期刊
EUROPEAN JOURNAL OF CANCER
卷 44, 期 15, 页码 2144-2151出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2008.06.044
关键词
PIM1; Kinase; Lymphomas; Carcinomas; Target inhibitors
类别
资金
- SCS [MN-005, MN-077]
- Singapore Cancer Syndicate, Agency for Science, Technology and Research, Singapore
In vitro experiments have shown the PIM1 kinase to have diverse biological roles in cell survival, proliferation and differentiation. In humans, PIM1 is often expressed in both normal and transformed cells. The PIM1 kinase is a true oncogene implicated in early transformation and tumour progression in haematopoietic malignancies and prostate carcinomas. it is associated with aggressive subgroups of lymphoma, is a marker of poor prognosis in prostate carcinomas and has been suggested to have a role in hormone insensitivity of prostate malignancies. PIM1 has a possible role in other carcinomas with 6p21 genomic alterations. On one hand, PIM1 (due to its role in malignancy) appears to be a promising target for drug development programmes but, on the other hand, the complexity of its molecular structure has posed challenges in the development of PIM1 inhibitors. In this review we discuss PIM1 expression in human tissues (including some new data from our laboratory), its role in human malignancies, as well as the possibilities and challenges in the development of target therapy for PIM1. (c) 2008 Elsevier Ltd. All rights reserved.
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