A consideration of the evidence that genetic defects in planar cell polarity contribute to the etiology of human neural tube defects

Role of the planar cell polarity gene CELSR1 in neural tube defects and caudal agenesis

(2012) Redouane Allache et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis

(2012) Hirotaka Tao et al.   DEVELOPMENTAL BIOLOGY

Identification of novel rare mutations of DACT1 in human neural tube defects

(2012) Yan Shi et al.   HUMAN MUTATION

Getting to the heart of planar cell polarity signaling

(2011) Deborah J. Henderson et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Principles of planar polarity in animal development

(2011) L. V. Goodrich et al.   DEVELOPMENT

Cdx mediates neural tube closure through transcriptional regulation of the planar cell polarity gene Ptk7

(2011) Joanne G. A. Savory et al.   DEVELOPMENT

Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development

(2011) Y. Mao et al.   DEVELOPMENT

Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

(2011) Ryan S. Gray et al.   DEVELOPMENTAL CELL

Wnt Signaling Gradients Establish Planar Cell Polarity by Inducing Vangl2 Phosphorylation through Ror2

(2011) Bo Gao et al.   DEVELOPMENTAL CELL

PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube

(2011) Westley Heydeck et al.   DEVELOPMENTAL DYNAMICS

Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans

(2011) J. H. Seo et al.   HUMAN MOLECULAR GENETICS

FZD6is a novel gene for human neural tube defects

(2011) Patrizia De Marco et al.   HUMAN MUTATION

Mutations in the planar cell polarity genesCELSR1andSCRIBare associated with the severe neural tube defect craniorachischisis

(2011) Alexis Robinson et al.   HUMAN MUTATION

Identification and characterization of novel rare mutations in the planar cell polarity genePRICKLE1in human neural tube defects

(2011) Ciprian M. Bosoi et al.   HUMAN MUTATION

Pointing in the right direction: new developments in the field of planar cell polarity

(2011) Roy Bayly et al.   NATURE REVIEWS GENETICS

An ENU-Mutagenesis Screen in the Mouse: Identification of Novel Developmental Gene Functions

(2011) Carolien Wansleeben et al.   PLoS One

Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects

(2010) Li Wang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Planar cell polarity pathway genes and risk for spina bifida

(2010) Shu Wen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Mosaic expression of Med12 in female mice leads to exencephaly, spina bifida, and craniorachischisis

(2010) Pedro P. Rocha et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

The relationship between sonic Hedgehog signaling, cilia, and neural tube defects

(2010) Jennifer N. Murdoch et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure

(2010) Muriel J. Harris et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear

(2010) Anju Paudyal et al.   BMC DEVELOPMENTAL BIOLOGY

Contribution of VANGL2 mutations to isolated neural tube defects

(2010) Z Kibar et al.   CLINICAL GENETICS

Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling

(2010) P. P. Rocha et al.   DEVELOPMENT

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes

(2010) H. Yu et al.   DEVELOPMENT

Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b

(2010) C. Wansleeben et al.   DEVELOPMENT

PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals

(2010) Huiqing Zeng et al.   DEVELOPMENTAL BIOLOGY

Epidermal Wound Repair Is Regulated by the Planar Cell Polarity Signaling Pathway

(2010) Jacinta Caddy et al.   DEVELOPMENTAL CELL

The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation

(2010) Laura L. Yates et al.   HUMAN MOLECULAR GENETICS

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

(2010) Laura L. Yates et al.   HUMAN MOLECULAR GENETICS

Loss of Dact1 Disrupts Planar Cell Polarity Signaling by Altering Dishevelled Activity and Leads to Posterior Malformation in Mice

(2010) Jun Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VANGL1 rare variants associated with neural tube defects affect convergent extension in zebrafish

(2010) Annie Reynolds et al.   MECHANISMS OF DEVELOPMENT

Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning

(2010) Hai Song et al.   NATURE

Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia

(2010) Antonia Borovina et al.   NATURE CELL BIOLOGY

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus

(2010) Fadel Tissir et al.   NATURE NEUROSCIENCE

VANGL2Mutations in Human Cranial Neural-Tube Defects

(2010) Yun-Ping Lei et al.   NEW ENGLAND JOURNAL OF MEDICINE

Planar Cell Polarity Enables Posterior Localization of Nodal Cilia and Left-Right Axis Determination during Mouse and Xenopus Embryogenesis

(2010) Dragana Antic et al.   PLoS One

Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and β-catenin expression

(2009) Irina I. Nagy et al.   CARDIOVASCULAR RESEARCH

Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases

(2009) Masahiro Narimatsu et al.   CELL

Planar cell polarity effector geneFuzzyregulates cilia formation and Hedgehog signal transduction in mouse

(2009) Westley Heydeck et al.   DEVELOPMENTAL DYNAMICS

Novel mutations inVANGL1in neural tube defects

(2009) Zoha Kibar et al.   HUMAN MUTATION

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development

(2009) Ryan S. Gray et al.   NATURE CELL BIOLOGY

Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak

(2009) Rowena Suriben et al.   NATURE GENETICS

Development of the vertebrate central nervous system: formation of the neural tube

(2009) Nicholas D. E. Greene et al.   PRENATAL DIAGNOSIS

Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity

(2009) H. Tao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Planar Cell Polarity Signaling: From Fly Development to Human Disease

(2008) Matias Simons et al.   Annual Review of Genetics

An essential role for frizzled 5 in mammalian ocular development

(2008) C. Liu et al.   DEVELOPMENT

Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development

(2008) F. He et al.   DEVELOPMENT

Cthrc1 Selectively Activates the Planar Cell Polarity Pathway of Wnt Signaling by Stabilizing the Wnt-Receptor Complex

(2008) Shinji Yamamoto et al.   DEVELOPMENTAL CELL

Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/β-catenin and the planar cell polarity pathways during early trunk formation in mouse

(2008) Wataru Satoh et al.   GENESIS

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

(2008) Sakura Saburi et al.   NATURE GENETICS

Genetic interaction between members of the Vangl family causes neural tube defects in mice

(2008) E. Torban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Murine Dishevelled 3 Functions in Redundant Pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea, and Neural Tube Development

(2008) S. Leah Etheridge et al.   PLoS Genetics