Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Agnese Fiori, Stefanie Uhlig, Harald Kluter, Karen Bieback
Summary: Mesenchymal stromal cells (MSC) have immunomodulatory effects on various immune cells. In this study, human adipose tissue-derived MSC (ASC) were found to inhibit CD4 + T cell proliferation, induce Treg cells, and modulate cytokine secretion, suggesting a potential role in immune regulation. These findings highlight the complex interplay between ASC and CD4 + T cells.
Review
Biochemistry & Molecular Biology
Kunal Dhume, Brandon Kaye, K. Kai McKinstry
Summary: CD4 T cells have both positive and negative impacts in infectious disease, cancer, autoimmunity, and allergy. They can differentiate into distinct effector subsets with specialized functions. Eomesodermin (Eomes) is an important transcription factor that may be targeted to improve clinical outcomes in CD4 T cell responses.
Review
Immunology
Carsten Riether
Summary: Adult bone marrow hematopoietic stem cells (HSCs) maintain their function through interactions with regulatory T cells (Tregs). In leukemia, these regulatory mechanisms are disrupted, leading to compromised treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Fabienne Mazerolles, Frederic Rieux-Laucat
Summary: The expression of co-signalling receptors on T cells plays a crucial role in regulating T cell responses, and an imbalance between activating and inhibitory signals may lead to autoimmunity. Research showed that activated TEFFs and TREGs express different co-signalling receptors, and the expression of PD-L1 on activated TEFFs is correlated with their proliferation.
Article
Immunology
Derek J. Hanson, Hu Xie, Danielle M. Zerr, Wendy M. Leisenring, Keith R. Jerome, Meei-Li Huang, Terry Stevens-Ayers, Michael Boeckh, David M. Koelle, Joshua A. Hill
Summary: This study aimed to determine the correlation between donor-derived HHV-6B-specific CD4(+) T-cell abundance and HHV-6B detection post allogeneic hematopoietic cell transplantation. The findings suggest that donor-derived immunity plays a critical role in controlling HHV-6B reactivation among transplant recipients.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Ying Pan, Huiping Wang, Furun An, Fan Wu, Qianshan Tao, Yingwei Li, Yanjie Ruan, Zhimin Zhai
Summary: This study found that higher levels of circulating Tregs, especially one week after CD19 CAR-T cell infusion, served as a poor predictor for CD19 CAR-T therapy in R/R B-ALL patients, indicating a significant association with treatment efficacy and prognosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Yuekang Xu, Fengge Wang, Meng Liu, Dan Ma, Zecheng Cai, Lei Liu, Juncheng Wang, Wenjie Zhang, Lin Zhao, Chengfeng Zhai
Summary: A study showed that metabolic products from dendritic cells (DCs) play an important role in the development of atherosclerosis. Through experiments on pro-atherosclerotic mice, researchers found that DCs-produced IDO can induce the expansion of CD4+CD25+Foxp3+Treg in the aorta through the IDO-Kyn-AHR axis, thereby reducing atherosclerotic lesions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Nicolas Sailliet, Hoa-Le Mai, Amandine Dupuy, Gaelle Tilly, Cynthia Fourgeux, Martin Braud, Magali Giral, Jean-Michel Robert, Nicolas Degauque, Richard Danger, Jeremie Poschmann, Sophie Brouard
Summary: In this study, single cell transcriptomics were used to characterize in vitro induced GZMB+ regulatory B cells (Bregs), showing differential gene expression involved in proliferation, apoptosis, metabolism, and antigen presentation. Compared to total B cells, Bregs exhibited strong inhibition of T cell genes associated with proliferation, activation, inflammation, and apoptosis. Lymphotoxin alpha (LTA) was identified as a new and potent Breg ligand implicated in Breg suppressive properties.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Aditi Narsale, Breanna Lam, Rosa Moya, TingTing Lu, Alessandra Mandelli, Irene Gotuzzo, Benedetta Pessina, Glanmaria Giamporcaro, Rhonda Geoffrey, Kerry Buchanan, Mark Harris, Anne-Sophie Bergot, Ranjeny Thomas, Martin J. Hessner, Manuela Battaglia, Elisavet Serti, Joanna D. Davies
Summary: The study confirms the important role of CD4(+)CD25(+)CD127(hi) cells in partial remission and immunotherapy outcomes in T1D patients, showing their maintenance of an antiinflammatory environment is crucial for partial remission, 11 cell survival, and response to antiinflammatory immunotherapy.
Article
Immunology
Clarissa Heck, Sophie Steiner, Eva M. Kaebisch, Marco Frentsch, Friedrich Wittenbecher, Carmen Scheibenbogen, Leif G. Hanitsch, Axel Nogai, Philipp le Coutre, Lars Bullinger, Igor-Wolfgang Blau, Il-Kang Na
Summary: This study revealed quantitative and functional B cell defects in multiple myeloma patients undergoing auto-HSCT, leading to compromised immune defense. Stimulation with CD40L/IL-21 partially restored TD B cell function, indicating potential extrinsic drivers of the functional B cell defect. Testing CD4+, CD19+, memory B cells, and MZ-like B cells as biomarkers in prospective studies is suggested.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Lea Flippe, Anne Gaignerie, Celine Serazin, Olivier Baron, Xavier Saulquin, Ignacio Anegon, Laurent David, Carole Guillonneau
Summary: Immunotherapy using primary T cells has greatly improved medical care in recent years, but limitations such as challenging cell genome editing and lack of standardized products have restricted its clinical use. The use of T cells derived from human pluripotent stem cells offers advantages of genetic modification and standardized allogeneic products. However, more research is needed to fully understand the feasibility and functionality of these T cells before clinical applications. This study successfully generated T cells from induced pluripotent stem cells, demonstrating the potential for therapeutic use and treatment of various diseases.
Article
Immunology
Qiao Liu, Lisha Wang, Huayu Lin, Zhiming Wang, Jialin Wu, Junyi Guo, Shuqiong Wen, Ling Ran, Zhengliang Yue, Xingxing Su, Qing Wu, Jianfang Tang, Zhirong Li, Li Hu, Lifan Xu, Lilin Ye, Qizhao Huang
Summary: Cytotoxic CD8(+) T cells are the main focus of anti-tumor immunity and immunotherapy research, but transferred tumor-specific CD8(+) T cells have limited effect on suppressing tumor growth. On the other hand, CD4(+) T cells play an important role in curtailing tumor metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sung Won Lee, Hyun Jung Park, Luc Van Kaer, Seokmann Hong
Summary: In this study, the deficiency of CD1d-restricted iNKT cells was found to lead to the expansion of Foxp3(-)CD25(+)CD4(+) T cells in colitis. The MLN dendritic cells in DSS-treated Yeti/CD1d KO mice were shown to promote the differentiation of these cells. Furthermore, Foxp3(-)CD25(+)CD4(+) T cells were found to be pathogenic in DSS-treated Yeti/CD1d KO mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Runfeng Miao, Harim Chun, Xing Feng, Ana Cordeiro Gomes, Jungmin Choi, Joao P. Pereira
Summary: This study reveals that a complex homeostatic balance between hematopoietic stem cells (HSCs) and hematopoietic progenitor cells is maintained through competition for a limited amount of cell signaling molecule. When early hematopoietic progenitors fail to interact with specific cells, HSC numbers increase.
NATURE COMMUNICATIONS
(2022)