ting Zhang, Yu-fen Yuan, Chen-xi Zhao, Zaiwuli Yeerjiang, Bing Cui, Fang Hua, Xiao-xi Lv, Xiao-wei Zhang, Jiao-jiao Yu, Shan-shan Liu, Jin-mei Yu, Shuang Shang, Yang Xiao, Zhuo-wei Hu
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Ke Li, Ting-ting Zhang, Chen-xi Zhao, Feng Wang, Bing Cui, Zhao-na Yang, Xiao-xi Lv, Zaiwuli Yeerjiang, Yu-fen Yuan, Jin-mei Yu, Zhen-he Wang, Xiao-wei Zhang, Jiao-jiao Yu, Shan-shan Liu, Shuang Shang, Bo Huang, Fang Hua, Zhuo-wei Hu
Summary: The study showed that FGD5 is associated with poor prognosis in BLBCs and interacts with EGFR in BLBC cells, affecting cell proliferation, invasion, and tumorsphere formation, providing a potential therapeutic option for BLBC.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Shan-Shan Liu, Chang Liu, Xiao-Xi Lv, Bing Cui, Jun Yan, Yun-Xuan Li, Ke Li, Fang Hua, Xiao-Wei Zhang, Jiao-Jiao Yu, Jin-Mei Yu, Feng Wang, Shuang Shang, Ping-Ping Li, Zhi-Guang Zhou, Yang Xiao, Zhuo-Wei Hu
Summary: Recruitment of immune cells to the site of inflammation by CCL1 is crucial in inflammatory diseases, including pulmonary fibrosis. The study found that alveolar macrophages and CD4(+) T cells are major producers of CCL1, and targeting CCL1 expression can attenuate the pathology of PF.
Article
Pharmacology & Pharmacy
Shanshan Liu, Xiaoxi Lv, Xupeng Wei, Chang Liu, Qiao Li, Jiali Min, Fang Hua, Xiaowei Zhang, Ke Li, Pingping Li, Yang Xiao, Zhuowei Hu, Bing Cui
Summary: This study reveals an intact profibrotic axis of TRIB3-GSK-3 beta-A20-C/EBP beta in alveolar macrophages, which represents a target that may provide a promising treatment strategy for pulmonary fibrosis.
ACTA PHARMACEUTICA SINICA B
(2021)
Correction
Immunology
Shan-shan Liu, Chang Liu, Xiao-xi Lv, Bing Cui, Jun Yan, Yun-xuan Li, Ke Li, Fang Hua, Xiao-wei Zhang, Jiao-jiao Yu, Jin-mei Yu, Feng Wang, Shuang Shang, Ping-ping Li, Zhi-guang Zhou, Yang Xiao, Zhuo-wei Hu
Article
Cell Biology
Shuang Shang, Yu-wei Yang, Fei Chen, Liang Yu, Shuo-hao Shen, Ke Li, Bing Cui, Xiao-Xi Lv, Cheng Zhang, Chen Yang, Jing Liu, Jiao-jiao Yu, Xiao-wei Zhang, Ping-ping Li, Sheng-tao Zhu, Hai-zeng Zhang, Fang Hua
Summary: TRIB3 inhibits CD8(+) T cell infiltration in colorectal cancer by inhibiting STAT1 activation and reducing tumor-infiltrating T cells. Acetyltransferase P300 acetylates TRIB3 and prevents its ubiquitination and degradation. Genetic ablation of TRIB3 or pharmacological acceleration of TRIB3 degradation with a P300 inhibitor increases T cell recruitment and sensitizes colorectal cancers to immune checkpoint blockade therapy.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Jiali Min, Qiao Li, Suosi Liu, Qianrong Wang, Min Yin, Yan Zhang, Jun Yan, Bing Cui, Shanshan Liu
Summary: This study explores the role of TNF receptor-associated factor 6 (TRAF6) in the pathogenesis of pulmonary fibrosis (PF). It demonstrates that decreased expression of TRAF6 in lung fibroblasts is essential for the progression of PF. Moreover, overexpression of TRAF6 can reverse the activation of myofibroblasts in PF mice by suppressing Wnt/beta-catenin signaling. The study also reveals a negative correlation between the abundance of TRIB3 and TRAF6 in lung fibroblasts, suggesting that disruption of the TRIB3-TRAF6 interaction could be a potential therapeutic strategy for fibroproliferative lung diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Xingfeng Liu, Kai Wang, Luhai Wang, Lijuan Kong, Shaocong Hou, Yanjun Wan, Chunxiao Ma, Jingwen Chen, Xiaowei Xing, Caiyi Xing, Qian Jiang, Qijin Zhao, Bing Cui, Zhifeng Huang, Pingping Li
Summary: This study found that Ltb4r1 plays a role in promoting hepatic lipogenesis in the development of NAFLD. It activates the PKA-IRE1α-XBP1s pathway to promote the expression of lipogenic genes. Inhibition of Ltb4r1 can improve hepatic steatosis and insulin resistance. The results suggest that Ltb4r1 may be a potential therapeutic target for NAFLD.
Article
Pharmacology & Pharmacy
Xiaoxi Lv, Shanshan Liu, Chang Liu, Yunxuan Li, Tingting Zhang, Jie Qi, Ke Li, Fang Hua, Bing Cui, Xiaowei Zhang, Yuxin Liu, Jiaojiao Yu, Jinmei Yu, Li Li, Xia Li, Zhigang Yao, Bo Huang
Summary: This study reveals that repetitive lung damage leads to the accumulation of the transcriptional repressor SLUG, inhibiting lung alveolar regeneration and causing the failure of pulmonary fibrosis. The elevated SLUG represses the expression of phosphate transporter SLC34A2, reducing intracellular phosphate and inhibiting key kinases JNK and P38 MAPK, resulting in LAR failure. Targeting the TRIB3/MDM2 interaction can restore LAR capacity and provide potential therapeutic efficacy against fibroproliferative lung diseases.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Pharmacology & Pharmacy
Ji-Chao Zhou, Cai-Cai Jin, Xiao-Li Wei, Rui-Bing Xu, Ruo-Yu Wang, Zhi-Meng Zhang, Bo Tang, Jin-Mei Yu, Jiao-Jiao Yu, Shuang Shang, Xiao-Xi Lv, Fang Hua, Ping-Ping Li, Zhuo-Wei Hu, Yong-Mei Shen, Feng-Peng Wang, Xiu-Ying Ma, Bing Cui, Fu-Neng Geng, Xiao-Wei Zhang
Summary: Aberrant mitophagy has been identified as a driver for energy metabolism disorder in most cardiac pathological processes. Fuzi, a traditional Chinese medicine, contains a compound called mesaconine, which has been proven effective in various cardiomyopathy models. In this study, it was found that mesaconine could reverse cardiac dysfunction, energy disorder, and impaired mitophagy in mice models of heart failure induced by doxorubicin. This cardioprotective effect of mesaconine was dependent on the activation of PINK1-induced mitophagy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Xingfeng Liu, Kai Wang, Shaocong Hou, Qian Jiang, Chunxiao Ma, Qijin Zhao, Lijuan Kong, Jingwen Chen, Zhenhe Wang, Huabing Zhang, Tao Yuan, Yuxiu Li, Yi Huan, Zhufang Shen, Zhuowei Hu, Zhifeng Huang, Bing Cui, Pingping Li
Summary: The tyrosine kinase receptor EphB4 interacts with the insulin receptor to promote its endocytosis and degradation, leading to decreased insulin signaling and insulin resistance. Inhibition of EphB4 can improve insulin resistance and glucose intolerance.
Article
Pharmacology & Pharmacy
Xiaoxi Lv, Chang Liu, Shanshan Liu, Yunxuan Li, Wanyu Wang, Ke Li, Fang Hua, Bing Cui, Xiaowei Zhang, Jiaojiao Yu, Jinmei Yu, ZhuoWei Hu
Summary: The cell cycle inhibitor P21 plays a crucial role in the development of pulmonary fibrosis (PF) by promoting cell senescence and inhibiting lung alveolar epithelial cell differentiation. Elevated P21 expression in lung alveolar epithelial type 2 cells (AEC2s) induces cell cycle arrest and disrupts the P300-beta-catenin interaction, leading to impaired AEC2 differentiation. Additionally, senescent AEC2s activate myofibroblasts by releasing profibrotic cytokines. Knockdown of P21 restores lung alveolar regeneration in a mouse model of chronic PF.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Medicine, Research & Experimental
Ke Li, Feng Wang, Zhao-Na Yang, Bing Cui, Ping-Ping Li, Zhen-Yu Li, Zhuo-Wei Hu, Hong-Hu Zhu
