Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat

Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)

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Evidence of Air Dispersion: HFPO–DA and PFOA in Ohio and West Virginia Surface Water and Soil near a Fluoropolymer Production Facility

(2020) Jason E. Galloway et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes

(2020) Aidan McGlinchey et al.   ENVIRONMENT INTERNATIONAL

Adverse Maternal, Fetal, and Postnatal Effects of Hexafluoropropylene Oxide Dimer Acid (GenX) from Oral Gestational Exposure in Sprague-Dawley Rats

(2019) Justin M. Conley et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Associations of Perfluoroalkyl and Polyfluoroalkyl Substances With Incident Diabetes and Microvascular Disease

(2019) Andres Cardenas et al.   DIABETES CARE

Comparing the toxic potency in vivo of long-chain perfluoroalkyl acids and fluorinated alternatives

(2018) Melissa I. Gomis et al.   ENVIRONMENT INTERNATIONAL

Validation of quantitative measurements and semi-quantitative estimates of emerging perfluoroethercarboxylic acids (PFECAs) and hexfluoroprolyene oxide acids (HFPOAs)

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The Opportunities and Challenges of Peroxisome Proliferator-Activated Receptors Ligands in Clinical Drug Discovery and Development

(2018) Fan Hong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Presence of Emerging Per- and Polyfluoroalkyl Substances (PFASs) in River and Drinking Water near a Fluorochemical Production Plant in the Netherlands

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The margin of internal exposure (MOIE) concept for dermal risk assessment based on oral toxicity data – A case study with caffeine

(2017) Jos G.M. Bessems et al.   TOXICOLOGY

PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling

(2017) Mitchell B. Rosen et al.   TOXICOLOGY

Perfluorooctanoic acid exposure disturbs glucose metabolism in mouse liver

(2017) Fei Zheng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

RNA-sequencing analysis reveals the hepatotoxic mechanism of perfluoroalkyl alternatives, HFPO2 and HFPO4, following exposure in mice

(2016) Jianshe Wang et al.   JOURNAL OF APPLIED TOXICOLOGY

Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production

(2016) Stephanie R. Wesolowski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Absorption, distribution, metabolism, excretion, and kinetics of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid ammonium salt following a single dose in rat, mouse, and cynomolgus monkey

(2016) Shawn A. Gannon et al.   TOXICOLOGY

Legacy and Emerging Perfluoroalkyl Substances Are Important Drinking Water Contaminants in the Cape Fear River Watershed of North Carolina

(2016) Mei Sun et al.   Environmental Science & Technology Letters

Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction

(2015) Laura D. Brown et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The impact of PPARα activation on whole genome gene expression in human precision cut liver slices

(2015) Aafke W.F. Janssen et al.   BMC GENOMICS

Identification of Novel Perfluoroalkyl Ether Carboxylic Acids (PFECAs) and Sulfonic Acids (PFESAs) in Natural Waters Using Accurate Mass Time-of-Flight Mass Spectrometry (TOFMS)

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Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: A systematic review

(2014) Cathrine Carlsen Bach et al.   CRITICAL REVIEWS IN TOXICOLOGY

Diagnosis and management of glycogen storage disease type I: a practice guideline of the American College of Medical Genetics and Genomics

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Integrated physiology and systems biology of PPARα

(2014) Sander Kersten   Molecular Metabolism

Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

(2013) J. Christopher Corton et al.   CRITICAL REVIEWS IN TOXICOLOGY

Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys

(2011) Shu-Ching Chang et al.   REPRODUCTIVE TOXICOLOGY

Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring

(2011) Tian Chen et al.   REPRODUCTIVE TOXICOLOGY

Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes

(2011) J.A. Bjork et al.   TOXICOLOGY

Nutritional programming of the metabolic syndrome

(2009) Michael E. Symonds et al.   Nature Reviews Endocrinology

Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human

(2009) Maryam Rakhshandehroo et al.   PLoS One

Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPARα) in the mouse

(2008) Barbara D. Abbott et al.   REPRODUCTIVE TOXICOLOGY