Article
Biochemistry & Molecular Biology
Hitomi Maruta, Reina Abe, Hiromi Yamashita
Summary: Acetic acid can improve age-related changes in skeletal muscle of aging rats by activating AMP-activated protein kinase, including decreasing the expression of atrophy-related genes, activating AMP-activated protein kinase, promoting mitochondrial proliferation, and affecting the expression of type I fiber-related molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jinzhi Li, Hequan Zhong, Songping Liu, Jimin Shi, Xiaohui Zhou, Bing Li
Summary: Sleep deprivation during pregnancy negatively affects fetal outcomes, potentially through the oxido-inflammatory process.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Pediatrics
Siti Rosmani Md Zin, Mohammed Abdullah Alshawsh, Zahurin Mohamed
Summary: The study evaluated the potential effects of different doses of A. hierochuntica aqueous extract on skeletal development of rat foetuses and developed a simplified skeletal staining procedure for assessment. Results indicated potential toxicity effects of AHAE on developing foetuses, leading to skeletal anomalies.
Article
Engineering, Environmental
Di Lv, Hongyun Liu, Qi An, Chengwei Lei, Yanxuan Wang, Jin Sun, Chuanhai Li, Yongfeng Lin, Qing Dong, Zhugen Yang, Kui Che, Wendong Liu, Wenchao Han
Summary: This study found that exposure to GenX in pregnant rats leads to developmental delays in their offspring and causes inflammation in the placenta. The results suggest that placental inflammation may play a key role in this process through the Rap1 signaling pathway.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Biochemistry & Molecular Biology
Yun Ma, Hitomi Maruta, Baojun Sun, Chengduo Wang, Chiaki Isono, Hiromi Yamashita
Summary: Taurine is a free amino acid present abundantly in mammalian tissues, and long-term administration of taurine at relatively low doses can attenuate age-related decline in oxygen consumption and spontaneous locomotor activity. This effect may be mediated through the modulation of respiratory metabolism and skeletal muscle function by various molecular factors.
Article
Biochemistry & Molecular Biology
Chinedum Eleazu, Joseph B. Suleiman, Zaidatul A. Othman, Zaida Zakaria, Victor U. Nna, Mahaneem Mohamed
Summary: Obesity is a global health problem, and bee bread has been shown to prevent or attenuate obesity-induced muscular pathology, making it a potential functional food for preventing or mitigating obesity-related issues.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Tyler C. Dunham, Jensen E. Murphy, Rebecca E. K. MacPherson, Val Andrew Fajardo, Wendy E. Ward, Brian D. Roy
Summary: This study found that there are sex- and tissue-dependent responses to creatine monohydrate (CM) supplementation in rats. Additionally, total creatine concentrations in muscles were significantly higher in female rats compared to males.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Raja Zaidatul Akhmar Raja Jamaluddin, Musa Ahmad, Lee Yook Heng, Ling Ling Tan
Summary: An optical microsensor based on poly(n- butyl acrylate) microspheres film was developed for the quantification of boric acid in food samples. The immobilized alizarin red S reagent on the polyacrylate microspheres film was characterized using fluorescence transduction. The developed microsensor showed a quick optical sensing response, a useful dynamic linear response range, and promising reproducibility results.
Article
Chemistry, Applied
Ying Jin, Soek Sin Teh, Harrison Lik Nang Lau, Siau Hui Mah
Summary: This study evaluated the toxicity effects of refined red palm-pressed mesocarp olein (PPMO) recovered from palm oil mill by-product. The results indicated that PPMO is safe up to a certain dosage and can be used as a food additive. Additionally, the study provides insights into alternative utilization of wastes from palm oil mills.
JOURNAL OF OLEO SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Juan Mauricio Minoia, Maria Fernanda Filia, Martin Ignacio Roma, Fernanda Teresa De Fino, Guillermo Javier Copello, Roxana Noemi Peroni
Summary: This study investigated the effect of sustained drug treatment in utero on MDR transporters in placenta and fetal tissues. The results showed that chronic exposure to AZT induced BCRP expression in the placenta and fetal liver, reducing its own accumulation and DNA damage in fetal liver cells, while 3TC caused higher levels of DNA damage.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Developmental Biology
Howard M. Solomon, Stacia Murzyn, Joyce Rendemonti, Sharon Chapman, Shih-Hsun Cheng, Beat M. Jucker, Dinesh Stanislaus, Andrew Gehman, Hasan Alsaid
Summary: This study aimed to compare alizarin red stain and micro-CT images for examining fetal rabbit skeletons, and determine if the results were consistent regardless of the method used. The results showed that micro-CT imaging is a realistic and robust alternative to staining for analyzing fetal rabbit skeletons in developmental toxicity studies.
BIRTH DEFECTS RESEARCH
(2023)
Article
Toxicology
Chelsea M. Cary, Talia N. Seymore, Dilpreet Singh, Kinal N. Vayas, Michael J. Goedken, Samantha Adams, Marianne Polunas, Vasanthi R. Sunil, Debra L. Laskin, Philip Demokritou, Phoebe A. Stapleton
Summary: This study assessed the toxicological consequences of inhalation exposure to polyamide micro- and nanoplastic particles (MNPs). The results showed that inhalation of MNPs can lead to inflammation, cardiovascular dysfunction, and endocrine disruption. These findings are important for understanding the toxicity of inhaled plastic particles.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Article
Environmental Sciences
Justin M. Conley, Christy S. Lambright, Nicola Evans, James McCord, Mark J. Strynar, Donna Hill, Elizabeth Medlock-Kakaley, Vickie S. Wilson, L. Earl Gray
Summary: HFPO-DA is a developmental toxicant in rats, causing biological changes in maternal and fetal livers, decreased pup birth weight and increased neonatal mortality, as well as metabolic abnormalities at birth. The potency of HFPO-DA in rats is comparable to PFOS based on serum concentration, and the spectrum of adverse effects is consistent with other PFAS such as PFOS and PFOA.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Pediatrics
Pascale Bach, Marie Cassart, Myriam Chami, Catherine Garel, Michel Panuel
Summary: This study discusses guidelines from the Fetal Imaging Task Force of the European Society of Paediatric Radiology for indications, protocols, and reporting of ultra-low-dose fetal CT. Ultra-low-dose fetal CT is a useful complementary tool that can significantly improve prenatal diagnostic accuracy in select cases.
PEDIATRIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shuzhe Wang, Yan Wang, Bohua Xu, Tian Qin, Yupeng Lv, Heng Yan, Yifei Shao, Yangyang Fang, Shaoqiu Zheng, Yunliang Qiu
Summary: This study developed a method to label human bone marrow mesenchymal stem cells (hMSCs) with Zr-89-oxine and characterized their biodistribution in rats using real-time micro-PET/CT imaging. The labeled hMSCs were mainly found in the liver and spleen, providing insights into the mechanism and migration dynamics of cell therapy products.
NUCLEAR MEDICINE COMMUNICATIONS
(2022)