Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling

(2019) Minhong Shen et al.   CANCER CELL

VE‐PTP inhibition stabilizes endothelial junctions by activating FGD5

(2019) Laura J Braun et al.   EMBO REPORTS

Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention

(2019) Pirashaanthy Tharmapalan et al.   EMBO JOURNAL

Rethink of EGFR in Cancer With Its Kinase Independent Function on Board

(2019) Rintu Thomas et al.   Frontiers in Oncology

TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription

(2019) Jin-mei Yu et al.   Nature Communications

Cancer stem cells in triple-negative breast cancer: a potential target and prognostic marker

(2018) Christopher J O'Conor et al.   Biomarkers in Medicine

Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

(2018) Aurélie S. Cazet et al.   Nature Communications

Advances in targeting epidermal growth factor receptor signaling pathway in mammary cancer

(2018) Konstantina Kyriakopoulou et al.   CELLULAR SIGNALLING

Characterization of FGD5 Expression in Primary Breast Cancers and Lymph Node Metastases

(2018) Marit Valla et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Molecular-Targeted Therapies for Epidermal Growth Factor Receptor and Its Resistance Mechanisms

(2017) Toshimitsu Yamaoka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a–LCOR axis

(2017) Toni Celià-Terrassa et al.   NATURE CELL BIOLOGY

Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation

(2017) Peiguo Shi et al.   Cell Discovery

Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2

(2016) Shen Kiat Lim et al.   CANCER RESEARCH

Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline

(2016) Lyndsay N. Harris et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer stem cells and chemoresistance: The smartest survives the raid

(2016) Jihe Zhao   PHARMACOLOGY & THERAPEUTICS

TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

(2015) Fang Hua et al.   Nature Communications

A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness

(2015) Tackhoon Kim et al.   Nature Communications

Mechanisms of resistance to EGFR tyrosine kinase inhibitors

(2015) Lihua Huang et al.   Acta Pharmaceutica Sinica B

The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway

(2015) Zaidoun Salah et al.   Oncotarget

Regulation of EGFR Protein Stability by the HECT-type Ubiquitin Ligase SMURF2

(2015) Dipankar Ray et al.   NEOPLASIA

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics

(2014) Carlos L. Arteaga et al.   CANCER CELL

Fgd5identifies hematopoietic stem cells in the murine bone marrow

(2014) Roi Gazit et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High EGFR gene copy number predicts poor outcome in triple-negative breast cancer

(2014) Heae Surng Park et al.   MODERN PATHOLOGY

ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling

(2014) Rumela Chakrabarti et al.   NATURE CELL BIOLOGY

An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer

(2014) Michael L Gatza et al.   NATURE GENETICS

Novel Medicines and Strategies in Cancer Treatment and Prevention

(2014) Chih-Hsin Tang et al.   Biomed Research International

Targeting acute myeloid leukemia with a proapoptotic peptide conjugated to a toll-like receptor 2-mediated cell-penetrating peptide

(2013) Ke Li et al.   INTERNATIONAL JOURNAL OF CANCER

Amot130 Adapts Atrophin-1 Interacting Protein 4 to Inhibit Yes-associated Protein Signaling and Cell Growth

(2013) Jacob J. Adler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization

(2013) Koji Ando et al.   JOURNAL OF CELL BIOLOGY

EGF receptor trafficking: consequences for signaling and cancer

(2013) Alejandra Tomas et al.   TRENDS IN CELL BIOLOGY

FGD5 Mediates Proangiogenic Action of Vascular Endothelial Growth Factor in Human Vascular Endothelial Cells

(2012) Yusuke Kurogane et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

Cdc42 promotes transendothelial migration of cancer cells through β1 integrin

(2012) Nicolas Reymond et al.   JOURNAL OF CELL BIOLOGY

HECT and RING finger families of E3 ubiquitin ligases at a glance

(2012) M. B. Metzger et al.   JOURNAL OF CELL SCIENCE

Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

(2012) Ryotaro Sakamori et al.   JOURNAL OF CLINICAL INVESTIGATION

TBCRC 001: Randomized Phase II Study of Cetuximab in Combination With Carboplatin in Stage IV Triple-Negative Breast Cancer

(2012) Lisa A. Carey et al.   JOURNAL OF CLINICAL ONCOLOGY

The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein

(2012) W. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

(2012) Sohrab P. Shah et al.   NATURE

Transducer of Cdc42-dependent actin assembly promotes breast cancer invasion and metastasis

(2012) H Chander et al.   ONCOGENE

Protein expression, gene amplification, and mutational analysis of EGFR in triple-negative breast cancer

(2012) Hiroki Nakajima et al.   Breast Cancer

Negative Regulation of the Hippo Pathway by E3 Ubiquitin Ligase ITCH Is Sufficient to Promote Tumorigenicity

(2011) Z. Salah et al.   CANCER RESEARCH

Overcoming resistance to tyrosine kinase inhibitors: Lessons learned from cancer cells treated with EGFR antagonists

(2011) Brent N. Rexer et al.   CELL CYCLE

Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability

(2011) K. C. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity for Stem Cell-Related Markers According to Tumor Subtype and Histologic Stage in Breast Cancer

(2010) S. Y. Park et al.   CLINICAL CANCER RESEARCH

Targeting Breast Cancer Stem Cells

(2010) Suling Liu et al.   JOURNAL OF CLINICAL ONCOLOGY

HECT E3 Ubiquitin Ligase Nedd4-1 Ubiquitinates ACK and Regulates Epidermal Growth Factor (EGF)-Induced Degradation of EGF Receptor and ACK

(2010) Q. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Minireview: Basal-Like Breast Cancer: From Molecular Profiles to Targeted Therapies

(2010) Daniel J. Toft et al.   MOLECULAR ENDOCRINOLOGY

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics

(2009) B. T. Hennessy et al.   CANCER RESEARCH

Gene-Expression Signatures in Breast Cancer

(2009) Christos Sotiriou et al.   NEW ENGLAND JOURNAL OF MEDICINE

KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program

(2008) J. H. J. M. van Krieken et al.   VIRCHOWS ARCHIV