Article
Clinical Neurology
Lars Vedel Kessing, Simon Christoffer Ziersen, Thomas Gerds, Esben Budtz-Jorgensen
Summary: This nationwide population-based longitudinal register linkage study aimed to investigate the long-term response to lithium in patients with bipolar disorder with and without comorbid epilepsy. The study also aimed to compare differences in responses between lithium, valproate, and lamotrigine within patients with comorbid bipolar disorder and epilepsy. The findings suggest that valproate and lamotrigine should be given priority in these patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Heinz Grunze, Martin Schaefer, Harald Scherk, Christoph Born, Ulrich W. Preuss
Summary: Comorbidity rates in Bipolar disorder are highest among major mental disorders, especially comorbid substance use. Alcohol is the most frequently abused substance, with significant influence on the severity and prognosis of Bipolar disorder. Further research is needed to develop evidence-based approaches for integrated treatment of this common comorbidity.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Gregory Jones, Carola Rong, Courtney M. Vecera, Christopher Gurguis, Roshan Chudal, Rushaniya Khairova, Edison Leung, Ana C. Ruiz, Lokesh Shahani, Marcus Zanetti, Rafael T. de Sousa, Geraldo Busatto, Jair Soares, Wagner F. Gattaz, Rodrigo Machado-Vieira
Summary: Lithium may play an important role in treating comorbid anxiety in bipolar disorder, both as adjunct and monotherapy. Lower doses of lithium may provide equivalent efficacy and enhance tolerability and compliance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Livia J. De Picker, Marion Leboyer, John R. Geddes, Manuel Morrens, Paul J. Harrison, Maxime Taquet
Summary: This study suggests that patients with therapeutic levels of lithium have a lower risk of COVID-19 infection, regardless of underlying psychiatric diagnosis or vaccination status, based on electronic health records.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
James A. Karantonis, Susan L. Rossell, Michael Berk, Tamsyn E. Van Rheenen
Summary: The study found a significant increase in subjective cognitive dysfunction in patients with bipolar disorder during the COVID-19 pandemic, but no substantial differences were observed in mood symptoms, fear of COVID-19, lifestyle factors, and social rhythms between patients and healthy controls, indicating a degree of resilience in bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Valentina Ciullo, Federica Piras, Nerisa Banaj, Daniela Vecchio, Fabrizio Piras, Gabriele Sani, Giuseppe Ducci, Gianfranco Spalletta
Summary: This study examines timing abilities in bipolar disorder patients and finds increased variability of the internal clock, which is related to major depressive episodes and working memory functioning.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Giovanna Fico, Gerard Anmella, Marta Gomez-Ramiro, Carlota de Miquel, Diego Hidalgo-Mazzei, Mirko Manchia, Martin Alda, Ana Gonzalez-Pinto, Andre F. Carvalho, Eduard Vieta, Andrea Murru
Summary: This study aimed to explore the associations between duration of untreated illness (DUI), treatment response, and functioning in bipolar disorder (BD) patients. Results showed no significant correlation between DUI and FAST scores, while patients with longer DUI had poorer treatment response to lithium. Good response to lithium was associated with better global functioning.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Roger S. McIntyre, Yena Lee, Nelson B. Rodrigues, Flora Nasri, Guohui Lao, Wan Zeng, Biru Ye, Ripeng Li, Joshua D. Rosenblat, Rodrigo B. Mansur, Mehala Subramaniapillai, Leanna M. W. Lui, Kayla M. Teopiz, Tao Liu, Jiaqi Xiong, Ruoxi Zhang, Weicong Lu, Guiyun Xu, Xiong Huang, Kangguang Lin
Summary: This pilot study investigated the effects of rTMS on cognitive function in patients with bipolar disorder, demonstrating significant improvements in select cognitive domains for the active rTMS group compared to the sham group. No dyscognitive effects were observed across subdomains.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Neurosciences
Mahmoud Suliman, Michael W. Schmidtke, Miriam L. Greenberg
Summary: The current drugs used to treat bipolar disorder are not always effective and have serious side effects. The main barrier to developing new drugs is the lack of understanding of the therapeutic mechanisms of currently available drugs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Yingxu Duan, Fangxinrui Qiu, Jingyuan Zhou, Shiyu Liu, Die Zhao, Changjian Qiu
Summary: The combination of lamotrigine and valproic acid can cause severe skin rash and lymphadenopathy, as shown in this rare case. Caution should be taken during titration of these two drugs, and early withdrawal is recommended when signs of hypersensitivity appear.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Anna Van Meter, Joel Stoddard, Ian Penton-Voak, Marcus R. Munafo
Summary: The study found that interpretation bias training may help improve depressed mood and social functioning in individuals with bipolar disorder. Participants who underwent IBT experienced shifts in emotion interpretation, decreased depressed mood, and increased perceived familial support. These results suggest that IBT could be a beneficial and easily disseminated intervention for individuals with bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Roger S. McIntyre, Joshua D. Rosenblat, Nelson B. Rodrigues, Orly Lipsitz, David Chen-Li, Jung Goo Lee, Flora Nasri, Mehala Subramaniapillai, Kevin Kratiuk, Andrew Wang, Hartej Gill, Rodrigo B. Mansur, Roger Ho, Kangguang Lin, Yena Lee
Summary: The study found that intravenous ketamine can significantly improve cognitive function in TRD patients, especially in tests like DSST and PDQ-5-D. This improvement is mainly mediated by reduced depressive symptoms, indicating that ketamine has independent and rapid effects in promoting cognition.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Bhupendra Khobragade, Vikas Sharma, Smita N. Deshpande
Summary: The cognitive effects of tobacco use among women with schizophrenia, bipolar disorder, or depression have not been extensively studied. However, a study found that female tobacco users in these groups demonstrated poorer cognitive functioning and smoking may exacerbate cognitive dysfunction associated with major mental illnesses among women.
PSYCHIATRY RESEARCH
(2021)
Review
Medicine, Research & Experimental
Clement Delage, Maeva Palayer, Bruno Etain, Monique Hagenimana, Nathan Blaise, Julie Smati, Margot Chouchana, Vanessa Bloch, Valerie C. Besson
Summary: In many countries, valproate is indicated for epilepsy only, while its derivatives divalproex and valpromide are indicated for bipolar disorders only. However, the absorbed and active substance in all these drugs is the valproate ion.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Alessio Simonetti, Sherin Kurian, Johanna Saxena, Christopher D. Verrico, Jair C. Soares, Gabriele Sani, Kirti Saxena
Summary: This study found that executive dysfunction in youth with BD and BD-OFF positively correlated with levels of verbal aggression, while altered affective processing in youth with BD positively correlated with aggression but negatively correlated in BD-OFF. This suggests that impulsive aggressive behaviors in youth with BD arise from a combination of altered affective processing and executive dysfunction, while BD-OFF may have mechanisms of resilience.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Sonja M. C. de Zwarte, Rachel M. Brouwer, Ingrid Agartz, Martin Alda, Silvia Alonso-Lana, Carrie E. Bearden, Alessandro Bertolino, Aurora Bonvino, Elvira Bramon, Elizabeth E. L. Buimer, Wiepke Cahn, Erick J. Canales-Rodriguez, Dara M. Cannon, Tyrone D. Cannon, Xavier Caseras, Josefina Castro-Fornieles, Qiang Chen, Yoonho Chung, Elena de la Serna, Caterina del Mar Bonnin, Caroline Demro, Annabella Di Giorgio, Gaelle E. Doucet, Mehmet Cagdas Eker, Susanne Erk, Mar Fatjo-Vilas, Scott C. Fears, Sonya F. Foley, Sophia Frangou, Janice M. Fullerton, David C. Glahn, Vina M. Goghari, Jose M. Goikolea, Aaron L. Goldman, Ali Saffet Gonul, Oliver Gruber, Tomas Hajek, Emma L. Hawkins, Andreas Heinz, Ceren Hidiroglu Ongun, Manon H. J. Hillegers, Josselin Houenou, Hilleke E. Hulshoff Pol, Christina M. Hultman, Martin Ingvar, Viktoria Johansson, Erik G. Jonsson, Fergus Kane, Matthew J. Kempton, Marinka M. G. Koenis, Miloslav Kopecek, Bernd Kraemer, Stephen M. Lawrie, Rhoshel K. Lenroot, Machteld Marcelis, Venkata S. Mattay, Colm McDonald, Andreas Meyer-Lindenberg, Stijn Michielse, Philip B. Mitchell, Dolores Moreno, Robin M. Murray, Benson Mwangi, Leila Nabulsi, Jason Newport, Cheryl A. Olman, Jim van Os, Bronwyn J. Overs, Aysegul Ozerdem, Giulio Pergola, Marco M. Picchioni, Camille Piguet, Edith Pomarol-Clotet, Joaquim Radua, Ian S. Ramsay, Anja Richter, Gloria Roberts, Raymond Salvador, Aybala Saricicek Aydogan, Salvador Sarro, Peter R. Schofield, Esma M. Simsek, Fatma Simsek, Jair C. Soares, Scott R. Sponheim, Gisela Sugranyes, Timothea Toulopoulou, Giulia Tronchin, Eduard Vieta, Henrik Walter, Daniel R. Weinberger, Heather C. Whalley, Mon-Ju Wu, Nefize Yalin, Ole A. Andreassen, Christopher R. K. Ching, Sophia I. Thomopoulos, Theo G. M. van Erp, Neda Jahanshad, Paul M. Thompson, Rene S. Kahn, Neeltje E. M. van Haren
Summary: First-degree relatives of patients diagnosed with schizophrenia show widespread thinner cortex, while relatives of patients diagnosed with bipolar disorder show widespread larger cortical surface area. Both groups have lower IQ scores compared to controls, with schizophrenia relatives showing more pronounced brain abnormalities and bipolar disorder relatives showing weaker effects after adjusting for IQ or educational attainment.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Lara M. Wierenga, Gaelle E. Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Ole A. Andreassen, Alan Anticevic, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Anouk den Braber, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Vince D. Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Vincent P. Clark, Patricia J. Conrod, Annette Conzelmann, Fabrice Crivello, Christopher G. Davey, Erin W. Dickie, Stefan Ehrlich, Dennis Van't Ent, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Paola Fuentes-Claramonte, Eco J. C. de Geus, Annabella Di Giorgio, David C. Glahn, Ian H. Gotlib, Hans J. Grabe, Oliver Gruber, Patricia Gruner, Raquel E. Gur, Ruben C. Gur, Tiril P. Gurholt, Lieuwe de Haan, Beathe Haatveit, Ben J. Harrison, Catharina A. Hartman, Sean N. Hatton, Dirk J. Heslenfeld, Odile A. van den Heuvel, Ian B. Hickie, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony C. James, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Andrew J. Kalnin, Marieke Klein, Laura Koenders, Knut K. Kolskar, Bernd Kramer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina S. Lebedeva, Phil H. Lee, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Brenna C. McDonald, Colm McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Dennis van der Meer, Jose M. Menchon, Jilly Naaijen, Lars Nyberg, Jaap Oosterlaan, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Joaquim Radua, Andreas Reif, Genevieve Richard, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Kang Sim, Andrew Simmons, Jordan W. Smoller, Iris E. Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Philip R. Szeszko, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Julian N. Trollor, Anne Uhlmann, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Volzke, Henrik Walter, Lei Wang, Yang Wang, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather C. Whalley, Steven C. R. Williams, Katharina Wittfeld, Daniel H. Wolf, Margaret J. Wright, Yuliya N. Yoncheva, Marcus Zanetti, Georg C. Ziegler, Greig de Zubicaray, Paul M. Thompson, Eveline A. Crone, Sophia Frangou, Christian K. Tamnes
Summary: Males exhibit greater variability than females in many traits, which may have implications for understanding sex differences in health and disease. A mega-analysis of brain structure variability based on MRI data of 16,683 healthy individuals spanning nine decades of life reveals significant patterns of greater male than female between-subject variance in subcortical volumes, cortical surface area, and cortical thickness. These sex differences are present in childhood and may be influenced by early life genetic or gene-environment interaction mechanisms. The findings underscore the importance of individual differences within each sex, which may contribute to sex-specific vulnerability to disorders.
HUMAN BRAIN MAPPING
(2022)
Letter
Psychology, Clinical
A. R. Bland, J. P. Roiser, M. A. Mehta, B. J. Sahakian, T. W. Robbins, R. Elliott
PSYCHOLOGICAL MEDICINE
(2022)
Correction
Neurosciences
Qiang Luo, Barbara J. Sahakian
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Clinical
Lizhu Luo, Christelle Langley, Laura Moreno-Lopez, Keith Kendrick, David K. Menon, Emmanuel A. Stamatakis, Barbara J. Sahakian
Summary: This study examined the association between depressive symptoms in traumatic brain injury (TBI) patients and altered resting-state functional connectivity (rs-fc) or voxel-based morphology in brain regions involved in emotional regulation and associated with depression. The results showed a positive association between depression scores and rs-fc between limbic regions and cognitive control regions, while there was a negative association between depression scores and rs-fc between limbic and frontal regions involved in emotion regulation. These findings contribute to a better understanding of the mechanisms underlying depression following TBI and can inform treatment decisions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Lizhu Luo, Ting Yang, Xiaoxiao Zheng, Xindi Zhang, Shan Gao, Yunge Li, Emmanuel A. Stamatakis, Barbara Sahakian, Benjamin Becker, Qiyuan Lin, Keith M. Kendrick
Summary: The present study explores the association between childhood maltreatment and amygdala-based functional networks, and their potential contributions to depression and anxiety. The findings provide evidence for altered functional connectivity of centromedial amygdala associated with childhood maltreatment, which moderates levels of depression and anxiety in adulthood.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Martine Skumlien, Claire Mokrysz, Tom P. Freeman, Vincent Valton, Matthew B. Wall, Michael Bloomfield, Rachel Lees, Anna Borissova, Kat Petrilli, Manuela Giugliano, Denisa Clisu, Christelle Langley, Barbara J. Sahakian, H. Valerie Curran, Will Lawn
Summary: This study examined the association between cannabis use and anhedonia, apathy, pleasure, and effort-based decision-making for reward, and explored the moderating effect of age group.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xinran Wu, Lena Palaniyappan, Gechang Yu, Kai Zhang, Jakob Seidlitz, Zhaowen Liu, Xiangzhen Kong, Gunter Schumann, Jianfeng Feng, Barbara J. Sahakian, Trevor W. Robbins, Edward Bullmore, Jie Zhang
Summary: This study constructed a whole-brain morphometric similarity network and found that developmental dissimilarities between cortical and subcortical regions were associated with cognitive and psychiatric status during preadolescence.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Christelle Langley, Sophia Armand, Qiang Luo, George Savulich, Tina Segerberg, Anna Sondergaard, Elisabeth B. Pedersen, Nanna Svart, Oliver Overgaard-Hansen, Annette Johansen, Camilla Borgsted, Rudolf N. Cardinal, Trevor W. Robbins, Dea S. Stenbaek, Gitte M. Knudsen, Barbara J. Sahakian
Summary: This study aimed to investigate the chronic effects of the SSRI escitalopram on cognition in healthy volunteers. The findings revealed that escitalopram decreased reinforcement sensitivity but had no significant impact on "cold" cognition and decision-making ability. These findings suggest that serotonin reuptake inhibition plays a role in reinforcement learning in healthy individuals.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Barbara J. Sahakian
Summary: In this article, the author discusses the important areas where scientists can have impact, including problem solving, new developments, and addressing neuroethical and societal concerns. The author emphasizes the importance of early detection, pharmacological treatment, and neuropsychological understanding of cognitive deficits in neurodegenerative and neuropsychiatric disorders. The author also highlights the role of books, articles, and media in influencing government policy and encourages young scientists to contribute to policy development and public engagement.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Roxanne W. Hook, Masanori Isobe, George Savulich, Jon E. Grant, Konstantinos Ioannidis, David Christmas, Barbara J. Sahakian, Trevor W. Robbins, Samuel R. Chamberlain
Summary: This study found that single-dose istradefylline can impact human cognition, particularly in the social information preference task with emotional loading. This indicates the under-studied role of the adenosine neurochemical system in human cognition, which requires further exploration.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Antoine Lefrere, Guillaume Auzias, Pauline Favre, Irene Kaltenmark, Josselin Houenou, Camille Piguet, Mircea Polosan, Lisa T. Eyler, Mary L. Phillips, Amelia Versace, Michele Wessa, Colm McDonald, Dara M. Cannon, Paolo Brambilla, Marcella Bellani, Christine Deruelle, Raoul Belzeaux
Summary: This study explores the cortical folding in relation to neuro-developmental disorders, focusing on a neurodevelopmental subtype of bipolar disorders (BD-ND). It finds that BD-ND is associated with specific brain morphology revealed by the analysis of sulcal pits, suggesting potential insights into the neurodevelopment process and stratification of patients based on pathophysiological hypothesis.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Michal M. Graczyk, Barbara J. Sahakian, Trevor W. Robbins, Karen D. Ersche
Summary: Not everyone who uses drugs loses control over their intake, which is a hallmark of addiction. Although familial risk studies suggest significant addiction heritability, the genetic basis of vulnerability to drug addiction remains largely unknown. In this study, the researchers examined the relationship between self-control, cocaine use, and a specific gene variant (rs36024) associated with the noradrenaline transporter gene. They found that individuals carrying the C-allele of this gene exhibited impaired self-control, particularly in the context of chronic cocaine use. Patients with cocaine use disorder who had the CC genotype showed longer stop-signal reaction time and fewer successful stops compared to healthy controls and patients with the TT genotype. These findings suggest that rs36024 may be a potential genetic vulnerability marker for cocaine addiction.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Cell Biology
Yuzhu Li, Barbara J. Sahakian, Jujiao Kang, Christelle Langley, Wei Zhang, Chao Xie, Shitong Xiang, Jintai Yu, Wei Cheng, Jianfeng Feng
Summary: Sleep duration is closely connected with psychiatric disorders and dementias in older adults, with possible genetic mechanisms and brain structural changes underlying the relationship.
Correction
Cell Biology
Yuzhu Li, Barbara J. Sahakian, Jujiao Kang, Christelle Langley, Wei Zhang, Chao Xie, Shitong Xiang, Jintai Yu, Wei Cheng, Jianfeng Feng