LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells

Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture

(2012) Suresh Selvarasu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Flavogenomics - a genomic and structural view of flavin-dependent proteins

(2011) Peter Macheroux et al.   FEBS Journal

Glutathionylation Acts as a Control Switch for Uncoupling Proteins UCP2 and UCP3

(2011) Ryan J. Mailloux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of metabolic limitations during recombinant protein production in Escherichia coli

(2011) Jan Heyland et al.   JOURNAL OF BIOTECHNOLOGY

IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines

(2011) Steven C.L. Ho et al.   JOURNAL OF BIOTECHNOLOGY

Reexamination of the Role of Interplay between Glutathione and Protein Disulfide Isomerase

(2011) Anna-Kaisa Lappi et al.   JOURNAL OF MOLECULAR BIOLOGY

Biochemical and biophysical characterization of humanized IgG1 produced inPichia pastoris

(2011) Sha Ha et al.   mAbs

What's fueling the biotech engine—2010 to 2011

(2011) Saurabh Aggarwal   NATURE BIOTECHNOLOGY

Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation

(2010) Irina F. Sevrioukova   ANTIOXIDANTS & REDOX SIGNALING

Cell Engineering and Cultivation of Chinese Hamster Ovary (CHO) Cells

(2010) Takeshi Omasa et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Oxidatively generated base damage to cellular DNA

(2010) Jean Cadet et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase

(2010) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media

(2010) William P.K. Chong et al.   JOURNAL OF BIOTECHNOLOGY

Biopharmaceutical benchmarks 2010

(2010) Gary Walsh   NATURE BIOTECHNOLOGY

Rapid characterization of high/low producer CHO cells using matrix-assisted laser desorption/ionization time-of-flight

(2010) Hua-tao Feng et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

(2009) Célio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism

(2009) Ningning Ma et al.   BIOTECHNOLOGY PROGRESS

Positional effects of the matrix attachment region on transgene expression in stably transfected CHO cells

(2009) Tian‑Yun Wang et al.   CELL BIOLOGY INTERNATIONAL

Electron Transport Chain-dependent and -independent Mechanisms of Mitochondrial H2O2Emission during Long-chain Fatty Acid Oxidation

(2009) Erin L. Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomics for high-resolution monitoring of the cellular physiological state in cell culture engineering

(2009) Panagiotis K. Chrysanthopoulos et al.   METABOLIC ENGINEERING

Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture

(2009) William P. K. Chong et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

A study of monoclonal antibody-producing CHO cell lines: What makes a stable high producer?

(2008) Janet Chusainow et al.   BIOTECHNOLOGY AND BIOENGINEERING

Enhanced expression of transgene in CHO cells using matrix attachment region

(2008) T WANG et al.   CELL BIOLOGY INTERNATIONAL

Transcriptional Profiling of Gene Expression Changes in a PACE-Transfected CHO DUKX Cell Line Secreting High Levels of rhBMP-2

(2008) Padraig Doolan et al.   MOLECULAR BIOTECHNOLOGY